Motif ID: Runx2_Bcl11a
Z-value: 1.605


Transcription factors associated with Runx2_Bcl11a:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Bcl11a | ENSMUSG00000000861.9 | Bcl11a |
Runx2 | ENSMUSG00000039153.10 | Runx2 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Bcl11a | mm10_v2_chr11_+_24078173_24078219 | -0.41 | 1.9e-04 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 319 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
3.0 | 33.0 | GO:0042572 | retinol metabolic process(GO:0042572) |
2.9 | 26.5 | GO:0043615 | astrocyte cell migration(GO:0043615) |
3.9 | 19.5 | GO:0034162 | toll-like receptor 9 signaling pathway(GO:0034162) |
0.3 | 17.9 | GO:0038083 | peptidyl-tyrosine autophosphorylation(GO:0038083) |
2.4 | 17.1 | GO:0045650 | negative regulation of macrophage differentiation(GO:0045650) |
2.7 | 16.4 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
0.4 | 16.2 | GO:0045744 | negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744) |
0.2 | 14.8 | GO:0003073 | regulation of systemic arterial blood pressure(GO:0003073) |
1.2 | 14.2 | GO:0032000 | positive regulation of fatty acid beta-oxidation(GO:0032000) |
4.7 | 14.0 | GO:0046110 | xanthine metabolic process(GO:0046110) |
1.9 | 13.0 | GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) |
1.8 | 12.5 | GO:0019532 | oxalate transport(GO:0019532) |
2.5 | 12.3 | GO:0019852 | L-ascorbic acid metabolic process(GO:0019852) |
4.0 | 12.0 | GO:1903279 | regulation of calcium:sodium antiporter activity(GO:1903279) |
1.6 | 11.4 | GO:0043553 | negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) |
2.2 | 11.0 | GO:0045347 | negative regulation of MHC class II biosynthetic process(GO:0045347) negative regulation of cytolysis(GO:0045918) |
1.8 | 10.8 | GO:0097646 | calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647) |
3.5 | 10.5 | GO:0014738 | regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900) |
3.4 | 10.3 | GO:0050703 | interleukin-1 alpha secretion(GO:0050703) |
3.4 | 10.2 | GO:0072378 | blood coagulation, fibrin clot formation(GO:0072378) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 162 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 50.1 | GO:0005615 | extracellular space(GO:0005615) |
11.7 | 46.8 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
0.5 | 42.4 | GO:0072562 | blood microparticle(GO:0072562) |
0.1 | 31.8 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
2.6 | 26.3 | GO:0032009 | early phagosome(GO:0032009) |
0.1 | 19.5 | GO:0045177 | apical part of cell(GO:0045177) |
0.0 | 18.2 | GO:0070062 | extracellular exosome(GO:0070062) |
1.3 | 15.6 | GO:0020005 | symbiont-containing vacuole membrane(GO:0020005) |
2.0 | 14.0 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
1.7 | 13.8 | GO:0042629 | mast cell granule(GO:0042629) |
0.1 | 13.0 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
0.3 | 12.8 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
0.0 | 11.9 | GO:0019898 | extrinsic component of membrane(GO:0019898) |
2.2 | 10.8 | GO:1903440 | calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440) |
0.4 | 10.1 | GO:0030137 | COPI-coated vesicle(GO:0030137) |
1.0 | 9.2 | GO:0031254 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
0.2 | 9.2 | GO:0048786 | presynaptic active zone(GO:0048786) |
0.0 | 8.8 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
0.5 | 8.6 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
0.4 | 8.1 | GO:0097225 | sperm midpiece(GO:0097225) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 251 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
11.7 | 46.8 | GO:0031721 | haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721) |
4.7 | 32.9 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
1.4 | 32.9 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
1.2 | 18.8 | GO:0035325 | Toll-like receptor binding(GO:0035325) |
0.8 | 18.3 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
1.0 | 17.9 | GO:0050811 | GABA receptor binding(GO:0050811) |
4.1 | 16.4 | GO:0001851 | complement component C3b binding(GO:0001851) |
0.5 | 14.3 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
3.5 | 14.0 | GO:0030151 | molybdenum ion binding(GO:0030151) |
1.4 | 14.0 | GO:0008556 | sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556) |
0.4 | 13.6 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
0.2 | 13.4 | GO:0008083 | growth factor activity(GO:0008083) |
0.4 | 13.0 | GO:0043539 | insulin-like growth factor receptor binding(GO:0005159) protein serine/threonine kinase activator activity(GO:0043539) |
1.1 | 12.5 | GO:0019531 | secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531) |
4.1 | 12.2 | GO:0036313 | phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313) |
0.4 | 11.7 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
2.9 | 11.4 | GO:0031727 | CCR2 chemokine receptor binding(GO:0031727) |
2.2 | 11.0 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
2.2 | 10.8 | GO:0097643 | amylin receptor activity(GO:0097643) |
2.6 | 10.2 | GO:0003810 | protein-glutamine gamma-glutamyltransferase activity(GO:0003810) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 67 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 83.3 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
0.2 | 22.8 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
0.1 | 18.4 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
0.5 | 15.5 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
0.2 | 14.5 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
0.5 | 14.4 | PID_INTEGRIN_A9B1_PATHWAY | Alpha9 beta1 integrin signaling events |
0.3 | 12.7 | PID_FGF_PATHWAY | FGF signaling pathway |
0.3 | 12.2 | SIG_IL4RECEPTOR_IN_B_LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
0.1 | 12.0 | PID_PDGFRB_PATHWAY | PDGFR-beta signaling pathway |
0.3 | 11.4 | PID_SHP2_PATHWAY | SHP2 signaling |
0.2 | 10.4 | PID_ENDOTHELIN_PATHWAY | Endothelins |
1.0 | 10.0 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
0.1 | 9.2 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
0.2 | 9.1 | PID_BMP_PATHWAY | BMP receptor signaling |
0.3 | 8.6 | ST_GA12_PATHWAY | G alpha 12 Pathway |
0.3 | 6.8 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
0.1 | 5.5 | PID_TCR_PATHWAY | TCR signaling in naïve CD4+ T cells |
0.1 | 5.5 | PID_RHOA_REG_PATHWAY | Regulation of RhoA activity |
0.1 | 5.3 | PID_ERBB1_INTERNALIZATION_PATHWAY | Internalization of ErbB1 |
0.1 | 5.0 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 111 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.6 | 37.4 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
3.5 | 21.3 | REACTOME_COMMON_PATHWAY | Genes involved in Common Pathway |
2.2 | 19.5 | REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR | Genes involved in Trafficking and processing of endosomal TLR |
3.1 | 18.5 | REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
0.6 | 17.1 | REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING | Genes involved in DCC mediated attractive signaling |
1.0 | 16.5 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
4.1 | 16.4 | REACTOME_REGULATION_OF_COMPLEMENT_CASCADE | Genes involved in Regulation of Complement cascade |
0.8 | 14.4 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
0.5 | 14.0 | REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
0.1 | 13.4 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
0.1 | 12.4 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
0.6 | 12.2 | REACTOME_SOS_MEDIATED_SIGNALLING | Genes involved in SOS-mediated signalling |
0.4 | 10.9 | REACTOME_GLUTATHIONE_CONJUGATION | Genes involved in Glutathione conjugation |
0.3 | 10.6 | REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
0.4 | 9.2 | REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
0.3 | 9.2 | REACTOME_CA_DEPENDENT_EVENTS | Genes involved in Ca-dependent events |
0.2 | 8.4 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
0.8 | 7.9 | REACTOME_KERATAN_SULFATE_DEGRADATION | Genes involved in Keratan sulfate degradation |
0.3 | 7.9 | REACTOME_RAP1_SIGNALLING | Genes involved in Rap1 signalling |
0.1 | 7.9 | REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |