Motif ID: Rora

Z-value: 0.503


Transcription factors associated with Rora:

Gene SymbolEntrez IDGene Name
Rora ENSMUSG00000032238.11 Rora

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Roramm10_v2_chr9_+_68653761_68653786-0.028.6e-01Click!


Activity profile for motif Rora.

activity profile for motif Rora


Sorted Z-values histogram for motif Rora

Sorted Z-values for motif Rora



Network of associatons between targets according to the STRING database.



First level regulatory network of Rora

PNG image of the network

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Top targets:


Showing 1 to 20 of 194 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66801577 5.584 ENSMUST00000168589.1
 Sla
src-like adaptor
chr11_+_42419729 3.211 ENSMUST00000007797.4
 Gabrb2
gamma-aminobutyric acid (GABA) A receptor, subunit beta 2
chr1_+_159737510 2.892 ENSMUST00000111669.3
 Tnr
tenascin R
chr2_-_5676046 2.711 ENSMUST00000114987.3
 Camk1d
calcium/calmodulin-dependent protein kinase ID
chr19_-_57314896 2.704 ENSMUST00000111524.1
 Ablim1
actin-binding LIM protein 1
chr9_-_75597643 2.594 ENSMUST00000164100.1
 Tmod2
tropomodulin 2
chr1_+_32172711 2.421 ENSMUST00000027226.5
 Khdrbs2
KH domain containing, RNA binding, signal transduction associated 2
chr7_-_79386943 2.384 ENSMUST00000053718.8
ENSMUST00000179243.1
 Rlbp1

retinaldehyde binding protein 1

chr5_-_106696819 2.047 ENSMUST00000127434.1
ENSMUST00000112696.1
ENSMUST00000112698.1
 Zfp644


zinc finger protein 644


chr12_-_110695860 1.988 ENSMUST00000149189.1
 Hsp90aa1
heat shock protein 90, alpha (cytosolic), class A member 1
chr3_-_158562199 1.910 ENSMUST00000106044.1
 Lrrc7
leucine rich repeat containing 7
chr7_-_12422751 1.804 ENSMUST00000080348.5
 Zfp551
zinc fingr protein 551
chr3_-_107517321 1.754 ENSMUST00000166892.1
 Slc6a17
solute carrier family 6 (neurotransmitter transporter), member 17
chr3_+_36863102 1.714 ENSMUST00000057272.8
 4932438A13Rik
RIKEN cDNA 4932438A13 gene
chr15_+_99224976 1.678 ENSMUST00000041415.3
 Kcnh3
potassium voltage-gated channel, subfamily H (eag-related), member 3
chr12_+_33314277 1.669 ENSMUST00000133549.1
 Atxn7l1
ataxin 7-like 1
chr15_-_98221056 1.651 ENSMUST00000170618.1
ENSMUST00000141911.1
 Olfr287

olfactory receptor 287

chr5_-_106696530 1.638 ENSMUST00000137285.1
ENSMUST00000124263.1
ENSMUST00000112695.1
ENSMUST00000155495.1
ENSMUST00000135108.1
 Zfp644




zinc finger protein 644




chr4_+_156215920 1.603 ENSMUST00000105572.1
 2310042D19Rik
RIKEN cDNA 2310042D19 gene
chr17_-_17624458 1.597 ENSMUST00000041047.2
 Lnpep
leucyl/cystinyl aminopeptidase

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 85 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.6 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.4 3.2 GO:0071420 cellular response to histamine(GO:0071420)
0.0 3.2 GO:0030032 lamellipodium assembly(GO:0030032)
0.6 3.0 GO:0033140 negative regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033140)
0.7 2.9 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.5 2.9 GO:0045583 regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585)
0.4 2.7 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.9 2.6 GO:0002182 cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
0.4 2.6 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 2.6 GO:0048024 regulation of mRNA splicing, via spliceosome(GO:0048024)
0.0 2.4 GO:0007601 visual perception(GO:0007601)
0.1 2.2 GO:0007183 SMAD protein complex assembly(GO:0007183)
0.4 1.8 GO:0015803 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.1 1.8 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.3 1.7 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.2 1.7 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.0 1.7 GO:0007608 sensory perception of smell(GO:0007608)
0.0 1.7 GO:0051647 nucleus localization(GO:0051647)
0.1 1.6 GO:0043171 peptide catabolic process(GO:0043171)
0.5 1.4 GO:0048014 Tie signaling pathway(GO:0048014)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.8 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 3.4 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.2 3.2 GO:1902711 GABA-A receptor complex(GO:1902711)
1.0 2.9 GO:0072534 perineuronal net(GO:0072534)
0.4 2.9 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 2.7 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 2.7 GO:0008021 synaptic vesicle(GO:0008021)
0.1 2.6 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 2.5 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 2.0 GO:0031901 early endosome membrane(GO:0031901)
0.1 1.9 GO:0043194 axon initial segment(GO:0043194)
0.2 1.8 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.2 1.4 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 1.4 GO:0010369 chromocenter(GO:0010369)
0.1 1.4 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.3 1.3 GO:0032437 cuticular plate(GO:0032437)
0.2 1.3 GO:0031415 NatA complex(GO:0031415)
0.0 1.2 GO:0031594 neuromuscular junction(GO:0031594)
0.0 1.1 GO:0005902 microvillus(GO:0005902)
0.1 0.9 GO:0071439 clathrin complex(GO:0071439)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.0 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.8 3.2 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.5 2.9 GO:0002135 CTP binding(GO:0002135)
0.2 2.9 GO:0046625 sphingolipid binding(GO:0046625)
0.0 2.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.3 2.6 GO:0005523 tropomyosin binding(GO:0005523)
0.2 2.6 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.3 2.4 GO:0016918 retinal binding(GO:0016918)
0.1 2.4 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 2.2 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 1.9 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 1.9 GO:0030507 spectrin binding(GO:0030507)
0.1 1.8 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.3 1.7 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.3 1.7 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 1.7 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.1 1.6 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 1.6 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 1.5 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.5 1.4 GO:0004473 malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)

Gene overrepresentation in C2:CP category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.2 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.0 3.5 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.2 2.9 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 1.7 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.1 1.6 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.1 1.5 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.5 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 1.4 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 1.4 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 1.3 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 1.3 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 1.0 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 1.0 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.7 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.5 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.5 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.4 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 0.4 PID_TXA2PATHWAY Thromboxane A2 receptor signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.6 REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.2 3.2 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.1 2.7 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.1 2.7 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.1 2.2 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.1 1.9 REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING Genes involved in Integrin alphaIIb beta3 signaling
0.1 1.8 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 1.7 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.5 1.6 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 1.4 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.1 1.4 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.1 1.4 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.1 1.4 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.1 1.4 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 1.4 REACTOME_SIGNALING_BY_EGFR_IN_CANCER Genes involved in Signaling by EGFR in Cancer
0.0 1.3 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION Genes involved in PPARA Activates Gene Expression
0.2 1.1 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 1.1 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.0 0.9 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.1 0.8 REACTOME_REGULATION_OF_IFNG_SIGNALING Genes involved in Regulation of IFNG signaling