Motif ID: Rorc_Nr1d1

Z-value: 0.564

Transcription factors associated with Rorc_Nr1d1:

Gene SymbolEntrez IDGene Name
Nr1d1 ENSMUSG00000020889.11 Nr1d1
Rorc ENSMUSG00000028150.8 Rorc

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr1d1mm10_v2_chr11_-_98775333_98775354-0.379.9e-04Click!
Rorcmm10_v2_chr3_+_94372794_943728720.315.7e-03Click!


Activity profile for motif Rorc_Nr1d1.

activity profile for motif Rorc_Nr1d1


Sorted Z-values histogram for motif Rorc_Nr1d1

Sorted Z-values for motif Rorc_Nr1d1



Network of associatons between targets according to the STRING database.



First level regulatory network of Rorc_Nr1d1

PNG image of the network

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Top targets:


Showing 1 to 20 of 129 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_14310198 5.816 ENSMUST00000168081.2
ENSMUST00000027066.6
 Eya1

eyes absent 1 homolog (Drosophila)

chr7_-_79386943 5.410 ENSMUST00000053718.8
ENSMUST00000179243.1
 Rlbp1

retinaldehyde binding protein 1

chr12_-_34528844 5.167 ENSMUST00000110819.2
 Hdac9
histone deacetylase 9
chr11_-_84069179 4.413 ENSMUST00000138208.1
 Dusp14
dual specificity phosphatase 14
chrX_+_103422010 4.030 ENSMUST00000182089.1
 Gm26992
predicted gene, 26992
chr3_-_89764581 3.918 ENSMUST00000029562.3
 Chrnb2
cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)
chr5_+_64803513 2.748 ENSMUST00000165536.1
 Klf3
Kruppel-like factor 3 (basic)
chr13_+_6548154 2.708 ENSMUST00000021611.8
 Pitrm1
pitrilysin metallepetidase 1
chr11_+_94327984 2.600 ENSMUST00000107818.2
ENSMUST00000051221.6
 Ankrd40

ankyrin repeat domain 40

chr7_+_45705088 2.235 ENSMUST00000080885.3
 Dbp
D site albumin promoter binding protein
chr11_+_94328242 2.093 ENSMUST00000021227.5
 Ankrd40
ankyrin repeat domain 40
chr15_-_50882806 2.003 ENSMUST00000184885.1
 Trps1
trichorhinophalangeal syndrome I (human)
chr6_+_61180313 1.804 ENSMUST00000126214.1
 Ccser1
coiled-coil serine rich 1
chr5_+_64970069 1.617 ENSMUST00000031080.8
 Fam114a1
family with sequence similarity 114, member A1
chr6_-_93913678 1.593 ENSMUST00000093769.5
 Magi1
membrane associated guanylate kinase, WW and PDZ domain containing 1
chr10_+_57784859 1.547 ENSMUST00000020024.5
 Fabp7
fatty acid binding protein 7, brain
chr3_-_101307079 1.521 ENSMUST00000097146.2
 Gm10355
predicted gene 10355
chr1_+_6734827 1.500 ENSMUST00000139838.1
 St18
suppression of tumorigenicity 18
chr1_-_180193475 1.436 ENSMUST00000160482.1
ENSMUST00000170472.1
 Adck3

aarF domain containing kinase 3

chr3_-_84304762 1.400 ENSMUST00000107692.1
 Trim2
tripartite motif-containing 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 5.9 GO:0034983 peptidyl-lysine deacetylation(GO:0034983)
1.0 5.8 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.1 4.4 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 4.1 GO:0007601 visual perception(GO:0007601)
1.3 3.9 GO:0060084 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) synaptic transmission involved in micturition(GO:0060084)
0.1 2.1 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.1 2.0 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.5 1.9 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.0 1.8 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.1 1.5 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.1 1.5 GO:0060134 prepulse inhibition(GO:0060134)
0.3 1.3 GO:0038163 thrombopoietin-mediated signaling pathway(GO:0038163)
0.3 1.3 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.1 1.3 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.1 1.1 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 1.1 GO:0051567 histone H3-K9 methylation(GO:0051567)
0.0 1.1 GO:0009062 fatty acid catabolic process(GO:0009062)
0.1 1.0 GO:0032875 regulation of DNA endoreduplication(GO:0032875) DNA endoreduplication(GO:0042023)
0.0 1.0 GO:0000132 establishment of mitotic spindle orientation(GO:0000132)
0.3 0.9 GO:0090403 oxidative stress-induced premature senescence(GO:0090403)

Gene overrepresentation in cellular_component category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.7 GO:0032993 protein-DNA complex(GO:0032993)
0.1 5.2 GO:0035097 histone methyltransferase complex(GO:0035097)
0.0 4.8 GO:0005759 mitochondrial matrix(GO:0005759)
0.4 3.9 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 1.8 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 1.6 GO:0016605 PML body(GO:0016605)
0.0 1.1 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 0.9 GO:0033391 chromatoid body(GO:0033391)
0.0 0.9 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.8 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.7 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.3 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.1 0.2 GO:0017109 glutamate-cysteine ligase complex(GO:0017109)
0.0 0.1 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.0 0.1 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 5.4 GO:0019841 retinol binding(GO:0019841)
0.2 5.2 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 5.2 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.3 4.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 4.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.4 3.9 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 2.2 GO:0005179 hormone activity(GO:0005179)
0.3 2.1 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 2.1 GO:0005504 fatty acid binding(GO:0005504)
0.5 1.9 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.0 1.8 GO:0019905 syntaxin binding(GO:0019905)
0.1 1.6 GO:0051393 alpha-actinin binding(GO:0051393)
0.0 1.5 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 1.3 GO:0005109 frizzled binding(GO:0005109)
0.0 1.2 GO:0017022 myosin binding(GO:0017022)
0.4 1.1 GO:0004658 propionyl-CoA carboxylase activity(GO:0004658)
0.0 1.1 GO:0070491 repressing transcription factor binding(GO:0070491)
0.1 0.9 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.1 0.9 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 0.8 GO:0034979 NAD-dependent protein deacetylase activity(GO:0034979)

Gene overrepresentation in C2:CP category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.2 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.1 2.1 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 1.1 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 0.9 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.9 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.8 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 0.7 PID_LKB1_PATHWAY LKB1 signaling events
0.0 0.5 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 0.3 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.2 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.5 3.9 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 3.1 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 2.1 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.0 2.1 REACTOME_SIGNALING_BY_EGFR_IN_CANCER Genes involved in Signaling by EGFR in Cancer
0.1 1.9 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 1.5 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 1.3 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 1.1 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.1 0.9 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.6 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.5 REACTOME_PLATELET_AGGREGATION_PLUG_FORMATION Genes involved in Platelet Aggregation (Plug Formation)
0.0 0.2 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin