Motif ID: Rela_Rel_Nfkb1

Z-value: 1.911

Transcription factors associated with Rela_Rel_Nfkb1:

Gene SymbolEntrez IDGene Name
Nfkb1 ENSMUSG00000028163.11 Nfkb1
Rel ENSMUSG00000020275.8 Rel
Rela ENSMUSG00000024927.7 Rela

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfkb1mm10_v2_chr3_-_135691512_1356915640.621.8e-09Click!
Relamm10_v2_chr19_+_5637475_56374860.315.4e-03Click!


Activity profile for motif Rela_Rel_Nfkb1.

activity profile for motif Rela_Rel_Nfkb1


Sorted Z-values histogram for motif Rela_Rel_Nfkb1

Sorted Z-values for motif Rela_Rel_Nfkb1



Network of associatons between targets according to the STRING database.



First level regulatory network of Rela_Rel_Nfkb1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_74791516 44.615 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a
chr8_-_61902669 27.204 ENSMUST00000121785.1
ENSMUST00000034057.7
 Palld

palladin, cytoskeletal associated protein

chr6_-_48840988 23.458 ENSMUST00000164733.1
 Tmem176b
transmembrane protein 176B
chr6_-_48841098 23.353 ENSMUST00000101429.4
 Tmem176b
transmembrane protein 176B
chr2_-_165234689 23.342 ENSMUST00000065438.6
 Cdh22
cadherin 22
chr6_-_48841373 22.589 ENSMUST00000166247.1
 Tmem176b
transmembrane protein 176B
chr1_+_64532790 22.342 ENSMUST00000049932.5
ENSMUST00000087366.4
ENSMUST00000171164.1
 Creb1


cAMP responsive element binding protein 1


chr6_+_48841476 20.383 ENSMUST00000101426.4
 Tmem176a
transmembrane protein 176A
chr6_+_48841633 19.934 ENSMUST00000168406.1
 Tmem176a
transmembrane protein 176A
chr9_-_119093468 17.695 ENSMUST00000010804.2
 Plcd1
phospholipase C, delta 1
chr5_+_92925400 17.200 ENSMUST00000172706.1
 Shroom3
shroom family member 3
chr17_-_35000848 16.635 ENSMUST00000166828.3
 D17H6S56E-5
DNA segment, Chr 17, human D6S56E 5
chr1_+_185454803 16.516 ENSMUST00000061093.6
 Slc30a10
solute carrier family 30, member 10
chr2_-_151973387 15.115 ENSMUST00000109863.1
 Fam110a
family with sequence similarity 110, member A
chr17_-_35702040 14.808 ENSMUST00000166980.2
ENSMUST00000145900.1
 Ddr1

discoidin domain receptor family, member 1

chr6_+_4755327 14.202 ENSMUST00000176551.1
 Peg10
paternally expressed 10
chr17_-_35701937 13.885 ENSMUST00000155628.1
 Ddr1
discoidin domain receptor family, member 1
chr2_-_151973840 13.297 ENSMUST00000109865.1
ENSMUST00000109864.1
 Fam110a

family with sequence similarity 110, member A

chr7_-_102250086 12.549 ENSMUST00000106923.1
ENSMUST00000098230.4
 Rhog

ras homolog gene family, member G

chr17_-_35000746 12.457 ENSMUST00000163360.1
 D17H6S56E-5
DNA segment, Chr 17, human D6S56E 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 270 entries
Log-likelihood per target Total log-likelihoodTermDescription
16.9 118.2 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
3.8 41.4 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
3.4 40.6 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
1.5 29.0 GO:0003334 keratinocyte development(GO:0003334)
7.4 22.3 GO:0032916 positive regulation of transforming growth factor beta3 production(GO:0032916)
2.7 21.9 GO:1903003 positive regulation of protein deubiquitination(GO:1903003)
0.4 21.9 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)
0.3 21.3 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
6.5 19.6 GO:0072554 arterial endothelial cell fate commitment(GO:0060844) blood vessel endothelial cell fate commitment(GO:0060846) endothelial cell fate specification(GO:0060847) Notch signaling pathway involved in arterial endothelial cell fate commitment(GO:0060853) blood vessel lumenization(GO:0072554) blood vessel endothelial cell fate specification(GO:0097101) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) positive regulation of heart induction(GO:1901321) regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066)
1.9 18.9 GO:0000022 mitotic spindle elongation(GO:0000022) mitotic spindle midzone assembly(GO:0051256)
3.0 18.3 GO:0070094 positive regulation of glucagon secretion(GO:0070094)
2.5 17.8 GO:0098535 de novo centriole assembly(GO:0098535)
3.5 17.7 GO:0010701 positive regulation of norepinephrine secretion(GO:0010701) positive regulation of inositol trisphosphate biosynthetic process(GO:0032962)
5.6 16.9 GO:0016115 terpenoid catabolic process(GO:0016115)
5.5 16.5 GO:0071579 regulation of zinc ion transport(GO:0071579)
1.7 15.5 GO:0008063 Toll signaling pathway(GO:0008063)
1.2 15.2 GO:0002467 germinal center formation(GO:0002467)
0.9 15.0 GO:0060213 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
4.7 14.1 GO:0070428 granuloma formation(GO:0002432) negative regulation of toll-like receptor 3 signaling pathway(GO:0034140) toll-like receptor 5 signaling pathway(GO:0034146) regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424) regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428) regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070432)
0.2 14.0 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 141 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 33.1 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.3 32.7 GO:0031225 anchored component of membrane(GO:0031225)
0.7 32.5 GO:0002102 podosome(GO:0002102)
0.0 28.4 GO:0070062 extracellular exosome(GO:0070062)
0.1 26.5 GO:0005925 focal adhesion(GO:0005925)
3.3 23.3 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
3.1 21.8 GO:0042613 MHC class II protein complex(GO:0042613)
0.2 20.4 GO:0000922 spindle pole(GO:0000922)
0.4 20.1 GO:0005719 nuclear euchromatin(GO:0005719)
0.1 19.8 GO:0043235 receptor complex(GO:0043235)
3.9 19.6 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.1 18.7 GO:0043296 apical junction complex(GO:0043296)
1.1 16.7 GO:0030127 COPII vesicle coat(GO:0030127)
0.2 14.7 GO:0000118 histone deacetylase complex(GO:0000118)
0.9 13.9 GO:0035631 CD40 receptor complex(GO:0035631)
0.1 13.7 GO:0005913 cell-cell adherens junction(GO:0005913)
2.2 13.4 GO:0098536 deuterosome(GO:0098536)
0.1 11.5 GO:0005902 microvillus(GO:0005902)
1.8 10.7 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.3 10.2 GO:0090544 BAF-type complex(GO:0090544)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 180 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 49.8 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
1.2 46.2 GO:0005109 frizzled binding(GO:0005109)
4.5 40.6 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 33.3 GO:0005509 calcium ion binding(GO:0005509)
0.7 31.3 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.2 27.7 GO:0005178 integrin binding(GO:0005178)
0.1 27.0 GO:0051015 actin filament binding(GO:0051015)
7.4 22.3 GO:0001225 RNA polymerase II transcription coactivator binding(GO:0001225)
0.4 21.0 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 20.0 GO:0003723 RNA binding(GO:0003723)
0.9 17.7 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.8 16.6 GO:0070410 co-SMAD binding(GO:0070410)
0.6 16.5 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
1.3 15.5 GO:0031996 thioesterase binding(GO:0031996)
0.3 13.6 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
1.9 13.0 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
1.2 11.6 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
2.2 10.9 GO:0042289 MHC class II protein binding(GO:0042289)
1.8 10.7 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
1.8 10.6 GO:0019841 retinol binding(GO:0019841)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 40.7 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.7 39.9 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.7 39.4 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.6 28.2 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.4 22.5 PID_IL12_2PATHWAY IL12-mediated signaling events
1.3 22.3 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.3 19.1 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.5 17.9 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.2 17.8 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.5 17.1 PID_CD40_PATHWAY CD40/CD40L signaling
0.6 13.9 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.1 11.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.3 11.7 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.3 11.1 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 10.9 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.2 9.0 PID_CDC42_PATHWAY CDC42 signaling events
0.2 8.7 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 8.3 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 8.1 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.2 7.3 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 39.5 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.6 28.8 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
1.3 24.2 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
1.0 22.3 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
1.1 17.9 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.5 16.7 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.2 16.6 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
1.1 15.6 REACTOME_ACTIVATION_OF_IRF3_IRF7_MEDIATED_BY_TBK1_IKK_EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.2 15.3 REACTOME_G_ALPHA1213_SIGNALLING_EVENTS Genes involved in G alpha (12/13) signalling events
0.8 15.1 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.3 15.0 REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE Genes involved in GPVI-mediated activation cascade
0.4 13.9 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.6 12.5 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.5 11.8 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.4 11.6 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.6 10.7 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
1.5 10.6 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.6 8.6 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.3 7.4 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 7.2 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening