Motif ID: Rfx5

Z-value: 0.933


Transcription factors associated with Rfx5:

Gene SymbolEntrez IDGene Name
Rfx5 ENSMUSG00000005774.6 Rfx5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rfx5mm10_v2_chr3_+_94954075_949542260.446.8e-05Click!


Activity profile for motif Rfx5.

activity profile for motif Rfx5


Sorted Z-values histogram for motif Rfx5

Sorted Z-values for motif Rfx5



Network of associatons between targets according to the STRING database.



First level regulatory network of Rfx5

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_37376359 10.916 ENSMUST00000012587.3
 Kif11
kinesin family member 11
chr18_+_60803838 10.676 ENSMUST00000050487.8
ENSMUST00000097563.2
ENSMUST00000167610.1
 Cd74


CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)


chr17_+_34263209 8.669 ENSMUST00000040828.5
 H2-Ab1
histocompatibility 2, class II antigen A, beta 1
chr7_-_45092130 7.549 ENSMUST00000148175.1
 Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr7_-_45091713 7.063 ENSMUST00000141576.1
 Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr17_+_34305883 6.991 ENSMUST00000074557.8
 H2-Eb1
histocompatibility 2, class II antigen E beta
chr11_+_117523526 6.969 ENSMUST00000132261.1
 Gm11734
predicted gene 11734
chr7_-_105752193 6.420 ENSMUST00000033184.4
 Tpp1
tripeptidyl peptidase I
chr5_+_139150211 5.643 ENSMUST00000026975.6
 Heatr2
HEAT repeat containing 2
chr14_+_55618023 5.526 ENSMUST00000002395.7
 Rec8
REC8 homolog (yeast)
chr11_-_3539228 5.476 ENSMUST00000075118.3
ENSMUST00000136243.1
ENSMUST00000170588.1
ENSMUST00000020721.8
 Smtn



smoothelin



chr5_-_36830647 5.307 ENSMUST00000031002.3
 Man2b2
mannosidase 2, alpha B2
chr4_-_126325641 4.691 ENSMUST00000131113.1
 Tekt2
tektin 2
chr8_+_94214567 4.581 ENSMUST00000079961.6
 Nup93
nucleoporin 93
chr10_-_19011948 4.388 ENSMUST00000105527.1
 Tnfaip3
tumor necrosis factor, alpha-induced protein 3
chr17_+_35379608 4.350 ENSMUST00000081435.4
 H2-Q4
histocompatibility 2, Q region locus 4
chr2_+_122147680 4.210 ENSMUST00000102476.4
 B2m
beta-2 microglobulin
chr17_-_34187219 3.864 ENSMUST00000173831.1
 Psmb9
proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
chr11_+_61505138 3.818 ENSMUST00000102657.3
 B9d1
B9 protein domain 1
chr17_+_35439155 3.613 ENSMUST00000071951.6
ENSMUST00000078205.7
ENSMUST00000116598.3
ENSMUST00000076256.7
 H2-Q7



histocompatibility 2, Q region locus 7



chr17_+_35861318 3.497 ENSMUST00000074259.8
ENSMUST00000174873.1
 Nrm

nurim (nuclear envelope membrane protein)

chr1_+_194619815 3.467 ENSMUST00000027952.5
 Plxna2
plexin A2
chr17_+_34197715 3.383 ENSMUST00000173441.1
ENSMUST00000025196.8
 Psmb8

proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)

chr7_-_30664986 3.277 ENSMUST00000019697.8
 Haus5
HAUS augmin-like complex, subunit 5
chr7_+_28180226 2.946 ENSMUST00000172467.1
 Dyrk1b
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b
chr8_-_89187560 2.944 ENSMUST00000093326.2
 Gm5356
predicted pseudogene 5356
chr7_+_100537052 2.811 ENSMUST00000054310.3
 Coa4
cytochrome c oxidase assembly factor 4
chr19_-_4615647 2.528 ENSMUST00000113822.2
 Lrfn4
leucine rich repeat and fibronectin type III domain containing 4
chr7_+_100537192 2.496 ENSMUST00000120454.1
 Coa4
cytochrome c oxidase assembly factor 4
chr19_-_10482874 2.427 ENSMUST00000038842.3
 Ppp1r32
protein phosphatase 1, regulatory subunit 32
chr7_+_28180272 2.381 ENSMUST00000173223.1
 Dyrk1b
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b
chr8_+_84969587 2.380 ENSMUST00000109734.1
ENSMUST00000005292.8
 Prdx2

peroxiredoxin 2

chr1_-_183147461 2.268 ENSMUST00000171366.1
 Disp1
dispatched homolog 1 (Drosophila)
chr18_-_51865881 2.110 ENSMUST00000091905.2
 Gm4950
predicted pseudogene 4950
chr17_+_35861343 2.056 ENSMUST00000172931.1
 Nrm
nurim (nuclear envelope membrane protein)
chr6_-_8259098 1.981 ENSMUST00000012627.4
 Rpa3
replication protein A3
chr7_+_28179469 1.967 ENSMUST00000085901.6
ENSMUST00000172761.1
 Dyrk1b

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b

chr9_-_21291124 1.631 ENSMUST00000086374.6
 Cdkn2d
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chr8_-_69996326 1.481 ENSMUST00000177851.1
ENSMUST00000065169.4
 Gatad2a

GATA zinc finger domain containing 2A

chr7_+_44467980 1.444 ENSMUST00000035844.4
 Josd2
Josephin domain containing 2
chr7_+_44468020 1.401 ENSMUST00000117324.1
ENSMUST00000120852.1
ENSMUST00000118628.1
 Josd2


Josephin domain containing 2


chr4_+_107968332 1.353 ENSMUST00000106713.3
 Slc1a7
solute carrier family 1 (glutamate transporter), member 7
chr10_-_7663245 1.333 ENSMUST00000163085.1
ENSMUST00000159917.1
 Pcmt1

protein-L-isoaspartate (D-aspartate) O-methyltransferase 1

chr1_-_155146755 1.210 ENSMUST00000027744.8
 Mr1
major histocompatibility complex, class I-related
chr2_+_163438455 1.164 ENSMUST00000109420.3
ENSMUST00000109421.3
ENSMUST00000018087.6
ENSMUST00000137070.1
 Gdap1l1



ganglioside-induced differentiation-associated protein 1-like 1



chr3_-_95882193 1.096 ENSMUST00000159863.1
ENSMUST00000159739.1
ENSMUST00000036418.3
 Gm129


predicted gene 129


chr7_+_44468051 1.072 ENSMUST00000118493.1
 Josd2
Josephin domain containing 2
chr17_+_34187789 1.036 ENSMUST00000041633.8
 Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr17_+_37270214 1.030 ENSMUST00000038580.6
 H2-M3
histocompatibility 2, M region locus 3
chr3_+_16183177 1.013 ENSMUST00000108345.2
ENSMUST00000108346.2
 Ythdf3

YTH domain family 3

chr3_-_95882232 0.816 ENSMUST00000161866.1
 Gm129
predicted gene 129
chr10_-_7663569 0.702 ENSMUST00000162606.1
 Pcmt1
protein-L-isoaspartate (D-aspartate) O-methyltransferase 1
chr13_+_24831661 0.697 ENSMUST00000038039.2
 Tdp2
tyrosyl-DNA phosphodiesterase 2
chr9_+_44772951 0.653 ENSMUST00000128150.1
 Ift46
intraflagellar transport 46
chr17_+_34187545 0.635 ENSMUST00000170086.1
 Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr15_+_36179530 0.597 ENSMUST00000171205.1
 Spag1
sperm associated antigen 1
chr7_-_101921186 0.489 ENSMUST00000106965.1
ENSMUST00000106968.1
ENSMUST00000106967.1
 Lrrc51


leucine rich repeat containing 51


chr7_-_101921175 0.486 ENSMUST00000098236.2
 Lrrc51
leucine rich repeat containing 51
chr15_+_36179299 0.483 ENSMUST00000047348.3
 Spag1
sperm associated antigen 1
chr1_+_134405984 0.382 ENSMUST00000173908.1
 Cyb5r1
cytochrome b5 reductase 1
chr16_+_20696175 0.292 ENSMUST00000128273.1
 Fam131a
family with sequence similarity 131, member A
chr11_+_98682554 0.223 ENSMUST00000017365.8
 Psmd3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr17_-_24886304 0.188 ENSMUST00000044252.5
 Nubp2
nucleotide binding protein 2
chr2_-_128687354 0.180 ENSMUST00000110332.1
ENSMUST00000110333.1
ENSMUST00000014499.3
 Anapc1


anaphase promoting complex subunit 1


chr11_+_72441341 0.174 ENSMUST00000045633.5
 Mybbp1a
MYB binding protein (P160) 1a
chr9_+_44773191 0.170 ENSMUST00000147559.1
 Ift46
intraflagellar transport 46
chr1_+_136676413 0.115 ENSMUST00000181491.1
 Gm19705
predicted gene, 19705
chr3_-_95882031 0.012 ENSMUST00000161994.1
 Gm129
predicted gene 129

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 10.7 GO:0002901 mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
1.7 8.7 GO:0002339 B cell selection(GO:0002339)
1.5 4.4 GO:0070428 granuloma formation(GO:0002432) negative regulation of toll-like receptor 3 signaling pathway(GO:0034140) toll-like receptor 5 signaling pathway(GO:0034146) regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424) regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428) regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070432)
1.3 5.2 GO:0002481 antigen processing and presentation of exogenous peptide antigen via MHC class Ib(GO:0002477) antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent(GO:0002481)
1.1 10.9 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
0.9 4.6 GO:0090521 glomerular visceral epithelial cell migration(GO:0090521)
0.8 1.7 GO:0046967 cytosol to ER transport(GO:0046967)
0.6 5.3 GO:0006013 mannose metabolic process(GO:0006013)
0.4 4.7 GO:0036159 inner dynein arm assembly(GO:0036159)
0.4 5.5 GO:0007141 male meiosis I(GO:0007141)
0.4 3.5 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
0.4 1.5 GO:0021506 anterior neuropore closure(GO:0021506) neuropore closure(GO:0021995)
0.3 2.8 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.3 5.3 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.3 2.4 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.3 9.2 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.2 6.4 GO:0043171 peptide catabolic process(GO:0043171)
0.2 2.3 GO:0060539 diaphragm development(GO:0060539)
0.2 7.3 GO:0007520 myoblast fusion(GO:0007520)
0.2 1.6 GO:0048102 autophagic cell death(GO:0048102)
0.2 7.2 GO:0019882 antigen processing and presentation(GO:0019882)
0.1 2.0 GO:0046498 S-adenosylhomocysteine metabolic process(GO:0046498)
0.1 1.4 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.1 2.0 GO:0006298 mismatch repair(GO:0006298)
0.1 3.8 GO:0042733 embryonic digit morphogenesis(GO:0042733)
0.0 1.0 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.0 0.2 GO:2000210 positive regulation of anoikis(GO:2000210)
0.0 3.3 GO:0051225 spindle assembly(GO:0051225)
0.0 1.2 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.3 GO:0001539 cilium or flagellum-dependent cell motility(GO:0001539) cilium-dependent cell motility(GO:0060285)
0.0 1.7 GO:0016579 protein deubiquitination(GO:0016579)
0.0 1.1 GO:0007338 single fertilization(GO:0007338)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 22.1 GO:0042613 MHC class II protein complex(GO:0042613)
1.8 7.2 GO:1990111 spermatoproteasome complex(GO:1990111)
1.4 5.5 GO:0034991 nuclear meiotic cohesin complex(GO:0034991)
1.1 13.4 GO:0042612 MHC class I protein complex(GO:0042612)
1.0 1.0 GO:0042611 MHC protein complex(GO:0042611)
0.4 3.3 GO:0070652 HAUS complex(GO:0070652)
0.4 1.6 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.3 5.6 GO:0005652 nuclear lamina(GO:0005652)
0.2 1.7 GO:0042825 TAP complex(GO:0042825)
0.2 3.8 GO:0036038 MKS complex(GO:0036038)
0.2 10.9 GO:0005876 spindle microtubule(GO:0005876)
0.1 2.0 GO:0005662 DNA replication factor A complex(GO:0005662)
0.1 5.3 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 1.5 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 0.2 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.1 4.6 GO:0005643 nuclear pore(GO:0005643)
0.0 3.2 GO:0036126 sperm flagellum(GO:0036126)
0.0 2.0 GO:0031526 brush border membrane(GO:0031526)
0.0 15.0 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 0.2 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.7 GO:0016235 aggresome(GO:0016235)
0.0 0.2 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.3 GO:0030992 intraciliary transport particle B(GO:0030992)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 10.7 GO:0042289 MHC class II protein binding(GO:0042289)
1.6 6.4 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
1.3 3.8 GO:0008158 hedgehog receptor activity(GO:0008158)
0.8 8.7 GO:1990405 protein antigen binding(GO:1990405)
0.6 9.6 GO:0046977 TAP binding(GO:0046977)
0.6 4.4 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.4 2.0 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.4 5.3 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.3 7.2 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.3 8.3 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.2 3.5 GO:0017154 semaphorin receptor activity(GO:0017154)
0.2 2.4 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.2 2.3 GO:0015197 peptide transporter activity(GO:0015197)
0.2 4.6 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 7.3 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 1.6 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 1.0 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.1 1.0 GO:0042605 peptide antigen binding(GO:0042605)
0.1 1.4 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.1 2.0 GO:0003684 damaged DNA binding(GO:0003684)
0.0 0.4 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0 1.2 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 14.6 GO:0005509 calcium ion binding(GO:0005509)
0.0 1.7 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 0.7 GO:0030145 manganese ion binding(GO:0030145)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.4 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.1 4.2 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 3.5 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.7 PID_CD40_PATHWAY CD40/CD40L signaling
0.0 1.5 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 1.6 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.2 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.3 8.3 REACTOME_KINESINS Genes involved in Kinesins
0.2 3.5 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.2 2.0 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.1 7.5 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.1 4.6 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.1 4.4 REACTOME_NOD1_2_SIGNALING_PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.1 6.4 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 1.7 REACTOME_ER_PHAGOSOME_PATHWAY Genes involved in ER-Phagosome pathway
0.1 10.7 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.1 5.5 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.1 1.4 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 1.6 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 0.2 REACTOME_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC_C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C