Motif ID: Rarg

Z-value: 1.281


Transcription factors associated with Rarg:

Gene SymbolEntrez IDGene Name
Rarg ENSMUSG00000001288.8 Rarg

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rargmm10_v2_chr15_-_102257306_1022573700.481.1e-05Click!


Activity profile for motif Rarg.

activity profile for motif Rarg


Sorted Z-values histogram for motif Rarg

Sorted Z-values for motif Rarg



Network of associatons between targets according to the STRING database.



First level regulatory network of Rarg

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_70501116 10.829 ENSMUST00000127983.1
 Crlf1
cytokine receptor-like factor 1
chr1_-_171059390 10.006 ENSMUST00000164044.1
ENSMUST00000169017.1
 Fcgr3

Fc receptor, IgG, low affinity III

chr11_+_32283511 8.079 ENSMUST00000093209.3
 Hba-a1
hemoglobin alpha, adult chain 1
chr10_+_58813359 7.040 ENSMUST00000135526.2
ENSMUST00000153031.1
 Sh3rf3

SH3 domain containing ring finger 3

chr5_-_113015473 6.935 ENSMUST00000065167.4
 Adrbk2
adrenergic receptor kinase, beta 2
chr9_+_27790947 6.856 ENSMUST00000115243.2
 Opcml
opioid binding protein/cell adhesion molecule-like
chr14_+_101840602 6.795 ENSMUST00000159314.1
 Lmo7
LIM domain only 7
chr7_-_46179929 6.204 ENSMUST00000033123.6
 Abcc8
ATP-binding cassette, sub-family C (CFTR/MRP), member 8
chr19_-_57008187 5.913 ENSMUST00000118800.1
ENSMUST00000111584.2
ENSMUST00000122359.1
ENSMUST00000148049.1
 Afap1l2



actin filament associated protein 1-like 2



chr16_+_41532999 5.909 ENSMUST00000099761.3
 Lsamp
limbic system-associated membrane protein
chr3_+_86070915 5.802 ENSMUST00000182666.1
 Sh3d19
SH3 domain protein D19
chr12_+_81026800 5.676 ENSMUST00000110347.2
ENSMUST00000021564.4
ENSMUST00000129362.1
 Smoc1


SPARC related modular calcium binding 1


chr14_+_101840501 5.641 ENSMUST00000159026.1
 Lmo7
LIM domain only 7
chr12_-_54203860 5.484 ENSMUST00000039516.3
 Egln3
EGL nine homolog 3 (C. elegans)
chr14_+_70890099 4.922 ENSMUST00000022699.8
 Gfra2
glial cell line derived neurotrophic factor family receptor alpha 2
chr5_-_146585239 4.741 ENSMUST00000036211.6
 Gpr12
G-protein coupled receptor 12
chr13_-_51567084 4.723 ENSMUST00000021898.5
 Shc3
src homology 2 domain-containing transforming protein C3
chr8_+_40862379 4.708 ENSMUST00000098816.3
ENSMUST00000057784.8
ENSMUST00000141505.1
 Slc7a2


solute carrier family 7 (cationic amino acid transporter, y+ system), member 2


chr2_+_14229390 4.584 ENSMUST00000028045.2
 Mrc1
mannose receptor, C type 1
chr1_-_186705980 4.452 ENSMUST00000045288.8
 Tgfb2
transforming growth factor, beta 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 289 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 11.3 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
3.6 10.8 GO:0001803 antibody-dependent cellular cytotoxicity(GO:0001788) type III hypersensitivity(GO:0001802) regulation of type III hypersensitivity(GO:0001803) positive regulation of type III hypersensitivity(GO:0001805)
1.5 10.2 GO:0015862 uridine transport(GO:0015862)
1.0 8.7 GO:0001574 ganglioside biosynthetic process(GO:0001574)
1.0 8.1 GO:0080184 response to stilbenoid(GO:0035634) response to phenylpropanoid(GO:0080184)
0.3 8.1 GO:0035641 locomotory exploration behavior(GO:0035641)
2.5 7.5 GO:1900673 olefin metabolic process(GO:1900673)
2.1 6.2 GO:1901079 positive regulation of relaxation of muscle(GO:1901079)
0.3 6.1 GO:0032757 positive regulation of interleukin-8 production(GO:0032757)
0.3 5.8 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.7 5.5 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.8 5.3 GO:0061718 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.3 5.2 GO:0016322 neuron remodeling(GO:0016322)
0.1 5.2 GO:0045667 regulation of osteoblast differentiation(GO:0045667)
1.6 4.9 GO:0043181 vacuolar sequestering(GO:0043181)
1.6 4.7 GO:1902022 L-lysine transport(GO:1902022)
0.1 4.6 GO:0051865 protein autoubiquitination(GO:0051865)
1.5 4.5 GO:1902256 endocardial cushion fusion(GO:0003274) apoptotic process involved in outflow tract morphogenesis(GO:0003275) atrial septum primum morphogenesis(GO:0003289) positive regulation of catagen(GO:0051795) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256)
0.6 4.5 GO:0098707 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.2 4.5 GO:0035036 binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 147 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 14.2 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 13.7 GO:0031225 anchored component of membrane(GO:0031225)
0.1 13.5 GO:0005604 basement membrane(GO:0005604)
3.6 10.8 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.0 10.5 GO:0016324 apical plasma membrane(GO:0016324)
0.0 8.4 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
2.0 8.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 7.3 GO:0000139 Golgi membrane(GO:0000139)
0.3 6.8 GO:0002080 acrosomal membrane(GO:0002080)
1.6 6.2 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
1.5 6.0 GO:0044307 dendritic branch(GO:0044307)
0.3 5.3 GO:0097228 sperm principal piece(GO:0097228)
0.0 4.8 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.6 4.5 GO:0097433 dense body(GO:0097433)
0.0 4.5 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 4.4 GO:0043197 dendritic spine(GO:0043197)
0.5 4.2 GO:0001520 outer dense fiber(GO:0001520)
1.4 4.1 GO:0098855 HCN channel complex(GO:0098855)
1.0 4.1 GO:0097574 lateral part of cell(GO:0097574) basolateral part of cell(GO:1990794) rod bipolar cell terminal bouton(GO:1990795)
0.6 3.9 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 215 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 12.4 GO:0042805 actinin binding(GO:0042805)
2.2 10.8 GO:0019770 IgG receptor activity(GO:0019770)
1.5 10.8 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
1.5 10.4 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.4 10.2 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.3 9.0 GO:0070064 proline-rich region binding(GO:0070064)
2.0 8.1 GO:0031720 haptoglobin binding(GO:0031720)
1.2 7.5 GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.1 7.1 GO:0005267 potassium channel activity(GO:0005267)
0.1 6.8 GO:0005518 collagen binding(GO:0005518)
0.4 6.7 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.1 5.9 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
1.4 5.5 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.6 5.5 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.4 5.5 GO:0005537 mannose binding(GO:0005537)
0.1 5.5 GO:0005178 integrin binding(GO:0005178)
1.1 5.3 GO:0008865 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.2 5.3 GO:0071617 lysophospholipid acyltransferase activity(GO:0071617)
0.3 5.2 GO:0070403 NAD+ binding(GO:0070403)
0.1 5.2 GO:0050840 extracellular matrix binding(GO:0050840)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 15.9 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 14.9 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.3 6.7 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.2 6.2 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 5.5 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 4.7 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.4 4.5 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 4.4 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.1 4.4 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 3.9 PID_TXA2PATHWAY Thromboxane A2 receptor signaling
0.2 3.8 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.1 3.5 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.1 3.5 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.1 3.1 NABA_COLLAGENS Genes encoding collagen proteins
0.2 3.0 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 2.9 PID_P53_REGULATION_PATHWAY p53 pathway
0.1 2.7 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.1 2.7 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.2 2.5 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.1 2.3 PID_IL1_PATHWAY IL1-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 84 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 10.8 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.2 10.0 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.2 8.7 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.4 7.6 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.2 7.5 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 6.4 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.2 6.0 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 6.0 REACTOME_MUSCLE_CONTRACTION Genes involved in Muscle contraction
0.3 5.3 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2 5.3 REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT Genes involved in ABC-family proteins mediated transport
0.1 5.3 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.1 5.2 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 5.0 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.2 4.9 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 4.9 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.2 4.7 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.1 4.2 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.2 3.8 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.3 3.7 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 3.7 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)