Motif ID: Ptf1a

Z-value: 0.650


Transcription factors associated with Ptf1a:

Gene SymbolEntrez IDGene Name
Ptf1a ENSMUSG00000026735.2 Ptf1a



Activity profile for motif Ptf1a.

activity profile for motif Ptf1a


Sorted Z-values histogram for motif Ptf1a

Sorted Z-values for motif Ptf1a



Network of associatons between targets according to the STRING database.



First level regulatory network of Ptf1a

PNG image of the network

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Top targets:


Showing 1 to 20 of 89 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_91269759 12.963 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr7_-_79386943 9.792 ENSMUST00000053718.8
ENSMUST00000179243.1
 Rlbp1

retinaldehyde binding protein 1

chr4_-_64046925 8.567 ENSMUST00000107377.3
 Tnc
tenascin C
chr9_-_112187898 6.447 ENSMUST00000178410.1
ENSMUST00000172380.3
 Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr19_+_7056731 5.730 ENSMUST00000040261.5
 Macrod1
MACRO domain containing 1
chr9_-_112187766 5.445 ENSMUST00000111872.2
ENSMUST00000164754.2
 Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr9_-_112234956 5.044 ENSMUST00000162097.1
ENSMUST00000159055.1
 Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr11_+_78324200 4.160 ENSMUST00000102478.3
 Aldoc
aldolase C, fructose-bisphosphate
chr18_+_24709436 3.731 ENSMUST00000037097.7
 Fhod3
formin homology 2 domain containing 3
chr2_+_71981184 3.521 ENSMUST00000090826.5
ENSMUST00000102698.3
 Rapgef4

Rap guanine nucleotide exchange factor (GEF) 4

chr10_-_75932468 3.472 ENSMUST00000120281.1
ENSMUST00000000924.6
 Mmp11

matrix metallopeptidase 11

chr11_-_118355496 3.431 ENSMUST00000017610.3
 Timp2
tissue inhibitor of metalloproteinase 2
chr8_-_105295934 3.358 ENSMUST00000057855.3
 Exoc3l
exocyst complex component 3-like
chr14_-_70207637 2.799 ENSMUST00000022682.5
 Sorbs3
sorbin and SH3 domain containing 3
chr9_+_106477269 2.733 ENSMUST00000047721.8
 Rrp9
RRP9, small subunit (SSU) processome component, homolog (yeast)
chr2_+_31470207 2.705 ENSMUST00000102840.4
 Ass1
argininosuccinate synthetase 1
chr3_-_141931523 2.667 ENSMUST00000106232.1
 Bmpr1b
bone morphogenetic protein receptor, type 1B
chr7_-_99182681 2.499 ENSMUST00000033001.4
 Dgat2
diacylglycerol O-acyltransferase 2
chr18_+_37477768 2.425 ENSMUST00000051442.5
 Pcdhb16
protocadherin beta 16
chr15_+_80097866 2.413 ENSMUST00000143928.1
 Syngr1
synaptogyrin 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 16.9 GO:0034605 cellular response to heat(GO:0034605)
0.1 13.0 GO:0048663 neuron fate commitment(GO:0048663)
2.1 8.6 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
1.4 5.7 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.4 4.2 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.3 3.7 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.9 3.5 GO:1904457 positive regulation of neuronal action potential(GO:1904457)
0.2 3.5 GO:0030574 collagen catabolic process(GO:0030574)
0.6 3.4 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.3 3.4 GO:0051601 exocyst localization(GO:0051601)
0.4 3.2 GO:1903207 neuron death in response to hydrogen peroxide(GO:0036476) regulation of hydrogen peroxide-induced neuron death(GO:1903207) negative regulation of hydrogen peroxide-induced neuron death(GO:1903208)
0.0 2.8 GO:0051496 positive regulation of stress fiber assembly(GO:0051496)
0.7 2.7 GO:0010046 arginine biosynthetic process(GO:0006526) response to mycotoxin(GO:0010046)
0.7 2.7 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.0 2.7 GO:0006364 rRNA processing(GO:0006364)
0.4 2.5 GO:0035356 cellular triglyceride homeostasis(GO:0035356)
0.1 2.4 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.1 2.4 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.5 2.3 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.2 2.3 GO:0048711 positive regulation of astrocyte differentiation(GO:0048711)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 13.0 GO:0005667 transcription factor complex(GO:0005667)
0.5 8.6 GO:0005614 interstitial matrix(GO:0005614)
0.0 4.1 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 3.7 GO:0005865 striated muscle thin filament(GO:0005865)
0.7 3.5 GO:0044316 cone cell pedicle(GO:0044316)
0.2 3.4 GO:0000145 exocyst(GO:0000145)
0.0 3.4 GO:0030426 growth cone(GO:0030426)
0.6 3.2 GO:1990037 Lewy body core(GO:1990037)
0.0 2.8 GO:0030424 axon(GO:0030424)
0.4 2.7 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.2 2.7 GO:0070852 cell body fiber(GO:0070852)
0.0 2.5 GO:0005811 lipid particle(GO:0005811)
0.1 2.4 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 2.4 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.2 2.3 GO:0043196 varicosity(GO:0043196)
0.0 1.9 GO:0031526 brush border membrane(GO:0031526)
0.0 1.6 GO:0005882 intermediate filament(GO:0005882)
0.1 1.2 GO:0044754 autolysosome(GO:0044754)
0.1 1.1 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 1.1 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 17.2 GO:0005516 calmodulin binding(GO:0005516)
1.6 9.8 GO:0019841 retinol binding(GO:0019841)
1.4 8.6 GO:0045545 syndecan binding(GO:0045545)
0.1 5.7 GO:0019213 deacetylase activity(GO:0019213)
0.7 4.2 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 3.5 GO:0030552 cAMP binding(GO:0030552)
0.3 3.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 3.4 GO:0000149 SNARE binding(GO:0000149)
0.0 3.2 GO:0043130 ubiquitin binding(GO:0043130)
0.2 2.8 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.2 2.8 GO:0017166 vinculin binding(GO:0017166)
0.7 2.7 GO:0034511 U3 snoRNA binding(GO:0034511)
0.3 2.7 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.2 2.7 GO:0015643 toxic substance binding(GO:0015643)
0.1 2.6 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.8 2.5 GO:0003846 2-acylglycerol O-acyltransferase activity(GO:0003846)
0.1 2.3 GO:0031418 L-ascorbic acid binding(GO:0031418)
0.1 2.3 GO:0048156 tau protein binding(GO:0048156)
0.1 2.3 GO:0001968 fibronectin binding(GO:0001968)
0.1 2.1 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)

Gene overrepresentation in C2:CP category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 10.9 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 4.4 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 3.9 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.1 2.7 PID_BMP_PATHWAY BMP receptor signaling
0.0 2.0 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 1.4 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 1.2 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.7 PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 0.6 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.6 PID_TCR_PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.5 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 0.4 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.3 PID_IL2_1PATHWAY IL2-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 9.8 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.1 4.2 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 3.5 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.0 3.2 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 2.8 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 2.7 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 2.7 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 2.5 REACTOME_TRIGLYCERIDE_BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis
0.1 2.1 REACTOME_IRON_UPTAKE_AND_TRANSPORT Genes involved in Iron uptake and transport
0.0 1.7 REACTOME_TRANSPORT_TO_THE_GOLGI_AND_SUBSEQUENT_MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.1 1.6 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 1.1 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 0.9 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.1 0.7 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.7 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.0 0.5 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.4 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.4 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.4 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.3 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling