Motif ID: Rorc_Nr1d1
Z-value: 0.564
Transcription factors associated with Rorc_Nr1d1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Nr1d1 | ENSMUSG00000020889.11 | Nr1d1 |
| Rorc | ENSMUSG00000028150.8 | Rorc |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nr1d1 | mm10_v2_chr11_-_98775333_98775354 | -0.37 | 9.9e-04 | Click! |
| Rorc | mm10_v2_chr3_+_94372794_94372872 | 0.31 | 5.7e-03 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 3.9 | GO:0060084 | regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) synaptic transmission involved in micturition(GO:0060084) |
| 1.0 | 5.8 | GO:0072513 | positive regulation of secondary heart field cardioblast proliferation(GO:0072513) |
| 0.6 | 5.9 | GO:0034983 | peptidyl-lysine deacetylation(GO:0034983) |
| 0.5 | 1.9 | GO:2000158 | positive regulation of ubiquitin-specific protease activity(GO:2000158) |
| 0.3 | 1.3 | GO:0038163 | thrombopoietin-mediated signaling pathway(GO:0038163) |
| 0.3 | 0.9 | GO:0090403 | oxidative stress-induced premature senescence(GO:0090403) |
| 0.3 | 0.3 | GO:0007113 | endomitotic cell cycle(GO:0007113) |
| 0.3 | 1.3 | GO:0035426 | extracellular matrix-cell signaling(GO:0035426) |
| 0.2 | 0.2 | GO:1904995 | negative regulation of leukocyte adhesion to vascular endothelial cell(GO:1904995) |
| 0.2 | 0.5 | GO:0060244 | negative regulation of cell proliferation involved in contact inhibition(GO:0060244) |
| 0.2 | 0.6 | GO:0060316 | positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316) |
| 0.1 | 2.1 | GO:0006107 | oxaloacetate metabolic process(GO:0006107) |
| 0.1 | 0.9 | GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) |
| 0.1 | 4.4 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 0.1 | 0.3 | GO:0050859 | negative regulation of B cell receptor signaling pathway(GO:0050859) |
| 0.1 | 1.5 | GO:2001269 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269) |
| 0.1 | 0.9 | GO:0035331 | negative regulation of hippo signaling(GO:0035331) |
| 0.1 | 0.1 | GO:0060266 | negative regulation of respiratory burst involved in inflammatory response(GO:0060266) |
| 0.1 | 0.3 | GO:2000297 | negative regulation of synapse maturation(GO:2000297) |
| 0.1 | 0.3 | GO:1902162 | regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) |
| 0.1 | 0.3 | GO:0031860 | telomeric 3' overhang formation(GO:0031860) |
| 0.1 | 1.5 | GO:0060134 | prepulse inhibition(GO:0060134) |
| 0.1 | 2.0 | GO:1902043 | positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043) |
| 0.1 | 0.4 | GO:1902563 | regulation of neutrophil activation(GO:1902563) |
| 0.1 | 1.3 | GO:0050901 | leukocyte tethering or rolling(GO:0050901) |
| 0.1 | 0.6 | GO:0071285 | cellular response to lithium ion(GO:0071285) |
| 0.1 | 1.0 | GO:0032875 | regulation of DNA endoreduplication(GO:0032875) DNA endoreduplication(GO:0042023) |
| 0.1 | 1.1 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 0.1 | 0.2 | GO:0019852 | L-ascorbic acid metabolic process(GO:0019852) |
| 0.1 | 0.1 | GO:1904339 | negative regulation of dopaminergic neuron differentiation(GO:1904339) |
| 0.1 | 0.2 | GO:0006578 | amino-acid betaine biosynthetic process(GO:0006578) |
| 0.0 | 4.1 | GO:0007601 | visual perception(GO:0007601) |
| 0.0 | 0.6 | GO:0016246 | RNA interference(GO:0016246) |
| 0.0 | 0.2 | GO:0035752 | lysosomal lumen pH elevation(GO:0035752) |
| 0.0 | 1.8 | GO:0046676 | negative regulation of insulin secretion(GO:0046676) |
| 0.0 | 0.3 | GO:0007000 | nucleolus organization(GO:0007000) |
| 0.0 | 0.1 | GO:0071105 | response to interleukin-9(GO:0071104) response to interleukin-11(GO:0071105) |
| 0.0 | 0.3 | GO:0006228 | UTP biosynthetic process(GO:0006228) |
| 0.0 | 0.3 | GO:2000194 | regulation of female gonad development(GO:2000194) |
| 0.0 | 1.0 | GO:0000132 | establishment of mitotic spindle orientation(GO:0000132) |
| 0.0 | 1.1 | GO:0051567 | histone H3-K9 methylation(GO:0051567) |
| 0.0 | 0.7 | GO:0060351 | cartilage development involved in endochondral bone morphogenesis(GO:0060351) |
| 0.0 | 0.5 | GO:0097435 | fibril organization(GO:0097435) |
| 0.0 | 0.1 | GO:0032811 | negative regulation of gamma-aminobutyric acid secretion(GO:0014053) negative regulation of epinephrine secretion(GO:0032811) |
| 0.0 | 0.6 | GO:0050819 | negative regulation of coagulation(GO:0050819) |
| 0.0 | 0.3 | GO:0098780 | response to mitochondrial depolarisation(GO:0098780) |
| 0.0 | 0.1 | GO:0010587 | miRNA catabolic process(GO:0010587) nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'(GO:0034427) |
| 0.0 | 0.2 | GO:0000038 | very long-chain fatty acid metabolic process(GO:0000038) |
| 0.0 | 1.1 | GO:0009062 | fatty acid catabolic process(GO:0009062) |
| 0.0 | 0.7 | GO:0045454 | cell redox homeostasis(GO:0045454) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 3.9 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.1 | 0.9 | GO:0033391 | chromatoid body(GO:0033391) |
| 0.1 | 0.2 | GO:0017109 | glutamate-cysteine ligase complex(GO:0017109) |
| 0.1 | 5.2 | GO:0035097 | histone methyltransferase complex(GO:0035097) |
| 0.0 | 7.7 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.0 | 0.1 | GO:1990851 | Wnt-Frizzled-LRP5/6 complex(GO:1990851) |
| 0.0 | 0.3 | GO:1990316 | ATG1/ULK1 kinase complex(GO:1990316) |
| 0.0 | 0.1 | GO:0038039 | G-protein coupled receptor heterodimeric complex(GO:0038039) |
| 0.0 | 0.8 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.0 | 4.8 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 1.6 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 1.8 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
| 0.0 | 0.7 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 1.1 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.0 | 0.9 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 5.4 | GO:0019841 | retinol binding(GO:0019841) |
| 0.5 | 1.9 | GO:0035800 | deubiquitinase activator activity(GO:0035800) |
| 0.4 | 3.9 | GO:0022848 | acetylcholine-gated cation channel activity(GO:0022848) |
| 0.4 | 1.1 | GO:0004658 | propionyl-CoA carboxylase activity(GO:0004658) |
| 0.3 | 2.1 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
| 0.3 | 4.4 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.2 | 5.2 | GO:0031078 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
| 0.2 | 0.5 | GO:0070139 | ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139) |
| 0.1 | 0.8 | GO:0034979 | NAD-dependent protein deacetylase activity(GO:0034979) |
| 0.1 | 1.6 | GO:0051393 | alpha-actinin binding(GO:0051393) |
| 0.1 | 0.9 | GO:0017162 | aryl hydrocarbon receptor binding(GO:0017162) |
| 0.1 | 0.2 | GO:0004357 | glutamate-cysteine ligase activity(GO:0004357) |
| 0.1 | 0.9 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 0.1 | 0.8 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
| 0.1 | 0.5 | GO:0001075 | transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075) |
| 0.1 | 4.4 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 2.1 | GO:0005504 | fatty acid binding(GO:0005504) |
| 0.0 | 5.2 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.0 | 0.2 | GO:0001010 | transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010) |
| 0.0 | 0.2 | GO:0070991 | medium-chain-acyl-CoA dehydrogenase activity(GO:0070991) |
| 0.0 | 0.1 | GO:0005110 | frizzled-2 binding(GO:0005110) |
| 0.0 | 0.7 | GO:0015035 | protein disulfide oxidoreductase activity(GO:0015035) |
| 0.0 | 1.3 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.0 | 2.2 | GO:0005179 | hormone activity(GO:0005179) |
| 0.0 | 0.3 | GO:0008429 | phosphatidylethanolamine binding(GO:0008429) |
| 0.0 | 0.3 | GO:0035312 | 5'-3' exodeoxyribonuclease activity(GO:0035312) |
| 0.0 | 0.6 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.0 | 0.3 | GO:0008649 | rRNA methyltransferase activity(GO:0008649) |
| 0.0 | 0.2 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
| 0.0 | 0.1 | GO:0004965 | G-protein coupled GABA receptor activity(GO:0004965) |
| 0.0 | 0.2 | GO:0042609 | CD4 receptor binding(GO:0042609) |
| 0.0 | 0.3 | GO:0008641 | small protein activating enzyme activity(GO:0008641) |
| 0.0 | 0.5 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.0 | 1.2 | GO:0017022 | myosin binding(GO:0017022) |
| 0.0 | 1.8 | GO:0019905 | syntaxin binding(GO:0019905) |
| 0.0 | 0.3 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
| 0.0 | 1.1 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
| 0.0 | 0.1 | GO:0050786 | RAGE receptor binding(GO:0050786) |
| 0.0 | 0.3 | GO:0070888 | E-box binding(GO:0070888) |
| 0.0 | 0.0 | GO:0030350 | iron-responsive element binding(GO:0030350) |
| 0.0 | 0.1 | GO:0050693 | LBD domain binding(GO:0050693) |
| 0.0 | 1.5 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |
| 0.0 | 0.3 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.2 | PID_HDAC_CLASSII_PATHWAY | Signaling events mediated by HDAC Class II |
| 0.1 | 2.1 | PID_SYNDECAN_4_PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 0.9 | PID_CIRCADIAN_PATHWAY | Circadian rhythm pathway |
| 0.0 | 0.3 | PID_ERB_GENOMIC_PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 1.1 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 0.9 | PID_AJDISS_2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 0.8 | PID_HDAC_CLASSI_PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 0.7 | PID_LKB1_PATHWAY | LKB1 signaling events |
| 0.0 | 0.5 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 3.9 | REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
| 0.1 | 1.9 | REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.1 | 1.3 | REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.1 | 5.2 | REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.1 | 3.1 | REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.1 | 2.1 | REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS | Genes involved in Fatty Acyl-CoA Biosynthesis |
| 0.1 | 0.9 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 1.5 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 0.6 | REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 1.1 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.0 | 0.5 | REACTOME_PLATELET_AGGREGATION_PLUG_FORMATION | Genes involved in Platelet Aggregation (Plug Formation) |
| 0.0 | 0.2 | REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.0 | 2.1 | REACTOME_SIGNALING_BY_EGFR_IN_CANCER | Genes involved in Signaling by EGFR in Cancer |
|
|
|