Motif ID: Six3_Six1_Six2

Z-value: 0.946

Transcription factors associated with Six3_Six1_Six2:

Gene SymbolEntrez IDGene Name
Six1 ENSMUSG00000051367.8 Six1
Six2 ENSMUSG00000024134.10 Six2
Six3 ENSMUSG00000038805.9 Six3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Six1mm10_v2_chr12_-_73047179_730471790.271.9e-02Click!
Six2mm10_v2_chr17_-_85688252_856882750.171.3e-01Click!
Six3mm10_v2_chr17_+_85621017_856210310.037.9e-01Click!


Activity profile for motif Six3_Six1_Six2.

activity profile for motif Six3_Six1_Six2


Sorted Z-values histogram for motif Six3_Six1_Six2

Sorted Z-values for motif Six3_Six1_Six2



Network of associatons between targets according to the STRING database.



First level regulatory network of Six3_Six1_Six2

PNG image of the network

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Top targets:


Showing 1 to 20 of 72 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_85722474 20.948 ENSMUST00000119077.1
 Fam160a1
family with sequence similarity 160, member A1
chr13_+_94083490 14.384 ENSMUST00000156071.1
 Lhfpl2
lipoma HMGIC fusion partner-like 2
chr15_-_75894474 9.802 ENSMUST00000023237.6
 Naprt1
nicotinate phosphoribosyltransferase domain containing 1
chr1_+_139454747 9.268 ENSMUST00000053364.8
ENSMUST00000097554.3
 Aspm

asp (abnormal spindle)-like, microcephaly associated (Drosophila)

chr5_+_139423151 6.658 ENSMUST00000066211.4
 Gper1
G protein-coupled estrogen receptor 1
chr9_+_65141154 6.543 ENSMUST00000034961.4
 Igdcc3
immunoglobulin superfamily, DCC subclass, member 3
chrX_-_142966709 6.302 ENSMUST00000041317.2
 Ammecr1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr7_-_80115294 6.195 ENSMUST00000107384.3
 Idh2
isocitrate dehydrogenase 2 (NADP+), mitochondrial
chr7_-_126676357 5.982 ENSMUST00000106371.1
ENSMUST00000106372.3
ENSMUST00000155419.1
 Sult1a1


sulfotransferase family 1A, phenol-preferring, member 1


chr15_-_82244716 5.597 ENSMUST00000089155.4
ENSMUST00000089157.3
 Cenpm

centromere protein M

chr4_-_32950813 5.065 ENSMUST00000084750.1
ENSMUST00000084748.2
 Ankrd6

ankyrin repeat domain 6

chr9_+_72958785 4.989 ENSMUST00000098567.2
ENSMUST00000034734.8
 Dyx1c1

dyslexia susceptibility 1 candidate 1 homolog (human)

chr7_-_126676428 4.875 ENSMUST00000106373.1
 Sult1a1
sulfotransferase family 1A, phenol-preferring, member 1
chr18_+_56432116 4.824 ENSMUST00000070166.5
 Gramd3
GRAM domain containing 3
chrX_+_169685191 4.198 ENSMUST00000112104.1
ENSMUST00000112107.1
 Mid1

midline 1

chr3_+_94398517 3.305 ENSMUST00000050975.3
 Lingo4
leucine rich repeat and Ig domain containing 4
chr10_-_128180265 3.294 ENSMUST00000099139.1
 Rbms2
RNA binding motif, single stranded interacting protein 2
chr15_+_98571004 3.253 ENSMUST00000023728.6
 4930415O20Rik
RIKEN cDNA 4930415O20 gene
chr8_+_57455898 2.665 ENSMUST00000034023.3
 Scrg1
scrapie responsive gene 1
chr2_+_131491764 2.614 ENSMUST00000028806.5
ENSMUST00000110179.2
ENSMUST00000110189.2
ENSMUST00000110182.2
ENSMUST00000110183.2
ENSMUST00000110186.2
ENSMUST00000110188.1
 Smox






spermine oxidase







Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 10.9 GO:0051923 sulfation(GO:0051923)
1.9 9.3 GO:0051661 maintenance of centrosome location(GO:0051661)
1.7 6.7 GO:1904706 regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010578) positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010579) negative regulation of vascular smooth muscle cell proliferation(GO:1904706) positive regulation of vascular smooth muscle cell differentiation(GO:1905065)
2.1 6.2 GO:0006097 glyoxylate cycle(GO:0006097) negative regulation of glial cell migration(GO:1903976)
0.1 5.6 GO:0050885 neuromuscular process controlling balance(GO:0050885)
0.3 5.1 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.5 5.0 GO:0036159 outer dynein arm assembly(GO:0036158) inner dynein arm assembly(GO:0036159)
0.5 4.2 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 3.5 GO:2000179 positive regulation of neural precursor cell proliferation(GO:2000179)
0.0 3.3 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.5 2.6 GO:0046208 spermine catabolic process(GO:0046208)
0.5 2.2 GO:0021698 cerebellar cortex structural organization(GO:0021698)
0.1 1.9 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.4 1.6 GO:0060032 notochord regression(GO:0060032)
0.1 1.4 GO:0035855 megakaryocyte development(GO:0035855)
0.0 1.3 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway(GO:2001238)
0.3 0.8 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.2 0.8 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.2 0.8 GO:0031581 hemidesmosome assembly(GO:0031581)
0.2 0.7 GO:1990046 positive regulation of mitochondrial DNA replication(GO:0090297) regulation of cardiolipin metabolic process(GO:1900208) positive regulation of cardiolipin metabolic process(GO:1900210) stress-induced mitochondrial fusion(GO:1990046)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 9.3 GO:0036449 microtubule minus-end(GO:0036449)
0.1 9.0 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 6.8 GO:0000776 kinetochore(GO:0000776)
0.7 6.7 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 6.4 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
1.0 3.9 GO:0045098 type III intermediate filament(GO:0045098)
0.0 2.4 GO:0044306 neuron projection terminus(GO:0044306)
0.1 2.2 GO:0051233 spindle midzone(GO:0051233)
0.7 2.0 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.1 1.6 GO:0097542 ciliary tip(GO:0097542)
0.1 1.4 GO:0031209 SCAR complex(GO:0031209)
0.1 1.1 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.1 0.8 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.8 GO:0005801 cis-Golgi network(GO:0005801)
0.1 0.7 GO:0061574 ASAP complex(GO:0061574)
0.0 0.7 GO:0042101 T cell receptor complex(GO:0042101)
0.2 0.6 GO:0097543 ciliary inversin compartment(GO:0097543)
0.0 0.5 GO:0031143 pseudopodium(GO:0031143)
0.0 0.4 GO:0071564 npBAF complex(GO:0071564)
0.0 0.3 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.6 10.9 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0 9.3 GO:0005516 calmodulin binding(GO:0005516)
1.1 6.7 GO:0030284 estrogen receptor activity(GO:0030284)
2.1 6.2 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.1 5.0 GO:0030331 estrogen receptor binding(GO:0030331)
0.0 4.2 GO:0051219 phosphoprotein binding(GO:0051219)
0.3 3.9 GO:0019215 intermediate filament binding(GO:0019215)
0.9 2.6 GO:0046592 polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901)
0.1 2.2 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.2 2.0 GO:0008428 ribonuclease inhibitor activity(GO:0008428)
0.0 1.9 GO:0051087 chaperone binding(GO:0051087)
0.1 1.6 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 1.3 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 1.0 GO:0030506 ankyrin binding(GO:0030506)
0.3 0.8 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.0 0.8 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 0.7 GO:1901612 phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612)
0.0 0.6 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.5 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 0.4 GO:0032184 SUMO polymer binding(GO:0032184)

Gene overrepresentation in C2:CP category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.1 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.1 1.6 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.4 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.8 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.0 0.7 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.5 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.4 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 10.9 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 6.8 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.3 6.2 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 3.5 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.2 2.6 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.0 1.9 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.8 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.8 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.5 REACTOME_RAF_MAP_KINASE_CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.3 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis