Motif ID: Rest
Z-value: 2.772
Transcription factors associated with Rest:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Rest | ENSMUSG00000029249.9 | Rest |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Rest | mm10_v2_chr5_+_77265454_77265549 | 0.44 | 5.6e-05 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 20.6 | 61.7 | GO:1900673 | olefin metabolic process(GO:1900673) |
| 8.1 | 73.1 | GO:0060373 | regulation of atrial cardiac muscle cell membrane depolarization(GO:0060371) regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373) |
| 6.4 | 19.2 | GO:0006566 | threonine metabolic process(GO:0006566) |
| 6.3 | 69.6 | GO:0018230 | peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231) |
| 5.5 | 11.0 | GO:0021586 | pons maturation(GO:0021586) |
| 5.0 | 29.8 | GO:0045162 | clustering of voltage-gated sodium channels(GO:0045162) |
| 4.4 | 22.1 | GO:0018364 | peptidyl-glutamine methylation(GO:0018364) |
| 3.9 | 15.4 | GO:0090126 | protein complex assembly involved in synapse maturation(GO:0090126) |
| 3.5 | 10.4 | GO:0021557 | oculomotor nerve development(GO:0021557) |
| 3.4 | 27.5 | GO:2000301 | negative regulation of synaptic vesicle exocytosis(GO:2000301) |
| 3.3 | 13.2 | GO:0035021 | negative regulation of Rac protein signal transduction(GO:0035021) |
| 3.3 | 9.9 | GO:0046032 | ADP catabolic process(GO:0046032) |
| 2.6 | 39.3 | GO:0050910 | detection of mechanical stimulus involved in sensory perception of sound(GO:0050910) |
| 2.6 | 10.3 | GO:0030860 | regulation of polarized epithelial cell differentiation(GO:0030860) |
| 2.6 | 7.7 | GO:0030827 | negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283) |
| 2.3 | 60.5 | GO:2000311 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311) |
| 2.2 | 56.9 | GO:0032011 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
| 1.9 | 5.7 | GO:0014063 | negative regulation of serotonin secretion(GO:0014063) |
| 1.7 | 10.4 | GO:0072318 | clathrin coat disassembly(GO:0072318) |
| 1.6 | 21.4 | GO:0043084 | penile erection(GO:0043084) |
| 1.3 | 11.9 | GO:0033631 | cell-cell adhesion mediated by integrin(GO:0033631) |
| 1.3 | 17.8 | GO:0097091 | synaptic vesicle clustering(GO:0097091) |
| 1.3 | 6.3 | GO:0072235 | distal convoluted tubule development(GO:0072025) metanephric distal convoluted tubule development(GO:0072221) metanephric distal tubule development(GO:0072235) |
| 1.2 | 43.6 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 1.2 | 3.5 | GO:0038003 | opioid receptor signaling pathway(GO:0038003) regulation of opioid receptor signaling pathway(GO:2000474) |
| 1.1 | 16.9 | GO:0007220 | Notch receptor processing(GO:0007220) |
| 1.1 | 13.2 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
| 1.1 | 23.5 | GO:0071625 | vocalization behavior(GO:0071625) |
| 0.9 | 19.4 | GO:0051482 | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482) |
| 0.7 | 11.2 | GO:0045956 | positive regulation of calcium ion-dependent exocytosis(GO:0045956) |
| 0.7 | 5.6 | GO:0090336 | positive regulation of brown fat cell differentiation(GO:0090336) |
| 0.7 | 14.8 | GO:0099517 | anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517) |
| 0.6 | 7.7 | GO:0044331 | cell-cell adhesion mediated by cadherin(GO:0044331) |
| 0.6 | 33.2 | GO:0030901 | midbrain development(GO:0030901) |
| 0.3 | 6.8 | GO:0006828 | manganese ion transport(GO:0006828) |
| 0.3 | 0.8 | GO:0016256 | N-glycan processing to lysosome(GO:0016256) |
| 0.3 | 0.8 | GO:0070093 | negative regulation of glucagon secretion(GO:0070093) |
| 0.2 | 15.7 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 0.2 | 0.5 | GO:0006295 | pyrimidine dimer repair by nucleotide-excision repair(GO:0000720) nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295) nucleotide-excision repair, DNA incision, 5'-to lesion(GO:0006296) positive regulation of t-circle formation(GO:1904431) |
| 0.2 | 1.1 | GO:0060056 | mammary gland involution(GO:0060056) |
| 0.1 | 17.3 | GO:0007286 | spermatid development(GO:0007286) |
| 0.1 | 4.0 | GO:0006099 | tricarboxylic acid cycle(GO:0006099) |
| 0.1 | 19.3 | GO:0071805 | potassium ion transmembrane transport(GO:0071805) |
| 0.1 | 1.9 | GO:0015991 | ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662) |
| 0.1 | 15.5 | GO:0060828 | regulation of canonical Wnt signaling pathway(GO:0060828) |
| 0.1 | 0.4 | GO:0007258 | JUN phosphorylation(GO:0007258) |
| 0.1 | 5.5 | GO:0006639 | acylglycerol metabolic process(GO:0006639) |
| 0.0 | 33.0 | GO:0030334 | regulation of cell migration(GO:0030334) |
| 0.0 | 1.1 | GO:0014065 | phosphatidylinositol 3-kinase signaling(GO:0014065) |
| 0.0 | 12.6 | GO:0030097 | hemopoiesis(GO:0030097) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 15.4 | 61.7 | GO:0044307 | dendritic branch(GO:0044307) |
| 5.8 | 69.6 | GO:0002178 | palmitoyltransferase complex(GO:0002178) |
| 5.0 | 29.8 | GO:0008091 | spectrin(GO:0008091) |
| 4.9 | 73.1 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 3.7 | 11.0 | GO:0016533 | cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533) |
| 3.2 | 22.1 | GO:0031428 | box C/D snoRNP complex(GO:0031428) |
| 2.9 | 11.5 | GO:0002141 | stereocilia ankle link(GO:0002141) |
| 2.8 | 27.8 | GO:0032426 | stereocilium tip(GO:0032426) |
| 2.6 | 10.3 | GO:0089717 | spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717) |
| 1.8 | 27.5 | GO:0097449 | astrocyte projection(GO:0097449) |
| 1.7 | 15.4 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 1.4 | 46.9 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 1.3 | 56.5 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 1.1 | 14.8 | GO:0030123 | AP-3 adaptor complex(GO:0030123) |
| 1.0 | 12.2 | GO:0044294 | dendritic growth cone(GO:0044294) |
| 0.8 | 7.7 | GO:0044327 | dendritic spine head(GO:0044327) |
| 0.6 | 17.8 | GO:0000795 | synaptonemal complex(GO:0000795) |
| 0.4 | 4.0 | GO:0045252 | oxoglutarate dehydrogenase complex(GO:0045252) |
| 0.4 | 11.4 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.3 | 21.4 | GO:0030667 | secretory granule membrane(GO:0030667) |
| 0.2 | 19.3 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.2 | 1.9 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
| 0.2 | 7.7 | GO:0097440 | apical dendrite(GO:0097440) |
| 0.2 | 3.5 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.2 | 0.5 | GO:0000110 | nucleotide-excision repair factor 1 complex(GO:0000110) |
| 0.2 | 48.8 | GO:0019898 | extrinsic component of membrane(GO:0019898) |
| 0.1 | 6.8 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.1 | 10.4 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.1 | 76.5 | GO:0043025 | neuronal cell body(GO:0043025) |
| 0.1 | 12.0 | GO:0014069 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.1 | 12.6 | GO:0005938 | cell cortex(GO:0005938) |
| 0.0 | 9.9 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.0 | 5.7 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 5.6 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 39.5 | GO:0005794 | Golgi apparatus(GO:0005794) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.4 | 73.1 | GO:0086006 | voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006) |
| 10.3 | 61.7 | GO:1904315 | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315) |
| 6.9 | 27.5 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 6.4 | 19.2 | GO:0008732 | threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732) |
| 4.8 | 19.4 | GO:0004966 | galanin receptor activity(GO:0004966) |
| 4.4 | 43.6 | GO:0042301 | phosphate ion binding(GO:0042301) |
| 2.4 | 69.6 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 2.0 | 11.9 | GO:0033691 | sialic acid binding(GO:0033691) |
| 1.9 | 56.9 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 1.5 | 60.5 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 1.4 | 90.8 | GO:0005179 | hormone activity(GO:0005179) |
| 1.4 | 22.1 | GO:0008649 | rRNA methyltransferase activity(GO:0008649) |
| 1.3 | 15.4 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 1.2 | 9.9 | GO:0047631 | ADP-ribose diphosphatase activity(GO:0047631) |
| 1.1 | 19.3 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 1.0 | 22.0 | GO:0030506 | ankyrin binding(GO:0030506) |
| 0.6 | 4.0 | GO:0004591 | oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591) |
| 0.6 | 6.8 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.5 | 11.0 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
| 0.5 | 16.9 | GO:0005112 | Notch binding(GO:0005112) |
| 0.4 | 5.7 | GO:0008227 | G-protein coupled amine receptor activity(GO:0008227) |
| 0.4 | 26.1 | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding(GO:0005546) |
| 0.4 | 10.8 | GO:0008432 | JUN kinase binding(GO:0008432) |
| 0.4 | 20.8 | GO:0015485 | cholesterol binding(GO:0015485) |
| 0.3 | 13.2 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.3 | 39.9 | GO:0051219 | phosphoprotein binding(GO:0051219) |
| 0.3 | 5.5 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
| 0.2 | 0.8 | GO:0003976 | UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976) |
| 0.2 | 28.5 | GO:0005261 | cation channel activity(GO:0005261) |
| 0.2 | 6.3 | GO:0005496 | steroid binding(GO:0005496) |
| 0.1 | 9.6 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.1 | 12.0 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.1 | 10.3 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 0.1 | 7.7 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.1 | 0.5 | GO:1990599 | 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599) |
| 0.0 | 13.2 | GO:0008022 | protein C-terminus binding(GO:0008022) |
| 0.0 | 8.1 | GO:0000287 | magnesium ion binding(GO:0000287) |
| 0.0 | 7.7 | GO:0003779 | actin binding(GO:0003779) |
| 0.0 | 1.9 | GO:0016820 | hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) |
| 0.0 | 2.1 | GO:0008168 | methyltransferase activity(GO:0008168) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 73.1 | PID_P53_DOWNSTREAM_PATHWAY | Direct p53 effectors |
| 0.3 | 11.9 | PID_INTEGRIN3_PATHWAY | Beta3 integrin cell surface interactions |
| 0.3 | 11.0 | PID_LIS1_PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.3 | 10.4 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.2 | 16.9 | PID_NOTCH_PATHWAY | Notch signaling pathway |
| 0.1 | 7.7 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 0.4 | ST_GRANULE_CELL_SURVIVAL_PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.2 | 114.8 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 2.5 | 61.7 | REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
| 1.5 | 56.5 | REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 1.2 | 17.8 | REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 1.1 | 6.8 | REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS | Genes involved in Elevation of cytosolic Ca2+ levels |
| 0.7 | 58.7 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.6 | 11.0 | REACTOME_CRMPS_IN_SEMA3A_SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.5 | 7.7 | REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.5 | 19.3 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.4 | 16.9 | REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.4 | 5.7 | REACTOME_AMINE_LIGAND_BINDING_RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.3 | 10.4 | REACTOME_LYSOSOME_VESICLE_BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.2 | 5.5 | REACTOME_SYNTHESIS_OF_PA | Genes involved in Synthesis of PA |
| 0.1 | 10.4 | REACTOME_SIGNALING_BY_NOTCH1 | Genes involved in Signaling by NOTCH1 |
| 0.1 | 1.9 | REACTOME_INSULIN_RECEPTOR_RECYCLING | Genes involved in Insulin receptor recycling |
| 0.1 | 1.4 | REACTOME_KERATAN_SULFATE_BIOSYNTHESIS | Genes involved in Keratan sulfate biosynthesis |
| 0.0 | 0.5 | REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER | Genes involved in Formation of incision complex in GG-NER |
