Motif ID: Rad21_Smc3
Z-value: 0.788
Transcription factors associated with Rad21_Smc3:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Rad21 | ENSMUSG00000022314.9 | Rad21 |
Smc3 | ENSMUSG00000024974.10 | Smc3 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Smc3 | mm10_v2_chr19_+_53600377_53600435 | -0.34 | 2.9e-03 | Click! |
Rad21 | mm10_v2_chr15_-_51991679_51991760 | -0.07 | 5.6e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.7 | 8.0 | GO:1903002 | regulation of lipid transport across blood brain barrier(GO:1903000) positive regulation of lipid transport across blood brain barrier(GO:1903002) |
2.5 | 7.6 | GO:0009814 | defense response, incompatible interaction(GO:0009814) |
2.3 | 6.9 | GO:0006001 | fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) glycolytic process through fructose-1-phosphate(GO:0061625) |
2.1 | 6.3 | GO:0072382 | minus-end-directed vesicle transport along microtubule(GO:0072382) |
2.0 | 5.9 | GO:0060598 | dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598) |
1.7 | 5.1 | GO:0060167 | regulation of adenosine receptor signaling pathway(GO:0060167) regulation of G-protein coupled receptor internalization(GO:1904020) |
1.1 | 3.4 | GO:0070634 | transepithelial ammonium transport(GO:0070634) |
1.1 | 3.2 | GO:0018199 | peptidyl-glutamine modification(GO:0018199) |
1.0 | 7.7 | GO:0000050 | urea cycle(GO:0000050) urea metabolic process(GO:0019627) |
1.0 | 2.9 | GO:0006011 | UDP-glucose metabolic process(GO:0006011) |
0.9 | 3.6 | GO:2001137 | positive regulation of endocytic recycling(GO:2001137) |
0.9 | 4.5 | GO:0019236 | response to pheromone(GO:0019236) |
0.9 | 2.6 | GO:2000314 | negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000314) |
0.8 | 2.4 | GO:2000418 | positive regulation of eosinophil migration(GO:2000418) |
0.7 | 2.9 | GO:0060800 | regulation of cell differentiation involved in embryonic placenta development(GO:0060800) |
0.7 | 7.5 | GO:0032825 | positive regulation of natural killer cell differentiation(GO:0032825) |
0.7 | 2.0 | GO:0072076 | nephrogenic mesenchyme development(GO:0072076) |
0.6 | 1.8 | GO:0046061 | dATP catabolic process(GO:0046061) |
0.6 | 1.7 | GO:1902071 | positive regulation of cellular response to hypoxia(GO:1900039) regulation of hypoxia-inducible factor-1alpha signaling pathway(GO:1902071) |
0.5 | 3.2 | GO:0003350 | pulmonary myocardium development(GO:0003350) |
0.5 | 2.2 | GO:0006776 | vitamin A metabolic process(GO:0006776) |
0.5 | 1.6 | GO:0010533 | regulation of activation of Janus kinase activity(GO:0010533) |
0.5 | 1.5 | GO:0036233 | glycine import(GO:0036233) |
0.5 | 1.0 | GO:2000510 | positive regulation of dendritic cell chemotaxis(GO:2000510) |
0.5 | 2.5 | GO:1903232 | melanosome assembly(GO:1903232) |
0.5 | 2.5 | GO:0003105 | negative regulation of glomerular filtration(GO:0003105) positive regulation of NAD(P)H oxidase activity(GO:0033864) positive regulation of toll-like receptor 2 signaling pathway(GO:0034137) |
0.5 | 1.9 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
0.5 | 1.4 | GO:1903630 | regulation of aminoacyl-tRNA ligase activity(GO:1903630) positive regulation of aminoacyl-tRNA ligase activity(GO:1903632) regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435) |
0.5 | 2.8 | GO:0097368 | establishment of Sertoli cell barrier(GO:0097368) |
0.4 | 1.8 | GO:0046013 | regulation of T cell homeostatic proliferation(GO:0046013) |
0.4 | 1.8 | GO:0031161 | phosphatidylinositol catabolic process(GO:0031161) |
0.4 | 1.3 | GO:1902162 | regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) |
0.4 | 2.8 | GO:0035331 | negative regulation of hippo signaling(GO:0035331) |
0.4 | 1.2 | GO:0098974 | postsynaptic actin cytoskeleton organization(GO:0098974) |
0.4 | 2.3 | GO:0007406 | negative regulation of neuroblast proliferation(GO:0007406) |
0.4 | 3.3 | GO:1900194 | negative regulation of oocyte maturation(GO:1900194) |
0.4 | 2.5 | GO:0006369 | termination of RNA polymerase II transcription(GO:0006369) |
0.3 | 2.4 | GO:1903715 | regulation of aerobic respiration(GO:1903715) |
0.3 | 1.4 | GO:0010891 | negative regulation of sequestering of triglyceride(GO:0010891) positive regulation of triglyceride catabolic process(GO:0010898) |
0.3 | 2.0 | GO:0032202 | telomere assembly(GO:0032202) |
0.3 | 0.7 | GO:0032493 | response to bacterial lipoprotein(GO:0032493) |
0.3 | 1.0 | GO:0032286 | central nervous system myelin maintenance(GO:0032286) |
0.3 | 3.0 | GO:0070236 | negative regulation of activation-induced cell death of T cells(GO:0070236) |
0.3 | 1.6 | GO:0045347 | negative regulation of MHC class II biosynthetic process(GO:0045347) |
0.3 | 1.3 | GO:0060709 | glycogen cell differentiation involved in embryonic placenta development(GO:0060709) |
0.3 | 1.9 | GO:0051987 | positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987) |
0.3 | 0.9 | GO:2000170 | positive regulation of peptidyl-cysteine S-nitrosylation(GO:2000170) |
0.3 | 0.9 | GO:0046104 | thymidine metabolic process(GO:0046104) deoxyribonucleoside catabolic process(GO:0046121) |
0.3 | 1.1 | GO:1900740 | regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740) |
0.3 | 2.3 | GO:0006729 | tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146) |
0.3 | 1.6 | GO:0043654 | recognition of apoptotic cell(GO:0043654) |
0.3 | 0.5 | GO:0090202 | transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579) |
0.3 | 1.3 | GO:0098706 | ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706) |
0.3 | 0.8 | GO:0002432 | granuloma formation(GO:0002432) |
0.2 | 0.7 | GO:0036090 | cleavage furrow ingression(GO:0036090) |
0.2 | 2.9 | GO:0001779 | natural killer cell differentiation(GO:0001779) |
0.2 | 2.9 | GO:0075522 | IRES-dependent viral translational initiation(GO:0075522) |
0.2 | 3.5 | GO:0032464 | positive regulation of protein homooligomerization(GO:0032464) |
0.2 | 1.2 | GO:0007223 | Wnt signaling pathway, calcium modulating pathway(GO:0007223) regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020) |
0.2 | 1.4 | GO:0045919 | positive regulation of cytolysis(GO:0045919) |
0.2 | 0.7 | GO:0042097 | interleukin-4 biosynthetic process(GO:0042097) regulation of interleukin-4 biosynthetic process(GO:0045402) |
0.2 | 1.1 | GO:0019230 | proprioception(GO:0019230) |
0.2 | 1.6 | GO:0048318 | axial mesoderm development(GO:0048318) |
0.2 | 1.8 | GO:0051503 | adenine nucleotide transport(GO:0051503) |
0.2 | 4.2 | GO:0016558 | protein import into peroxisome matrix(GO:0016558) |
0.2 | 4.0 | GO:0007263 | nitric oxide mediated signal transduction(GO:0007263) |
0.2 | 1.5 | GO:0007342 | fusion of sperm to egg plasma membrane(GO:0007342) |
0.2 | 2.7 | GO:0016191 | synaptic vesicle uncoating(GO:0016191) |
0.2 | 0.6 | GO:0060399 | positive regulation of growth hormone receptor signaling pathway(GO:0060399) |
0.2 | 0.8 | GO:0045163 | clustering of voltage-gated potassium channels(GO:0045163) |
0.2 | 0.6 | GO:0035799 | ureter maturation(GO:0035799) |
0.2 | 0.8 | GO:0010989 | negative regulation of low-density lipoprotein particle clearance(GO:0010989) |
0.2 | 1.0 | GO:0016127 | cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127) |
0.2 | 0.9 | GO:0035511 | oxidative DNA demethylation(GO:0035511) |
0.2 | 1.1 | GO:2001170 | negative regulation of ATP biosynthetic process(GO:2001170) |
0.2 | 0.7 | GO:1902774 | late endosome to lysosome transport(GO:1902774) |
0.2 | 1.7 | GO:0001682 | tRNA 5'-leader removal(GO:0001682) |
0.2 | 1.0 | GO:0060040 | retinal bipolar neuron differentiation(GO:0060040) |
0.2 | 0.3 | GO:0003383 | apical constriction(GO:0003383) |
0.2 | 0.5 | GO:0007181 | transforming growth factor beta receptor complex assembly(GO:0007181) |
0.2 | 0.8 | GO:0032364 | oxygen homeostasis(GO:0032364) |
0.2 | 1.7 | GO:0045607 | regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980) |
0.2 | 0.8 | GO:0002667 | lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911) negative regulation of protein kinase C signaling(GO:0090038) |
0.1 | 0.4 | GO:0015886 | heme transport(GO:0015886) |
0.1 | 1.1 | GO:0016576 | histone dephosphorylation(GO:0016576) |
0.1 | 1.0 | GO:2000138 | positive regulation of cell proliferation involved in heart morphogenesis(GO:2000138) |
0.1 | 0.5 | GO:0010940 | positive regulation of necrotic cell death(GO:0010940) |
0.1 | 1.6 | GO:0038180 | nerve growth factor signaling pathway(GO:0038180) |
0.1 | 1.3 | GO:0033603 | positive regulation of dopamine secretion(GO:0033603) |
0.1 | 1.9 | GO:0045974 | miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974) |
0.1 | 0.4 | GO:0060160 | negative regulation of dopamine receptor signaling pathway(GO:0060160) |
0.1 | 1.6 | GO:1902018 | negative regulation of cilium assembly(GO:1902018) |
0.1 | 0.5 | GO:2000525 | regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525) |
0.1 | 2.2 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
0.1 | 1.3 | GO:0060253 | negative regulation of glial cell proliferation(GO:0060253) |
0.1 | 0.2 | GO:0003100 | regulation of systemic arterial blood pressure by endothelin(GO:0003100) |
0.1 | 2.6 | GO:0001539 | cilium or flagellum-dependent cell motility(GO:0001539) cilium-dependent cell motility(GO:0060285) |
0.1 | 2.5 | GO:0007205 | protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205) |
0.1 | 1.4 | GO:0031468 | nuclear envelope reassembly(GO:0031468) |
0.1 | 0.7 | GO:0050861 | positive regulation of B cell receptor signaling pathway(GO:0050861) |
0.1 | 1.3 | GO:0046855 | inositol phosphate dephosphorylation(GO:0046855) |
0.1 | 1.3 | GO:0044406 | adhesion of symbiont to host(GO:0044406) |
0.1 | 0.8 | GO:0015670 | carbon dioxide transport(GO:0015670) |
0.1 | 1.5 | GO:0032288 | myelin assembly(GO:0032288) |
0.1 | 0.3 | GO:0021759 | globus pallidus development(GO:0021759) |
0.1 | 0.7 | GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590) |
0.1 | 2.5 | GO:0032292 | myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292) |
0.1 | 0.3 | GO:0090063 | positive regulation of microtubule nucleation(GO:0090063) |
0.1 | 0.9 | GO:0051490 | negative regulation of filopodium assembly(GO:0051490) |
0.1 | 0.6 | GO:0030854 | positive regulation of granulocyte differentiation(GO:0030854) |
0.1 | 0.7 | GO:0060662 | tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662) |
0.1 | 0.4 | GO:0039536 | negative regulation of RIG-I signaling pathway(GO:0039536) |
0.1 | 0.3 | GO:0032439 | endosome localization(GO:0032439) |
0.1 | 2.0 | GO:0044550 | secondary metabolite biosynthetic process(GO:0044550) |
0.1 | 1.1 | GO:0002467 | germinal center formation(GO:0002467) |
0.1 | 3.0 | GO:0007131 | reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825) |
0.1 | 0.7 | GO:0006228 | UTP biosynthetic process(GO:0006228) |
0.1 | 0.2 | GO:0072319 | abscission(GO:0009838) vesicle uncoating(GO:0072319) positive regulation of viral budding via host ESCRT complex(GO:1903774) |
0.1 | 0.5 | GO:0048739 | cardiac muscle fiber development(GO:0048739) |
0.1 | 0.3 | GO:0002755 | MyD88-dependent toll-like receptor signaling pathway(GO:0002755) |
0.1 | 0.4 | GO:0031580 | membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580) |
0.1 | 0.4 | GO:0003431 | growth plate cartilage chondrocyte differentiation(GO:0003418) growth plate cartilage chondrocyte development(GO:0003431) |
0.1 | 5.3 | GO:0051865 | protein autoubiquitination(GO:0051865) |
0.1 | 0.2 | GO:0060830 | ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830) |
0.1 | 3.7 | GO:0051290 | protein heterotetramerization(GO:0051290) |
0.1 | 1.8 | GO:0071353 | response to interleukin-4(GO:0070670) cellular response to interleukin-4(GO:0071353) |
0.1 | 3.4 | GO:0051973 | positive regulation of telomerase activity(GO:0051973) |
0.1 | 0.8 | GO:0010825 | positive regulation of centrosome duplication(GO:0010825) |
0.1 | 2.3 | GO:0045746 | negative regulation of Notch signaling pathway(GO:0045746) |
0.1 | 2.0 | GO:0000002 | mitochondrial genome maintenance(GO:0000002) |
0.1 | 3.3 | GO:0071277 | cellular response to calcium ion(GO:0071277) |
0.1 | 0.8 | GO:2001241 | positive regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001241) |
0.1 | 0.8 | GO:0071260 | cellular response to mechanical stimulus(GO:0071260) |
0.1 | 0.2 | GO:1900864 | tRNA wobble position uridine thiolation(GO:0002143) mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864) |
0.1 | 0.3 | GO:0071985 | multivesicular body sorting pathway(GO:0071985) |
0.1 | 0.3 | GO:0015803 | branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820) |
0.1 | 0.4 | GO:0070423 | nucleotide-binding oligomerization domain containing signaling pathway(GO:0070423) nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070431) |
0.1 | 0.2 | GO:0006083 | acetate metabolic process(GO:0006083) |
0.1 | 0.6 | GO:0036296 | cellular response to increased oxygen levels(GO:0036295) response to increased oxygen levels(GO:0036296) |
0.1 | 0.8 | GO:0007216 | G-protein coupled glutamate receptor signaling pathway(GO:0007216) |
0.0 | 0.3 | GO:0071169 | establishment of protein localization to chromatin(GO:0071169) |
0.0 | 0.6 | GO:0045351 | type I interferon biosynthetic process(GO:0045351) |
0.0 | 0.3 | GO:1904355 | positive regulation of telomere capping(GO:1904355) |
0.0 | 2.9 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
0.0 | 0.5 | GO:0032402 | melanosome transport(GO:0032402) |
0.0 | 0.6 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
0.0 | 2.0 | GO:2001238 | positive regulation of extrinsic apoptotic signaling pathway(GO:2001238) |
0.0 | 0.3 | GO:1900029 | positive regulation of ruffle assembly(GO:1900029) |
0.0 | 2.4 | GO:0002181 | cytoplasmic translation(GO:0002181) |
0.0 | 0.5 | GO:0090201 | negative regulation of release of cytochrome c from mitochondria(GO:0090201) |
0.0 | 1.6 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
0.0 | 0.2 | GO:1903300 | negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300) |
0.0 | 0.3 | GO:0043983 | histone H4-K12 acetylation(GO:0043983) |
0.0 | 1.1 | GO:0035458 | cellular response to interferon-beta(GO:0035458) |
0.0 | 0.6 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
0.0 | 0.1 | GO:0006751 | glutathione catabolic process(GO:0006751) |
0.0 | 0.2 | GO:0006621 | protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437) |
0.0 | 0.2 | GO:0046645 | positive regulation of gamma-delta T cell differentiation(GO:0045588) positive regulation of gamma-delta T cell activation(GO:0046645) |
0.0 | 0.6 | GO:0030150 | protein import into mitochondrial matrix(GO:0030150) |
0.0 | 0.7 | GO:0034389 | lipid particle organization(GO:0034389) |
0.0 | 1.1 | GO:0071480 | cellular response to gamma radiation(GO:0071480) |
0.0 | 1.2 | GO:0036075 | endochondral ossification(GO:0001958) replacement ossification(GO:0036075) |
0.0 | 1.8 | GO:0006687 | glycosphingolipid metabolic process(GO:0006687) |
0.0 | 0.5 | GO:0071712 | ER-associated misfolded protein catabolic process(GO:0071712) |
0.0 | 0.9 | GO:0032933 | response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501) |
0.0 | 0.7 | GO:0014002 | astrocyte development(GO:0014002) |
0.0 | 0.1 | GO:0046654 | tetrahydrofolate biosynthetic process(GO:0046654) |
0.0 | 0.2 | GO:0072086 | specification of loop of Henle identity(GO:0072086) |
0.0 | 0.1 | GO:1903207 | neuron death in response to hydrogen peroxide(GO:0036476) regulation of hydrogen peroxide-induced neuron death(GO:1903207) negative regulation of hydrogen peroxide-induced neuron death(GO:1903208) |
0.0 | 0.2 | GO:0001980 | regulation of systemic arterial blood pressure by ischemic conditions(GO:0001980) |
0.0 | 0.7 | GO:0035518 | histone H2A monoubiquitination(GO:0035518) |
0.0 | 1.1 | GO:0031648 | protein destabilization(GO:0031648) |
0.0 | 1.3 | GO:0006506 | GPI anchor biosynthetic process(GO:0006506) |
0.0 | 0.7 | GO:0000027 | ribosomal large subunit assembly(GO:0000027) |
0.0 | 0.6 | GO:0030262 | apoptotic nuclear changes(GO:0030262) |
0.0 | 0.3 | GO:0019985 | translesion synthesis(GO:0019985) |
0.0 | 1.3 | GO:0005978 | glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250) |
0.0 | 0.3 | GO:0033273 | response to vitamin(GO:0033273) |
0.0 | 0.9 | GO:0042491 | auditory receptor cell differentiation(GO:0042491) |
0.0 | 0.9 | GO:0097031 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
0.0 | 2.5 | GO:2001235 | positive regulation of apoptotic signaling pathway(GO:2001235) |
0.0 | 0.1 | GO:0070127 | tRNA aminoacylation for mitochondrial protein translation(GO:0070127) |
0.0 | 0.3 | GO:0071378 | growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378) |
0.0 | 0.8 | GO:0018279 | peptidyl-asparagine modification(GO:0018196) protein N-linked glycosylation via asparagine(GO:0018279) |
0.0 | 0.2 | GO:0019243 | methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727) |
0.0 | 0.9 | GO:0042982 | amyloid precursor protein metabolic process(GO:0042982) |
0.0 | 0.1 | GO:0060431 | primary lung bud formation(GO:0060431) |
0.0 | 0.5 | GO:0061036 | positive regulation of cartilage development(GO:0061036) |
0.0 | 0.2 | GO:0043982 | histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982) |
0.0 | 1.1 | GO:0050868 | negative regulation of T cell activation(GO:0050868) |
0.0 | 0.4 | GO:0000469 | cleavage involved in rRNA processing(GO:0000469) |
0.0 | 0.1 | GO:0072718 | response to cisplatin(GO:0072718) |
0.0 | 1.5 | GO:0016575 | histone deacetylation(GO:0016575) |
0.0 | 0.1 | GO:0030206 | chondroitin sulfate biosynthetic process(GO:0030206) |
0.0 | 0.7 | GO:0045599 | negative regulation of fat cell differentiation(GO:0045599) |
0.0 | 0.3 | GO:0044458 | motile cilium assembly(GO:0044458) |
0.0 | 0.3 | GO:0031297 | replication fork processing(GO:0031297) |
0.0 | 0.5 | GO:0018345 | protein palmitoylation(GO:0018345) |
0.0 | 0.5 | GO:0038202 | TORC1 signaling(GO:0038202) |
0.0 | 0.2 | GO:1902187 | negative regulation of viral release from host cell(GO:1902187) |
0.0 | 0.1 | GO:0051014 | actin filament severing(GO:0051014) |
0.0 | 0.2 | GO:0003351 | epithelial cilium movement(GO:0003351) |
0.0 | 0.9 | GO:1900181 | negative regulation of protein localization to nucleus(GO:1900181) |
0.0 | 0.8 | GO:0061077 | chaperone-mediated protein folding(GO:0061077) |
0.0 | 0.1 | GO:0015014 | heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014) |
0.0 | 0.7 | GO:0030593 | neutrophil chemotaxis(GO:0030593) |
0.0 | 0.1 | GO:0046602 | regulation of mitotic centrosome separation(GO:0046602) |
0.0 | 0.1 | GO:0070266 | necroptotic process(GO:0070266) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.7 | 8.0 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
2.3 | 6.9 | GO:0036488 | CHOP-C/EBP complex(GO:0036488) |
0.8 | 4.7 | GO:0032983 | kainate selective glutamate receptor complex(GO:0032983) |
0.7 | 2.0 | GO:0045009 | melanosome membrane(GO:0033162) chitosome(GO:0045009) |
0.5 | 2.5 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
0.5 | 1.5 | GO:0071438 | integrin alpha3-beta1 complex(GO:0034667) invadopodium membrane(GO:0071438) |
0.5 | 1.4 | GO:1990730 | VCP-NSFL1C complex(GO:1990730) |
0.4 | 2.2 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
0.4 | 1.6 | GO:0030289 | protein phosphatase 4 complex(GO:0030289) |
0.4 | 4.7 | GO:0016442 | RISC complex(GO:0016442) RNAi effector complex(GO:0031332) |
0.4 | 0.7 | GO:0034679 | integrin alpha9-beta1 complex(GO:0034679) |
0.3 | 8.6 | GO:0005921 | gap junction(GO:0005921) |
0.3 | 2.0 | GO:0045179 | apical cortex(GO:0045179) |
0.3 | 1.6 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
0.3 | 3.1 | GO:0016593 | Cdc73/Paf1 complex(GO:0016593) |
0.3 | 6.3 | GO:0031616 | spindle pole centrosome(GO:0031616) |
0.3 | 1.4 | GO:1990131 | Iml1 complex(GO:1990130) Gtr1-Gtr2 GTPase complex(GO:1990131) |
0.2 | 1.7 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
0.2 | 1.2 | GO:0000172 | ribonuclease MRP complex(GO:0000172) |
0.2 | 1.8 | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541) |
0.2 | 1.6 | GO:0005742 | mitochondrial outer membrane translocase complex(GO:0005742) |
0.2 | 1.9 | GO:1990023 | mitotic spindle midzone(GO:1990023) |
0.2 | 2.8 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
0.2 | 1.1 | GO:0097452 | GAIT complex(GO:0097452) |
0.2 | 0.8 | GO:0097361 | CIA complex(GO:0097361) |
0.2 | 2.6 | GO:0065010 | extracellular membrane-bounded organelle(GO:0065010) |
0.1 | 1.9 | GO:0070852 | cell body fiber(GO:0070852) |
0.1 | 1.3 | GO:0005883 | neurofilament(GO:0005883) |
0.1 | 1.5 | GO:0008541 | proteasome regulatory particle, lid subcomplex(GO:0008541) |
0.1 | 3.1 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
0.1 | 8.5 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
0.1 | 6.3 | GO:0045171 | intercellular bridge(GO:0045171) |
0.1 | 1.4 | GO:0005687 | U4 snRNP(GO:0005687) |
0.1 | 0.4 | GO:0030677 | ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681) |
0.1 | 0.7 | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
0.1 | 0.5 | GO:0030485 | smooth muscle contractile fiber(GO:0030485) |
0.1 | 0.3 | GO:0035101 | FACT complex(GO:0035101) |
0.1 | 0.7 | GO:0070187 | telosome(GO:0070187) |
0.1 | 0.7 | GO:0042825 | TAP complex(GO:0042825) |
0.1 | 4.0 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
0.1 | 1.6 | GO:0097225 | sperm midpiece(GO:0097225) |
0.1 | 5.0 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
0.1 | 2.0 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
0.1 | 1.6 | GO:0001891 | phagocytic cup(GO:0001891) |
0.1 | 0.7 | GO:0000813 | ESCRT I complex(GO:0000813) |
0.1 | 3.0 | GO:0005637 | nuclear inner membrane(GO:0005637) |
0.1 | 3.6 | GO:0032420 | stereocilium(GO:0032420) |
0.1 | 0.5 | GO:0097255 | R2TP complex(GO:0097255) |
0.1 | 0.7 | GO:0016272 | prefoldin complex(GO:0016272) |
0.1 | 0.5 | GO:0071203 | WASH complex(GO:0071203) |
0.1 | 1.5 | GO:0016580 | Sin3 complex(GO:0016580) |
0.1 | 0.8 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
0.1 | 1.1 | GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506) |
0.1 | 4.7 | GO:0005844 | polysome(GO:0005844) |
0.1 | 0.8 | GO:0030057 | desmosome(GO:0030057) |
0.1 | 1.5 | GO:0043218 | compact myelin(GO:0043218) |
0.1 | 0.8 | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098) |
0.1 | 5.1 | GO:0016529 | sarcoplasmic reticulum(GO:0016529) |
0.1 | 0.4 | GO:0030914 | STAGA complex(GO:0030914) |
0.1 | 0.7 | GO:0002080 | acrosomal membrane(GO:0002080) |
0.1 | 1.1 | GO:0005605 | basal lamina(GO:0005605) |
0.1 | 5.5 | GO:0072562 | blood microparticle(GO:0072562) |
0.1 | 2.1 | GO:0060077 | inhibitory synapse(GO:0060077) |
0.1 | 0.3 | GO:0070876 | SOSS complex(GO:0070876) |
0.1 | 0.8 | GO:0005869 | dynactin complex(GO:0005869) |
0.1 | 0.5 | GO:0030688 | preribosome, small subunit precursor(GO:0030688) |
0.1 | 3.7 | GO:0045178 | basal part of cell(GO:0045178) |
0.1 | 0.5 | GO:0031931 | TORC1 complex(GO:0031931) |
0.1 | 0.6 | GO:0033179 | proton-transporting V-type ATPase, V0 domain(GO:0033179) |
0.1 | 0.8 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
0.1 | 1.2 | GO:0031082 | BLOC complex(GO:0031082) |
0.0 | 0.7 | GO:0070938 | contractile ring(GO:0070938) |
0.0 | 0.3 | GO:0070776 | H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776) |
0.0 | 4.9 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
0.0 | 0.2 | GO:1990584 | cardiac Troponin complex(GO:1990584) |
0.0 | 1.4 | GO:0035145 | exon-exon junction complex(GO:0035145) |
0.0 | 0.9 | GO:0045334 | clathrin-coated endocytic vesicle(GO:0045334) |
0.0 | 0.3 | GO:0031933 | telomeric heterochromatin(GO:0031933) |
0.0 | 1.3 | GO:0043034 | costamere(GO:0043034) |
0.0 | 0.2 | GO:0048476 | Holliday junction resolvase complex(GO:0048476) |
0.0 | 1.3 | GO:0001772 | immunological synapse(GO:0001772) |
0.0 | 0.2 | GO:0090571 | RNA polymerase II transcription repressor complex(GO:0090571) |
0.0 | 0.8 | GO:0005797 | Golgi medial cisterna(GO:0005797) |
0.0 | 1.4 | GO:0015030 | Cajal body(GO:0015030) |
0.0 | 1.3 | GO:0044429 | mitochondrial envelope(GO:0005740) mitochondrial part(GO:0044429) |
0.0 | 0.5 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
0.0 | 0.2 | GO:0090543 | Flemming body(GO:0090543) |
0.0 | 1.8 | GO:0001669 | acrosomal vesicle(GO:0001669) |
0.0 | 0.4 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
0.0 | 5.6 | GO:0001726 | ruffle(GO:0001726) |
0.0 | 0.3 | GO:0005652 | nuclear lamina(GO:0005652) |
0.0 | 0.4 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
0.0 | 0.4 | GO:1990635 | proximal dendrite(GO:1990635) |
0.0 | 1.5 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
0.0 | 0.4 | GO:0030125 | clathrin vesicle coat(GO:0030125) |
0.0 | 0.4 | GO:0048188 | Set1C/COMPASS complex(GO:0048188) |
0.0 | 0.1 | GO:1990037 | Lewy body core(GO:1990037) |
0.0 | 1.9 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
0.0 | 0.3 | GO:0031105 | septin complex(GO:0031105) |
0.0 | 0.2 | GO:0097550 | transcriptional preinitiation complex(GO:0097550) |
0.0 | 0.1 | GO:0043541 | UDP-N-acetylglucosamine transferase complex(GO:0043541) |
0.0 | 0.3 | GO:0035631 | CD40 receptor complex(GO:0035631) |
0.0 | 1.3 | GO:0005811 | lipid particle(GO:0005811) |
0.0 | 0.5 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
0.0 | 3.7 | GO:0005759 | mitochondrial matrix(GO:0005759) |
0.0 | 1.4 | GO:0005840 | ribosome(GO:0005840) |
0.0 | 0.3 | GO:0030008 | TRAPP complex(GO:0030008) |
0.0 | 0.5 | GO:0005746 | mitochondrial respiratory chain(GO:0005746) |
0.0 | 0.1 | GO:0070069 | cytochrome complex(GO:0070069) |
0.0 | 0.3 | GO:0035102 | PRC1 complex(GO:0035102) |
0.0 | 0.3 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
0.0 | 0.7 | GO:0031519 | PcG protein complex(GO:0031519) |
0.0 | 6.0 | GO:0005667 | transcription factor complex(GO:0005667) |
0.0 | 3.3 | GO:0000151 | ubiquitin ligase complex(GO:0000151) |
0.0 | 0.5 | GO:1990391 | DNA repair complex(GO:1990391) |
0.0 | 1.1 | GO:0000794 | condensed nuclear chromosome(GO:0000794) |
0.0 | 1.3 | GO:0031514 | motile cilium(GO:0031514) |
0.0 | 1.5 | GO:0036064 | ciliary basal body(GO:0036064) |
0.0 | 4.0 | GO:0019866 | mitochondrial inner membrane(GO:0005743) organelle inner membrane(GO:0019866) |
0.0 | 1.4 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
0.0 | 0.6 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
0.0 | 0.2 | GO:0071339 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
0.0 | 3.2 | GO:0005925 | focal adhesion(GO:0005925) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.7 | 8.0 | GO:0046911 | hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
2.3 | 6.9 | GO:0004454 | ketohexokinase activity(GO:0004454) |
1.3 | 5.1 | GO:0031687 | A2A adenosine receptor binding(GO:0031687) |
1.1 | 4.3 | GO:0034714 | type III transforming growth factor beta receptor binding(GO:0034714) |
0.8 | 3.2 | GO:0003810 | protein-glutamine gamma-glutamyltransferase activity(GO:0003810) |
0.7 | 2.9 | GO:0004921 | interleukin-11 receptor activity(GO:0004921) interleukin-11 binding(GO:0019970) |
0.7 | 2.0 | GO:0035651 | AP-1 adaptor complex binding(GO:0035650) AP-3 adaptor complex binding(GO:0035651) |
0.7 | 7.3 | GO:0019992 | diacylglycerol binding(GO:0019992) |
0.6 | 3.7 | GO:0005087 | Ran guanyl-nucleotide exchange factor activity(GO:0005087) |
0.6 | 2.5 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
0.6 | 1.8 | GO:0046964 | 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity(GO:0046964) |
0.5 | 2.5 | GO:0004165 | dodecenoyl-CoA delta-isomerase activity(GO:0004165) |
0.5 | 3.0 | GO:0043426 | MRF binding(GO:0043426) |
0.5 | 1.9 | GO:0016842 | amidine-lyase activity(GO:0016842) |
0.4 | 6.3 | GO:0008569 | ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569) |
0.4 | 1.3 | GO:0008823 | cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851) |
0.4 | 2.2 | GO:0061731 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
0.4 | 1.3 | GO:0016314 | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314) |
0.4 | 3.8 | GO:0005523 | tropomyosin binding(GO:0005523) |
0.4 | 1.2 | GO:0098973 | structural constituent of synapse(GO:0098918) structural constituent of postsynaptic actin cytoskeleton(GO:0098973) |
0.4 | 5.8 | GO:0001013 | RNA polymerase I regulatory region DNA binding(GO:0001013) |
0.3 | 1.0 | GO:0003858 | 3-hydroxybutyrate dehydrogenase activity(GO:0003858) |
0.3 | 1.0 | GO:0016501 | prostacyclin receptor activity(GO:0016501) |
0.3 | 0.9 | GO:0003963 | RNA-3'-phosphate cyclase activity(GO:0003963) |
0.3 | 1.2 | GO:0004035 | alkaline phosphatase activity(GO:0004035) |
0.3 | 0.9 | GO:0051747 | cytosine C-5 DNA demethylase activity(GO:0051747) |
0.3 | 1.6 | GO:0051525 | NFAT protein binding(GO:0051525) |
0.3 | 2.9 | GO:0070569 | uridylyltransferase activity(GO:0070569) |
0.3 | 1.5 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
0.2 | 1.0 | GO:0030984 | kininogen binding(GO:0030984) |
0.2 | 2.3 | GO:0001727 | lipid kinase activity(GO:0001727) |
0.2 | 1.1 | GO:0004322 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
0.2 | 0.9 | GO:0070573 | tripeptidyl-peptidase activity(GO:0008240) metallodipeptidase activity(GO:0070573) |
0.2 | 1.7 | GO:0047429 | nucleoside-triphosphate diphosphatase activity(GO:0047429) |
0.2 | 0.6 | GO:0019966 | interleukin-1 binding(GO:0019966) |
0.2 | 1.4 | GO:1990948 | ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948) |
0.2 | 1.6 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
0.2 | 1.8 | GO:0035251 | UDP-glucosyltransferase activity(GO:0035251) |
0.2 | 0.8 | GO:0035473 | lipase binding(GO:0035473) |
0.2 | 3.4 | GO:0008519 | ammonium transmembrane transporter activity(GO:0008519) |
0.2 | 1.2 | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity(GO:0004726) |
0.2 | 1.0 | GO:1990829 | C-rich single-stranded DNA binding(GO:1990829) |
0.2 | 3.0 | GO:0034236 | protein kinase A catalytic subunit binding(GO:0034236) |
0.2 | 3.0 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
0.2 | 0.8 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) |
0.2 | 0.8 | GO:0004839 | ubiquitin activating enzyme activity(GO:0004839) |
0.2 | 1.0 | GO:0045322 | unmethylated CpG binding(GO:0045322) |
0.2 | 3.2 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
0.2 | 1.0 | GO:0003854 | 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854) |
0.2 | 1.7 | GO:0004526 | ribonuclease P activity(GO:0004526) |
0.2 | 2.0 | GO:0008301 | DNA binding, bending(GO:0008301) |
0.2 | 1.4 | GO:1990446 | U1 snRNP binding(GO:1990446) |
0.1 | 1.0 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
0.1 | 0.9 | GO:0002054 | nucleobase binding(GO:0002054) |
0.1 | 0.4 | GO:0015232 | heme transporter activity(GO:0015232) |
0.1 | 1.3 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
0.1 | 3.2 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
0.1 | 1.3 | GO:0015187 | glycine transmembrane transporter activity(GO:0015187) |
0.1 | 2.3 | GO:0035256 | G-protein coupled glutamate receptor binding(GO:0035256) |
0.1 | 0.4 | GO:0031750 | D3 dopamine receptor binding(GO:0031750) |
0.1 | 0.6 | GO:0004028 | 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028) |
0.1 | 5.7 | GO:0030332 | cyclin binding(GO:0030332) |
0.1 | 4.4 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
0.1 | 1.4 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
0.1 | 0.7 | GO:0046978 | TAP1 binding(GO:0046978) TAP2 binding(GO:0046979) |
0.1 | 1.1 | GO:0043262 | adenosine-diphosphatase activity(GO:0043262) |
0.1 | 0.8 | GO:0051879 | Hsp90 protein binding(GO:0051879) |
0.1 | 1.9 | GO:0035198 | miRNA binding(GO:0035198) |
0.1 | 1.3 | GO:0030235 | nitric-oxide synthase regulator activity(GO:0030235) |
0.1 | 1.1 | GO:0017176 | phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176) |
0.1 | 1.5 | GO:0051959 | dynein light intermediate chain binding(GO:0051959) |
0.1 | 1.8 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
0.1 | 2.9 | GO:0043236 | laminin binding(GO:0043236) |
0.1 | 0.5 | GO:0043141 | ATP-dependent 5'-3' DNA helicase activity(GO:0043141) |
0.1 | 1.4 | GO:0070034 | telomerase RNA binding(GO:0070034) |
0.1 | 2.1 | GO:0098632 | protein binding involved in cell-cell adhesion(GO:0098632) |
0.1 | 0.3 | GO:0008802 | betaine-aldehyde dehydrogenase activity(GO:0008802) |
0.1 | 14.4 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
0.1 | 1.0 | GO:0043024 | ribosomal small subunit binding(GO:0043024) |
0.1 | 1.9 | GO:0003746 | translation elongation factor activity(GO:0003746) |
0.1 | 3.0 | GO:0005507 | copper ion binding(GO:0005507) |
0.1 | 0.2 | GO:0042610 | CD8 receptor binding(GO:0042610) |
0.1 | 0.6 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
0.1 | 2.5 | GO:0017147 | Wnt-protein binding(GO:0017147) |
0.1 | 0.5 | GO:0004169 | dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169) |
0.1 | 0.7 | GO:0003847 | 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847) |
0.1 | 2.3 | GO:0005112 | Notch binding(GO:0005112) |
0.1 | 0.8 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
0.1 | 0.6 | GO:0000268 | peroxisome targeting sequence binding(GO:0000268) |
0.1 | 0.2 | GO:0030172 | troponin C binding(GO:0030172) |
0.1 | 0.8 | GO:0004576 | oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
0.1 | 1.9 | GO:0003954 | NADH dehydrogenase activity(GO:0003954) |
0.1 | 5.4 | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980) |
0.1 | 0.2 | GO:0046923 | ER retention sequence binding(GO:0046923) |
0.1 | 0.2 | GO:0003986 | acetyl-CoA hydrolase activity(GO:0003986) |
0.1 | 1.6 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
0.1 | 1.8 | GO:0031369 | translation initiation factor binding(GO:0031369) |
0.1 | 0.8 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
0.1 | 0.2 | GO:0003987 | acetate-CoA ligase activity(GO:0003987) |
0.1 | 0.2 | GO:0051377 | mannose-ethanolamine phosphotransferase activity(GO:0051377) |
0.1 | 0.3 | GO:0016888 | endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888) |
0.0 | 0.2 | GO:0008853 | exodeoxyribonuclease III activity(GO:0008853) |
0.0 | 0.4 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
0.0 | 0.6 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
0.0 | 1.4 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
0.0 | 0.9 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
0.0 | 0.3 | GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) |
0.0 | 0.7 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
0.0 | 0.6 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
0.0 | 0.1 | GO:0034481 | chondroitin sulfotransferase activity(GO:0034481) |
0.0 | 1.5 | GO:0004407 | histone deacetylase activity(GO:0004407) |
0.0 | 0.1 | GO:0004477 | methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488) |
0.0 | 0.3 | GO:0031996 | thioesterase binding(GO:0031996) |
0.0 | 0.5 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
0.0 | 2.7 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
0.0 | 3.5 | GO:0001046 | core promoter sequence-specific DNA binding(GO:0001046) |
0.0 | 2.5 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
0.0 | 0.3 | GO:0016634 | oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634) |
0.0 | 0.2 | GO:0043995 | histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972) |
0.0 | 0.2 | GO:0000990 | transcription factor activity, core RNA polymerase binding(GO:0000990) |
0.0 | 0.2 | GO:0048256 | flap endonuclease activity(GO:0048256) |
0.0 | 10.6 | GO:0005525 | GTP binding(GO:0005525) |
0.0 | 0.9 | GO:0042162 | telomeric DNA binding(GO:0042162) |
0.0 | 0.6 | GO:0001047 | core promoter binding(GO:0001047) |
0.0 | 1.7 | GO:0035064 | methylated histone binding(GO:0035064) |
0.0 | 0.6 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
0.0 | 0.5 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
0.0 | 0.2 | GO:0004416 | hydroxyacylglutathione hydrolase activity(GO:0004416) |
0.0 | 0.3 | GO:0005537 | mannose binding(GO:0005537) |
0.0 | 0.6 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
0.0 | 3.6 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
0.0 | 1.2 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
0.0 | 0.3 | GO:0051400 | BH domain binding(GO:0051400) |
0.0 | 3.3 | GO:0017137 | Rab GTPase binding(GO:0017137) |
0.0 | 0.1 | GO:0008242 | omega peptidase activity(GO:0008242) |
0.0 | 0.8 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
0.0 | 0.9 | GO:0032934 | cholesterol binding(GO:0015485) sterol binding(GO:0032934) |
0.0 | 0.5 | GO:0004521 | endoribonuclease activity(GO:0004521) |
0.0 | 0.2 | GO:0016783 | sulfurtransferase activity(GO:0016783) |
0.0 | 0.1 | GO:0042328 | heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328) |
0.0 | 0.3 | GO:0042608 | T cell receptor binding(GO:0042608) |
0.0 | 0.2 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
0.0 | 1.0 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
0.0 | 0.5 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
0.0 | 0.7 | GO:0016706 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706) |
0.0 | 0.1 | GO:0008097 | 5S rRNA binding(GO:0008097) |
0.0 | 0.4 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
0.0 | 0.4 | GO:0050840 | extracellular matrix binding(GO:0050840) |
0.0 | 1.0 | GO:0004004 | RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) |
0.0 | 0.5 | GO:0008307 | structural constituent of muscle(GO:0008307) |
0.0 | 3.5 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
0.0 | 0.5 | GO:0030507 | spectrin binding(GO:0030507) |
0.0 | 0.1 | GO:0032454 | histone demethylase activity (H3-K9 specific)(GO:0032454) |
0.0 | 0.5 | GO:0048487 | beta-tubulin binding(GO:0048487) |
0.0 | 1.7 | GO:0003714 | transcription corepressor activity(GO:0003714) |
0.0 | 0.5 | GO:0046332 | SMAD binding(GO:0046332) |
0.0 | 1.1 | GO:0051117 | ATPase binding(GO:0051117) |
0.0 | 1.2 | GO:0005125 | cytokine activity(GO:0005125) |
0.0 | 0.0 | GO:0034046 | poly(G) binding(GO:0034046) |
0.0 | 0.9 | GO:0051087 | chaperone binding(GO:0051087) |
0.0 | 0.4 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
0.0 | 0.8 | GO:0019902 | phosphatase binding(GO:0019902) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 5.2 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
0.2 | 8.2 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
0.2 | 5.9 | PID_PDGFRA_PATHWAY | PDGFR-alpha signaling pathway |
0.2 | 4.2 | PID_INTEGRIN_A9B1_PATHWAY | Alpha9 beta1 integrin signaling events |
0.1 | 3.5 | PID_PRL_SIGNALING_EVENTS_PATHWAY | Signaling events mediated by PRL |
0.1 | 8.0 | ST_T_CELL_SIGNAL_TRANSDUCTION | T Cell Signal Transduction |
0.1 | 8.5 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
0.1 | 0.9 | SA_CASPASE_CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
0.1 | 1.0 | PID_IL5_PATHWAY | IL5-mediated signaling events |
0.1 | 1.9 | PID_AR_NONGENOMIC_PATHWAY | Nongenotropic Androgen signaling |
0.1 | 3.2 | PID_NFAT_TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
0.1 | 3.2 | PID_IL4_2PATHWAY | IL4-mediated signaling events |
0.1 | 3.7 | PID_ILK_PATHWAY | Integrin-linked kinase signaling |
0.1 | 2.1 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
0.1 | 2.6 | PID_FAK_PATHWAY | Signaling events mediated by focal adhesion kinase |
0.1 | 1.7 | PID_AURORA_A_PATHWAY | Aurora A signaling |
0.1 | 1.7 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
0.1 | 1.5 | PID_A6B1_A6B4_INTEGRIN_PATHWAY | a6b1 and a6b4 Integrin signaling |
0.0 | 1.5 | PID_HIF2PATHWAY | HIF-2-alpha transcription factor network |
0.0 | 5.4 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
0.0 | 0.8 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
0.0 | 3.4 | PID_MYC_ACTIV_PATHWAY | Validated targets of C-MYC transcriptional activation |
0.0 | 0.1 | PID_TCR_JNK_PATHWAY | JNK signaling in the CD4+ TCR pathway |
0.0 | 2.2 | PID_E2F_PATHWAY | E2F transcription factor network |
0.0 | 0.9 | PID_INSULIN_GLUCOSE_PATHWAY | Insulin-mediated glucose transport |
0.0 | 0.2 | ST_TYPE_I_INTERFERON_PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
0.0 | 0.5 | PID_PI3KCI_AKT_PATHWAY | Class I PI3K signaling events mediated by Akt |
0.0 | 3.7 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
0.0 | 1.0 | PID_PS1_PATHWAY | Presenilin action in Notch and Wnt signaling |
0.0 | 1.3 | PID_MYC_REPRESS_PATHWAY | Validated targets of C-MYC transcriptional repression |
0.0 | 1.0 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
0.0 | 1.4 | PID_P53_REGULATION_PATHWAY | p53 pathway |
0.0 | 1.8 | WNT_SIGNALING | Genes related to Wnt-mediated signal transduction |
0.0 | 0.6 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
0.0 | 0.2 | PID_CXCR4_PATHWAY | CXCR4-mediated signaling events |
0.0 | 1.0 | PID_P73PATHWAY | p73 transcription factor network |
0.0 | 0.3 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
0.0 | 0.3 | SIG_CD40PATHWAYMAP | Genes related to CD40 signaling |
0.0 | 0.7 | PID_TELOMERASE_PATHWAY | Regulation of Telomerase |
0.0 | 0.2 | PID_HDAC_CLASSIII_PATHWAY | Signaling events mediated by HDAC Class III |
0.0 | 0.3 | PID_FANCONI_PATHWAY | Fanconi anemia pathway |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.7 | 8.5 | REACTOME_HDL_MEDIATED_LIPID_TRANSPORT | Genes involved in HDL-mediated lipid transport |
0.3 | 4.7 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
0.2 | 3.5 | REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
0.2 | 1.8 | REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
0.2 | 2.4 | REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
0.2 | 4.3 | REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
0.2 | 3.4 | REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS | Genes involved in Amine compound SLC transporters |
0.2 | 5.5 | REACTOME_RAP1_SIGNALLING | Genes involved in Rap1 signalling |
0.2 | 3.7 | REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS | Genes involved in Host Interactions of HIV factors |
0.2 | 4.5 | REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA | Genes involved in G beta:gamma signalling through PLC beta |
0.1 | 1.6 | REACTOME_REGULATION_OF_IFNG_SIGNALING | Genes involved in Regulation of IFNG signaling |
0.1 | 0.7 | REACTOME_PACKAGING_OF_TELOMERE_ENDS | Genes involved in Packaging Of Telomere Ends |
0.1 | 1.0 | REACTOME_PD1_SIGNALING | Genes involved in PD-1 signaling |
0.1 | 3.5 | REACTOME_KINESINS | Genes involved in Kinesins |
0.1 | 4.0 | REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
0.1 | 1.0 | REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
0.1 | 1.8 | REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
0.1 | 2.2 | REACTOME_G1_S_SPECIFIC_TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
0.1 | 3.0 | REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
0.1 | 11.7 | REACTOME_PEPTIDE_CHAIN_ELONGATION | Genes involved in Peptide chain elongation |
0.1 | 1.0 | REACTOME_INTRINSIC_PATHWAY | Genes involved in Intrinsic Pathway |
0.1 | 0.9 | REACTOME_PYRIMIDINE_CATABOLISM | Genes involved in Pyrimidine catabolism |
0.1 | 1.6 | REACTOME_ARMS_MEDIATED_ACTIVATION | Genes involved in ARMS-mediated activation |
0.1 | 0.7 | REACTOME_MEMBRANE_BINDING_AND_TARGETTING_OF_GAG_PROTEINS | Genes involved in Membrane binding and targetting of GAG proteins |
0.1 | 0.8 | REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
0.1 | 1.7 | REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI | Genes involved in RIP-mediated NFkB activation via DAI |
0.1 | 1.0 | REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
0.1 | 1.3 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |
0.1 | 0.3 | REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1 | Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
0.1 | 0.6 | REACTOME_FRS2_MEDIATED_CASCADE | Genes involved in FRS2-mediated cascade |
0.1 | 1.9 | REACTOME_EXTENSION_OF_TELOMERES | Genes involved in Extension of Telomeres |
0.1 | 1.1 | REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS | Genes involved in Activation of BH3-only proteins |
0.1 | 2.1 | REACTOME_BASIGIN_INTERACTIONS | Genes involved in Basigin interactions |
0.1 | 2.7 | REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT | Genes involved in Mitochondrial Protein Import |
0.1 | 0.3 | REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION | Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
0.0 | 1.3 | REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
0.0 | 0.7 | REACTOME_SIGNAL_TRANSDUCTION_BY_L1 | Genes involved in Signal transduction by L1 |
0.0 | 1.4 | REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC | Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC |
0.0 | 2.2 | REACTOME_MEIOTIC_RECOMBINATION | Genes involved in Meiotic Recombination |
0.0 | 0.2 | REACTOME_ETHANOL_OXIDATION | Genes involved in Ethanol oxidation |
0.0 | 1.3 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
0.0 | 2.4 | REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
0.0 | 3.4 | REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
0.0 | 0.8 | REACTOME_CA_DEPENDENT_EVENTS | Genes involved in Ca-dependent events |
0.0 | 1.1 | REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
0.0 | 1.5 | REACTOME_MRNA_SPLICING_MINOR_PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
0.0 | 2.0 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT | Genes involved in Respiratory electron transport |
0.0 | 0.4 | REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
0.0 | 0.5 | REACTOME_CD28_DEPENDENT_PI3K_AKT_SIGNALING | Genes involved in CD28 dependent PI3K/Akt signaling |
0.0 | 0.4 | REACTOME_P38MAPK_EVENTS | Genes involved in p38MAPK events |
0.0 | 0.6 | REACTOME_INTERFERON_GAMMA_SIGNALING | Genes involved in Interferon gamma signaling |
0.0 | 0.3 | REACTOME_REGULATION_OF_WATER_BALANCE_BY_RENAL_AQUAPORINS | Genes involved in Regulation of Water Balance by Renal Aquaporins |
0.0 | 1.2 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
0.0 | 1.3 | REACTOME_GLUCOSE_METABOLISM | Genes involved in Glucose metabolism |
0.0 | 1.7 | REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
0.0 | 0.2 | REACTOME_METABOLISM_OF_NON_CODING_RNA | Genes involved in Metabolism of non-coding RNA |
0.0 | 0.8 | REACTOME_CDK_MEDIATED_PHOSPHORYLATION_AND_REMOVAL_OF_CDC6 | Genes involved in CDK-mediated phosphorylation and removal of Cdc6 |
0.0 | 0.1 | REACTOME_G_PROTEIN_ACTIVATION | Genes involved in G-protein activation |
0.0 | 1.0 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
0.0 | 1.7 | REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |