Motif ID: Rxrb

Z-value: 0.647


Transcription factors associated with Rxrb:

Gene SymbolEntrez IDGene Name
Rxrb ENSMUSG00000039656.10 Rxrb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rxrbmm10_v2_chr17_+_34032348_340324010.094.4e-01Click!


Activity profile for motif Rxrb.

activity profile for motif Rxrb


Sorted Z-values histogram for motif Rxrb

Sorted Z-values for motif Rxrb



Network of associatons between targets according to the STRING database.



First level regulatory network of Rxrb

PNG image of the network

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Top targets:


Showing 1 to 20 of 115 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_6487231 9.045 ENSMUST00000140079.1
ENSMUST00000131494.1
 St18

suppression of tumorigenicity 18

chr4_-_117178726 8.830 ENSMUST00000153953.1
ENSMUST00000106436.1
 Kif2c

kinesin family member 2C

chr6_-_23248264 7.739 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr10_+_93641041 6.929 ENSMUST00000020204.4
 Ntn4
netrin 4
chr4_+_44300876 5.974 ENSMUST00000045607.5
 Melk
maternal embryonic leucine zipper kinase
chr1_+_74791516 5.856 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a
chr10_-_88146867 5.744 ENSMUST00000164121.1
ENSMUST00000164803.1
ENSMUST00000168163.1
ENSMUST00000048518.9
 Parpbp



PARP1 binding protein



chr14_+_54476100 5.301 ENSMUST00000164766.1
ENSMUST00000164697.1
 Rem2

rad and gem related GTP binding protein 2

chr11_-_40733373 5.290 ENSMUST00000020579.8
 Hmmr
hyaluronan mediated motility receptor (RHAMM)
chr6_+_113531675 4.957 ENSMUST00000036340.5
ENSMUST00000101051.2
 Fancd2

Fanconi anemia, complementation group D2

chr5_+_110839973 4.905 ENSMUST00000066160.1
 Chek2
checkpoint kinase 2
chr5_+_47984571 4.898 ENSMUST00000174313.1
 Slit2
slit homolog 2 (Drosophila)
chr12_-_98737405 4.437 ENSMUST00000170188.1
 Ptpn21
protein tyrosine phosphatase, non-receptor type 21
chr14_-_118052235 4.293 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr1_-_170306332 4.263 ENSMUST00000179801.1
 Gm7694
predicted gene 7694
chr17_-_35704000 4.056 ENSMUST00000097333.3
ENSMUST00000003628.6
 Ddr1

discoidin domain receptor family, member 1

chrX_-_23365044 3.831 ENSMUST00000115313.1
 Klhl13
kelch-like 13
chr5_+_137630116 3.696 ENSMUST00000175968.1
 Lrch4
leucine-rich repeats and calponin homology (CH) domain containing 4
chr13_+_44729794 3.679 ENSMUST00000172830.1
 Jarid2
jumonji, AT rich interactive domain 2
chr6_+_29396576 3.390 ENSMUST00000115275.1
 Ccdc136
coiled-coil domain containing 136

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 8.8 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.7 8.0 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
1.3 7.7 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.4 6.9 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.5 6.6 GO:0001675 acrosome assembly(GO:0001675)
0.5 5.9 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.4 5.7 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.1 5.5 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631)
0.5 5.3 GO:1901386 negative regulation of voltage-gated calcium channel activity(GO:1901386)
0.7 5.0 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
1.6 4.9 GO:0021972 corticospinal neuron axon guidance through spinal cord(GO:0021972) positive regulation of negative chemotaxis(GO:0050924) induction of negative chemotaxis(GO:0050929) negative regulation of mononuclear cell migration(GO:0071676) negative regulation of retinal ganglion cell axon guidance(GO:0090260)
1.2 4.9 GO:1903463 regulation of mitotic cell cycle DNA replication(GO:1903463)
1.1 4.3 GO:0021847 ventricular zone neuroblast division(GO:0021847)
0.3 4.1 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.3 3.7 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.3 3.7 GO:0045199 maintenance of epithelial cell apical/basal polarity(GO:0045199)
1.0 3.1 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.4 3.1 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.1 3.1 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.5 2.6 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.7 GO:0032993 protein-DNA complex(GO:0032993)
0.2 8.5 GO:0035371 microtubule plus-end(GO:0035371)
0.0 7.1 GO:0005938 cell cortex(GO:0005938)
0.3 6.6 GO:0002080 acrosomal membrane(GO:0002080)
0.1 6.5 GO:0005604 basement membrane(GO:0005604)
0.2 6.2 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 5.1 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 5.0 GO:0000793 condensed chromosome(GO:0000793)
0.0 4.9 GO:0000781 chromosome, telomeric region(GO:0000781)
0.0 4.8 GO:0000785 chromatin(GO:0000785)
0.2 4.3 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 3.9 GO:0000776 kinetochore(GO:0000776)
0.1 3.1 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.1 3.1 GO:0030673 axolemma(GO:0030673)
0.0 3.1 GO:0032587 ruffle membrane(GO:0032587)
0.2 2.8 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.2 2.3 GO:0005916 fascia adherens(GO:0005916)
0.0 2.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.3 1.9 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.1 1.8 GO:0001891 phagocytic cup(GO:0001891)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 11.8 GO:0043237 laminin-1 binding(GO:0043237)
0.0 8.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 8.7 GO:0001047 core promoter binding(GO:0001047)
0.5 8.0 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 6.5 GO:0003924 GTPase activity(GO:0003924)
0.1 6.0 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 5.9 GO:0005109 frizzled binding(GO:0005109)
0.3 5.3 GO:0005540 hyaluronic acid binding(GO:0005540)
0.2 5.0 GO:0070182 DNA polymerase binding(GO:0070182)
0.3 4.3 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.5 4.1 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 3.7 GO:0032452 histone demethylase activity(GO:0032452)
0.6 3.1 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.5 3.1 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 3.1 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 2.8 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 2.8 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 2.7 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 2.6 GO:0035064 methylated histone binding(GO:0035064)
0.2 2.3 GO:0002162 dystroglycan binding(GO:0002162)

Gene overrepresentation in C2:CP category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 12.7 PID_AURORA_B_PATHWAY Aurora B signaling
0.2 9.9 PID_ATM_PATHWAY ATM pathway
0.2 6.9 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 6.8 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.0 5.9 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.2 4.9 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 2.7 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 1.9 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.1 1.7 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 1.3 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.8 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.4 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 8.8 REACTOME_KINESINS Genes involved in Kinesins
0.1 6.9 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 5.9 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.5 5.3 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.5 5.3 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.1 5.1 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.7 4.9 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.2 4.8 REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT Genes involved in ABC-family proteins mediated transport
0.3 4.6 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 3.8 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 3.1 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 1.9 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 1.7 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 1.3 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 1.3 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 0.9 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 0.9 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.8 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.6 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.4 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha