Motif ID: Relb
Z-value: 0.633
Transcription factors associated with Relb:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Relb | ENSMUSG00000002983.10 | Relb |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Relb | mm10_v2_chr7_-_19629355_19629451 | 0.28 | 1.4e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 6.0 | GO:1904139 | microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139) |
| 2.0 | 7.9 | GO:0001920 | negative regulation of receptor recycling(GO:0001920) |
| 1.1 | 3.3 | GO:0035963 | response to interleukin-13(GO:0035962) cellular response to interleukin-13(GO:0035963) |
| 1.0 | 2.9 | GO:1903011 | negative regulation of bone development(GO:1903011) |
| 0.9 | 6.2 | GO:0060267 | positive regulation of respiratory burst(GO:0060267) |
| 0.8 | 3.4 | GO:0070942 | neutrophil mediated cytotoxicity(GO:0070942) neutrophil mediated killing of symbiont cell(GO:0070943) |
| 0.8 | 3.2 | GO:0009597 | detection of virus(GO:0009597) |
| 0.8 | 4.8 | GO:0042699 | follicle-stimulating hormone signaling pathway(GO:0042699) |
| 0.8 | 4.7 | GO:0071499 | response to laminar fluid shear stress(GO:0034616) cellular response to laminar fluid shear stress(GO:0071499) |
| 0.6 | 3.7 | GO:0007253 | cytoplasmic sequestering of NF-kappaB(GO:0007253) |
| 0.5 | 1.5 | GO:0061744 | motor behavior(GO:0061744) |
| 0.4 | 1.8 | GO:0036015 | response to interleukin-3(GO:0036015) cellular response to interleukin-3(GO:0036016) |
| 0.4 | 1.3 | GO:1900226 | negative regulation of NLRP3 inflammasome complex assembly(GO:1900226) |
| 0.4 | 2.1 | GO:0010626 | negative regulation of Schwann cell proliferation(GO:0010626) |
| 0.3 | 0.9 | GO:2000170 | positive regulation of peptidyl-cysteine S-nitrosylation(GO:2000170) |
| 0.3 | 2.3 | GO:0060842 | arterial endothelial cell differentiation(GO:0060842) |
| 0.3 | 1.0 | GO:1900740 | regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740) |
| 0.2 | 1.2 | GO:0021993 | initiation of neural tube closure(GO:0021993) |
| 0.2 | 4.0 | GO:0016322 | neuron remodeling(GO:0016322) |
| 0.2 | 1.1 | GO:0007256 | activation of JNKK activity(GO:0007256) |
| 0.2 | 6.1 | GO:0010842 | retina layer formation(GO:0010842) |
| 0.2 | 4.8 | GO:0030212 | hyaluronan metabolic process(GO:0030212) |
| 0.2 | 7.8 | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading(GO:1900026) |
| 0.2 | 2.2 | GO:0006490 | oligosaccharide-lipid intermediate biosynthetic process(GO:0006490) |
| 0.2 | 0.8 | GO:0033140 | negative regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033140) |
| 0.1 | 1.9 | GO:0043011 | myeloid dendritic cell differentiation(GO:0043011) |
| 0.1 | 0.8 | GO:0006646 | phosphatidylethanolamine biosynthetic process(GO:0006646) |
| 0.1 | 1.4 | GO:0032060 | bleb assembly(GO:0032060) |
| 0.1 | 1.1 | GO:0038063 | collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) |
| 0.1 | 2.3 | GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I(GO:0002474) |
| 0.1 | 0.7 | GO:0001731 | formation of translation preinitiation complex(GO:0001731) |
| 0.0 | 0.6 | GO:0002467 | germinal center formation(GO:0002467) |
| 0.0 | 2.3 | GO:0008542 | visual learning(GO:0008542) |
| 0.0 | 0.2 | GO:0048149 | behavioral response to ethanol(GO:0048149) |
| 0.0 | 3.1 | GO:0007416 | synapse assembly(GO:0007416) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 6.0 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
| 0.6 | 7.8 | GO:0042581 | specific granule(GO:0042581) |
| 0.4 | 3.0 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.3 | 4.8 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.3 | 2.1 | GO:0031315 | extrinsic component of mitochondrial outer membrane(GO:0031315) |
| 0.2 | 1.1 | GO:0005587 | collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651) |
| 0.2 | 0.9 | GO:1902937 | inward rectifier potassium channel complex(GO:1902937) |
| 0.2 | 2.9 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.2 | 1.3 | GO:0033010 | paranodal junction(GO:0033010) |
| 0.2 | 2.3 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.1 | 1.1 | GO:0097431 | mitotic spindle pole(GO:0097431) |
| 0.0 | 0.7 | GO:0030008 | TRAPP complex(GO:0030008) |
| 0.0 | 7.9 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 2.5 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 1.0 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.0 | 1.7 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.0 | 4.6 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.0 | 1.8 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.0 | 1.8 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 4.8 | GO:0031896 | V2 vasopressin receptor binding(GO:0031896) |
| 0.9 | 7.9 | GO:0001025 | RNA polymerase III transcription factor binding(GO:0001025) |
| 0.4 | 1.6 | GO:0032422 | purine-rich negative regulatory element binding(GO:0032422) |
| 0.3 | 1.3 | GO:0034739 | histone deacetylase activity (H4-K16 specific)(GO:0034739) tubulin deacetylase activity(GO:0042903) |
| 0.3 | 3.4 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.2 | 1.8 | GO:0005131 | growth hormone receptor binding(GO:0005131) |
| 0.2 | 0.8 | GO:0004103 | choline kinase activity(GO:0004103) |
| 0.2 | 2.3 | GO:0030881 | beta-2-microglobulin binding(GO:0030881) |
| 0.2 | 6.2 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.1 | 2.2 | GO:0046527 | glucosyltransferase activity(GO:0046527) |
| 0.1 | 0.7 | GO:0071074 | eukaryotic initiation factor eIF2 binding(GO:0071074) |
| 0.1 | 4.8 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 2.7 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.1 | 2.9 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.1 | 1.2 | GO:0051864 | histone demethylase activity (H3-K36 specific)(GO:0051864) |
| 0.1 | 6.0 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.1 | 3.3 | GO:0004896 | cytokine receptor activity(GO:0004896) |
| 0.1 | 2.1 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.0 | 3.2 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
| 0.0 | 0.9 | GO:0050998 | nitric-oxide synthase binding(GO:0050998) |
| 0.0 | 2.5 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 0.0 | 7.8 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.0 | 1.7 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.0 | 3.1 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.0 | 1.9 | GO:0001047 | core promoter binding(GO:0001047) |
| 0.0 | 1.0 | GO:0051117 | ATPase binding(GO:0051117) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 5.1 | ST_IL_13_PATHWAY | Interleukin 13 (IL-13) Pathway |
| 0.6 | 6.0 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.2 | 5.4 | PID_IL23_PATHWAY | IL23-mediated signaling events |
| 0.2 | 2.9 | PID_INTEGRIN5_PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.1 | 4.8 | PID_IL8_CXCR1_PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.1 | 3.0 | PID_IL12_2PATHWAY | IL12-mediated signaling events |
| 0.0 | 1.3 | PID_HDAC_CLASSIII_PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 4.8 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 1.1 | ST_GAQ_PATHWAY | G alpha q Pathway |
| 0.0 | 1.1 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
| 0.0 | 1.0 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 0.2 | PID_TCR_RAS_PATHWAY | Ras signaling in the CD4+ TCR pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 8.0 | REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION | Genes involved in TRAF6 mediated NF-kB activation |
| 0.2 | 4.0 | REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.2 | 6.4 | REACTOME_LYSOSOME_VESICLE_BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.1 | 1.8 | REACTOME_IL_6_SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.1 | 3.4 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 1.4 | REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.1 | 2.2 | REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.1 | 0.8 | REACTOME_SYNTHESIS_OF_PE | Genes involved in Synthesis of PE |
| 0.0 | 1.0 | REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.0 | 4.0 | REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS | Genes involved in Integrin cell surface interactions |
