Motif ID: Relb

Z-value: 0.633


Transcription factors associated with Relb:

Gene SymbolEntrez IDGene Name
Relb ENSMUSG00000002983.10 Relb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Relbmm10_v2_chr7_-_19629355_196294510.281.4e-02Click!


Activity profile for motif Relb.

activity profile for motif Relb


Sorted Z-values histogram for motif Relb

Sorted Z-values for motif Relb



Network of associatons between targets according to the STRING database.



First level regulatory network of Relb

PNG image of the network

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Top targets:


Showing 1 to 20 of 71 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_+_80000292 7.810 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr2_-_5714490 6.193 ENSMUST00000044009.7
 Camk1d
calcium/calmodulin-dependent protein kinase ID
chr3_-_107760221 6.012 ENSMUST00000153114.1
ENSMUST00000118593.1
ENSMUST00000120243.1
 Csf1


colony stimulating factor 1 (macrophage)


chr2_+_10153563 4.783 ENSMUST00000026886.7
 Itih5
inter-alpha (globulin) inhibitor H5
chr8_+_72319033 4.733 ENSMUST00000067912.7
 Klf2
Kruppel-like factor 2 (lung)
chr4_+_130915949 4.584 ENSMUST00000030316.6
 Laptm5
lysosomal-associated protein transmembrane 5
chr4_+_129985098 4.542 ENSMUST00000106017.1
ENSMUST00000121049.1
 Bai2

brain-specific angiogenesis inhibitor 2

chr2_-_5063996 4.237 ENSMUST00000114996.1
 Optn
optineurin
chr15_-_98677451 3.981 ENSMUST00000120997.1
ENSMUST00000109149.2
ENSMUST00000003451.4
 Rnd1


Rho family GTPase 1


chr4_+_129984833 3.953 ENSMUST00000120204.1
 Bai2
brain-specific angiogenesis inhibitor 2
chr3_-_9610074 3.793 ENSMUST00000041124.7
 Zfp704
zinc finger protein 704
chr2_-_5063932 3.661 ENSMUST00000027986.4
 Optn
optineurin
chr9_+_64385626 3.328 ENSMUST00000093829.2
ENSMUST00000118485.1
ENSMUST00000164113.1
 Megf11


multiple EGF-like-domains 11


chrX_+_36112110 3.292 ENSMUST00000033418.7
 Il13ra1
interleukin 13 receptor, alpha 1
chr18_+_37484955 3.133 ENSMUST00000053856.4
 Pcdhb17
protocadherin beta 17
chr2_-_125506385 2.870 ENSMUST00000028633.6
 Fbn1
fibrillin 1
chr9_+_64385675 2.744 ENSMUST00000068967.4
 Megf11
multiple EGF-like-domains 11
chr5_+_90891234 2.700 ENSMUST00000031327.8
 Cxcl1
chemokine (C-X-C motif) ligand 1
chr12_-_55492587 2.683 ENSMUST00000021413.7
 Nfkbia
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
chr7_+_99535652 2.401 ENSMUST00000032995.8
ENSMUST00000162404.1
 Arrb1

arrestin, beta 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 7.9 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.2 7.8 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.9 6.2 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.2 6.1 GO:0010842 retina layer formation(GO:0010842)
2.0 6.0 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.8 4.8 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.2 4.8 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.8 4.7 GO:0071499 response to laminar fluid shear stress(GO:0034616) cellular response to laminar fluid shear stress(GO:0071499)
0.2 4.0 GO:0016322 neuron remodeling(GO:0016322)
0.6 3.7 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.8 3.4 GO:0070942 neutrophil mediated cytotoxicity(GO:0070942) neutrophil mediated killing of symbiont cell(GO:0070943)
1.1 3.3 GO:0035963 response to interleukin-13(GO:0035962) cellular response to interleukin-13(GO:0035963)
0.8 3.2 GO:0009597 detection of virus(GO:0009597)
0.0 3.1 GO:0007416 synapse assembly(GO:0007416)
1.0 2.9 GO:1903011 negative regulation of bone development(GO:1903011)
0.3 2.3 GO:0060842 arterial endothelial cell differentiation(GO:0060842)
0.1 2.3 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.0 2.3 GO:0008542 visual learning(GO:0008542)
0.2 2.2 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.4 2.1 GO:0010626 negative regulation of Schwann cell proliferation(GO:0010626)

Gene overrepresentation in cellular_component category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.9 GO:0005802 trans-Golgi network(GO:0005802)
0.6 7.8 GO:0042581 specific granule(GO:0042581)
2.0 6.0 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.3 4.8 GO:0031143 pseudopodium(GO:0031143)
0.0 4.6 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.4 3.0 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.2 2.9 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 2.5 GO:0032587 ruffle membrane(GO:0032587)
0.2 2.3 GO:0042612 MHC class I protein complex(GO:0042612)
0.3 2.1 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0 1.8 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 1.8 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 1.7 GO:0005905 clathrin-coated pit(GO:0005905)
0.2 1.3 GO:0033010 paranodal junction(GO:0033010)
0.2 1.1 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.1 1.1 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 1.0 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.2 0.9 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.0 0.7 GO:0030008 TRAPP complex(GO:0030008)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 7.9 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.0 7.8 GO:0045296 cadherin binding(GO:0045296)
0.2 6.2 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 6.0 GO:0005125 cytokine activity(GO:0005125)
1.6 4.8 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.1 4.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.3 3.4 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.1 3.3 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 3.2 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 3.1 GO:0003924 GTPase activity(GO:0003924)
0.1 2.9 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 2.7 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 2.5 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.2 2.3 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.1 2.2 GO:0046527 glucosyltransferase activity(GO:0046527)
0.1 2.1 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 1.9 GO:0001047 core promoter binding(GO:0001047)
0.2 1.8 GO:0005131 growth hormone receptor binding(GO:0005131)
0.0 1.7 GO:0008565 protein transporter activity(GO:0008565)
0.4 1.6 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)

Gene overrepresentation in C2:CP category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 6.0 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.2 5.4 PID_IL23_PATHWAY IL23-mediated signaling events
1.3 5.1 ST_IL_13_PATHWAY Interleukin 13 (IL-13) Pathway
0.1 4.8 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.0 4.8 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 3.0 PID_IL12_2PATHWAY IL12-mediated signaling events
0.2 2.9 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.3 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 1.1 ST_GAQ_PATHWAY G alpha q Pathway
0.0 1.1 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 1.0 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.2 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 8.0 REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.2 6.4 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.2 4.0 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 4.0 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 3.4 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 2.2 REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.1 1.8 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.1 1.4 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 1.0 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.1 0.8 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE