Motif ID: Runx3
Z-value: 0.611
Transcription factors associated with Runx3:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Runx3 | ENSMUSG00000070691.4 | Runx3 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 4.2 | GO:0003195 | tricuspid valve formation(GO:0003195) right ventricular cardiac muscle tissue morphogenesis(GO:0003221) |
| 0.9 | 17.3 | GO:0045653 | negative regulation of megakaryocyte differentiation(GO:0045653) |
| 0.7 | 2.0 | GO:0006083 | acetate metabolic process(GO:0006083) |
| 0.6 | 1.7 | GO:0014891 | striated muscle atrophy(GO:0014891) |
| 0.5 | 1.4 | GO:0090071 | negative regulation of ribosome biogenesis(GO:0090071) |
| 0.4 | 1.7 | GO:0006933 | negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933) |
| 0.3 | 1.5 | GO:1903378 | positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378) |
| 0.3 | 2.7 | GO:0006013 | mannose metabolic process(GO:0006013) |
| 0.3 | 6.5 | GO:0060009 | Sertoli cell development(GO:0060009) |
| 0.3 | 0.8 | GO:1990859 | cellular response to endothelin(GO:1990859) |
| 0.3 | 2.4 | GO:0051409 | response to nitrosative stress(GO:0051409) |
| 0.3 | 0.5 | GO:0071351 | interleukin-18-mediated signaling pathway(GO:0035655) cellular response to interleukin-18(GO:0071351) |
| 0.2 | 4.1 | GO:0031295 | T cell costimulation(GO:0031295) |
| 0.2 | 0.9 | GO:0075525 | viral translational termination-reinitiation(GO:0075525) |
| 0.2 | 4.7 | GO:2001224 | positive regulation of neuron migration(GO:2001224) |
| 0.2 | 0.8 | GO:0001561 | fatty acid alpha-oxidation(GO:0001561) |
| 0.2 | 7.7 | GO:0006284 | base-excision repair(GO:0006284) |
| 0.2 | 0.9 | GO:1904491 | protein localization to ciliary transition zone(GO:1904491) |
| 0.1 | 1.3 | GO:1902416 | positive regulation of mRNA binding(GO:1902416) |
| 0.1 | 0.4 | GO:0035441 | cell migration involved in vasculogenesis(GO:0035441) |
| 0.1 | 0.9 | GO:0009235 | cobalamin metabolic process(GO:0009235) |
| 0.1 | 3.2 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.1 | 0.9 | GO:0035269 | protein O-linked mannosylation(GO:0035269) |
| 0.1 | 1.0 | GO:2000671 | regulation of motor neuron apoptotic process(GO:2000671) |
| 0.1 | 4.2 | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) |
| 0.1 | 1.4 | GO:0015693 | magnesium ion transport(GO:0015693) |
| 0.1 | 2.7 | GO:0006687 | glycosphingolipid metabolic process(GO:0006687) |
| 0.1 | 0.5 | GO:0033631 | cell-cell adhesion mediated by integrin(GO:0033631) |
| 0.0 | 2.1 | GO:0050435 | beta-amyloid metabolic process(GO:0050435) |
| 0.0 | 2.4 | GO:0015807 | L-amino acid transport(GO:0015807) |
| 0.0 | 1.1 | GO:0043330 | response to exogenous dsRNA(GO:0043330) |
| 0.0 | 0.5 | GO:0006336 | DNA replication-independent nucleosome assembly(GO:0006336) |
| 0.0 | 0.4 | GO:0001682 | tRNA 5'-leader removal(GO:0001682) |
| 0.0 | 0.9 | GO:1903427 | negative regulation of reactive oxygen species biosynthetic process(GO:1903427) |
| 0.0 | 0.4 | GO:0046036 | CTP biosynthetic process(GO:0006241) CTP metabolic process(GO:0046036) |
| 0.0 | 1.0 | GO:0021884 | forebrain neuron development(GO:0021884) |
| 0.0 | 1.0 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 0.0 | 0.9 | GO:0048488 | synaptic vesicle endocytosis(GO:0048488) |
| 0.0 | 0.3 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.0 | 2.3 | GO:0070507 | regulation of microtubule cytoskeleton organization(GO:0070507) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 7.7 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 0.8 | 2.4 | GO:0017109 | glutamate-cysteine ligase complex(GO:0017109) |
| 0.4 | 14.5 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.3 | 1.7 | GO:0031265 | CD95 death-inducing signaling complex(GO:0031265) |
| 0.2 | 1.7 | GO:0045261 | mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261) |
| 0.2 | 1.0 | GO:0001674 | female germ cell nucleus(GO:0001674) |
| 0.1 | 1.5 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
| 0.1 | 2.9 | GO:0000786 | nucleosome(GO:0000786) |
| 0.1 | 4.2 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.1 | 1.0 | GO:0042788 | polysomal ribosome(GO:0042788) |
| 0.1 | 1.3 | GO:0045120 | pronucleus(GO:0045120) |
| 0.1 | 0.3 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
| 0.1 | 0.9 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 0.1 | 0.4 | GO:0005655 | nucleolar ribonuclease P complex(GO:0005655) |
| 0.1 | 4.8 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.1 | 0.9 | GO:0016010 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.0 | 0.4 | GO:0070652 | HAUS complex(GO:0070652) |
| 0.0 | 0.4 | GO:0042587 | glycogen granule(GO:0042587) |
| 0.0 | 0.5 | GO:0044294 | dendritic growth cone(GO:0044294) |
| 0.0 | 0.8 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) |
| 0.0 | 1.4 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 0.9 | GO:0035869 | ciliary transition zone(GO:0035869) |
| 0.0 | 0.9 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 4.2 | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575) |
| 0.8 | 2.4 | GO:0004357 | glutamate-cysteine ligase activity(GO:0004357) |
| 0.8 | 7.7 | GO:0051575 | 5'-deoxyribose-5-phosphate lyase activity(GO:0051575) |
| 0.7 | 2.0 | GO:0003987 | acetate-CoA ligase activity(GO:0003987) |
| 0.3 | 1.7 | GO:0043532 | angiostatin binding(GO:0043532) |
| 0.3 | 2.1 | GO:0008242 | omega peptidase activity(GO:0008242) |
| 0.2 | 1.0 | GO:0008545 | JUN kinase kinase activity(GO:0008545) |
| 0.2 | 1.7 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
| 0.2 | 2.7 | GO:0004559 | alpha-mannosidase activity(GO:0004559) |
| 0.2 | 1.5 | GO:0051434 | BH3 domain binding(GO:0051434) |
| 0.2 | 3.2 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.1 | 1.1 | GO:0097322 | 7SK snRNA binding(GO:0097322) |
| 0.1 | 1.3 | GO:1990715 | mRNA CDS binding(GO:1990715) |
| 0.1 | 0.4 | GO:0003883 | CTP synthase activity(GO:0003883) |
| 0.1 | 4.9 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.1 | 0.8 | GO:0000268 | peroxisome targeting sequence binding(GO:0000268) |
| 0.1 | 0.5 | GO:0033691 | sialic acid binding(GO:0033691) |
| 0.1 | 3.2 | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity(GO:0003755) |
| 0.1 | 18.2 | GO:0042393 | histone binding(GO:0042393) |
| 0.1 | 1.4 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.1 | 0.4 | GO:0046975 | histone methyltransferase activity (H3-K36 specific)(GO:0046975) |
| 0.1 | 2.3 | GO:0008028 | monocarboxylic acid transmembrane transporter activity(GO:0008028) |
| 0.1 | 2.1 | GO:0015175 | neutral amino acid transmembrane transporter activity(GO:0015175) |
| 0.0 | 0.9 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.0 | 0.4 | GO:0004526 | ribonuclease P activity(GO:0004526) |
| 0.0 | 0.4 | GO:0031996 | thioesterase binding(GO:0031996) |
| 0.0 | 0.3 | GO:0005314 | high-affinity glutamate transmembrane transporter activity(GO:0005314) |
| 0.0 | 4.2 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |
| 0.0 | 0.1 | GO:0004311 | farnesyltranstransferase activity(GO:0004311) |
| 0.0 | 0.2 | GO:0070181 | small ribosomal subunit rRNA binding(GO:0070181) |
| 0.0 | 1.9 | GO:0001046 | core promoter sequence-specific DNA binding(GO:0001046) |
| 0.0 | 0.9 | GO:0035255 | ionotropic glutamate receptor binding(GO:0035255) |
| 0.0 | 0.9 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.0 | 1.4 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.0 | 1.5 | GO:0052689 | carboxylic ester hydrolase activity(GO:0052689) |
| 0.0 | 0.8 | GO:0004004 | RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) |
| 0.0 | 1.8 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.7 | SA_FAS_SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.1 | 4.1 | PID_EPHRINB_REV_PATHWAY | Ephrin B reverse signaling |
| 0.1 | 10.7 | PID_MYC_ACTIV_PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 2.0 | PID_HDAC_CLASSIII_PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 0.8 | PID_TCR_JNK_PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.1 | 2.4 | PID_TCR_CALCIUM_PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 1.0 | PID_ANTHRAX_PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 2.6 | PID_AJDISS_2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 0.5 | PID_IL23_PATHWAY | IL23-mediated signaling events |
| 0.0 | 1.5 | PID_IL6_7_PATHWAY | IL6-mediated signaling events |
| 0.0 | 3.2 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 0.9 | PID_RHOA_REG_PATHWAY | Regulation of RhoA activity |
| 0.0 | 0.5 | PID_INTEGRIN3_PATHWAY | Beta3 integrin cell surface interactions |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 7.7 | REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.5 | 2.0 | REACTOME_ETHANOL_OXIDATION | Genes involved in Ethanol oxidation |
| 0.4 | 14.5 | REACTOME_PACKAGING_OF_TELOMERE_ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.1 | 3.7 | REACTOME_OTHER_SEMAPHORIN_INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.1 | 1.7 | REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.1 | 1.7 | REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.1 | 2.4 | REACTOME_SULFUR_AMINO_ACID_METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.1 | 2.1 | REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.1 | 0.8 | REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.0 | 1.0 | REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 | Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| 0.0 | 4.2 | REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 0.5 | REACTOME_BASIGIN_INTERACTIONS | Genes involved in Basigin interactions |
| 0.0 | 1.3 | REACTOME_PEPTIDE_CHAIN_ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 0.9 | REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.0 | 0.4 | REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
