Motif ID: Six6

Z-value: 0.470


Transcription factors associated with Six6:

Gene SymbolEntrez IDGene Name
Six6 ENSMUSG00000021099.5 Six6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Six6mm10_v2_chr12_+_72939724_729397580.047.3e-01Click!


Activity profile for motif Six6.

activity profile for motif Six6


Sorted Z-values histogram for motif Six6

Sorted Z-values for motif Six6



Network of associatons between targets according to the STRING database.



First level regulatory network of Six6

PNG image of the network

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Top targets:


Showing 1 to 20 of 180 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 2.727 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr3_+_88207308 1.902 ENSMUST00000180582.1
 Gm3764
predicted gene 3764
chr4_-_97584605 1.732 ENSMUST00000107067.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr14_+_67234620 1.712 ENSMUST00000176029.1
 Ebf2
early B cell factor 2
chr4_-_97584612 1.691 ENSMUST00000107068.2
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr17_+_43568269 1.658 ENSMUST00000024706.5
 Pla2g7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr4_-_43653542 1.581 ENSMUST00000084646.4
 Spag8
sperm associated antigen 8
chr17_+_43568641 1.523 ENSMUST00000169694.1
 Pla2g7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr2_+_131491764 1.457 ENSMUST00000028806.5
ENSMUST00000110179.2
ENSMUST00000110189.2
ENSMUST00000110182.2
ENSMUST00000110183.2
ENSMUST00000110186.2
ENSMUST00000110188.1
 Smox






spermine oxidase






chr5_+_140607334 1.398 ENSMUST00000031555.1
 Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr13_-_66852017 1.385 ENSMUST00000059329.6
 Gm17449
predicted gene, 17449
chr4_-_43653560 1.381 ENSMUST00000107870.2
 Spag8
sperm associated antigen 8
chr4_+_156013835 1.328 ENSMUST00000030952.5
 Tnfrsf4
tumor necrosis factor receptor superfamily, member 4
chr17_+_43568096 1.280 ENSMUST00000167214.1
 Pla2g7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr1_-_118982551 1.244 ENSMUST00000159678.1
 Gli2
GLI-Kruppel family member GLI2
chr15_+_55557575 1.179 ENSMUST00000170046.1
 Mtbp
Mdm2, transformed 3T3 cell double minute p53 binding protein
chrX_-_142966709 1.172 ENSMUST00000041317.2
 Ammecr1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr7_+_82611777 1.128 ENSMUST00000172784.1
 Adamtsl3
ADAMTS-like 3
chr19_+_4154606 1.115 ENSMUST00000061086.8
 Ptprcap
protein tyrosine phosphatase, receptor type, C polypeptide-associated protein
chr1_+_139454747 1.112 ENSMUST00000053364.8
ENSMUST00000097554.3
 Aspm

asp (abnormal spindle)-like, microcephaly associated (Drosophila)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 72 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 5.6 GO:0034441 plasma lipoprotein particle oxidation(GO:0034441)
0.5 2.7 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 2.6 GO:0007338 single fertilization(GO:0007338)
0.4 2.2 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.1 1.7 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.3 1.5 GO:0046208 spermine catabolic process(GO:0046208)
0.3 1.4 GO:0007386 compartment pattern specification(GO:0007386)
0.1 1.4 GO:0006337 nucleosome disassembly(GO:0006337)
0.1 1.3 GO:0070236 positive regulation of immunoglobulin secretion(GO:0051024) negative regulation of activation-induced cell death of T cells(GO:0070236)
0.3 1.2 GO:0060032 notochord regression(GO:0060032)
0.3 1.1 GO:0006776 vitamin A metabolic process(GO:0006776)
0.2 1.1 GO:0051661 maintenance of centrosome location(GO:0051661)
0.1 1.1 GO:0051923 sulfation(GO:0051923)
0.3 0.9 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
0.2 0.9 GO:0032196 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) transposition(GO:0032196)
0.1 0.9 GO:0071474 cellular hyperosmotic response(GO:0071474)
0.1 0.8 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.1 0.8 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 0.8 GO:0050868 negative regulation of T cell activation(GO:0050868)
0.2 0.7 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 5.6 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.0 3.1 GO:0000776 kinetochore(GO:0000776)
0.0 2.5 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 1.8 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 1.4 GO:0016514 SWI/SNF complex(GO:0016514)
0.1 1.2 GO:0097542 ciliary tip(GO:0097542)
0.2 1.1 GO:0036449 microtubule minus-end(GO:0036449)
0.0 1.0 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.9 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.3 0.8 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.1 0.7 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 0.7 GO:0001741 XY body(GO:0001741)
0.2 0.6 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.1 0.6 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 0.6 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.5 GO:0043219 lateral loop(GO:0043219)
0.0 0.5 GO:0042555 MCM complex(GO:0042555)
0.1 0.4 GO:0097543 ciliary inversin compartment(GO:0097543)
0.0 0.4 GO:0005688 U6 snRNP(GO:0005688)
0.0 0.4 GO:0032593 insulin-responsive compartment(GO:0032593)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 5.6 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.0 3.3 GO:0008017 microtubule binding(GO:0008017)
0.0 2.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.5 1.5 GO:0046592 polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901)
0.5 1.4 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 1.4 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 1.2 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 1.2 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 1.2 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.4 1.1 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.2 1.1 GO:0019841 retinol binding(GO:0019841)
0.2 0.9 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.0 0.9 GO:0001222 transcription corepressor binding(GO:0001222)
0.1 0.8 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.8 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 0.7 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.7 GO:0003743 translation initiation factor activity(GO:0003743)
0.2 0.6 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.2 0.6 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.2 0.6 GO:0042903 tubulin deacetylase activity(GO:0042903)

Gene overrepresentation in C2:CP category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.6 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.8 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.0 1.6 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 1.2 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.1 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.6 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.0 0.6 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 0.5 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 0.5 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.4 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.4 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.4 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 5.7 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 1.5 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.1 1.4 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.2 1.1 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 1.1 REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL Genes involved in Cell surface interactions at the vascular wall
0.1 0.9 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 0.8 REACTOME_GRB2_EVENTS_IN_ERBB2_SIGNALING Genes involved in GRB2 events in ERBB2 signaling
0.0 0.8 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.8 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.8 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.7 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.7 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.6 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 0.5 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.5 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 0.5 REACTOME_TRANSPORT_OF_MATURE_MRNA_DERIVED_FROM_AN_INTRONLESS_TRANSCRIPT Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.1 0.4 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION_IN_TLR7_8_OR_9_SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0 0.4 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.4 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 0.3 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)