Motif ID: Smad1

Z-value: 1.593


Transcription factors associated with Smad1:

Gene SymbolEntrez IDGene Name
Smad1 ENSMUSG00000031681.8 Smad1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad1mm10_v2_chr8_-_79399513_79399532-0.281.5e-02Click!


Activity profile for motif Smad1.

activity profile for motif Smad1


Sorted Z-values histogram for motif Smad1

Sorted Z-values for motif Smad1



Network of associatons between targets according to the STRING database.



First level regulatory network of Smad1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_+_73483602 15.993 ENSMUST00000033741.8
ENSMUST00000169489.1
 Bgn

biglycan

chr15_-_66812593 7.912 ENSMUST00000100572.3
 Sla
src-like adaptor
chr1_-_171234290 7.441 ENSMUST00000079957.6
 Fcer1g
Fc receptor, IgE, high affinity I, gamma polypeptide
chr18_+_20665250 7.019 ENSMUST00000075312.3
 Ttr
transthyretin
chr6_+_55336424 6.821 ENSMUST00000004774.3
 Aqp1
aquaporin 1
chr11_-_55419898 6.806 ENSMUST00000108858.1
ENSMUST00000141530.1
 Sparc

secreted acidic cysteine rich glycoprotein

chr11_+_32296489 6.612 ENSMUST00000093207.3
 Hba-a2
hemoglobin alpha, adult chain 2
chr12_-_24680890 6.063 ENSMUST00000156453.2
 Cys1
cystin 1
chr8_+_104101625 5.792 ENSMUST00000034339.8
 Cdh5
cadherin 5
chr2_-_93452679 5.611 ENSMUST00000111257.1
ENSMUST00000145553.1
 Cd82

CD82 antigen

chr7_-_103813913 4.761 ENSMUST00000098192.3
 Hbb-bt
hemoglobin, beta adult t chain
chr7_-_103827922 4.592 ENSMUST00000023934.6
ENSMUST00000153218.1
 Hbb-bs

hemoglobin, beta adult s chain

chr6_+_17306335 4.486 ENSMUST00000007799.6
ENSMUST00000115456.1
ENSMUST00000115455.2
ENSMUST00000130505.1
 Cav1



caveolin 1, caveolae protein



chr19_-_57118981 4.269 ENSMUST00000111528.1
ENSMUST00000111529.1
ENSMUST00000104902.2
 Ablim1


actin-binding LIM protein 1


chr10_+_79988584 4.230 ENSMUST00000004784.4
ENSMUST00000105374.1
 Cnn2

calponin 2

chr3_+_137341103 4.203 ENSMUST00000119475.1
 Emcn
endomucin
chr10_-_117282262 4.174 ENSMUST00000092163.7
 Lyz2
lysozyme 2
chr15_+_3270767 4.128 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr2_+_32646586 4.106 ENSMUST00000009705.7
ENSMUST00000167841.1
 Eng

endoglin

chr2_-_152951547 4.053 ENSMUST00000037715.6
 Dusp15
dual specificity phosphatase-like 15

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 803 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 15.5 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.2 12.1 GO:0030032 lamellipodium assembly(GO:0030032)
3.1 9.2 GO:0001803 type III hypersensitivity(GO:0001802) regulation of type III hypersensitivity(GO:0001803) positive regulation of type III hypersensitivity(GO:0001805)
1.8 9.2 GO:0070327 thyroid hormone transport(GO:0070327)
0.5 8.6 GO:0042178 xenobiotic catabolic process(GO:0042178)
1.3 8.1 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.3 7.9 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.3 7.3 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.1 7.3 GO:0015992 proton transport(GO:0015992)
0.2 7.0 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.2 7.0 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
2.3 6.8 GO:0072488 ammonium transmembrane transport(GO:0072488)
1.1 6.8 GO:1901552 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.3 6.4 GO:0035455 response to interferon-alpha(GO:0035455)
1.2 6.1 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
1.2 5.9 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.2 5.8 GO:0095500 acetylcholine receptor signaling pathway(GO:0095500) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.1 5.8 GO:0002181 cytoplasmic translation(GO:0002181)
1.9 5.7 GO:0002586 positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002582) regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002586) positive regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002588)
0.5 5.7 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 325 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 44.3 GO:0016021 integral component of membrane(GO:0016021)
0.4 27.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 24.9 GO:0031012 extracellular matrix(GO:0031012)
0.3 19.7 GO:0072562 blood microparticle(GO:0072562)
0.0 19.7 GO:0005768 endosome(GO:0005768)
0.1 17.8 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 17.6 GO:0005739 mitochondrion(GO:0005739)
4.0 16.0 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 14.0 GO:0005740 mitochondrial envelope(GO:0005740)
0.4 13.0 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 12.6 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.3 12.4 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 12.4 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 11.9 GO:0005925 focal adhesion(GO:0005925)
0.9 10.2 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 10.0 GO:0005615 extracellular space(GO:0005615)
0.2 9.6 GO:0031526 brush border membrane(GO:0031526)
2.2 8.8 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.2 8.6 GO:0031902 late endosome membrane(GO:0031902)
0.2 8.6 GO:0048786 presynaptic active zone(GO:0048786)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 516 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 41.5 GO:0003735 structural constituent of ribosome(GO:0003735)
0.4 20.9 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 18.7 GO:0003924 GTPase activity(GO:0003924)
4.0 16.0 GO:0031720 haptoglobin binding(GO:0031720)
0.6 15.5 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
2.1 12.6 GO:0019864 immunoglobulin receptor activity(GO:0019763) IgG binding(GO:0019864)
0.3 9.9 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.8 9.0 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.1 8.7 GO:0044325 ion channel binding(GO:0044325)
0.9 7.7 GO:0070324 thyroid hormone binding(GO:0070324)
0.3 7.3 GO:0051787 misfolded protein binding(GO:0051787)
0.2 7.3 GO:0031369 translation initiation factor binding(GO:0031369)
1.4 7.1 GO:0005534 galactose binding(GO:0005534)
0.6 7.0 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.4 7.0 GO:0034987 immunoglobulin receptor binding(GO:0034987)
1.4 6.8 GO:0015166 polyol transmembrane transporter activity(GO:0015166) glycerol transmembrane transporter activity(GO:0015168)
0.2 6.5 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
1.5 6.2 GO:0070891 lipoteichoic acid binding(GO:0070891)
1.5 6.1 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
1.2 6.1 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 90 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 21.6 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.6 19.8 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 14.6 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.4 12.2 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 11.9 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 11.6 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.3 10.9 PID_ALK1_PATHWAY ALK1 signaling events
0.2 10.7 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells
0.2 9.4 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.3 9.2 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.2 9.0 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.2 7.7 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.2 7.5 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 7.3 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 7.1 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.2 7.0 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.2 6.4 PID_ENDOTHELIN_PATHWAY Endothelins
0.3 6.3 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.2 6.2 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.3 5.8 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 185 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 34.5 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.4 27.1 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.7 16.7 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
1.1 16.0 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.2 12.1 REACTOME_AMYLOIDS Genes involved in Amyloids
0.9 11.7 REACTOME_PECAM1_INTERACTIONS Genes involved in PECAM1 interactions
0.9 11.6 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.2 11.3 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.4 9.4 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.2 9.3 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.2 9.0 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.4 8.9 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.4 8.6 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.3 8.4 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.1 8.0 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 7.0 REACTOME_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G Genes involved in Vif-mediated degradation of APOBEC3G
0.8 6.6 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.4 6.4 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.3 6.4 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.2 6.0 REACTOME_INHIBITION_OF_INSULIN_SECRETION_BY_ADRENALINE_NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline