Motif ID: Runx1

Z-value: 0.943


Transcription factors associated with Runx1:

Gene SymbolEntrez IDGene Name
Runx1 ENSMUSG00000022952.10 Runx1



Activity profile for motif Runx1.

activity profile for motif Runx1


Sorted Z-values histogram for motif Runx1

Sorted Z-values for motif Runx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Runx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 117 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66801577 28.105 ENSMUST00000168589.1
 Sla
src-like adaptor
chr4_-_14621805 12.847 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr17_+_3397189 12.383 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chr13_+_76579670 10.732 ENSMUST00000126960.1
ENSMUST00000109583.2
 Mctp1

multiple C2 domains, transmembrane 1

chr11_-_83649349 9.692 ENSMUST00000001008.5
 Ccl3
chemokine (C-C motif) ligand 3
chr5_+_104435112 9.597 ENSMUST00000031243.8
ENSMUST00000086833.6
ENSMUST00000112748.1
ENSMUST00000112746.1
ENSMUST00000145084.1
ENSMUST00000132457.1
 Spp1





secreted phosphoprotein 1





chr15_-_37459327 8.857 ENSMUST00000119730.1
ENSMUST00000120746.1
 Ncald

neurocalcin delta

chr2_+_37516618 8.625 ENSMUST00000065441.6
 Gpr21
G protein-coupled receptor 21
chr6_+_17491216 8.519 ENSMUST00000080469.5
 Met
met proto-oncogene
chr16_+_42907563 7.928 ENSMUST00000151244.1
ENSMUST00000114694.2
 Zbtb20

zinc finger and BTB domain containing 20

chr11_-_110168073 7.290 ENSMUST00000044850.3
 Abca9
ATP-binding cassette, sub-family A (ABC1), member 9
chr11_-_52282564 7.165 ENSMUST00000086844.3
 Tcf7
transcription factor 7, T cell specific
chr12_-_25096080 7.145 ENSMUST00000020974.6
 Id2
inhibitor of DNA binding 2
chr4_-_14621494 7.008 ENSMUST00000149633.1
 Slc26a7
solute carrier family 26, member 7
chr15_-_76090013 6.982 ENSMUST00000019516.4
 Nrbp2
nuclear receptor binding protein 2
chr8_-_11008458 6.957 ENSMUST00000040514.6
 Irs2
insulin receptor substrate 2
chr1_-_140183404 6.897 ENSMUST00000066859.6
ENSMUST00000111976.2
 Cfh

complement component factor h

chr17_+_35236556 6.772 ENSMUST00000068261.8
 Atp6v1g2
ATPase, H+ transporting, lysosomal V1 subunit G2
chr1_-_169747634 6.693 ENSMUST00000027991.5
ENSMUST00000111357.1
 Rgs4

regulator of G-protein signaling 4

chr14_-_124677089 6.646 ENSMUST00000095529.3
 Fgf14
fibroblast growth factor 14

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 28.5 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
3.7 26.2 GO:0019532 oxalate transport(GO:0019532)
2.2 12.9 GO:0045919 complement activation, alternative pathway(GO:0006957) positive regulation of cytolysis(GO:0045919)
0.1 12.8 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.3 11.0 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
1.1 9.7 GO:0043615 astrocyte cell migration(GO:0043615)
2.4 9.6 GO:0035937 androgen catabolic process(GO:0006710) estrogen secretion(GO:0035937) estradiol secretion(GO:0035938) regulation of estrogen secretion(GO:2000861) regulation of estradiol secretion(GO:2000864)
0.1 8.9 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.2 8.6 GO:0040018 positive regulation of multicellular organism growth(GO:0040018)
1.2 8.5 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.9 7.2 GO:0002681 somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153)
1.4 7.1 GO:0045578 negative regulation of B cell differentiation(GO:0045578) epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.7 7.0 GO:0002903 negative regulation of B cell apoptotic process(GO:0002903)
0.1 6.7 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
1.3 6.6 GO:1901843 positive regulation of high voltage-gated calcium channel activity(GO:1901843)
0.1 6.5 GO:0015992 proton transport(GO:0015992)
2.1 6.4 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
2.1 6.3 GO:0010752 signal complex assembly(GO:0007172) regulation of cGMP-mediated signaling(GO:0010752)
0.1 6.1 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.3 5.8 GO:0006883 cellular sodium ion homeostasis(GO:0006883)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 27.7 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 25.1 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 12.6 GO:0072562 blood microparticle(GO:0072562)
0.0 9.8 GO:0000785 chromatin(GO:0000785)
0.1 8.2 GO:0009925 basal plasma membrane(GO:0009925)
0.2 7.2 GO:0005719 nuclear euchromatin(GO:0005719)
0.4 6.8 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
2.1 6.4 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.4 6.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 6.0 GO:0005911 cell-cell junction(GO:0005911)
0.0 4.4 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 4.2 GO:0045177 apical part of cell(GO:0045177)
0.4 3.5 GO:0001520 outer dense fiber(GO:0001520)
0.0 3.4 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 3.2 GO:0043235 receptor complex(GO:0043235)
0.0 3.0 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 2.8 GO:0005925 focal adhesion(GO:0005925)
0.1 2.7 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 2.2 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.1 2.0 GO:0005844 polysome(GO:0005844)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.4 26.2 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.6 24.2 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.2 15.5 GO:0005125 cytokine activity(GO:0005125)
0.1 15.5 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
3.2 12.9 GO:0001851 complement component C3b binding(GO:0001851)
0.3 9.7 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.3 8.9 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 8.7 GO:0044325 ion channel binding(GO:0044325)
2.2 8.6 GO:0004952 dopamine neurotransmitter receptor activity(GO:0004952)
2.1 8.5 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.0 7.8 GO:0005509 calcium ion binding(GO:0005509)
0.3 7.5 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 7.2 GO:0008013 beta-catenin binding(GO:0008013)
0.0 6.9 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.6 6.8 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.2 6.7 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.2 6.5 GO:0005158 insulin receptor binding(GO:0005158)
0.8 6.3 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.1 6.1 GO:0008083 growth factor activity(GO:0008083)
0.1 5.8 GO:0042562 hormone binding(GO:0042562)

Gene overrepresentation in C2:CP category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 25.7 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.4 18.7 PID_AVB3_OPN_PATHWAY Osteopontin-mediated events
0.2 15.5 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.1 14.3 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.2 10.1 PID_IL12_2PATHWAY IL12-mediated signaling events
0.2 8.5 PID_ARF6_PATHWAY Arf6 signaling events
0.2 7.0 PID_EPO_PATHWAY EPO signaling pathway
0.6 6.4 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.2 6.1 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 6.1 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 5.4 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.1 4.4 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.1 4.3 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 4.0 PID_BMP_PATHWAY BMP receptor signaling
0.1 3.3 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 0.9 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 0.4 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.2 PID_HNF3A_PATHWAY FOXA1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 24.3 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 15.5 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
2.6 12.9 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.4 9.1 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.5 8.9 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.2 8.5 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.4 7.3 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.4 7.0 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.3 6.8 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.4 6.3 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 6.2 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.6 6.1 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.1 5.9 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 5.8 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 4.4 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 4.0 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.1 3.5 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.2 3.4 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.1 3.3 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.2 2.9 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix