Motif ID: Rreb1

Z-value: 1.329


Transcription factors associated with Rreb1:

Gene SymbolEntrez IDGene Name
Rreb1 ENSMUSG00000039087.10 Rreb1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rreb1mm10_v2_chr13_+_37826225_378263150.377.8e-04Click!


Activity profile for motif Rreb1.

activity profile for motif Rreb1


Sorted Z-values histogram for motif Rreb1

Sorted Z-values for motif Rreb1



Network of associatons between targets according to the STRING database.



First level regulatory network of Rreb1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_67586520 16.693 ENSMUST00000108682.2
 Gas7
growth arrest specific 7
chr11_+_67586675 16.334 ENSMUST00000108680.1
 Gas7
growth arrest specific 7
chr15_+_83791939 14.947 ENSMUST00000172115.1
ENSMUST00000172398.1
 Mpped1

metallophosphoesterase domain containing 1

chr19_-_12501996 14.678 ENSMUST00000045521.7
 Dtx4
deltex 4 homolog (Drosophila)
chr14_+_68083853 14.672 ENSMUST00000022639.7
 Nefl
neurofilament, light polypeptide
chr7_+_5056706 13.896 ENSMUST00000144802.1
 Ccdc106
coiled-coil domain containing 106
chr7_+_5056856 13.697 ENSMUST00000131368.1
ENSMUST00000123956.1
 Ccdc106

coiled-coil domain containing 106

chr14_-_34201604 12.906 ENSMUST00000096019.2
 Gprin2
G protein regulated inducer of neurite outgrowth 2
chr11_-_70229677 11.783 ENSMUST00000153449.1
ENSMUST00000000326.5
 Bcl6b

B cell CLL/lymphoma 6, member B

chr6_+_17306335 11.697 ENSMUST00000007799.6
ENSMUST00000115456.1
ENSMUST00000115455.2
ENSMUST00000130505.1
 Cav1



caveolin 1, caveolae protein



chr16_-_67620880 11.623 ENSMUST00000114292.1
ENSMUST00000120898.1
 Cadm2

cell adhesion molecule 2

chr16_-_67620805 10.664 ENSMUST00000120594.1
 Cadm2
cell adhesion molecule 2
chr19_+_8664005 10.413 ENSMUST00000035444.3
ENSMUST00000163785.1
 Chrm1

cholinergic receptor, muscarinic 1, CNS

chr18_-_74961252 10.319 ENSMUST00000066532.4
 Lipg
lipase, endothelial
chr5_+_37047464 9.944 ENSMUST00000137019.1
 Jakmip1
janus kinase and microtubule interacting protein 1
chrX_+_7919816 9.938 ENSMUST00000041096.3
 Pcsk1n
proprotein convertase subtilisin/kexin type 1 inhibitor
chr7_-_98178254 9.921 ENSMUST00000040971.7
 Capn5
calpain 5
chr13_+_43615710 9.776 ENSMUST00000059986.2
 Rnf182
ring finger protein 182
chr4_-_15149051 9.654 ENSMUST00000041606.7
 Necab1
N-terminal EF-hand calcium binding protein 1
chr13_-_41079628 9.584 ENSMUST00000165087.1
ENSMUST00000070193.6
 Mak

male germ cell-associated kinase


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 177 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 39.0 GO:0051017 actin filament bundle assembly(GO:0051017) actin filament bundle organization(GO:0061572)
4.9 24.4 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
0.3 16.4 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
4.9 14.7 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.6 14.2 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.5 14.2 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
2.0 13.8 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
2.1 12.5 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
2.4 11.8 GO:0034436 glycoprotein transport(GO:0034436)
0.2 11.1 GO:1903078 positive regulation of protein localization to plasma membrane(GO:1903078)
0.4 10.7 GO:0042092 type 2 immune response(GO:0042092)
1.2 10.5 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
2.1 10.4 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
2.6 10.3 GO:0010986 positive regulation of lipoprotein particle clearance(GO:0010986)
1.5 10.3 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
2.5 10.2 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.6 9.9 GO:0016486 peptide hormone processing(GO:0016486)
0.1 9.9 GO:0071805 potassium ion transmembrane transport(GO:0071805)
1.4 9.6 GO:1902856 negative regulation of nonmotile primary cilium assembly(GO:1902856)
0.1 9.4 GO:0007051 spindle organization(GO:0007051)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 98 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 35.0 GO:0005884 actin filament(GO:0005884)
0.0 27.8 GO:0005615 extracellular space(GO:0005615)
0.6 25.7 GO:0032809 neuronal cell body membrane(GO:0032809)
1.9 24.4 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
1.0 23.2 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.2 20.4 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.3 16.9 GO:0005581 collagen trimer(GO:0005581)
3.8 15.4 GO:1990769 proximal neuron projection(GO:1990769)
0.1 15.0 GO:0000139 Golgi membrane(GO:0000139)
4.9 14.7 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.1 13.8 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.1 13.6 GO:0016323 basolateral plasma membrane(GO:0016323)
0.3 12.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
1.0 11.8 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.5 10.4 GO:0098984 asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.2 10.3 GO:0009925 basal plasma membrane(GO:0009925)
0.7 9.4 GO:0097542 ciliary tip(GO:0097542)
1.7 8.4 GO:0001533 cornified envelope(GO:0001533)
0.1 8.1 GO:0044306 neuron projection terminus(GO:0044306)
0.0 7.8 GO:0005874 microtubule(GO:0005874)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 146 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 26.0 GO:0051015 actin filament binding(GO:0051015)
4.9 24.4 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.1 21.3 GO:0008017 microtubule binding(GO:0008017)
0.0 16.7 GO:0005198 structural molecule activity(GO:0005198)
2.1 16.4 GO:0097322 7SK snRNA binding(GO:0097322)
0.1 16.0 GO:0005088 Ras guanyl-nucleotide exchange factor activity(GO:0005088)
0.4 15.8 GO:0070412 R-SMAD binding(GO:0070412)
0.7 14.7 GO:0043274 phospholipase binding(GO:0043274)
3.4 13.8 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
3.9 11.8 GO:0034437 very-low-density lipoprotein particle binding(GO:0034189) glycoprotein transporter activity(GO:0034437)
1.9 11.1 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.1 10.8 GO:0008565 protein transporter activity(GO:0008565)
2.1 10.4 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
2.6 10.3 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
2.6 10.3 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.6 9.9 GO:0050811 GABA receptor binding(GO:0050811)
0.5 9.9 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 9.7 GO:0004872 receptor activity(GO:0004872) molecular transducer activity(GO:0060089)
0.6 8.9 GO:0031005 filamin binding(GO:0031005)
0.4 8.8 GO:0003708 retinoic acid receptor activity(GO:0003708)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 31.1 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.4 23.8 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.4 11.8 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 9.6 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 9.5 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 8.8 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.2 7.8 PID_BMP_PATHWAY BMP receptor signaling
0.1 7.6 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.1 6.3 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.1 6.0 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.6 5.8 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 5.4 PID_CD40_PATHWAY CD40/CD40L signaling
0.1 5.4 PID_MTOR_4PATHWAY mTOR signaling pathway
0.1 5.1 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.2 4.8 PID_ARF_3PATHWAY Arf1 pathway
0.2 4.7 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 3.8 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.3 3.6 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.1 3.6 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 3.2 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 24.4 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.4 23.1 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.6 20.5 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.6 15.4 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
1.1 14.1 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.3 13.1 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.4 12.7 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.5 12.1 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.3 10.8 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.1 8.0 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.2 7.9 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 7.1 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.3 6.8 REACTOME_NEF_MEDIATES_DOWN_MODULATION_OF_CELL_SURFACE_RECEPTORS_BY_RECRUITING_THEM_TO_CLATHRIN_ADAPTERS Genes involved in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
0.4 6.2 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1 5.6 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.2 5.4 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 5.4 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.3 5.1 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.3 5.1 REACTOME_KERATAN_SULFATE_KERATIN_METABOLISM Genes involved in Keratan sulfate/keratin metabolism
0.2 5.1 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins