Motif ID: Six4

Z-value: 0.558


Transcription factors associated with Six4:

Gene SymbolEntrez IDGene Name
Six4 ENSMUSG00000034460.8 Six4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Six4mm10_v2_chr12_-_73113407_73113456-0.019.3e-01Click!


Activity profile for motif Six4.

activity profile for motif Six4


Sorted Z-values histogram for motif Six4

Sorted Z-values for motif Six4



Network of associatons between targets according to the STRING database.



First level regulatory network of Six4

PNG image of the network

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Top targets:


Showing 1 to 20 of 53 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 11.260 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr7_-_137314394 5.945 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
 Ebf3



early B cell factor 3



chr6_+_7555053 3.937 ENSMUST00000090679.2
ENSMUST00000184986.1
 Tac1

tachykinin 1

chr7_+_29307924 3.683 ENSMUST00000108230.1
ENSMUST00000065181.5
 Dpf1

D4, zinc and double PHD fingers family 1

chr7_+_29309429 3.475 ENSMUST00000137848.1
 Dpf1
D4, zinc and double PHD fingers family 1
chr13_+_54071815 3.121 ENSMUST00000021930.8
 Sfxn1
sideroflexin 1
chr7_-_143460989 2.999 ENSMUST00000167912.1
ENSMUST00000037287.6
 Cdkn1c

cyclin-dependent kinase inhibitor 1C (P57)

chr15_+_92051153 2.687 ENSMUST00000169825.1
 Cntn1
contactin 1
chr11_+_67078293 2.556 ENSMUST00000108689.1
ENSMUST00000165221.1
ENSMUST00000007301.7
 Myh3


myosin, heavy polypeptide 3, skeletal muscle, embryonic


chr8_+_62951361 2.530 ENSMUST00000119068.1
 Spock3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3
chr13_-_9878998 2.349 ENSMUST00000063093.9
 Chrm3
cholinergic receptor, muscarinic 3, cardiac
chr8_-_84237042 2.251 ENSMUST00000039480.5
 Zswim4
zinc finger SWIM-type containing 4
chr2_+_119351222 2.102 ENSMUST00000028780.3
 Chac1
ChaC, cation transport regulator 1
chr15_-_79834323 2.045 ENSMUST00000177316.2
ENSMUST00000175858.2
 Nptxr

neuronal pentraxin receptor

chr1_-_78968079 2.045 ENSMUST00000049117.5
 Gm5830
predicted pseudogene 5830
chr6_+_50110186 1.652 ENSMUST00000166318.1
ENSMUST00000036236.8
ENSMUST00000036225.8
 Mpp6


membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)


chr15_-_66831625 1.598 ENSMUST00000164163.1
 Sla
src-like adaptor
chr4_-_134018829 1.582 ENSMUST00000051674.2
 Lin28a
lin-28 homolog A (C. elegans)
chr17_-_48409729 1.394 ENSMUST00000160319.1
ENSMUST00000159535.1
ENSMUST00000078800.6
ENSMUST00000046719.7
ENSMUST00000162460.1
 Nfya




nuclear transcription factor-Y alpha




chr13_+_51645232 1.360 ENSMUST00000075853.5
 Cks2
CDC28 protein kinase regulatory subunit 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 11.3 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.3 3.9 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.1 3.1 GO:0006826 iron ion transport(GO:0006826)
0.4 3.0 GO:1902746 regulation of lens fiber cell differentiation(GO:1902746)
0.0 2.7 GO:0010765 positive regulation of sodium ion transport(GO:0010765)
0.1 2.6 GO:0003009 skeletal muscle contraction(GO:0003009)
0.3 2.5 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.5 2.3 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.5 2.1 GO:0006751 glutathione catabolic process(GO:0006751)
0.2 1.6 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 1.6 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 1.4 GO:2000036 regulation of stem cell population maintenance(GO:2000036)
0.0 1.4 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.1 1.3 GO:2001135 regulation of endocytic recycling(GO:2001135)
0.1 1.1 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 1.1 GO:0051560 mitochondrial calcium ion homeostasis(GO:0051560)
0.0 1.1 GO:1902476 chloride transmembrane transport(GO:1902476)
0.3 1.0 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743) alveolar secondary septum development(GO:0061144)
0.1 1.0 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 0.9 GO:0006754 ATP biosynthetic process(GO:0006754)

Gene overrepresentation in cellular_component category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 7.2 GO:0071565 nBAF complex(GO:0071565)
0.3 2.6 GO:0032982 myosin filament(GO:0032982)
0.1 2.3 GO:0032279 asymmetric synapse(GO:0032279)
0.0 2.1 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.2 1.4 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 1.4 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 1.1 GO:0034707 chloride channel complex(GO:0034707)
0.0 1.0 GO:0005902 microvillus(GO:0005902)
0.1 0.9 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 0.8 GO:0042405 nuclear inclusion body(GO:0042405)
0.1 0.6 GO:0005638 lamin filament(GO:0005638)
0.0 0.6 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.4 GO:0030687 preribosome, large subunit precursor(GO:0030687)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 8.3 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.2 3.9 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.2 3.0 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 2.7 GO:0030246 carbohydrate binding(GO:0030246)
0.1 2.6 GO:0000146 microfilament motor activity(GO:0000146)
0.2 2.5 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.5 2.3 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.4 2.1 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.5 2.0 GO:0001847 opsonin receptor activity(GO:0001847)
0.1 1.7 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 1.6 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.0 1.6 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.3 1.4 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.0 1.1 GO:0005254 chloride channel activity(GO:0005254)
0.2 1.0 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733)
0.0 0.9 GO:0016887 ATPase activity(GO:0016887)
0.0 0.8 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.1 0.5 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.0 0.3 GO:0017056 structural constituent of nuclear pore(GO:0017056)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.7 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 2.5 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.9 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.0 1.4 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.0 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.7 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 2.6 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 2.6 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.3 2.3 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.2 1.4 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 1.1 REACTOME_TRANSPORT_OF_MATURE_MRNA_DERIVED_FROM_AN_INTRONLESS_TRANSCRIPT Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.0 1.0 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.1 0.9 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling