Motif ID: Scrt2

Z-value: 1.117


Transcription factors associated with Scrt2:

Gene SymbolEntrez IDGene Name
Scrt2 ENSMUSG00000060257.2 Scrt2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Scrt2mm10_v2_chr2_+_152081529_152081624-0.689.4e-12Click!


Activity profile for motif Scrt2.

activity profile for motif Scrt2


Sorted Z-values histogram for motif Scrt2

Sorted Z-values for motif Scrt2



Network of associatons between targets according to the STRING database.



First level regulatory network of Scrt2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 104 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_111066154 21.096 ENSMUST00000042970.2
 Kcnj2
potassium inwardly-rectifying channel, subfamily J, member 2
chr3_-_53657339 17.169 ENSMUST00000091137.4
 Frem2
Fras1 related extracellular matrix protein 2
chr18_-_58209926 11.989 ENSMUST00000025497.6
 Fbn2
fibrillin 2
chr11_-_55419898 11.636 ENSMUST00000108858.1
ENSMUST00000141530.1
 Sparc

secreted acidic cysteine rich glycoprotein

chr15_-_71727815 11.512 ENSMUST00000022953.8
 Fam135b
family with sequence similarity 135, member B
chr7_+_126847908 11.240 ENSMUST00000147257.1
ENSMUST00000139174.1
 Doc2a

double C2, alpha

chr8_+_76902277 10.869 ENSMUST00000109912.1
ENSMUST00000128862.1
ENSMUST00000109911.1
 Nr3c2


nuclear receptor subfamily 3, group C, member 2


chr5_+_118169712 10.505 ENSMUST00000054836.6
 Hrk
harakiri, BCL2 interacting protein (contains only BH3 domain)
chr8_-_71537402 10.320 ENSMUST00000051672.7
 Bst2
bone marrow stromal cell antigen 2
chr9_+_45370185 10.142 ENSMUST00000085939.6
 Fxyd6
FXYD domain-containing ion transport regulator 6
chr12_-_40037387 9.727 ENSMUST00000146905.1
 Arl4a
ADP-ribosylation factor-like 4A
chr17_-_25570678 9.381 ENSMUST00000025003.3
ENSMUST00000173447.1
 Sox8

SRY-box containing gene 8

chr12_-_4592927 8.120 ENSMUST00000170816.1
 Gm3625
predicted gene 3625
chr11_+_103649498 8.065 ENSMUST00000057870.2
 Rprml
reprimo-like
chr19_-_57008187 7.261 ENSMUST00000118800.1
ENSMUST00000111584.2
ENSMUST00000122359.1
ENSMUST00000148049.1
 Afap1l2



actin filament associated protein 1-like 2



chr15_+_34306666 6.458 ENSMUST00000163455.2
ENSMUST00000022947.5
 Matn2

matrilin 2

chr4_-_119538769 6.227 ENSMUST00000079611.6
 AA415398
expressed sequence AA415398
chr15_+_6422240 5.809 ENSMUST00000163082.1
 Dab2
disabled 2, mitogen-responsive phosphoprotein
chrX_-_152769461 5.773 ENSMUST00000101141.2
ENSMUST00000062317.4
 Shroom2

shroom family member 2

chr16_+_42907563 5.542 ENSMUST00000151244.1
ENSMUST00000114694.2
 Zbtb20

zinc finger and BTB domain containing 20


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.3 23.3 GO:0014819 regulation of skeletal muscle contraction(GO:0014819)
0.1 13.2 GO:0048839 inner ear development(GO:0048839)
2.4 12.0 GO:0071692 protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694)
0.3 11.6 GO:0001937 negative regulation of endothelial cell proliferation(GO:0001937)
0.3 11.1 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.6 10.9 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
2.1 10.5 GO:0051365 cellular response to potassium ion starvation(GO:0051365)
2.6 10.3 GO:1901252 regulation of intracellular transport of viral material(GO:1901252)
0.2 10.1 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.3 9.7 GO:0050873 brown fat cell differentiation(GO:0050873)
3.1 9.4 GO:0072034 renal vesicle induction(GO:0072034)
0.3 7.3 GO:0032757 positive regulation of interleukin-8 production(GO:0032757)
0.1 6.5 GO:0031102 neuron projection regeneration(GO:0031102) response to axon injury(GO:0048678)
1.5 5.8 GO:0035026 leading edge cell differentiation(GO:0035026)
0.5 5.8 GO:0045217 cell-cell junction maintenance(GO:0045217)
0.2 5.5 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
1.7 5.2 GO:2000564 CD8-positive, alpha-beta T cell proliferation(GO:0035740) negative regulation of regulatory T cell differentiation(GO:0045590) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564)
1.2 4.9 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.7 4.9 GO:1990504 dense core granule exocytosis(GO:1990504)
0.3 4.8 GO:0042541 hemoglobin biosynthetic process(GO:0042541)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 21.1 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.2 20.8 GO:0005604 basement membrane(GO:0005604)
0.1 14.6 GO:0070382 exocytic vesicle(GO:0070382)
0.9 12.0 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
2.9 11.6 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 10.3 GO:0031225 anchored component of membrane(GO:0031225)
0.0 9.4 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 8.9 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 8.5 GO:0043235 receptor complex(GO:0043235)
0.2 8.1 GO:0031941 filamentous actin(GO:0031941)
0.2 6.8 GO:0043034 costamere(GO:0043034)
0.4 6.2 GO:0031045 dense core granule(GO:0031045)
1.5 5.8 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 4.8 GO:0001650 fibrillar center(GO:0001650)
0.0 4.1 GO:0055037 recycling endosome(GO:0055037)
0.0 3.9 GO:0016607 nuclear speck(GO:0016607)
0.8 3.8 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.2 3.6 GO:0032279 asymmetric synapse(GO:0032279)
0.2 3.4 GO:0071564 npBAF complex(GO:0071564)
0.0 3.4 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.6 21.1 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.4 16.5 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.2 15.7 GO:0005518 collagen binding(GO:0005518)
0.2 10.9 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.9 10.3 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.2 10.1 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 9.4 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1 9.3 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.0 9.3 GO:0003924 GTPase activity(GO:0003924)
0.3 9.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 9.2 GO:0005509 calcium ion binding(GO:0005509)
0.6 7.3 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.1 6.0 GO:0008013 beta-catenin binding(GO:0008013)
0.4 5.3 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 5.0 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
1.6 4.8 GO:0016748 succinyltransferase activity(GO:0016748)
0.9 4.6 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.5 4.1 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.7 4.0 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.1 3.8 GO:0048306 calcium-dependent protein binding(GO:0048306)

Gene overrepresentation in C2:CP category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 34.1 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 21.8 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 10.5 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.1 5.8 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.2 5.2 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 5.2 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 3.4 PID_E2F_PATHWAY E2F transcription factor network
0.1 3.2 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 2.9 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 2.7 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.1 1.9 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 1.8 PID_ATR_PATHWAY ATR signaling pathway
0.1 1.5 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 1.3 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 0.2 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 21.1 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 11.4 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.2 10.9 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.5 9.0 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.1 7.2 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.3 5.2 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.2 4.8 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.2 4.6 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.2 4.0 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 3.7 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 3.4 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 2.7 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.1 2.7 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.1 2.3 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 2.2 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 1.8 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 1.6 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 1.5 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 1.3 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 1.2 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions