Motif ID: Rreb1
Z-value: 1.329
Transcription factors associated with Rreb1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Rreb1 | ENSMUSG00000039087.10 | Rreb1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Rreb1 | mm10_v2_chr13_+_37826225_37826315 | 0.37 | 7.8e-04 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.9 | 14.7 | GO:0045110 | intermediate filament bundle assembly(GO:0045110) |
| 4.9 | 24.4 | GO:1903609 | negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609) |
| 2.6 | 10.3 | GO:0010986 | positive regulation of lipoprotein particle clearance(GO:0010986) |
| 2.5 | 10.2 | GO:0051725 | protein de-ADP-ribosylation(GO:0051725) |
| 2.4 | 11.8 | GO:0034436 | glycoprotein transport(GO:0034436) |
| 2.1 | 10.4 | GO:0007197 | adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207) |
| 2.1 | 12.5 | GO:1903056 | positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056) |
| 2.1 | 6.2 | GO:0009298 | GDP-mannose biosynthetic process(GO:0009298) |
| 2.1 | 6.2 | GO:0001757 | somite specification(GO:0001757) |
| 2.0 | 6.1 | GO:0030827 | negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283) |
| 2.0 | 8.1 | GO:2000313 | fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313) |
| 2.0 | 8.0 | GO:0003430 | growth plate cartilage chondrocyte growth(GO:0003430) |
| 2.0 | 13.8 | GO:0035093 | spermatogenesis, exchange of chromosomal proteins(GO:0035093) |
| 1.9 | 5.8 | GO:1903011 | negative regulation of bone development(GO:1903011) |
| 1.8 | 5.3 | GO:0002940 | tRNA N2-guanine methylation(GO:0002940) |
| 1.8 | 8.8 | GO:1900748 | positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748) |
| 1.6 | 4.8 | GO:1900126 | negative regulation of hyaluronan biosynthetic process(GO:1900126) |
| 1.6 | 3.2 | GO:0045963 | negative regulation of catecholamine metabolic process(GO:0045914) negative regulation of dopamine metabolic process(GO:0045963) |
| 1.5 | 10.3 | GO:0070494 | regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) |
| 1.5 | 4.4 | GO:0001830 | trophectodermal cell fate commitment(GO:0001830) |
| 1.4 | 9.6 | GO:1902856 | negative regulation of nonmotile primary cilium assembly(GO:1902856) |
| 1.3 | 5.1 | GO:1900740 | regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740) |
| 1.2 | 3.7 | GO:1900133 | renin secretion into blood stream(GO:0002001) regulation of the force of heart contraction by chemical signal(GO:0003057) regulation of renin secretion into blood stream(GO:1900133) |
| 1.2 | 8.4 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
| 1.2 | 10.5 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 1.1 | 3.4 | GO:1904020 | regulation of G-protein coupled receptor internalization(GO:1904020) |
| 1.1 | 5.4 | GO:0060355 | positive regulation of toll-like receptor 3 signaling pathway(GO:0034141) positive regulation of cell adhesion molecule production(GO:0060355) |
| 1.1 | 2.1 | GO:0014738 | regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900) |
| 1.0 | 4.1 | GO:1900110 | negative regulation of histone H3-K9 dimethylation(GO:1900110) |
| 1.0 | 7.9 | GO:1901844 | regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) |
| 1.0 | 2.9 | GO:0048687 | positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) |
| 1.0 | 3.8 | GO:0032914 | positive regulation of transforming growth factor beta1 production(GO:0032914) |
| 0.9 | 3.6 | GO:0015888 | thiamine transport(GO:0015888) |
| 0.9 | 2.6 | GO:0002636 | positive regulation of germinal center formation(GO:0002636) |
| 0.9 | 8.6 | GO:0061470 | interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619) |
| 0.8 | 3.3 | GO:0046604 | positive regulation of mitotic centrosome separation(GO:0046604) |
| 0.8 | 0.8 | GO:0042271 | susceptibility to natural killer cell mediated cytotoxicity(GO:0042271) |
| 0.8 | 6.8 | GO:0071397 | cellular response to cholesterol(GO:0071397) |
| 0.8 | 5.3 | GO:0035331 | negative regulation of hippo signaling(GO:0035331) |
| 0.7 | 5.1 | GO:0006012 | galactose metabolic process(GO:0006012) |
| 0.7 | 2.2 | GO:0002554 | serotonin secretion by platelet(GO:0002554) interleukin-3 production(GO:0032632) beta selection(GO:0043366) |
| 0.7 | 5.1 | GO:0060056 | mammary gland involution(GO:0060056) |
| 0.7 | 3.4 | GO:2000987 | positive regulation of fear response(GO:1903367) positive regulation of behavioral fear response(GO:2000987) |
| 0.7 | 8.6 | GO:0014052 | regulation of gamma-aminobutyric acid secretion(GO:0014052) |
| 0.7 | 3.9 | GO:1903223 | cellular response to purine-containing compound(GO:0071415) positive regulation of oxidative stress-induced neuron death(GO:1903223) |
| 0.6 | 2.6 | GO:0044330 | canonical Wnt signaling pathway involved in positive regulation of wound healing(GO:0044330) lactic acid secretion(GO:0046722) regulation of metanephric cap mesenchymal cell proliferation(GO:0090095) positive regulation of metanephric cap mesenchymal cell proliferation(GO:0090096) |
| 0.6 | 5.6 | GO:0061002 | negative regulation of dendritic spine morphogenesis(GO:0061002) |
| 0.6 | 14.2 | GO:0099517 | anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517) |
| 0.6 | 3.6 | GO:0051790 | short-chain fatty acid biosynthetic process(GO:0051790) |
| 0.6 | 8.9 | GO:0033623 | regulation of integrin activation(GO:0033623) |
| 0.6 | 3.0 | GO:0046684 | response to pyrethroid(GO:0046684) |
| 0.6 | 4.0 | GO:0098909 | establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200) regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909) |
| 0.6 | 1.7 | GO:1904049 | negative regulation of spontaneous neurotransmitter secretion(GO:1904049) |
| 0.6 | 2.3 | GO:1900150 | neutrophil mediated cytotoxicity(GO:0070942) neutrophil mediated killing of symbiont cell(GO:0070943) regulation of defense response to fungus(GO:1900150) |
| 0.6 | 9.9 | GO:0016486 | peptide hormone processing(GO:0016486) |
| 0.6 | 1.1 | GO:0071442 | positive regulation of histone H3-K14 acetylation(GO:0071442) |
| 0.5 | 3.2 | GO:0061622 | glycolytic process through glucose-1-phosphate(GO:0061622) |
| 0.5 | 2.0 | GO:0007023 | post-chaperonin tubulin folding pathway(GO:0007023) |
| 0.5 | 7.4 | GO:0042541 | hemoglobin biosynthetic process(GO:0042541) |
| 0.5 | 1.5 | GO:0042939 | glutathione transport(GO:0034635) tripeptide transport(GO:0042939) |
| 0.5 | 5.9 | GO:0060052 | neurofilament cytoskeleton organization(GO:0060052) |
| 0.5 | 14.2 | GO:0045736 | negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030) |
| 0.5 | 2.3 | GO:0032485 | regulation of Ral protein signal transduction(GO:0032485) |
| 0.4 | 2.7 | GO:0007258 | JUN phosphorylation(GO:0007258) |
| 0.4 | 10.7 | GO:0042092 | type 2 immune response(GO:0042092) |
| 0.4 | 5.6 | GO:0033211 | adiponectin-activated signaling pathway(GO:0033211) |
| 0.4 | 3.8 | GO:0038203 | TORC2 signaling(GO:0038203) |
| 0.4 | 7.1 | GO:0010954 | positive regulation of protein processing(GO:0010954) |
| 0.4 | 1.6 | GO:0002143 | tRNA wobble position uridine thiolation(GO:0002143) |
| 0.4 | 5.4 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
| 0.4 | 1.9 | GO:0048597 | post-embryonic camera-type eye morphogenesis(GO:0048597) |
| 0.4 | 1.5 | GO:0006121 | mitochondrial electron transport, succinate to ubiquinone(GO:0006121) |
| 0.4 | 5.6 | GO:0048681 | negative regulation of axon regeneration(GO:0048681) |
| 0.4 | 2.8 | GO:0070314 | G1 to G0 transition(GO:0070314) |
| 0.4 | 1.4 | GO:0046391 | 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391) |
| 0.3 | 8.5 | GO:0008340 | determination of adult lifespan(GO:0008340) |
| 0.3 | 1.0 | GO:1903070 | negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070) |
| 0.3 | 3.7 | GO:2000653 | regulation of genetic imprinting(GO:2000653) |
| 0.3 | 1.0 | GO:0046618 | urate transport(GO:0015747) drug export(GO:0046618) negative regulation of intestinal absorption(GO:1904479) |
| 0.3 | 4.3 | GO:0030828 | positive regulation of cGMP biosynthetic process(GO:0030828) |
| 0.3 | 2.3 | GO:0035434 | copper ion transmembrane transport(GO:0035434) |
| 0.3 | 3.2 | GO:0033089 | positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400) |
| 0.3 | 16.4 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 0.3 | 4.8 | GO:0006883 | cellular sodium ion homeostasis(GO:0006883) |
| 0.3 | 5.6 | GO:0033169 | histone H3-K9 demethylation(GO:0033169) |
| 0.3 | 4.7 | GO:0046688 | response to copper ion(GO:0046688) |
| 0.3 | 2.3 | GO:0051534 | negative regulation of NFAT protein import into nucleus(GO:0051534) |
| 0.3 | 2.9 | GO:0060081 | membrane hyperpolarization(GO:0060081) |
| 0.3 | 1.8 | GO:0034214 | protein hexamerization(GO:0034214) |
| 0.2 | 1.5 | GO:0042748 | circadian sleep/wake cycle, non-REM sleep(GO:0042748) |
| 0.2 | 1.7 | GO:0019532 | oxalate transport(GO:0019532) |
| 0.2 | 5.6 | GO:0032933 | response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501) |
| 0.2 | 1.6 | GO:0043201 | response to leucine(GO:0043201) cellular response to leucine(GO:0071233) |
| 0.2 | 1.5 | GO:0060666 | dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666) |
| 0.2 | 1.8 | GO:0002903 | negative regulation of B cell apoptotic process(GO:0002903) |
| 0.2 | 1.7 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 0.2 | 4.8 | GO:0070208 | protein heterotrimerization(GO:0070208) |
| 0.2 | 0.6 | GO:0060217 | hemangioblast cell differentiation(GO:0060217) |
| 0.2 | 39.0 | GO:0051017 | actin filament bundle assembly(GO:0051017) actin filament bundle organization(GO:0061572) |
| 0.2 | 2.2 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 0.2 | 11.1 | GO:1903078 | positive regulation of protein localization to plasma membrane(GO:1903078) |
| 0.2 | 0.9 | GO:0090666 | scaRNA localization to Cajal body(GO:0090666) |
| 0.2 | 6.7 | GO:0045747 | positive regulation of Notch signaling pathway(GO:0045747) |
| 0.2 | 8.4 | GO:0046579 | positive regulation of Ras protein signal transduction(GO:0046579) |
| 0.2 | 2.6 | GO:0030213 | hyaluronan biosynthetic process(GO:0030213) |
| 0.2 | 3.1 | GO:0070262 | peptidyl-serine dephosphorylation(GO:0070262) |
| 0.2 | 0.2 | GO:0002925 | positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925) |
| 0.2 | 3.5 | GO:0022401 | desensitization of G-protein coupled receptor protein signaling pathway(GO:0002029) negative adaptation of signaling pathway(GO:0022401) |
| 0.2 | 5.0 | GO:0048665 | neuron fate specification(GO:0048665) |
| 0.2 | 1.6 | GO:0090084 | negative regulation of inclusion body assembly(GO:0090084) |
| 0.2 | 1.4 | GO:0007000 | nucleolus organization(GO:0007000) |
| 0.2 | 1.8 | GO:0038180 | nerve growth factor signaling pathway(GO:0038180) |
| 0.2 | 0.3 | GO:0010726 | positive regulation of hydrogen peroxide metabolic process(GO:0010726) |
| 0.1 | 3.9 | GO:0032469 | endoplasmic reticulum calcium ion homeostasis(GO:0032469) |
| 0.1 | 0.4 | GO:2000510 | positive regulation of dendritic cell chemotaxis(GO:2000510) |
| 0.1 | 1.3 | GO:0018095 | protein polyglutamylation(GO:0018095) |
| 0.1 | 0.4 | GO:0030049 | muscle filament sliding(GO:0030049) |
| 0.1 | 0.7 | GO:1902237 | positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902237) |
| 0.1 | 1.0 | GO:0043653 | mitochondrial fragmentation involved in apoptotic process(GO:0043653) |
| 0.1 | 6.8 | GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771) |
| 0.1 | 3.6 | GO:0051926 | negative regulation of calcium ion transport(GO:0051926) |
| 0.1 | 1.4 | GO:0036158 | outer dynein arm assembly(GO:0036158) |
| 0.1 | 0.5 | GO:0070460 | thyroid-stimulating hormone secretion(GO:0070460) |
| 0.1 | 0.4 | GO:0006624 | vacuolar protein processing(GO:0006624) |
| 0.1 | 1.3 | GO:0007252 | I-kappaB phosphorylation(GO:0007252) |
| 0.1 | 1.0 | GO:0010587 | miRNA catabolic process(GO:0010587) |
| 0.1 | 0.7 | GO:0034773 | histone H4-K20 trimethylation(GO:0034773) |
| 0.1 | 0.3 | GO:0051342 | regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051342) negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344) |
| 0.1 | 0.5 | GO:0090259 | regulation of retinal ganglion cell axon guidance(GO:0090259) |
| 0.1 | 8.8 | GO:1900181 | negative regulation of protein localization to nucleus(GO:1900181) |
| 0.1 | 1.8 | GO:0006622 | protein targeting to lysosome(GO:0006622) |
| 0.1 | 0.4 | GO:1903028 | regulation of opsonization(GO:1903027) positive regulation of opsonization(GO:1903028) |
| 0.1 | 4.7 | GO:0001541 | ovarian follicle development(GO:0001541) |
| 0.1 | 1.0 | GO:0045056 | transcytosis(GO:0045056) |
| 0.1 | 0.3 | GO:0090315 | negative regulation of protein targeting to membrane(GO:0090315) |
| 0.1 | 1.0 | GO:0090435 | protein localization to nuclear envelope(GO:0090435) |
| 0.1 | 1.7 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.1 | 1.5 | GO:0072348 | sulfur compound transport(GO:0072348) |
| 0.1 | 0.3 | GO:0033540 | fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540) |
| 0.1 | 1.3 | GO:0043045 | DNA methylation involved in embryo development(GO:0043045) changes to DNA methylation involved in embryo development(GO:1901538) |
| 0.1 | 2.6 | GO:0086010 | membrane depolarization during action potential(GO:0086010) |
| 0.1 | 2.5 | GO:0030513 | positive regulation of BMP signaling pathway(GO:0030513) |
| 0.1 | 1.0 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.1 | 1.9 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.1 | 0.2 | GO:0046077 | dUDP biosynthetic process(GO:0006227) pyrimidine nucleoside diphosphate metabolic process(GO:0009138) pyrimidine nucleoside diphosphate biosynthetic process(GO:0009139) deoxyribonucleoside diphosphate biosynthetic process(GO:0009189) pyrimidine deoxyribonucleoside diphosphate metabolic process(GO:0009196) pyrimidine deoxyribonucleoside diphosphate biosynthetic process(GO:0009197) dUDP metabolic process(GO:0046077) |
| 0.1 | 9.9 | GO:0071805 | potassium ion transmembrane transport(GO:0071805) |
| 0.1 | 9.4 | GO:0007051 | spindle organization(GO:0007051) |
| 0.1 | 4.0 | GO:0032543 | mitochondrial translation(GO:0032543) |
| 0.1 | 0.4 | GO:1901837 | negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837) |
| 0.1 | 1.0 | GO:0046597 | negative regulation of viral entry into host cell(GO:0046597) |
| 0.1 | 2.3 | GO:0046039 | GTP metabolic process(GO:0046039) |
| 0.1 | 3.6 | GO:0050775 | positive regulation of dendrite morphogenesis(GO:0050775) |
| 0.1 | 0.5 | GO:0046085 | adenosine metabolic process(GO:0046085) |
| 0.1 | 0.1 | GO:0033085 | negative regulation of T cell differentiation in thymus(GO:0033085) negative regulation of thymocyte aggregation(GO:2000399) |
| 0.1 | 1.5 | GO:0006099 | tricarboxylic acid cycle(GO:0006099) |
| 0.1 | 0.2 | GO:2001168 | regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168) |
| 0.1 | 0.7 | GO:0034497 | protein localization to pre-autophagosomal structure(GO:0034497) |
| 0.0 | 1.2 | GO:2001240 | negative regulation of signal transduction in absence of ligand(GO:1901099) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240) |
| 0.0 | 1.2 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 0.0 | 0.7 | GO:0032211 | negative regulation of telomere maintenance via telomerase(GO:0032211) |
| 0.0 | 0.5 | GO:1901032 | negative regulation of response to reactive oxygen species(GO:1901032) negative regulation of hydrogen peroxide-induced cell death(GO:1903206) |
| 0.0 | 2.3 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
| 0.0 | 0.5 | GO:0034453 | microtubule anchoring(GO:0034453) |
| 0.0 | 0.1 | GO:0075525 | viral translational termination-reinitiation(GO:0075525) |
| 0.0 | 0.2 | GO:2001184 | regulation of interleukin-12 secretion(GO:2001182) positive regulation of interleukin-12 secretion(GO:2001184) |
| 0.0 | 0.2 | GO:0009404 | toxin metabolic process(GO:0009404) |
| 0.0 | 0.3 | GO:0044406 | adhesion of symbiont to host(GO:0044406) |
| 0.0 | 1.4 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 0.0 | 0.0 | GO:0061357 | Wnt protein secretion(GO:0061355) regulation of Wnt protein secretion(GO:0061356) positive regulation of Wnt protein secretion(GO:0061357) |
| 0.0 | 0.7 | GO:0043001 | Golgi to plasma membrane protein transport(GO:0043001) |
| 0.0 | 0.8 | GO:1902653 | cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653) |
| 0.0 | 0.7 | GO:0002209 | behavioral fear response(GO:0001662) behavioral defense response(GO:0002209) |
| 0.0 | 0.6 | GO:0036075 | endochondral ossification(GO:0001958) replacement ossification(GO:0036075) |
| 0.0 | 0.3 | GO:0070536 | protein K63-linked deubiquitination(GO:0070536) |
| 0.0 | 0.1 | GO:0043137 | DNA replication, removal of RNA primer(GO:0043137) |
| 0.0 | 0.7 | GO:0030968 | endoplasmic reticulum unfolded protein response(GO:0030968) |
| 0.0 | 0.7 | GO:0046513 | ceramide biosynthetic process(GO:0046513) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.9 | 14.7 | GO:0033596 | TSC1-TSC2 complex(GO:0033596) |
| 3.8 | 15.4 | GO:1990769 | proximal neuron projection(GO:1990769) |
| 1.9 | 24.4 | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098) |
| 1.7 | 8.4 | GO:0001533 | cornified envelope(GO:0001533) |
| 1.3 | 5.1 | GO:0042567 | insulin-like growth factor ternary complex(GO:0042567) |
| 1.2 | 6.2 | GO:1990357 | terminal web(GO:1990357) |
| 1.0 | 11.8 | GO:0034361 | very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385) |
| 1.0 | 23.2 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.9 | 3.4 | GO:0032280 | symmetric synapse(GO:0032280) |
| 0.8 | 3.2 | GO:0005945 | 6-phosphofructokinase complex(GO:0005945) |
| 0.7 | 9.4 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.6 | 25.7 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
| 0.6 | 5.4 | GO:0031254 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
| 0.6 | 4.1 | GO:0097255 | R2TP complex(GO:0097255) |
| 0.5 | 2.6 | GO:0044316 | cone cell pedicle(GO:0044316) |
| 0.5 | 10.4 | GO:0098984 | asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984) |
| 0.4 | 5.8 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.4 | 3.7 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
| 0.4 | 2.6 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.4 | 1.4 | GO:0002189 | ribose phosphate diphosphokinase complex(GO:0002189) |
| 0.3 | 1.7 | GO:1990761 | growth cone lamellipodium(GO:1990761) |
| 0.3 | 1.7 | GO:1990462 | omegasome(GO:1990462) |
| 0.3 | 1.3 | GO:0019815 | B cell receptor complex(GO:0019815) |
| 0.3 | 3.8 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.3 | 1.6 | GO:1990131 | Gtr1-Gtr2 GTPase complex(GO:1990131) |
| 0.3 | 7.2 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.3 | 1.5 | GO:0038039 | G-protein coupled receptor heterodimeric complex(GO:0038039) |
| 0.3 | 7.3 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.3 | 16.9 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.3 | 12.7 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.3 | 4.8 | GO:0032433 | filopodium tip(GO:0032433) |
| 0.2 | 20.4 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.2 | 3.8 | GO:0031932 | TORC2 complex(GO:0031932) |
| 0.2 | 35.0 | GO:0005884 | actin filament(GO:0005884) |
| 0.2 | 2.5 | GO:0043240 | Fanconi anaemia nuclear complex(GO:0043240) |
| 0.2 | 4.3 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.2 | 0.4 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.2 | 7.2 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.2 | 4.4 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.2 | 0.6 | GO:0033193 | Lsd1/2 complex(GO:0033193) |
| 0.2 | 1.0 | GO:0032437 | cuticular plate(GO:0032437) |
| 0.2 | 3.0 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.2 | 10.3 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.2 | 7.5 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.2 | 2.1 | GO:0046930 | pore complex(GO:0046930) |
| 0.2 | 1.4 | GO:0036157 | outer dynein arm(GO:0036157) |
| 0.1 | 1.5 | GO:0045252 | oxoglutarate dehydrogenase complex(GO:0045252) |
| 0.1 | 3.1 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.1 | 1.8 | GO:0044754 | autolysosome(GO:0044754) |
| 0.1 | 0.3 | GO:0034751 | aryl hydrocarbon receptor complex(GO:0034751) |
| 0.1 | 0.7 | GO:0017059 | serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211) |
| 0.1 | 1.3 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 0.1 | 1.4 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.1 | 4.0 | GO:0014704 | intercalated disc(GO:0014704) |
| 0.1 | 1.0 | GO:0016272 | prefoldin complex(GO:0016272) |
| 0.1 | 0.4 | GO:0016461 | unconventional myosin complex(GO:0016461) |
| 0.1 | 1.4 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 0.1 | 1.7 | GO:0043189 | NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562) |
| 0.1 | 4.4 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 7.1 | GO:0042641 | actomyosin(GO:0042641) |
| 0.1 | 13.6 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.1 | 0.9 | GO:0005832 | chaperonin-containing T-complex(GO:0005832) |
| 0.1 | 13.8 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.1 | 0.7 | GO:0030688 | preribosome, small subunit precursor(GO:0030688) |
| 0.1 | 2.8 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.1 | 0.7 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
| 0.1 | 2.6 | GO:0005719 | nuclear euchromatin(GO:0005719) |
| 0.1 | 2.0 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
| 0.1 | 2.4 | GO:0016592 | mediator complex(GO:0016592) |
| 0.1 | 1.9 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.1 | 3.0 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.1 | 2.3 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.1 | 8.1 | GO:0044306 | neuron projection terminus(GO:0044306) |
| 0.1 | 0.4 | GO:0042824 | MHC class I peptide loading complex(GO:0042824) |
| 0.1 | 0.7 | GO:0036513 | Derlin-1 retrotranslocation complex(GO:0036513) |
| 0.1 | 15.0 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.0 | 2.8 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 2.8 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.0 | 3.2 | GO:0043204 | perikaryon(GO:0043204) |
| 0.0 | 1.3 | GO:0005875 | microtubule associated complex(GO:0005875) |
| 0.0 | 0.3 | GO:0020005 | symbiont-containing vacuole(GO:0020003) symbiont-containing vacuole membrane(GO:0020005) extracellular membrane-bounded organelle(GO:0065010) |
| 0.0 | 6.6 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 0.3 | GO:0008541 | proteasome regulatory particle, lid subcomplex(GO:0008541) |
| 0.0 | 27.8 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 4.6 | GO:0014069 | postsynaptic density(GO:0014069) |
| 0.0 | 3.2 | GO:0043197 | dendritic spine(GO:0043197) |
| 0.0 | 1.0 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.0 | 1.8 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 2.3 | GO:0005770 | late endosome(GO:0005770) |
| 0.0 | 1.6 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 1.0 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 7.8 | GO:0005874 | microtubule(GO:0005874) |
| 0.0 | 3.1 | GO:0043235 | receptor complex(GO:0043235) |
| 0.0 | 0.1 | GO:0005742 | mitochondrial outer membrane translocase complex(GO:0005742) |
| 0.0 | 0.3 | GO:0005839 | proteasome core complex(GO:0005839) |
| 0.0 | 0.4 | GO:0030496 | midbody(GO:0030496) |
| 0.0 | 4.1 | GO:0005813 | centrosome(GO:0005813) |
| 0.0 | 0.5 | GO:0000502 | proteasome complex(GO:0000502) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.9 | 24.4 | GO:0070320 | inward rectifier potassium channel inhibitor activity(GO:0070320) |
| 3.9 | 11.8 | GO:0034437 | very-low-density lipoprotein particle binding(GO:0034189) glycoprotein transporter activity(GO:0034437) |
| 3.4 | 13.8 | GO:0061628 | H3K27me3 modified histone binding(GO:0061628) |
| 2.6 | 10.3 | GO:0005008 | hepatocyte growth factor-activated receptor activity(GO:0005008) |
| 2.6 | 10.3 | GO:0008970 | phosphatidylcholine 1-acylhydrolase activity(GO:0008970) |
| 2.1 | 10.4 | GO:0016907 | G-protein coupled acetylcholine receptor activity(GO:0016907) |
| 2.1 | 16.4 | GO:0097322 | 7SK snRNA binding(GO:0097322) |
| 1.9 | 11.1 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
| 1.7 | 5.2 | GO:0016748 | succinyltransferase activity(GO:0016748) |
| 1.6 | 4.7 | GO:0060072 | large conductance calcium-activated potassium channel activity(GO:0060072) |
| 1.5 | 4.6 | GO:0043758 | acetate-CoA ligase (ADP-forming) activity(GO:0043758) |
| 1.2 | 3.7 | GO:0051379 | epinephrine binding(GO:0051379) |
| 1.2 | 4.7 | GO:0004720 | protein-lysine 6-oxidase activity(GO:0004720) |
| 1.2 | 3.5 | GO:0030549 | acetylcholine receptor activator activity(GO:0030549) |
| 1.1 | 3.2 | GO:0016206 | catechol O-methyltransferase activity(GO:0016206) |
| 1.1 | 5.3 | GO:0004809 | tRNA (guanine-N2-)-methyltransferase activity(GO:0004809) |
| 1.0 | 5.1 | GO:0001517 | N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) |
| 0.9 | 3.6 | GO:0004315 | 3-oxoacyl-[acyl-carrier-protein] synthase activity(GO:0004315) |
| 0.8 | 3.2 | GO:0003872 | 6-phosphofructokinase activity(GO:0003872) |
| 0.8 | 2.3 | GO:0046899 | nucleoside triphosphate adenylate kinase activity(GO:0046899) |
| 0.7 | 3.0 | GO:0072345 | NAADP-sensitive calcium-release channel activity(GO:0072345) |
| 0.7 | 2.2 | GO:0030350 | iron-responsive element binding(GO:0030350) |
| 0.7 | 3.5 | GO:0004563 | beta-N-acetylhexosaminidase activity(GO:0004563) |
| 0.7 | 5.6 | GO:0042809 | vitamin D receptor binding(GO:0042809) |
| 0.7 | 14.7 | GO:0043274 | phospholipase binding(GO:0043274) |
| 0.7 | 2.7 | GO:0016909 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
| 0.7 | 2.6 | GO:0005222 | intracellular cAMP activated cation channel activity(GO:0005222) |
| 0.6 | 7.1 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.6 | 3.2 | GO:0004499 | N,N-dimethylaniline monooxygenase activity(GO:0004499) |
| 0.6 | 8.9 | GO:0031005 | filamin binding(GO:0031005) |
| 0.6 | 5.1 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 0.6 | 3.6 | GO:0051429 | corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430) |
| 0.6 | 2.9 | GO:0005030 | neurotrophin receptor activity(GO:0005030) |
| 0.6 | 9.9 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.5 | 1.6 | GO:0046964 | 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity(GO:0046964) |
| 0.5 | 9.9 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.5 | 6.2 | GO:0016868 | intramolecular transferase activity, phosphotransferases(GO:0016868) |
| 0.5 | 3.9 | GO:0047631 | ADP-ribose diphosphatase activity(GO:0047631) |
| 0.5 | 3.4 | GO:0001515 | opioid peptide activity(GO:0001515) |
| 0.5 | 6.0 | GO:0050897 | cobalt ion binding(GO:0050897) |
| 0.4 | 8.8 | GO:0003708 | retinoic acid receptor activity(GO:0003708) |
| 0.4 | 5.6 | GO:1990459 | transferrin receptor binding(GO:1990459) |
| 0.4 | 2.1 | GO:0001010 | transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010) |
| 0.4 | 15.8 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.4 | 2.3 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
| 0.4 | 1.4 | GO:0004749 | ribose phosphate diphosphokinase activity(GO:0004749) |
| 0.3 | 1.7 | GO:1904288 | BAT3 complex binding(GO:1904288) |
| 0.3 | 1.3 | GO:0070740 | tubulin-glutamic acid ligase activity(GO:0070740) |
| 0.3 | 2.2 | GO:0004716 | receptor signaling protein tyrosine kinase activity(GO:0004716) |
| 0.3 | 2.1 | GO:0015288 | porin activity(GO:0015288) |
| 0.3 | 1.5 | GO:0016941 | natriuretic peptide receptor activity(GO:0016941) |
| 0.3 | 8.7 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.3 | 2.3 | GO:0016717 | oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717) |
| 0.3 | 1.7 | GO:0042296 | ISG15 transferase activity(GO:0042296) |
| 0.3 | 2.3 | GO:0005375 | copper ion transmembrane transporter activity(GO:0005375) |
| 0.3 | 1.9 | GO:0005021 | vascular endothelial growth factor-activated receptor activity(GO:0005021) |
| 0.3 | 4.1 | GO:0001163 | RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164) |
| 0.3 | 2.8 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
| 0.2 | 1.5 | GO:0004965 | G-protein coupled GABA receptor activity(GO:0004965) |
| 0.2 | 1.0 | GO:0097003 | adipokinetic hormone receptor activity(GO:0097003) |
| 0.2 | 3.4 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.2 | 0.7 | GO:0004758 | serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454) |
| 0.2 | 7.0 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.2 | 1.5 | GO:0004591 | oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591) |
| 0.2 | 1.5 | GO:0015651 | quaternary ammonium group transmembrane transporter activity(GO:0015651) |
| 0.2 | 2.3 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.2 | 1.0 | GO:0008559 | xenobiotic-transporting ATPase activity(GO:0008559) |
| 0.2 | 1.7 | GO:0008329 | signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187) |
| 0.2 | 4.5 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.2 | 2.8 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.2 | 0.7 | GO:0031800 | type 3 metabotropic glutamate receptor binding(GO:0031800) |
| 0.2 | 2.6 | GO:0023026 | MHC class II protein complex binding(GO:0023026) |
| 0.2 | 5.8 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.2 | 2.6 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.2 | 1.7 | GO:0019531 | secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531) |
| 0.2 | 5.3 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.2 | 5.3 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.1 | 4.8 | GO:0050750 | low-density lipoprotein particle receptor binding(GO:0050750) |
| 0.1 | 1.5 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.1 | 26.0 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.1 | 3.0 | GO:0005248 | voltage-gated sodium channel activity(GO:0005248) |
| 0.1 | 0.5 | GO:0030292 | protein tyrosine kinase inhibitor activity(GO:0030292) |
| 0.1 | 1.6 | GO:0016783 | sulfurtransferase activity(GO:0016783) |
| 0.1 | 1.2 | GO:0019865 | immunoglobulin binding(GO:0019865) |
| 0.1 | 5.6 | GO:0015485 | cholesterol binding(GO:0015485) |
| 0.1 | 7.1 | GO:0019213 | deacetylase activity(GO:0019213) |
| 0.1 | 0.3 | GO:0036004 | GAF domain binding(GO:0036004) |
| 0.1 | 2.3 | GO:0030506 | ankyrin binding(GO:0030506) |
| 0.1 | 2.1 | GO:0008266 | poly(U) RNA binding(GO:0008266) |
| 0.1 | 5.6 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
| 0.1 | 0.5 | GO:0004565 | beta-galactosidase activity(GO:0004565) |
| 0.1 | 0.2 | GO:0008330 | protein tyrosine/threonine phosphatase activity(GO:0008330) |
| 0.1 | 5.3 | GO:0042562 | hormone binding(GO:0042562) |
| 0.1 | 3.4 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.1 | 0.8 | GO:0046703 | natural killer cell lectin-like receptor binding(GO:0046703) |
| 0.1 | 10.8 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.1 | 2.1 | GO:0070566 | adenylyltransferase activity(GO:0070566) |
| 0.1 | 1.4 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.1 | 2.9 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
| 0.1 | 1.4 | GO:0001054 | RNA polymerase I activity(GO:0001054) |
| 0.1 | 16.0 | GO:0005088 | Ras guanyl-nucleotide exchange factor activity(GO:0005088) |
| 0.1 | 1.8 | GO:0008483 | transaminase activity(GO:0008483) |
| 0.1 | 1.0 | GO:0002151 | G-quadruplex RNA binding(GO:0002151) |
| 0.1 | 4.0 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.1 | 21.3 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.1 | 3.6 | GO:0035255 | ionotropic glutamate receptor binding(GO:0035255) |
| 0.1 | 0.3 | GO:0005093 | Rab GDP-dissociation inhibitor activity(GO:0005093) |
| 0.1 | 0.2 | GO:0004127 | cytidylate kinase activity(GO:0004127) uridylate kinase activity(GO:0009041) |
| 0.1 | 5.3 | GO:0032947 | protein complex scaffold(GO:0032947) |
| 0.1 | 2.9 | GO:0015459 | potassium channel regulator activity(GO:0015459) |
| 0.1 | 3.8 | GO:0005518 | collagen binding(GO:0005518) |
| 0.1 | 1.5 | GO:0097602 | cullin family protein binding(GO:0097602) |
| 0.1 | 0.3 | GO:0016401 | palmitoyl-CoA oxidase activity(GO:0016401) |
| 0.1 | 1.0 | GO:0070628 | proteasome binding(GO:0070628) |
| 0.1 | 1.3 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 0.1 | 0.9 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.1 | 5.0 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.0 | 16.7 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.0 | 3.9 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.0 | 0.0 | GO:0031852 | mu-type opioid receptor binding(GO:0031852) |
| 0.0 | 3.4 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.0 | 0.1 | GO:0004887 | thyroid hormone receptor activity(GO:0004887) |
| 0.0 | 1.0 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.0 | 1.6 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.0 | 2.5 | GO:0019955 | cytokine binding(GO:0019955) |
| 0.0 | 2.4 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.0 | 7.3 | GO:0004871 | signal transducer activity(GO:0004871) |
| 0.0 | 0.7 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
| 0.0 | 0.5 | GO:0008253 | 5'-nucleotidase activity(GO:0008253) |
| 0.0 | 0.7 | GO:0035254 | glutamate receptor binding(GO:0035254) |
| 0.0 | 1.0 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.0 | 0.1 | GO:0001162 | RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162) |
| 0.0 | 0.8 | GO:0005112 | Notch binding(GO:0005112) |
| 0.0 | 2.7 | GO:0031625 | ubiquitin protein ligase binding(GO:0031625) |
| 0.0 | 2.4 | GO:0005539 | glycosaminoglycan binding(GO:0005539) |
| 0.0 | 1.8 | GO:0015399 | primary active transmembrane transporter activity(GO:0015399) P-P-bond-hydrolysis-driven transmembrane transporter activity(GO:0015405) ATPase activity, coupled to transmembrane movement of substances(GO:0042626) |
| 0.0 | 0.9 | GO:0005249 | voltage-gated potassium channel activity(GO:0005249) |
| 0.0 | 9.7 | GO:0004872 | receptor activity(GO:0004872) molecular transducer activity(GO:0060089) |
| 0.0 | 1.4 | GO:0015631 | tubulin binding(GO:0015631) |
| 0.0 | 0.5 | GO:0051539 | 4 iron, 4 sulfur cluster binding(GO:0051539) |
| 0.0 | 0.3 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.0 | 0.1 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
| 0.0 | 0.9 | GO:0008083 | growth factor activity(GO:0008083) |
| 0.0 | 1.9 | GO:0019887 | protein kinase regulator activity(GO:0019887) |
| 0.0 | 4.5 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.0 | 2.5 | GO:0005096 | GTPase activator activity(GO:0005096) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 31.1 | PID_WNT_CANONICAL_PATHWAY | Canonical Wnt signaling pathway |
| 0.6 | 5.8 | PID_INTEGRIN5_PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.4 | 23.8 | PID_SYNDECAN_1_PATHWAY | Syndecan-1-mediated signaling events |
| 0.4 | 11.8 | PID_UPA_UPAR_PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.3 | 3.6 | PID_S1P_S1P4_PATHWAY | S1P4 pathway |
| 0.2 | 8.8 | PID_RXR_VDR_PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.2 | 4.7 | SA_CASPASE_CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.2 | 7.8 | PID_BMP_PATHWAY | BMP receptor signaling |
| 0.2 | 4.8 | PID_ARF_3PATHWAY | Arf1 pathway |
| 0.2 | 1.9 | PID_VEGF_VEGFR_PATHWAY | VEGF and VEGFR signaling network |
| 0.1 | 5.4 | PID_CD40_PATHWAY | CD40/CD40L signaling |
| 0.1 | 6.0 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
| 0.1 | 7.6 | SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.1 | 1.8 | PID_EPO_PATHWAY | EPO signaling pathway |
| 0.1 | 2.3 | PID_IL23_PATHWAY | IL23-mediated signaling events |
| 0.1 | 3.8 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 0.3 | PID_IL27_PATHWAY | IL27-mediated signaling events |
| 0.1 | 2.9 | PID_SHP2_PATHWAY | SHP2 signaling |
| 0.1 | 5.1 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 1.3 | PID_NFKAPPAB_CANONICAL_PATHWAY | Canonical NF-kappaB pathway |
| 0.1 | 2.6 | PID_IL2_STAT5_PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.1 | 5.4 | PID_MTOR_4PATHWAY | mTOR signaling pathway |
| 0.1 | 6.3 | PID_HDAC_CLASSI_PATHWAY | Signaling events mediated by HDAC Class I |
| 0.1 | 2.5 | PID_BARD1_PATHWAY | BARD1 signaling events |
| 0.1 | 3.6 | PID_AP1_PATHWAY | AP-1 transcription factor network |
| 0.1 | 2.8 | PID_NFAT_TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.1 | 9.6 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 9.5 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 0.5 | PID_EPHA_FWDPATHWAY | EPHA forward signaling |
| 0.1 | 1.5 | PID_FCER1_PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.0 | 1.1 | ST_MYOCYTE_AD_PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 1.0 | PID_HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 3.2 | PID_MYC_ACTIV_PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 1.8 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 1.0 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 1.2 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 1.2 | PID_NOTCH_PATHWAY | Notch signaling pathway |
| 0.0 | 0.7 | PID_RAC1_PATHWAY | RAC1 signaling pathway |
| 0.0 | 0.3 | SIG_CHEMOTAXIS | Genes related to chemotaxis |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 14.1 | REACTOME_AMINE_LIGAND_BINDING_RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 1.1 | 24.4 | REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.6 | 15.4 | REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
| 0.6 | 20.5 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.5 | 12.1 | REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.4 | 6.2 | REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.4 | 3.8 | REACTOME_KERATAN_SULFATE_DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.4 | 23.1 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
| 0.4 | 12.7 | REACTOME_G_PROTEIN_ACTIVATION | Genes involved in G-protein activation |
| 0.3 | 13.1 | REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.3 | 5.1 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.3 | 5.1 | REACTOME_KERATAN_SULFATE_KERATIN_METABOLISM | Genes involved in Keratan sulfate/keratin metabolism |
| 0.3 | 10.8 | REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING | Genes involved in Sema4D in semaphorin signaling |
| 0.3 | 6.8 | REACTOME_NEF_MEDIATES_DOWN_MODULATION_OF_CELL_SURFACE_RECEPTORS_BY_RECRUITING_THEM_TO_CLATHRIN_ADAPTERS | Genes involved in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters |
| 0.3 | 1.8 | REACTOME_ARMS_MEDIATED_ACTIVATION | Genes involved in ARMS-mediated activation |
| 0.2 | 5.4 | REACTOME_METABOLISM_OF_PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.2 | 1.5 | REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.2 | 7.9 | REACTOME_DARPP_32_EVENTS | Genes involved in DARPP-32 events |
| 0.2 | 4.6 | REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 0.2 | 5.1 | REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.2 | 2.8 | REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.2 | 1.9 | REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.1 | 1.5 | REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.1 | 2.0 | REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.1 | 8.0 | REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 2.5 | REACTOME_FANCONI_ANEMIA_PATHWAY | Genes involved in Fanconi Anemia pathway |
| 0.1 | 1.8 | REACTOME_SOS_MEDIATED_SIGNALLING | Genes involved in SOS-mediated signalling |
| 0.1 | 1.5 | REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.1 | 1.0 | REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM | Genes involved in Abacavir transport and metabolism |
| 0.1 | 5.6 | REACTOME_NETRIN1_SIGNALING | Genes involved in Netrin-1 signaling |
| 0.1 | 1.5 | REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.1 | 3.3 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 2.3 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 5.4 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 7.1 | REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 2.5 | REACTOME_SIGNALING_BY_BMP | Genes involved in Signaling by BMP |
| 0.1 | 2.8 | REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.1 | 0.9 | REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.1 | 1.7 | REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.1 | 3.2 | REACTOME_PHASE_II_CONJUGATION | Genes involved in Phase II conjugation |
| 0.1 | 0.5 | REACTOME_PURINE_CATABOLISM | Genes involved in Purine catabolism |
| 0.1 | 3.4 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 2.0 | REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.1 | 3.6 | REACTOME_L1CAM_INTERACTIONS | Genes involved in L1CAM interactions |
| 0.1 | 0.8 | REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 1.4 | REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |
| 0.0 | 0.4 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.0 | 0.4 | REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR | Genes involved in Trafficking and processing of endosomal TLR |
| 0.0 | 0.5 | REACTOME_AMINE_DERIVED_HORMONES | Genes involved in Amine-derived hormones |
| 0.0 | 1.6 | REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.0 | 1.5 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 0.9 | REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.0 | 2.2 | REACTOME_POTASSIUM_CHANNELS | Genes involved in Potassium Channels |
| 0.0 | 1.0 | REACTOME_INTERFERON_ALPHA_BETA_SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 1.1 | REACTOME_AUTODEGRADATION_OF_THE_E3_UBIQUITIN_LIGASE_COP1 | Genes involved in Autodegradation of the E3 ubiquitin ligase COP1 |
| 0.0 | 4.2 | REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.0 | 0.3 | REACTOME_INTERFERON_GAMMA_SIGNALING | Genes involved in Interferon gamma signaling |
| 0.0 | 0.5 | REACTOME_SPHINGOLIPID_METABOLISM | Genes involved in Sphingolipid metabolism |
| 0.0 | 1.4 | REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.0 | 2.7 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 1.0 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 1.3 | REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION | Genes involved in Influenza Viral RNA Transcription and Replication |
