Motif ID: Rhox4e_Rhox6_Vax2

Z-value: 1.550

Transcription factors associated with Rhox4e_Rhox6_Vax2:

Gene SymbolEntrez IDGene Name
Rhox4e ENSMUSG00000071770.4 Rhox4e
Rhox6 ENSMUSG00000006200.3 Rhox6
Vax2 ENSMUSG00000034777.1 Vax2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Vax2mm10_v2_chr6_+_83711232_83711288-0.216.5e-02Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Rhox4e_Rhox6_Vax2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_67113909 36.849 ENSMUST00000092640.5
St3gal1
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr6_-_23248264 29.972 ENSMUST00000031709.5
Fezf1
Fez family zinc finger 1
chr9_+_53771499 23.897 ENSMUST00000048670.8
Slc35f2
solute carrier family 35, member F2
chr4_-_14621805 23.124 ENSMUST00000042221.7
Slc26a7
solute carrier family 26, member 7
chr14_+_5517172 14.747 ENSMUST00000178220.1
Gm3488
predicted gene, 3488
chr14_+_5164535 14.747 ENSMUST00000179659.1
Gm3317
predicted gene 3317
chr4_-_14621669 13.574 ENSMUST00000143105.1
Slc26a7
solute carrier family 26, member 7
chr14_+_3667518 13.440 ENSMUST00000112801.3
Gm3020
predicted gene 3020
chr13_-_102906046 12.738 ENSMUST00000171791.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr4_-_14621494 12.316 ENSMUST00000149633.1
Slc26a7
solute carrier family 26, member 7
chr14_-_7473073 12.232 ENSMUST00000167833.2
Gm3752
predicted gene 3752
chr14_+_4198185 12.069 ENSMUST00000180184.1
Gm2974
predicted gene 2974
chr14_+_3348089 12.019 ENSMUST00000178722.1
Gm2956
predicted gene 2956
chr14_-_6874257 11.991 ENSMUST00000178298.1
ENSMUST00000179374.1
Gm3667
Gm3629
predicted gene 3667
predicted gene 3629
chr14_+_4126066 11.707 ENSMUST00000167397.2
Gm8108
predicted gene 8108
chr14_+_4871156 11.466 ENSMUST00000166410.2
Gm3264
predicted gene 3264
chr14_+_4741737 11.443 ENSMUST00000178748.1
Gm3252
predicted gene 3252
chr14_+_3428103 11.441 ENSMUST00000178060.1
Gm3005
predicted gene 3005
chr7_-_25005895 11.348 ENSMUST00000102858.3
ENSMUST00000080882.6
Atp1a3

ATPase, Na+/K+ transporting, alpha 3 polypeptide

chr14_-_6411578 11.309 ENSMUST00000179312.1
Gm3591
predicted gene 3591
chr14_+_4430992 11.288 ENSMUST00000164603.1
ENSMUST00000166848.1
Gm3173

predicted gene 3173

chr14_-_6266620 11.186 ENSMUST00000096172.5
Gm3411
predicted gene 3411
chr14_+_3825596 11.024 ENSMUST00000178256.1
Gm3002
predicted gene 3002
chr14_+_4514758 10.949 ENSMUST00000112776.2
Gm3173
predicted gene 3173
chr12_+_109545390 10.568 ENSMUST00000146701.1
Meg3
maternally expressed 3
chr14_-_5863663 10.480 ENSMUST00000178594.1
Gm8237
predicted gene 8237
chr14_-_19569553 10.174 ENSMUST00000112595.2
Gm2237
predicted gene 2237
chr12_-_112511136 9.980 ENSMUST00000066791.5
Tmem179
transmembrane protein 179
chr1_+_72284367 9.807 ENSMUST00000027380.5
ENSMUST00000141783.1
Tmem169

transmembrane protein 169

chr14_+_4665094 9.746 ENSMUST00000169675.2
Gm3239
predicted gene 3239
chr13_-_102905740 9.414 ENSMUST00000167462.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr2_+_65845767 8.960 ENSMUST00000122912.1
Csrnp3
cysteine-serine-rich nuclear protein 3
chr14_-_6741430 8.749 ENSMUST00000100904.4
Gm3636
predicted gene 3636
chr5_+_37185897 8.686 ENSMUST00000094840.3
Gm1043
predicted gene 1043
chr16_-_42340595 8.628 ENSMUST00000102817.4
Gap43
growth associated protein 43
chr12_-_40037387 8.558 ENSMUST00000146905.1
Arl4a
ADP-ribosylation factor-like 4A
chr2_+_65845833 8.314 ENSMUST00000053910.3
Csrnp3
cysteine-serine-rich nuclear protein 3
chr2_+_65620829 7.206 ENSMUST00000028377.7
Scn2a1
sodium channel, voltage-gated, type II, alpha 1
chr4_+_15881255 6.893 ENSMUST00000029876.1
Calb1
calbindin 1
chr9_-_75597643 5.819 ENSMUST00000164100.1
Tmod2
tropomodulin 2
chr2_+_125136692 5.536 ENSMUST00000099452.2
Ctxn2
cortexin 2
chr9_-_112187766 5.498 ENSMUST00000111872.2
ENSMUST00000164754.2
Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr9_-_55919605 5.362 ENSMUST00000037408.8
Scaper
S phase cyclin A-associated protein in the ER
chr15_-_60824942 5.305 ENSMUST00000100635.3
Fam84b
family with sequence similarity 84, member B
chr8_-_54724317 4.997 ENSMUST00000129132.2
ENSMUST00000150488.1
ENSMUST00000127511.2
Wdr17


WD repeat domain 17


chr3_+_55782500 4.949 ENSMUST00000075422.4
Mab21l1
mab-21-like 1 (C. elegans)
chr3_+_55461758 4.771 ENSMUST00000070418.4
Dclk1
doublecortin-like kinase 1
chr5_-_118244861 4.666 ENSMUST00000117177.1
ENSMUST00000133372.1
ENSMUST00000154786.1
ENSMUST00000121369.1
Rnft2



ring finger protein, transmembrane 2



chr7_+_57387304 4.415 ENSMUST00000085241.5
Gm9962
predicted gene 9962
chr9_+_102720287 4.407 ENSMUST00000130602.1
Amotl2
angiomotin-like 2
chr1_-_89933290 4.260 ENSMUST00000036954.7
Gbx2
gastrulation brain homeobox 2
chr6_+_37870786 4.038 ENSMUST00000120428.1
ENSMUST00000031859.7
Trim24

tripartite motif-containing 24

chr18_+_12741324 3.657 ENSMUST00000115857.2
ENSMUST00000121018.1
ENSMUST00000119108.1
Cabyr


calcium-binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2)


chr3_+_121953213 3.655 ENSMUST00000037958.7
ENSMUST00000128366.1
Arhgap29

Rho GTPase activating protein 29

chr1_+_109983737 3.451 ENSMUST00000172005.1
Cdh7
cadherin 7, type 2
chr3_+_103575275 3.407 ENSMUST00000090697.4
Syt6
synaptotagmin VI
chr8_+_107031218 3.353 ENSMUST00000034388.9
Vps4a
vacuolar protein sorting 4a (yeast)
chr2_+_69897220 3.308 ENSMUST00000055758.9
ENSMUST00000112251.2
Ubr3

ubiquitin protein ligase E3 component n-recognin 3

chr15_+_59315030 2.901 ENSMUST00000022977.7
Sqle
squalene epoxidase
chr15_+_59315088 2.829 ENSMUST00000100640.4
Sqle
squalene epoxidase
chr3_+_103575231 2.803 ENSMUST00000121834.1
Syt6
synaptotagmin VI
chr3_-_10440054 2.698 ENSMUST00000099223.4
ENSMUST00000029047.6
Snx16

sorting nexin 16

chrM_+_7759 2.469 ENSMUST00000082407.1
ENSMUST00000082408.1
mt-Atp8
mt-Atp6
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chr10_-_33951190 2.445 ENSMUST00000048222.4
Zufsp
zinc finger with UFM1-specific peptidase domain
chr19_+_23723279 2.188 ENSMUST00000067077.1
Gm9938
predicted gene 9938
chr13_+_75967704 2.056 ENSMUST00000022081.1
Spata9
spermatogenesis associated 9
chr9_+_119063429 2.021 ENSMUST00000141185.1
ENSMUST00000126251.1
ENSMUST00000136561.1
Vill


villin-like


chr14_+_3224440 1.936 ENSMUST00000112797.4
D830030K20Rik
RIKEN cDNA D830030K20 gene
chr19_+_25406661 1.915 ENSMUST00000146647.1
Kank1
KN motif and ankyrin repeat domains 1
chr2_-_69712461 1.898 ENSMUST00000102706.3
ENSMUST00000073152.6
Fastkd1

FAST kinase domains 1

chr3_-_86548268 1.857 ENSMUST00000077524.3
Mab21l2
mab-21-like 2 (C. elegans)
chr18_+_4993795 1.818 ENSMUST00000153016.1
Svil
supervillin
chr2_-_71367749 1.805 ENSMUST00000151937.1
Slc25a12
solute carrier family 25 (mitochondrial carrier, Aralar), member 12
chr18_+_38418946 1.805 ENSMUST00000025293.3
Ndfip1
Nedd4 family interacting protein 1
chrX_-_143933204 1.796 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
Dcx


doublecortin


chr2_-_168767136 1.790 ENSMUST00000029061.5
ENSMUST00000103074.1
Sall4

sal-like 4 (Drosophila)

chr7_-_38019505 1.787 ENSMUST00000085513.4
Uri1
URI1, prefoldin-like chaperone
chr13_-_92030897 1.760 ENSMUST00000149630.1
Rasgrf2
RAS protein-specific guanine nucleotide-releasing factor 2
chr16_+_58408443 1.717 ENSMUST00000046663.7
Dcbld2
discoidin, CUB and LCCL domain containing 2
chr19_-_32196393 1.677 ENSMUST00000151822.1
Sgms1
sphingomyelin synthase 1
chr5_+_29195983 1.635 ENSMUST00000160888.1
ENSMUST00000159272.1
ENSMUST00000001247.5
ENSMUST00000161398.1
ENSMUST00000160246.1
Rnf32




ring finger protein 32




chr2_+_170731807 1.623 ENSMUST00000029075.4
Dok5
docking protein 5
chr14_+_3846245 1.570 ENSMUST00000180934.1
Gm3033
predicted gene 3033
chr12_+_10390756 1.519 ENSMUST00000020947.5
Rdh14
retinol dehydrogenase 14 (all-trans and 9-cis)
chr19_-_11604828 1.510 ENSMUST00000025582.4
Ms4a6d
membrane-spanning 4-domains, subfamily A, member 6D
chr3_-_90389884 1.504 ENSMUST00000029541.5
Slc27a3
solute carrier family 27 (fatty acid transporter), member 3
chr13_-_53473074 1.490 ENSMUST00000021922.8
Msx2
msh homeobox 2
chrX_+_150589907 1.430 ENSMUST00000080884.4
Pfkfb1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chrX_-_143933089 1.398 ENSMUST00000087313.3
Dcx
doublecortin
chr8_-_35495487 1.355 ENSMUST00000033927.6
Eri1
exoribonuclease 1
chr14_+_57524734 1.266 ENSMUST00000089494.4
Il17d
interleukin 17D
chr7_+_12927410 1.261 ENSMUST00000045870.4
2310014L17Rik
RIKEN cDNA 2310014L17 gene
chr8_+_64947177 1.233 ENSMUST00000079896.7
ENSMUST00000026595.5
Tmem192

transmembrane protein 192

chr5_-_34660068 1.184 ENSMUST00000041364.9
Nop14
NOP14 nucleolar protein
chr2_-_168767029 1.181 ENSMUST00000075044.3
Sall4
sal-like 4 (Drosophila)
chr17_-_15527281 1.149 ENSMUST00000154293.1
ENSMUST00000054450.6
Pdcd2

programmed cell death 2

chr18_+_4920509 1.146 ENSMUST00000126977.1
Svil
supervillin
chr19_+_60811574 1.113 ENSMUST00000128357.1
ENSMUST00000119633.1
ENSMUST00000025957.8
Fam45a


family with sequence similarity 45, member A


chr14_-_7450917 1.106 ENSMUST00000169555.1
Gm3755
predicted gene 3755
chr12_-_80643799 1.085 ENSMUST00000166931.1
Erh
enhancer of rudimentary homolog (Drosophila)
chr3_+_122274371 1.077 ENSMUST00000035776.8
Dnttip2
deoxynucleotidyltransferase, terminal, interacting protein 2
chr10_-_8886033 0.987 ENSMUST00000015449.5
Sash1
SAM and SH3 domain containing 1
chr17_+_8849974 0.924 ENSMUST00000115720.1
Pde10a
phosphodiesterase 10A
chr7_+_126950687 0.921 ENSMUST00000106333.1
Sez6l2
seizure related 6 homolog like 2
chrX_-_60893430 0.914 ENSMUST00000135107.2
Sox3
SRY-box containing gene 3
chr19_+_41933464 0.905 ENSMUST00000026154.7
Zdhhc16
zinc finger, DHHC domain containing 16
chr2_+_121956651 0.900 ENSMUST00000110574.1
Ctdspl2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr2_+_121956411 0.882 ENSMUST00000110578.1
Ctdspl2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chrX_-_160138375 0.880 ENSMUST00000033662.8
Pdha1
pyruvate dehydrogenase E1 alpha 1
chr5_-_136986829 0.867 ENSMUST00000034953.7
ENSMUST00000085941.5
Znhit1

zinc finger, HIT domain containing 1

chr13_+_67833235 0.845 ENSMUST00000060609.7
Gm10037
predicted gene 10037
chr18_-_56975333 0.828 ENSMUST00000139243.2
ENSMUST00000025488.8
C330018D20Rik

RIKEN cDNA C330018D20 gene

chr9_-_99568849 0.812 ENSMUST00000035043.5
Armc8
armadillo repeat containing 8
chr8_+_66386292 0.802 ENSMUST00000039540.5
ENSMUST00000110253.2
March1

membrane-associated ring finger (C3HC4) 1

chr13_+_90089705 0.796 ENSMUST00000012566.8
Tmem167
transmembrane protein 167
chr12_+_100110148 0.775 ENSMUST00000021595.8
Psmc1
protease (prosome, macropain) 26S subunit, ATPase 1
chr9_+_108339048 0.775 ENSMUST00000082429.5
Gpx1
glutathione peroxidase 1
chr18_-_24603791 0.765 ENSMUST00000070726.3
Slc39a6
solute carrier family 39 (metal ion transporter), member 6
chr11_+_69838514 0.703 ENSMUST00000133967.1
ENSMUST00000094065.4
Tmem256

transmembrane protein 256

chr15_+_82256023 0.700 ENSMUST00000143238.1
1500009C09Rik
RIKEN cDNA 1500009C09 gene
chr13_-_66852017 0.696 ENSMUST00000059329.6
Gm17449
predicted gene, 17449
chr12_+_72536342 0.682 ENSMUST00000044352.6
Pcnxl4
pecanex-like 4 (Drosophila)
chr1_-_135284075 0.655 ENSMUST00000077340.7
ENSMUST00000074357.7
Rnpep

arginyl aminopeptidase (aminopeptidase B)

chr1_+_87183310 0.655 ENSMUST00000044533.8
Prss56
protease, serine 56
chr15_-_36794498 0.652 ENSMUST00000110361.1
ENSMUST00000022894.7
ENSMUST00000110359.1
Ywhaz


tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide


chr14_-_20496780 0.646 ENSMUST00000022353.3
Mss51
MSS51 mitochondrial translational activator
chr6_+_71909046 0.634 ENSMUST00000055296.8
Polr1a
polymerase (RNA) I polypeptide A
chr2_-_155074447 0.634 ENSMUST00000137242.1
ENSMUST00000054607.9
Ahcy

S-adenosylhomocysteine hydrolase

chr12_+_52699297 0.606 ENSMUST00000095737.3
Akap6
A kinase (PRKA) anchor protein 6
chr4_+_103143052 0.595 ENSMUST00000106855.1
Mier1
mesoderm induction early response 1 homolog (Xenopus laevis
chr12_-_85824506 0.538 ENSMUST00000021676.5
ENSMUST00000142331.1
0610007P14Rik

RIKEN cDNA 0610007P14 gene

chr13_-_67332525 0.537 ENSMUST00000168892.1
ENSMUST00000109735.2
Zfp595

zinc finger protein 595

chr18_-_24603464 0.508 ENSMUST00000154205.1
Slc39a6
solute carrier family 39 (metal ion transporter), member 6
chr2_+_109917639 0.495 ENSMUST00000046548.7
ENSMUST00000111037.2
Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chrM_+_7005 0.462 ENSMUST00000082405.1
mt-Co2
mitochondrially encoded cytochrome c oxidase II
chr2_-_125782834 0.458 ENSMUST00000053699.6
Secisbp2l
SECIS binding protein 2-like
chr10_+_128337761 0.454 ENSMUST00000005826.7
Cs
citrate synthase
chr11_-_117873433 0.446 ENSMUST00000033230.7
Tha1
threonine aldolase 1
chr18_+_24603952 0.439 ENSMUST00000025120.6
Elp2
elongator acetyltransferase complex subunit 2
chr12_+_55303241 0.402 ENSMUST00000184766.1
ENSMUST00000183475.1
ENSMUST00000183654.1
1110008L16Rik


RIKEN cDNA 1110008L16 gene


chr4_+_43493345 0.398 ENSMUST00000030181.5
ENSMUST00000107922.2
Ccdc107

coiled-coil domain containing 107

chr11_+_86484647 0.378 ENSMUST00000020827.6
Rnft1
ring finger protein, transmembrane 1
chr3_-_67515487 0.343 ENSMUST00000178314.1
ENSMUST00000054825.4
Rarres1

retinoic acid receptor responder (tazarotene induced) 1

chr12_+_80644212 0.338 ENSMUST00000085245.5
Slc39a9
solute carrier family 39 (zinc transporter), member 9
chr9_-_71163224 0.312 ENSMUST00000074465.2
Aqp9
aquaporin 9
chr18_+_55057557 0.300 ENSMUST00000181765.1
Gm4221
predicted gene 4221
chr9_+_72806874 0.298 ENSMUST00000055535.8
Prtg
protogenin homolog (Gallus gallus)
chr17_-_48432723 0.275 ENSMUST00000046549.3
Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr12_-_79190955 0.269 ENSMUST00000085254.6
Rdh11
retinol dehydrogenase 11
chr7_+_38183217 0.268 ENSMUST00000165308.1
1600014C10Rik
RIKEN cDNA 1600014C10 gene
chr2_+_69897255 0.253 ENSMUST00000131553.1
Ubr3
ubiquitin protein ligase E3 component n-recognin 3
chrX_+_101429555 0.244 ENSMUST00000033673.6
Nono
non-POU-domain-containing, octamer binding protein
chr12_+_110601439 0.234 ENSMUST00000018851.7
Dync1h1
dynein cytoplasmic 1 heavy chain 1
chr5_-_134946917 0.216 ENSMUST00000051401.2
Cldn4
claudin 4
chr5_-_137531204 0.215 ENSMUST00000150063.2
Gnb2
guanine nucleotide binding protein (G protein), beta 2
chr13_+_59585259 0.204 ENSMUST00000168367.1
ENSMUST00000022038.7
ENSMUST00000166923.1
Naa35


N(alpha)-acetyltransferase 35, NatC auxiliary subunit


chr8_+_113635550 0.167 ENSMUST00000179926.1
Mon1b
MON1 homolog b (yeast)
chr17_+_27839974 0.154 ENSMUST00000071006.7
Snrpc
U1 small nuclear ribonucleoprotein C
chr4_+_108719649 0.137 ENSMUST00000178992.1
3110021N24Rik
RIKEN cDNA 3110021N24 gene
chr17_-_57031468 0.122 ENSMUST00000007814.8
Khsrp
KH-type splicing regulatory protein
chrX_+_170009892 0.116 ENSMUST00000180251.1
Gm21887
predicted gene, 21887
chr6_+_68161415 0.090 ENSMUST00000168090.1
Igkv1-115
immunoglobulin kappa variable 1-115
chr8_+_113635787 0.072 ENSMUST00000035777.8
Mon1b
MON1 homolog b (yeast)
chrM_+_14138 0.062 ENSMUST00000082421.1
mt-Cytb
mitochondrially encoded cytochrome b
chr4_-_40722307 0.050 ENSMUST00000181475.1
Gm6297
predicted gene 6297
chr11_+_115564434 0.050 ENSMUST00000021085.4
Nup85
nucleoporin 85
chr19_-_41933276 0.033 ENSMUST00000075280.4
ENSMUST00000112123.2
Exosc1

exosome component 1

chr10_+_115384951 0.021 ENSMUST00000036044.8
Zfc3h1
zinc finger, C3H1-type containing

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
7.0 49.0 GO:0019532 oxalate transport(GO:0019532)
5.0 30.0 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
2.1 6.2 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
1.4 6.9 GO:0072235 distal convoluted tubule development(GO:0072025) metanephric distal convoluted tubule development(GO:0072221) metanephric distal tubule development(GO:0072235)
1.1 11.3 GO:0036376 sodium ion export from cell(GO:0036376)
1.1 3.4 GO:0009838 abscission(GO:0009838) positive regulation of viral budding via host ESCRT complex(GO:1903774)
1.0 5.8 GO:0051694 pointed-end actin filament capping(GO:0051694)
1.0 8.6 GO:0016198 axon choice point recognition(GO:0016198)
0.9 3.6 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.8 36.8 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.7 4.0 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.6 1.9 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.6 4.3 GO:0021555 midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.6 1.8 GO:0048294 negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.5 1.5 GO:0035880 embryonic nail plate morphogenesis(GO:0035880) positive regulation of catagen(GO:0051795) frontal suture morphogenesis(GO:0060364)
0.5 1.0 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.5 1.8 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.4 10.6 GO:0008340 determination of adult lifespan(GO:0008340)
0.3 3.2 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.2 19.1 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.2 8.6 GO:0050873 brown fat cell differentiation(GO:0050873)
0.2 3.7 GO:0048240 sperm capacitation(GO:0048240)
0.2 1.7 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.2 1.4 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.2 0.5 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.2 3.0 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.2 1.1 GO:1902035 positive regulation of hematopoietic stem cell proliferation(GO:1902035)
0.2 0.6 GO:2000481 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316) positive regulation of cAMP-dependent protein kinase activity(GO:2000481)
0.1 0.4 GO:0006566 threonine metabolic process(GO:0006566)
0.1 0.9 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.1 1.5 GO:0042572 retinol metabolic process(GO:0042572)
0.1 1.4 GO:0031125 rRNA 3'-end processing(GO:0031125)
0.1 0.7 GO:0090168 Golgi reassembly(GO:0090168)
0.1 2.2 GO:0006622 protein targeting to lysosome(GO:0006622)
0.1 1.3 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.1 0.9 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
0.1 1.6 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.1 0.6 GO:1904749 regulation of protein localization to nucleolus(GO:1904749)
0.1 5.5 GO:0034605 cellular response to heat(GO:0034605)
0.1 4.4 GO:0035329 hippo signaling(GO:0035329)
0.1 4.8 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.1 0.8 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862) protein oxidation(GO:0018158)
0.1 0.3 GO:0016554 cytidine to uridine editing(GO:0016554)
0.1 0.3 GO:0016056 rhodopsin mediated signaling pathway(GO:0016056)
0.1 5.7 GO:0016126 sterol biosynthetic process(GO:0016126)
0.1 2.5 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 0.2 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.1 0.2 GO:0019085 early viral transcription(GO:0019085)
0.1 0.6 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.1 0.2 GO:0072382 minus-end-directed vesicle transport along microtubule(GO:0072382)
0.1 1.9 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.1 22.2 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.1 1.8 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.1 0.4 GO:0046689 response to mercury ion(GO:0046689)
0.1 0.8 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.1 0.9 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.1 0.5 GO:0006451 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.1 2.0 GO:0051693 actin filament capping(GO:0051693)
0.1 0.9 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.6 GO:0031937 positive regulation of chromatin silencing(GO:0031937)
0.0 0.8 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0 3.5 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.9 GO:0007530 sex determination(GO:0007530)
0.0 0.4 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.0 2.0 GO:0035383 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.0 0.9 GO:0018345 protein palmitoylation(GO:0018345)
0.0 1.2 GO:0030490 maturation of SSU-rRNA(GO:0030490)
0.0 0.2 GO:0061436 establishment of skin barrier(GO:0061436)
0.0 0.7 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.2 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.3 GO:0006829 zinc II ion transport(GO:0006829)
0.0 0.1 GO:2000628 regulation of miRNA metabolic process(GO:2000628)
0.0 0.3 GO:0051560 mitochondrial calcium ion homeostasis(GO:0051560)
0.0 0.2 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 11.3 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.6 4.0 GO:0005726 perichromatin fibrils(GO:0005726)
0.5 1.4 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.4 8.6 GO:0031527 filopodium membrane(GO:0031527)
0.4 3.4 GO:0090543 Flemming body(GO:0090543)
0.3 2.6 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.3 3.7 GO:0035686 sperm fibrous sheath(GO:0035686)
0.2 1.2 GO:0030689 Noc complex(GO:0030689)
0.2 6.2 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.2 1.3 GO:0031258 lamellipodium membrane(GO:0031258)
0.2 5.8 GO:0005865 striated muscle thin filament(GO:0005865)
0.2 1.4 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.2 2.5 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.2 1.7 GO:0000138 Golgi trans cisterna(GO:0000138)
0.2 43.5 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 0.9 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.1 1.1 GO:0034709 methylosome(GO:0034709)
0.1 35.6 GO:0000139 Golgi membrane(GO:0000139)
0.1 0.8 GO:0097413 Lewy body(GO:0097413)
0.1 3.0 GO:0043034 costamere(GO:0043034)
0.1 1.8 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 0.9 GO:0000812 Swr1 complex(GO:0000812)
0.1 0.8 GO:0031595 nuclear proteasome complex(GO:0031595)
0.1 0.2 GO:0031417 NatC complex(GO:0031417)
0.1 0.4 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.1 0.6 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.1 6.4 GO:0043195 terminal bouton(GO:0043195)
0.0 0.6 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 1.6 GO:0016235 aggresome(GO:0016235)
0.0 0.5 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.2 GO:0042382 paraspeckles(GO:0042382)
0.0 3.4 GO:0005923 bicellular tight junction(GO:0005923)
0.0 0.3 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 2.8 GO:0000792 heterochromatin(GO:0000792)
0.0 0.2 GO:0000243 commitment complex(GO:0000243)
0.0 2.8 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 0.1 GO:0002177 manchette(GO:0002177)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
9.2 36.8 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
4.5 49.0 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
1.2 8.6 GO:0035727 lysophosphatidic acid binding(GO:0035727)
1.1 11.3 GO:0008556 sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556)
0.6 5.8 GO:0005523 tropomyosin binding(GO:0005523)
0.6 4.0 GO:0034056 estrogen response element binding(GO:0034056)
0.5 1.4 GO:0071207 histone pre-mRNA stem-loop binding(GO:0071207)
0.5 1.8 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.4 1.5 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.4 1.5 GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982)
0.3 1.7 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.3 5.7 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.2 1.4 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.2 0.9 GO:0034604 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.2 30.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 1.8 GO:0008106 alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.1 0.4 GO:0008732 threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.1 0.9 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.1 5.7 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 0.8 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.1 22.2 GO:0000287 magnesium ion binding(GO:0000287)
0.1 6.5 GO:0019842 vitamin binding(GO:0019842)
0.1 0.5 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 0.6 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1 2.7 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 0.3 GO:0015254 glycerol channel activity(GO:0015254)
0.1 0.3 GO:0004126 cytidine deaminase activity(GO:0004126)
0.1 4.3 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.1 0.7 GO:0050897 cobalt ion binding(GO:0050897)
0.1 0.5 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)
0.1 1.8 GO:0050699 WW domain binding(GO:0050699)
0.0 1.1 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 1.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.6 GO:0043495 protein anchor(GO:0043495)
0.0 0.6 GO:0001054 RNA polymerase I activity(GO:0001054)
0.0 0.5 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 4.7 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.0 0.4 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 0.8 GO:0042287 MHC protein binding(GO:0042287)
0.0 1.0 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 0.8 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.9 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 8.2 GO:0003924 GTPase activity(GO:0003924)
0.0 3.7 GO:0030165 PDZ domain binding(GO:0030165)
0.0 3.4 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 9.9 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 1.9 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.6 GO:0004407 histone deacetylase activity(GO:0004407)
0.0 0.2 GO:1990446 U1 snRNP binding(GO:1990446)
0.0 0.8 GO:0005158 insulin receptor binding(GO:0005158)
0.0 0.2 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.4 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.2 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.2 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 0.5 GO:0005507 copper ion binding(GO:0005507)
0.0 0.0 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.0 1.8 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 8.2 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 3.4 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 1.8 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.7 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 3.6 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 0.4 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.
0.0 1.7 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.0 3.4 PID_CXCR4_PATHWAY CXCR4-mediated signaling events
0.0 3.0 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 0.8 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.2 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
3.7 36.8 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.5 48.8 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.3 11.3 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.2 5.7 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 4.4 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.1 4.0 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.1 3.4 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.1 3.5 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 3.2 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 1.3 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.1 0.8 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.1 0.9 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 1.8 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 1.7 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.3 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.8 REACTOME_DESTABILIZATION_OF_MRNA_BY_KSRP Genes involved in Destabilization of mRNA by KSRP
0.0 0.9 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 0.6 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.6 REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 3.2 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.0 0.5 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.3 REACTOME_METABOLISM_OF_STEROID_HORMONES_AND_VITAMINS_A_AND_D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.0 0.8 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)