Motif ID: Ptf1a

Z-value: 0.650


Transcription factors associated with Ptf1a:

Gene SymbolEntrez IDGene Name
Ptf1a ENSMUSG00000026735.2 Ptf1a



Activity profile for motif Ptf1a.

activity profile for motif Ptf1a


Sorted Z-values histogram for motif Ptf1a

Sorted Z-values for motif Ptf1a



Network of associatons between targets according to the STRING database.



First level regulatory network of Ptf1a

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_+_91269759 12.963 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr7_-_79386943 9.792 ENSMUST00000053718.8
ENSMUST00000179243.1
 Rlbp1

retinaldehyde binding protein 1

chr4_-_64046925 8.567 ENSMUST00000107377.3
 Tnc
tenascin C
chr9_-_112187898 6.447 ENSMUST00000178410.1
ENSMUST00000172380.3
 Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr19_+_7056731 5.730 ENSMUST00000040261.5
 Macrod1
MACRO domain containing 1
chr9_-_112187766 5.445 ENSMUST00000111872.2
ENSMUST00000164754.2
 Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr9_-_112234956 5.044 ENSMUST00000162097.1
ENSMUST00000159055.1
 Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr11_+_78324200 4.160 ENSMUST00000102478.3
 Aldoc
aldolase C, fructose-bisphosphate
chr18_+_24709436 3.731 ENSMUST00000037097.7
 Fhod3
formin homology 2 domain containing 3
chr2_+_71981184 3.521 ENSMUST00000090826.5
ENSMUST00000102698.3
 Rapgef4

Rap guanine nucleotide exchange factor (GEF) 4

chr10_-_75932468 3.472 ENSMUST00000120281.1
ENSMUST00000000924.6
 Mmp11

matrix metallopeptidase 11

chr11_-_118355496 3.431 ENSMUST00000017610.3
 Timp2
tissue inhibitor of metalloproteinase 2
chr8_-_105295934 3.358 ENSMUST00000057855.3
 Exoc3l
exocyst complex component 3-like
chr14_-_70207637 2.799 ENSMUST00000022682.5
 Sorbs3
sorbin and SH3 domain containing 3
chr9_+_106477269 2.733 ENSMUST00000047721.8
 Rrp9
RRP9, small subunit (SSU) processome component, homolog (yeast)
chr2_+_31470207 2.705 ENSMUST00000102840.4
 Ass1
argininosuccinate synthetase 1
chr3_-_141931523 2.667 ENSMUST00000106232.1
 Bmpr1b
bone morphogenetic protein receptor, type 1B
chr7_-_99182681 2.499 ENSMUST00000033001.4
 Dgat2
diacylglycerol O-acyltransferase 2
chr18_+_37477768 2.425 ENSMUST00000051442.5
 Pcdhb16
protocadherin beta 16
chr15_+_80097866 2.413 ENSMUST00000143928.1
 Syngr1
synaptogyrin 1
chr10_+_60346851 2.332 ENSMUST00000020301.7
ENSMUST00000105460.1
ENSMUST00000170507.1
 4632428N05Rik


RIKEN cDNA 4632428N05 gene


chr9_+_123021315 2.324 ENSMUST00000084733.5
 Tmem42
transmembrane protein 42
chr9_-_108597558 2.302 ENSMUST00000006853.5
 P4htm
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
chr2_+_164948219 2.284 ENSMUST00000017881.2
 Mmp9
matrix metallopeptidase 9
chr10_-_126901315 2.253 ENSMUST00000026504.5
ENSMUST00000168520.1
 Xrcc6bp1

XRCC6 binding protein 1

chr18_+_32377176 2.251 ENSMUST00000091967.5
ENSMUST00000025239.7
 Bin1

bridging integrator 1

chr11_+_19924403 2.043 ENSMUST00000093298.5
 Spred2
sprouty-related, EVH1 domain containing 2
chr10_+_86021961 2.043 ENSMUST00000130320.1
 Fbxo7
F-box protein 7
chr11_+_49247462 1.716 ENSMUST00000109194.1
 Mgat1
mannoside acetylglucosaminyltransferase 1
chr4_-_88438900 1.702 ENSMUST00000132493.1
ENSMUST00000030221.2
ENSMUST00000151280.1
 Ptplad2


protein tyrosine phosphatase-like A domain containing 2


chr11_-_93965957 1.618 ENSMUST00000021220.3
 Nme1
NME/NM23 nucleoside diphosphate kinase 1
chr5_+_64970069 1.618 ENSMUST00000031080.8
 Fam114a1
family with sequence similarity 114, member A1
chr11_-_103344651 1.382 ENSMUST00000041385.7
 Arhgap27
Rho GTPase activating protein 27
chr8_-_13890233 1.299 ENSMUST00000033839.7
 Coprs
coordinator of PRMT5, differentiation stimulator
chr19_+_9982694 1.166 ENSMUST00000025563.6
 Fth1
ferritin heavy chain 1
chr11_-_90390895 1.160 ENSMUST00000004051.7
 Hlf
hepatic leukemia factor
chr7_-_79842287 1.137 ENSMUST00000049004.6
 Anpep
alanyl (membrane) aminopeptidase
chr11_-_109611417 1.120 ENSMUST00000103060.3
ENSMUST00000047186.3
ENSMUST00000106689.1
 Wipi1


WD repeat domain, phosphoinositide interacting 1


chr10_+_86022189 1.116 ENSMUST00000120344.1
ENSMUST00000117597.1
 Fbxo7

F-box protein 7

chr7_-_4532419 1.116 ENSMUST00000094897.4
 Dnaaf3
dynein, axonemal assembly factor 3
chr11_-_100441006 1.111 ENSMUST00000092689.2
 Nt5c3b
5'-nucleotidase, cytosolic IIIB
chr11_-_100441058 1.073 ENSMUST00000107399.2
ENSMUST00000092688.5
 Nt5c3b

5'-nucleotidase, cytosolic IIIB

chr11_-_96916448 1.046 ENSMUST00000103152.4
 Cdk5rap3
CDK5 regulatory subunit associated protein 3
chr16_+_96145391 1.012 ENSMUST00000023913.8
ENSMUST00000135448.1
 Wrb

tryptophan rich basic protein

chr10_+_90829538 1.006 ENSMUST00000179694.2
 Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr4_+_152096719 0.996 ENSMUST00000105661.3
ENSMUST00000084115.3
 Plekhg5

pleckstrin homology domain containing, family G (with RhoGef domain) member 5

chr11_+_78465697 0.957 ENSMUST00000001126.3
 Slc46a1
solute carrier family 46, member 1
chr5_-_31048014 0.943 ENSMUST00000137223.1
 Slc5a6
solute carrier family 5 (sodium-dependent vitamin transporter), member 6
chr11_+_120633719 0.907 ENSMUST00000181502.1
 Gm17586
predicted gene, 17586
chr1_+_92910805 0.858 ENSMUST00000179711.1
 Rnpepl1
arginyl aminopeptidase (aminopeptidase B)-like 1
chr2_-_7396192 0.749 ENSMUST00000137733.2
 Celf2
CUGBP, Elav-like family member 2
chr4_-_133887765 0.745 ENSMUST00000003741.9
ENSMUST00000105894.4
 Rps6ka1

ribosomal protein S6 kinase polypeptide 1

chr3_+_138277489 0.738 ENSMUST00000004232.9
 Adh1
alcohol dehydrogenase 1 (class I)
chr15_+_31276491 0.730 ENSMUST00000068987.5
 Fam136b-ps
family with sequence similarity 136, member B, pseudogene
chr11_+_70017085 0.706 ENSMUST00000108589.2
 Dlg4
discs, large homolog 4 (Drosophila)
chr17_-_27513341 0.676 ENSMUST00000118161.1
 Grm4
glutamate receptor, metabotropic 4
chr2_-_7395968 0.644 ENSMUST00000002176.6
 Celf2
CUGBP, Elav-like family member 2
chr5_+_34525797 0.624 ENSMUST00000125817.1
ENSMUST00000067638.7
 Sh3bp2

SH3-domain binding protein 2

chr14_-_55944536 0.613 ENSMUST00000022834.6
 Cma1
chymase 1, mast cell
chr2_-_118703963 0.600 ENSMUST00000104937.1
 Ankrd63
ankyrin repeat domain 63
chr1_+_92910758 0.590 ENSMUST00000027487.8
 Rnpepl1
arginyl aminopeptidase (aminopeptidase B)-like 1
chr11_-_100440928 0.568 ENSMUST00000107397.1
 Nt5c3b
5'-nucleotidase, cytosolic IIIB
chr11_+_48800357 0.553 ENSMUST00000020640.7
 Gnb2l1
guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1
chr2_+_25500750 0.549 ENSMUST00000015239.3
 Fbxw5
F-box and WD-40 domain protein 5
chr11_-_96916366 0.541 ENSMUST00000144731.1
ENSMUST00000127048.1
 Cdk5rap3

CDK5 regulatory subunit associated protein 3

chr11_-_96916407 0.465 ENSMUST00000130774.1
 Cdk5rap3
CDK5 regulatory subunit associated protein 3
chr7_+_46396439 0.434 ENSMUST00000025202.6
 Kcnc1
potassium voltage gated channel, Shaw-related subfamily, member 1
chr11_+_98446826 0.410 ENSMUST00000019456.4
 Grb7
growth factor receptor bound protein 7
chr9_-_44735189 0.380 ENSMUST00000034611.8
 Phldb1
pleckstrin homology-like domain, family B, member 1
chr3_-_108445183 0.368 ENSMUST00000090553.5
ENSMUST00000153499.1
 Sars

seryl-aminoacyl-tRNA synthetase

chr15_-_99087817 0.351 ENSMUST00000064462.3
 C1ql4
complement component 1, q subcomponent-like 4
chr8_-_85299483 0.350 ENSMUST00000034131.8
 Vps35
vacuolar protein sorting 35
chr10_-_95417099 0.312 ENSMUST00000135822.1
 Socs2
suppressor of cytokine signaling 2
chr2_-_91950386 0.301 ENSMUST00000111303.1
 Dgkz
diacylglycerol kinase zeta
chr10_+_98915117 0.294 ENSMUST00000020107.7
 Atp2b1
ATPase, Ca++ transporting, plasma membrane 1
chr1_+_36691487 0.289 ENSMUST00000081180.4
 Cox5b
cytochrome c oxidase subunit Vb
chr18_+_34331132 0.260 ENSMUST00000072576.3
ENSMUST00000119329.1
 Srp19

signal recognition particle 19

chrX_+_166238923 0.250 ENSMUST00000060210.7
ENSMUST00000112233.1
 Gpm6b

glycoprotein m6b

chr17_-_28517509 0.236 ENSMUST00000114792.1
ENSMUST00000177939.1
 Fkbp5

FK506 binding protein 5

chr6_+_83078339 0.236 ENSMUST00000165164.2
ENSMUST00000092614.2
 Pcgf1

polycomb group ring finger 1

chr8_+_94857450 0.231 ENSMUST00000109521.3
 Polr2c
polymerase (RNA) II (DNA directed) polypeptide C
chrX_-_164076482 0.221 ENSMUST00000134272.1
 Siah1b
seven in absentia 1B
chr6_+_83078606 0.197 ENSMUST00000177177.1
ENSMUST00000176089.1
 Pcgf1

polycomb group ring finger 1

chrX_+_101383726 0.152 ENSMUST00000119190.1
 Gjb1
gap junction protein, beta 1
chr9_-_108305941 0.149 ENSMUST00000044725.7
 Tcta
T cell leukemia translocation altered gene
chr12_+_112760652 0.113 ENSMUST00000063888.3
 Pld4
phospholipase D family, member 4
chr10_+_42678890 0.088 ENSMUST00000040718.5
 Ostm1
osteopetrosis associated transmembrane protein 1
chr7_+_19131686 0.079 ENSMUST00000165913.1
 Fbxo46
F-box protein 46
chr4_+_115088708 0.059 ENSMUST00000171877.1
ENSMUST00000177647.1
ENSMUST00000106548.2
ENSMUST00000030488.2
 Pdzk1ip1



PDZK1 interacting protein 1




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 8.6 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
1.4 5.7 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.9 3.5 GO:1904457 positive regulation of neuronal action potential(GO:1904457)
0.7 2.7 GO:0010046 arginine biosynthetic process(GO:0006526) response to mycotoxin(GO:0010046)
0.7 2.7 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.6 3.4 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.5 2.3 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.4 1.7 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.4 2.5 GO:0035356 cellular triglyceride homeostasis(GO:0035356)
0.4 4.2 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.4 3.2 GO:1903207 neuron death in response to hydrogen peroxide(GO:0036476) regulation of hydrogen peroxide-induced neuron death(GO:1903207) negative regulation of hydrogen peroxide-induced neuron death(GO:1903208)
0.3 16.9 GO:0034605 cellular response to heat(GO:0034605)
0.3 1.0 GO:0015886 heme transport(GO:0015886)
0.3 3.7 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.3 3.4 GO:0051601 exocyst localization(GO:0051601)
0.3 1.3 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.2 0.7 GO:0034310 primary alcohol catabolic process(GO:0034310)
0.2 0.9 GO:0035461 vitamin transmembrane transport(GO:0035461)
0.2 3.5 GO:0030574 collagen catabolic process(GO:0030574)
0.2 2.1 GO:0071569 protein ufmylation(GO:0071569)
0.2 1.6 GO:0006228 UTP biosynthetic process(GO:0006228)
0.2 0.4 GO:1903181 regulation of dopamine biosynthetic process(GO:1903179) positive regulation of dopamine biosynthetic process(GO:1903181)
0.2 2.3 GO:0048711 positive regulation of astrocyte differentiation(GO:0048711)
0.1 2.0 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.1 13.0 GO:0048663 neuron fate commitment(GO:0048663)
0.1 1.0 GO:0071816 tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.1 0.4 GO:1904046 seryl-tRNA aminoacylation(GO:0006434) negative regulation of vascular endothelial growth factor production(GO:1904046)
0.1 2.4 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.1 0.7 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
0.1 0.7 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.1 2.4 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 1.1 GO:0035814 negative regulation of renal sodium excretion(GO:0035814)
0.1 1.1 GO:0048199 vesicle targeting, to, from or within Golgi(GO:0048199)
0.1 1.0 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.1 0.3 GO:1990034 calcium ion export from cell(GO:1990034)
0.1 0.7 GO:2000821 regulation of grooming behavior(GO:2000821)
0.1 1.2 GO:0097286 iron ion import(GO:0097286)
0.1 1.1 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.0 0.3 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0 2.8 GO:0051496 positive regulation of stress fiber assembly(GO:0051496)
0.0 0.3 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.0 2.3 GO:0045646 regulation of erythrocyte differentiation(GO:0045646)
0.0 0.4 GO:1903818 positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.0 0.3 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0 0.4 GO:2001197 regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
0.0 1.4 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 1.0 GO:0035767 endothelial cell chemotaxis(GO:0035767)
0.0 0.1 GO:0072675 osteoclast fusion(GO:0072675)
0.0 0.3 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.0 2.2 GO:0007601 visual perception(GO:0007601)
0.0 0.3 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.0 0.4 GO:0035518 histone H2A monoubiquitination(GO:0035518)
0.0 1.2 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 0.4 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.5 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.2 GO:0015868 purine ribonucleotide transport(GO:0015868)
0.0 2.7 GO:0006364 rRNA processing(GO:0006364)
0.0 0.6 GO:0032611 interleukin-1 beta production(GO:0032611)
0.0 0.4 GO:0048147 negative regulation of fibroblast proliferation(GO:0048147)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 3.5 GO:0044316 cone cell pedicle(GO:0044316)
0.6 3.2 GO:1990037 Lewy body core(GO:1990037)
0.5 8.6 GO:0005614 interstitial matrix(GO:0005614)
0.4 2.7 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.2 2.7 GO:0070852 cell body fiber(GO:0070852)
0.2 3.4 GO:0000145 exocyst(GO:0000145)
0.2 2.3 GO:0043196 varicosity(GO:0043196)
0.1 3.7 GO:0005865 striated muscle thin filament(GO:0005865)
0.1 0.4 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.1 1.2 GO:0044754 autolysosome(GO:0044754)
0.1 1.1 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.1 2.4 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.1 0.7 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 0.7 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 2.4 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 2.5 GO:0005811 lipid particle(GO:0005811)
0.0 0.3 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.0 0.3 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 13.0 GO:0005667 transcription factor complex(GO:0005667)
0.0 1.6 GO:0005882 intermediate filament(GO:0005882)
0.0 1.9 GO:0031526 brush border membrane(GO:0031526)
0.0 0.4 GO:0045180 basal cortex(GO:0045180)
0.0 4.1 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.4 GO:0005581 collagen trimer(GO:0005581)
0.0 0.3 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 1.1 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 0.4 GO:0032590 dendrite membrane(GO:0032590)
0.0 3.4 GO:0030426 growth cone(GO:0030426)
0.0 0.5 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.2 GO:0005922 connexon complex(GO:0005922)
0.0 0.2 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 2.8 GO:0030424 axon(GO:0030424)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 9.8 GO:0019841 retinol binding(GO:0019841)
1.4 8.6 GO:0045545 syndecan binding(GO:0045545)
0.8 2.5 GO:0003846 2-acylglycerol O-acyltransferase activity(GO:0003846)
0.7 4.2 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.7 2.7 GO:0034511 U3 snoRNA binding(GO:0034511)
0.4 1.7 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.3 2.0 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.3 1.0 GO:0015232 heme transporter activity(GO:0015232)
0.3 2.7 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.3 3.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.2 0.7 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.2 1.2 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.2 2.7 GO:0015643 toxic substance binding(GO:0015643)
0.2 2.8 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.2 2.8 GO:0017166 vinculin binding(GO:0017166)
0.1 0.7 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.1 1.6 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.1 2.3 GO:0031418 L-ascorbic acid binding(GO:0031418)
0.1 0.4 GO:0004828 serine-tRNA ligase activity(GO:0004828)
0.1 2.6 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 2.1 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.1 2.3 GO:0048156 tau protein binding(GO:0048156)
0.1 5.7 GO:0019213 deacetylase activity(GO:0019213)
0.1 0.7 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.1 3.5 GO:0030552 cAMP binding(GO:0030552)
0.1 0.9 GO:0090482 vitamin transmembrane transporter activity(GO:0090482)
0.1 2.3 GO:0001968 fibronectin binding(GO:0001968)
0.1 17.2 GO:0005516 calmodulin binding(GO:0005516)
0.1 0.3 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.0 1.1 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.3 GO:0008312 7S RNA binding(GO:0008312)
0.0 0.3 GO:0001727 lipid kinase activity(GO:0001727)
0.0 3.2 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.4 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 3.4 GO:0000149 SNARE binding(GO:0000149)
0.0 1.4 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.2 GO:0001055 RNA polymerase II activity(GO:0001055)
0.0 0.2 GO:0031748 D1 dopamine receptor binding(GO:0031748)
0.0 0.7 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.4 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 1.0 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.6 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.1 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.2 GO:0005243 gap junction channel activity(GO:0005243)
0.0 0.3 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.2 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.8 GO:0004222 metalloendopeptidase activity(GO:0004222)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 10.9 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.1 3.9 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.1 2.7 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.7 PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 4.4 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.6 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 2.0 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.5 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 0.4 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 1.4 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 1.2 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.6 PID_TCR_PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.3 PID_IL2_1PATHWAY IL2-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 9.8 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.1 4.2 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 3.5 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.1 2.7 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.1 2.8 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 0.9 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.1 1.6 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 2.1 REACTOME_IRON_UPTAKE_AND_TRANSPORT Genes involved in Iron uptake and transport
0.1 0.7 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 3.2 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 2.5 REACTOME_TRIGLYCERIDE_BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis
0.0 1.7 REACTOME_TRANSPORT_TO_THE_GOLGI_AND_SUBSEQUENT_MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 0.4 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 1.1 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.7 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.0 2.7 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.2 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.4 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.5 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.2 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 0.3 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling
0.0 0.4 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels