Motif ID: Sin3a

Z-value: 1.401


Transcription factors associated with Sin3a:

Gene SymbolEntrez IDGene Name
Sin3a ENSMUSG00000042557.8 Sin3a

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sin3amm10_v2_chr9_+_57076395_570764110.701.2e-12Click!


Activity profile for motif Sin3a.

activity profile for motif Sin3a


Sorted Z-values histogram for motif Sin3a

Sorted Z-values for motif Sin3a



Network of associatons between targets according to the STRING database.



First level regulatory network of Sin3a

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_64340225 21.817 ENSMUST00000175965.2
ENSMUST00000115145.3
 Onecut2

one cut domain, family member 2

chr14_-_98169542 20.482 ENSMUST00000069334.7
ENSMUST00000071533.6
 Dach1

dachshund 1 (Drosophila)

chr6_-_39206782 19.167 ENSMUST00000002305.8
 Jhdm1d
jumonji C domain-containing histone demethylase 1 homolog D (S. cerevisiae)
chr9_+_118478851 18.253 ENSMUST00000150633.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr10_-_120476469 16.445 ENSMUST00000072777.7
ENSMUST00000159699.1
 Hmga2

high mobility group AT-hook 2

chr2_-_34372004 15.638 ENSMUST00000113132.2
ENSMUST00000040638.8
 Pbx3

pre B cell leukemia homeobox 3

chr19_+_59458372 13.173 ENSMUST00000062216.3
 Emx2
empty spiracles homeobox 2
chr5_-_106458440 13.062 ENSMUST00000086795.6
 Barhl2
BarH-like 2 (Drosophila)
chr14_+_122475397 12.860 ENSMUST00000075888.5
 Zic2
zinc finger protein of the cerebellum 2
chr3_-_52104891 12.295 ENSMUST00000121440.1
 Maml3
mastermind like 3 (Drosophila)
chr6_+_34745952 11.467 ENSMUST00000123823.1
ENSMUST00000136907.1
ENSMUST00000126181.1
 Cald1


caldesmon 1


chr18_-_72351009 11.169 ENSMUST00000073379.5
 Dcc
deleted in colorectal carcinoma
chr7_-_70360593 11.135 ENSMUST00000032768.7
 Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr6_+_85587524 10.725 ENSMUST00000072018.5
 Alms1
Alstrom syndrome 1
chr18_-_72351029 10.581 ENSMUST00000114943.3
 Dcc
deleted in colorectal carcinoma
chrX_+_58030999 10.451 ENSMUST00000088631.4
ENSMUST00000088629.3
 Zic3

zinc finger protein of the cerebellum 3

chr6_+_34746368 10.018 ENSMUST00000142716.1
 Cald1
caldesmon 1
chr19_+_25610533 9.764 ENSMUST00000048935.4
 Dmrt3
doublesex and mab-3 related transcription factor 3
chr2_-_104816696 9.489 ENSMUST00000117237.1
 Qser1
glutamine and serine rich 1
chr6_-_38875923 9.392 ENSMUST00000162359.1
 Hipk2
homeodomain interacting protein kinase 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 565 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.3 32.0 GO:0021965 spinal cord ventral commissure morphogenesis(GO:0021965)
8.1 24.3 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
2.5 22.6 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
2.2 22.3 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
2.0 21.8 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.2 20.6 GO:0006334 nucleosome assembly(GO:0006334)
6.8 20.5 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.3 18.8 GO:0006940 regulation of smooth muscle contraction(GO:0006940)
1.7 17.3 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
1.9 17.0 GO:0060613 fat pad development(GO:0060613)
1.4 16.9 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
5.3 15.9 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
1.0 15.7 GO:0006337 nucleosome disassembly(GO:0006337)
2.5 15.2 GO:0048105 establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105)
1.4 15.0 GO:0035563 positive regulation of chromatin binding(GO:0035563)
1.1 14.8 GO:0021796 cerebral cortex regionalization(GO:0021796)
1.2 13.1 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
3.2 12.9 GO:1900224 positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900224)
1.4 12.3 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.8 12.1 GO:1990403 embryonic brain development(GO:1990403)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 204 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 175.7 GO:0005634 nucleus(GO:0005634)
0.1 39.4 GO:0016607 nuclear speck(GO:0016607)
0.5 38.4 GO:0005844 polysome(GO:0005844)
0.3 38.0 GO:0005814 centriole(GO:0005814)
2.6 23.4 GO:0030478 actin cap(GO:0030478)
0.2 23.4 GO:0016605 PML body(GO:0016605)
0.6 22.9 GO:0090544 BAF-type complex(GO:0090544)
1.2 21.9 GO:0097470 ribbon synapse(GO:0097470)
0.2 20.0 GO:0000922 spindle pole(GO:0000922)
1.8 19.5 GO:0032584 growth cone membrane(GO:0032584)
0.1 17.5 GO:0015629 actin cytoskeleton(GO:0015629)
0.2 16.4 GO:0000786 nucleosome(GO:0000786)
0.1 15.8 GO:0016604 nuclear body(GO:0016604)
3.8 15.2 GO:0060187 cell pole(GO:0060187)
0.1 12.5 GO:0072562 blood microparticle(GO:0072562)
0.9 12.2 GO:0097542 ciliary tip(GO:0097542)
0.1 12.1 GO:0005681 spliceosomal complex(GO:0005681)
0.3 11.2 GO:0016592 mediator complex(GO:0016592)
0.1 10.9 GO:0000775 chromosome, centromeric region(GO:0000775)
0.1 10.8 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 322 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 91.6 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
1.2 35.0 GO:0008187 poly-pyrimidine tract binding(GO:0008187)
0.4 29.6 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.2 25.0 GO:0003714 transcription corepressor activity(GO:0003714)
3.0 24.0 GO:0046790 virion binding(GO:0046790)
3.9 23.7 GO:0005042 netrin receptor activity(GO:0005042)
1.4 23.0 GO:0003680 AT DNA binding(GO:0003680)
0.4 22.7 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
2.8 22.2 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
2.6 21.2 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.9 20.7 GO:0070577 lysine-acetylated histone binding(GO:0070577)
1.1 20.6 GO:0001848 complement binding(GO:0001848)
0.5 17.6 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
1.9 16.9 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
2.3 16.4 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.5 16.3 GO:0070840 dynein complex binding(GO:0070840)
0.1 14.3 GO:0042393 histone binding(GO:0042393)
1.0 13.1 GO:0001972 retinoic acid binding(GO:0001972)
0.2 13.0 GO:0035064 methylated histone binding(GO:0035064)
0.4 12.0 GO:1990841 promoter-specific chromatin binding(GO:1990841)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 34.4 PID_P53_REGULATION_PATHWAY p53 pathway
0.4 33.9 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.3 29.6 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.5 25.5 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.4 24.6 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.5 24.4 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.5 20.5 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.4 16.5 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.3 15.6 PID_PLK1_PATHWAY PLK1 signaling events
0.3 13.7 PID_NOTCH_PATHWAY Notch signaling pathway
0.3 11.6 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.3 11.3 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.2 11.3 PID_E2F_PATHWAY E2F transcription factor network
0.5 11.0 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.4 10.6 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.5 9.8 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.2 8.9 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.5 8.6 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.4 7.9 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.6 7.8 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 112 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 23.7 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.3 23.1 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.5 20.8 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
1.1 18.2 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.2 18.1 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.9 17.3 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
1.6 15.9 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.2 15.6 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
1.2 13.6 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.6 12.7 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.4 12.3 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.5 11.8 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.2 10.6 REACTOME_RNA_POL_III_TRANSCRIPTION Genes involved in RNA Polymerase III Transcription
0.6 9.4 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.3 9.3 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 9.1 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.2 8.0 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.6 7.9 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.5 7.8 REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING Genes involved in Spry regulation of FGF signaling
0.4 7.1 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA