Motif ID: Six4

Z-value: 0.558


Transcription factors associated with Six4:

Gene SymbolEntrez IDGene Name
Six4 ENSMUSG00000034460.8 Six4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Six4mm10_v2_chr12_-_73113407_73113456-0.019.3e-01Click!


Activity profile for motif Six4.

activity profile for motif Six4


Sorted Z-values histogram for motif Six4

Sorted Z-values for motif Six4



Network of associatons between targets according to the STRING database.



First level regulatory network of Six4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_23248264 11.260 ENSMUST00000031709.5
Fezf1
Fez family zinc finger 1
chr7_-_137314394 5.945 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
Ebf3



early B cell factor 3



chr6_+_7555053 3.937 ENSMUST00000090679.2
ENSMUST00000184986.1
Tac1

tachykinin 1

chr7_+_29307924 3.683 ENSMUST00000108230.1
ENSMUST00000065181.5
Dpf1

D4, zinc and double PHD fingers family 1

chr7_+_29309429 3.475 ENSMUST00000137848.1
Dpf1
D4, zinc and double PHD fingers family 1
chr13_+_54071815 3.121 ENSMUST00000021930.8
Sfxn1
sideroflexin 1
chr7_-_143460989 2.999 ENSMUST00000167912.1
ENSMUST00000037287.6
Cdkn1c

cyclin-dependent kinase inhibitor 1C (P57)

chr15_+_92051153 2.687 ENSMUST00000169825.1
Cntn1
contactin 1
chr11_+_67078293 2.556 ENSMUST00000108689.1
ENSMUST00000165221.1
ENSMUST00000007301.7
Myh3


myosin, heavy polypeptide 3, skeletal muscle, embryonic


chr8_+_62951361 2.530 ENSMUST00000119068.1
Spock3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3
chr13_-_9878998 2.349 ENSMUST00000063093.9
Chrm3
cholinergic receptor, muscarinic 3, cardiac
chr8_-_84237042 2.251 ENSMUST00000039480.5
Zswim4
zinc finger SWIM-type containing 4
chr2_+_119351222 2.102 ENSMUST00000028780.3
Chac1
ChaC, cation transport regulator 1
chr15_-_79834323 2.045 ENSMUST00000177316.2
ENSMUST00000175858.2
Nptxr

neuronal pentraxin receptor

chr1_-_78968079 2.045 ENSMUST00000049117.5
Gm5830
predicted pseudogene 5830
chr6_+_50110186 1.652 ENSMUST00000166318.1
ENSMUST00000036236.8
ENSMUST00000036225.8
Mpp6


membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)


chr15_-_66831625 1.598 ENSMUST00000164163.1
Sla
src-like adaptor
chr4_-_134018829 1.582 ENSMUST00000051674.2
Lin28a
lin-28 homolog A (C. elegans)
chr17_-_48409729 1.394 ENSMUST00000160319.1
ENSMUST00000159535.1
ENSMUST00000078800.6
ENSMUST00000046719.7
ENSMUST00000162460.1
Nfya




nuclear transcription factor-Y alpha




chr13_+_51645232 1.360 ENSMUST00000075853.5
Cks2
CDC28 protein kinase regulatory subunit 2
chr8_+_95703037 1.280 ENSMUST00000073139.7
ENSMUST00000080666.7
Ndrg4

N-myc downstream regulated gene 4

chr7_+_38183787 1.105 ENSMUST00000067854.8
ENSMUST00000177983.1
1600014C10Rik

RIKEN cDNA 1600014C10 gene

chr3_+_40950631 1.084 ENSMUST00000048490.6
Larp1b
La ribonucleoprotein domain family, member 1B
chr17_+_35049966 1.061 ENSMUST00000007257.9
Clic1
chloride intracellular channel 1
chr3_+_145938004 1.045 ENSMUST00000039571.7
2410004B18Rik
RIKEN cDNA 2410004B18 gene
chr12_-_57546121 0.975 ENSMUST00000044380.6
Foxa1
forkhead box A1
chr11_+_3989924 0.957 ENSMUST00000109981.1
Gal3st1
galactose-3-O-sulfotransferase 1
chr5_-_145191511 0.922 ENSMUST00000161845.1
Atp5j2
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F2
chr19_+_8764934 0.811 ENSMUST00000184663.1
Nxf1
nuclear RNA export factor 1
chr8_-_85067982 0.783 ENSMUST00000177563.1
Gm5741
predicted gene 5741
chr2_+_131133497 0.659 ENSMUST00000110225.1
Gm11037
predicted gene 11037
chr1_+_37890477 0.571 ENSMUST00000027256.5
Mrpl30
mitochondrial ribosomal protein L30
chr6_+_124931378 0.565 ENSMUST00000032214.7
ENSMUST00000180095.1
Mlf2

myeloid leukemia factor 2

chr10_-_80918212 0.554 ENSMUST00000057623.7
ENSMUST00000179022.1
Lmnb2

lamin B2

chr15_-_79834224 0.542 ENSMUST00000109623.1
ENSMUST00000109625.1
ENSMUST00000023060.6
ENSMUST00000089299.5
Cbx6

Npcd

chromobox 6

neuronal pentraxin chromo domain

chr1_+_74284930 0.515 ENSMUST00000113805.1
ENSMUST00000027370.6
ENSMUST00000087226.4
Pnkd


paroxysmal nonkinesiogenic dyskinesia


chr2_-_103797617 0.502 ENSMUST00000028607.6
Caprin1
cell cycle associated protein 1
chr6_+_149130170 0.464 ENSMUST00000087348.3
Gm10203
predicted gene 10203
chr1_-_74284636 0.426 ENSMUST00000178235.1
ENSMUST00000006462.7
Aamp

angio-associated migratory protein

chr17_+_48409980 0.404 ENSMUST00000167180.1
ENSMUST00000046651.6
Oard1

O-acyl-ADP-ribose deacylase 1

chr1_-_37890333 0.363 ENSMUST00000139725.1
ENSMUST00000027257.8
Mitd1

MIT, microtubule interacting and transport, domain containing 1

chr2_-_91444622 0.357 ENSMUST00000064652.7
ENSMUST00000102594.4
ENSMUST00000094835.2
1110051M20Rik


RIKEN cDNA 1110051M20 gene


chr14_-_89898466 0.338 ENSMUST00000081204.4
Gm10110
predicted gene 10110
chrX_-_139714481 0.311 ENSMUST00000183728.1
Gm15013
predicted gene 15013
chr8_+_94214567 0.299 ENSMUST00000079961.6
Nup93
nucleoporin 93
chr19_-_6980420 0.290 ENSMUST00000070878.8
ENSMUST00000177752.1
Fkbp2

FK506 binding protein 2

chr2_-_93452679 0.277 ENSMUST00000111257.1
ENSMUST00000145553.1
Cd82

CD82 antigen

chr12_-_21417356 0.256 ENSMUST00000103002.1
Ywhaq
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
chr15_-_79834261 0.233 ENSMUST00000148358.1
Cbx6
chromobox 6
chr17_+_24896488 0.176 ENSMUST00000024978.6
Nme3
NME/NM23 nucleoside diphosphate kinase 3
chr9_-_70503718 0.097 ENSMUST00000034739.5
Rnf111
ring finger 111
chr7_-_132317198 0.034 ENSMUST00000080215.5
Chst15
carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
chr13_+_13590402 0.021 ENSMUST00000110559.1
Lyst
lysosomal trafficking regulator

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 11.3 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.3 3.9 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.5 2.1 GO:0006751 glutathione catabolic process(GO:0006751)
0.5 2.3 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.4 3.0 GO:1902746 regulation of lens fiber cell differentiation(GO:1902746)
0.3 1.0 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743) alveolar secondary septum development(GO:0061144)
0.3 2.5 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.2 1.6 GO:0010587 miRNA catabolic process(GO:0010587)
0.1 1.0 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.1 1.3 GO:2001135 regulation of endocytic recycling(GO:2001135)
0.1 2.6 GO:0003009 skeletal muscle contraction(GO:0003009)
0.1 3.1 GO:0006826 iron ion transport(GO:0006826)
0.1 1.1 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.1 0.5 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.0 1.1 GO:0051560 mitochondrial calcium ion homeostasis(GO:0051560)
0.0 2.7 GO:0010765 positive regulation of sodium ion transport(GO:0010765)
0.0 1.4 GO:2000036 regulation of stem cell population maintenance(GO:2000036)
0.0 1.4 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.0 1.1 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 1.6 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 0.2 GO:0006228 UTP biosynthetic process(GO:0006228)
0.0 0.1 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.9 GO:0006754 ATP biosynthetic process(GO:0006754)
0.0 0.5 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 7.2 GO:0071565 nBAF complex(GO:0071565)
0.3 2.6 GO:0032982 myosin filament(GO:0032982)
0.2 1.4 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.1 2.3 GO:0032279 asymmetric synapse(GO:0032279)
0.1 0.6 GO:0005638 lamin filament(GO:0005638)
0.1 0.9 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 0.8 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 2.1 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 1.1 GO:0034707 chloride channel complex(GO:0034707)
0.0 1.4 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.4 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 1.0 GO:0005902 microvillus(GO:0005902)
0.0 0.6 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.0 GO:0001847 opsonin receptor activity(GO:0001847)
0.5 2.3 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.4 2.1 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.3 1.4 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.2 1.0 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733)
0.2 3.0 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.2 2.5 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.2 3.9 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 1.6 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.1 2.6 GO:0000146 microfilament motor activity(GO:0000146)
0.1 1.7 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 0.5 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.1 10.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 1.6 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.3 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.8 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 8.3 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 1.1 GO:0005254 chloride channel activity(GO:0005254)
0.0 0.3 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.1 GO:0032184 SUMO polymer binding(GO:0032184)
0.0 0.9 GO:0016887 ATPase activity(GO:0016887)
0.0 2.7 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.0 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.5 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 2.7 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 1.0 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.4 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.9 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.3 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.2 1.4 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 2.6 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 2.7 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 0.9 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 2.6 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.1 REACTOME_TRANSPORT_OF_MATURE_MRNA_DERIVED_FROM_AN_INTRONLESS_TRANSCRIPT Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.0 1.0 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism