Motif ID: Runx2_Bcl11a

Z-value: 1.605

Transcription factors associated with Runx2_Bcl11a:

Gene SymbolEntrez IDGene Name
Bcl11a ENSMUSG00000000861.9 Bcl11a
Runx2 ENSMUSG00000039153.10 Runx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Bcl11amm10_v2_chr11_+_24078173_24078219-0.411.9e-04Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Runx2_Bcl11a

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_103827922 46.753 ENSMUST00000023934.6
ENSMUST00000153218.1
Hbb-bs

hemoglobin, beta adult s chain

chr11_-_83649349 23.396 ENSMUST00000001008.5
Ccl3
chemokine (C-C motif) ligand 3
chr15_-_66801577 19.560 ENSMUST00000168589.1
Sla
src-like adaptor
chr19_+_3935186 19.529 ENSMUST00000162708.1
ENSMUST00000165711.1
Unc93b1

unc-93 homolog B1 (C. elegans)

chr4_-_136892867 17.144 ENSMUST00000046332.5
C1qc
complement component 1, q subcomponent, C chain
chr3_-_87263518 16.933 ENSMUST00000090986.4
Fcrls
Fc receptor-like S, scavenger receptor
chr4_+_144892813 16.549 ENSMUST00000105744.1
ENSMUST00000171001.1
Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr5_-_77408034 14.833 ENSMUST00000163898.1
ENSMUST00000046746.6
Igfbp7

insulin-like growth factor binding protein 7

chr1_+_58210397 14.023 ENSMUST00000040442.5
Aox4
aldehyde oxidase 4
chr15_+_3270767 12.113 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
Sepp1



selenoprotein P, plasma, 1



chr1_-_172297989 11.990 ENSMUST00000085913.4
ENSMUST00000097464.2
ENSMUST00000137679.1
Atp1a2


ATPase, Na+/K+ transporting, alpha 2 polypeptide


chr3_-_87263703 11.552 ENSMUST00000146512.1
Fcrls
Fc receptor-like S, scavenger receptor
chr8_-_11008458 11.536 ENSMUST00000040514.6
Irs2
insulin receptor substrate 2
chr5_+_90772435 11.025 ENSMUST00000031320.6
Pf4
platelet factor 4
chr11_+_101246960 10.837 ENSMUST00000107282.3
Ramp2
receptor (calcitonin) activity modifying protein 2
chr1_-_140183404 10.561 ENSMUST00000066859.6
ENSMUST00000111976.2
Cfh

complement component factor h

chr15_-_37459327 10.548 ENSMUST00000119730.1
ENSMUST00000120746.1
Ncald

neurocalcin delta

chr13_-_37050237 10.245 ENSMUST00000164727.1
F13a1
coagulation factor XIII, A1 subunit
chr4_+_144893127 9.935 ENSMUST00000142808.1
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr1_+_169655493 9.531 ENSMUST00000027997.3
Rgs5
regulator of G-protein signaling 5

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 319 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.0 33.0 GO:0042572 retinol metabolic process(GO:0042572)
2.9 26.5 GO:0043615 astrocyte cell migration(GO:0043615)
3.9 19.5 GO:0034162 toll-like receptor 9 signaling pathway(GO:0034162)
0.3 17.9 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
2.4 17.1 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
2.7 16.4 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.4 16.2 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.2 14.8 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
1.2 14.2 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
4.7 14.0 GO:0046110 xanthine metabolic process(GO:0046110)
1.9 13.0 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
1.8 12.5 GO:0019532 oxalate transport(GO:0019532)
2.5 12.3 GO:0019852 L-ascorbic acid metabolic process(GO:0019852)
4.0 12.0 GO:1903279 regulation of calcium:sodium antiporter activity(GO:1903279)
1.6 11.4 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
2.2 11.0 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347) negative regulation of cytolysis(GO:0045918)
1.8 10.8 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
3.5 10.5 GO:0014738 regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900)
3.4 10.3 GO:0050703 interleukin-1 alpha secretion(GO:0050703)
3.4 10.2 GO:0072378 blood coagulation, fibrin clot formation(GO:0072378)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 162 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 50.1 GO:0005615 extracellular space(GO:0005615)
11.7 46.8 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.5 42.4 GO:0072562 blood microparticle(GO:0072562)
0.1 31.8 GO:0016323 basolateral plasma membrane(GO:0016323)
2.6 26.3 GO:0032009 early phagosome(GO:0032009)
0.1 19.5 GO:0045177 apical part of cell(GO:0045177)
0.0 18.2 GO:0070062 extracellular exosome(GO:0070062)
1.3 15.6 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
2.0 14.0 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
1.7 13.8 GO:0042629 mast cell granule(GO:0042629)
0.1 13.0 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.3 12.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 11.9 GO:0019898 extrinsic component of membrane(GO:0019898)
2.2 10.8 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.4 10.1 GO:0030137 COPI-coated vesicle(GO:0030137)
1.0 9.2 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.2 9.2 GO:0048786 presynaptic active zone(GO:0048786)
0.0 8.8 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.5 8.6 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.4 8.1 GO:0097225 sperm midpiece(GO:0097225)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 251 entries
Log-likelihood per target Total log-likelihoodTermDescription
11.7 46.8 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
4.7 32.9 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
1.4 32.9 GO:0048020 CCR chemokine receptor binding(GO:0048020)
1.2 18.8 GO:0035325 Toll-like receptor binding(GO:0035325)
0.8 18.3 GO:0005520 insulin-like growth factor binding(GO:0005520)
1.0 17.9 GO:0050811 GABA receptor binding(GO:0050811)
4.1 16.4 GO:0001851 complement component C3b binding(GO:0001851)
0.5 14.3 GO:0043014 alpha-tubulin binding(GO:0043014)
3.5 14.0 GO:0030151 molybdenum ion binding(GO:0030151)
1.4 14.0 GO:0008556 sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556)
0.4 13.6 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.2 13.4 GO:0008083 growth factor activity(GO:0008083)
0.4 13.0 GO:0043539 insulin-like growth factor receptor binding(GO:0005159) protein serine/threonine kinase activator activity(GO:0043539)
1.1 12.5 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
4.1 12.2 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.4 11.7 GO:0071889 14-3-3 protein binding(GO:0071889)
2.9 11.4 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
2.2 11.0 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
2.2 10.8 GO:0097643 amylin receptor activity(GO:0097643)
2.6 10.2 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 83.3 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.2 22.8 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 18.4 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.5 15.5 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.2 14.5 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.5 14.4 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.3 12.7 PID_FGF_PATHWAY FGF signaling pathway
0.3 12.2 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.1 12.0 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.3 11.4 PID_SHP2_PATHWAY SHP2 signaling
0.2 10.4 PID_ENDOTHELIN_PATHWAY Endothelins
1.0 10.0 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 9.2 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.2 9.1 PID_BMP_PATHWAY BMP receptor signaling
0.3 8.6 ST_GA12_PATHWAY G alpha 12 Pathway
0.3 6.8 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 5.5 PID_TCR_PATHWAY TCR signaling in naïve CD4+ T cells
0.1 5.5 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.1 5.3 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.1 5.0 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 111 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 37.4 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
3.5 21.3 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway
2.2 19.5 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR
3.1 18.5 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.6 17.1 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
1.0 16.5 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
4.1 16.4 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.8 14.4 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.5 14.0 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.1 13.4 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 12.4 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.6 12.2 REACTOME_SOS_MEDIATED_SIGNALLING Genes involved in SOS-mediated signalling
0.4 10.9 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.3 10.6 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.4 9.2 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.3 9.2 REACTOME_CA_DEPENDENT_EVENTS Genes involved in Ca-dependent events
0.2 8.4 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.8 7.9 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.3 7.9 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.1 7.9 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex