Motif ID: Smad2

Z-value: 0.607


Transcription factors associated with Smad2:

Gene SymbolEntrez IDGene Name
Smad2 ENSMUSG00000024563.9 Smad2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad2mm10_v2_chr18_+_76242135_76242174-0.047.4e-01Click!


Activity profile for motif Smad2.

activity profile for motif Smad2


Sorted Z-values histogram for motif Smad2

Sorted Z-values for motif Smad2



Network of associatons between targets according to the STRING database.



First level regulatory network of Smad2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_+_57694651 9.705 ENSMUST00000096430.4
 Zhx2
zinc fingers and homeoboxes 2
chr19_+_59458372 6.134 ENSMUST00000062216.3
 Emx2
empty spiracles homeobox 2
chr3_+_127633134 5.672 ENSMUST00000029587.7
 Neurog2
neurogenin 2
chr17_-_35700520 4.541 ENSMUST00000119825.1
 Ddr1
discoidin domain receptor family, member 1
chr6_+_83137089 4.441 ENSMUST00000121093.1
ENSMUST00000087938.4
 Rtkn

rhotekin

chr3_-_116968827 4.039 ENSMUST00000119557.1
 Palmd
palmdelphin
chr13_-_78199757 4.021 ENSMUST00000091458.6
 Nr2f1
nuclear receptor subfamily 2, group F, member 1
chr3_-_116968969 3.815 ENSMUST00000143611.1
ENSMUST00000040097.7
 Palmd

palmdelphin

chr4_-_155010984 3.436 ENSMUST00000105631.2
ENSMUST00000139976.2
ENSMUST00000145662.2
 Plch2


phospholipase C, eta 2


chr10_-_42583628 3.156 ENSMUST00000019938.4
 Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr5_-_113800356 2.882 ENSMUST00000160374.1
ENSMUST00000067853.5
 Tmem119

transmembrane protein 119

chr4_+_11191726 2.854 ENSMUST00000029866.9
ENSMUST00000108324.3
 Ccne2

cyclin E2

chr16_+_64851991 2.765 ENSMUST00000067744.7
 Cggbp1
CGG triplet repeat binding protein 1
chr9_-_119578981 2.755 ENSMUST00000117911.1
ENSMUST00000120420.1
 Scn5a

sodium channel, voltage-gated, type V, alpha

chr10_-_49788743 2.489 ENSMUST00000105483.1
ENSMUST00000105487.1
 Grik2

glutamate receptor, ionotropic, kainate 2 (beta 2)

chr7_+_82867327 2.323 ENSMUST00000082237.5
 Mex3b
mex3 homolog B (C. elegans)
chrX_-_94123359 2.133 ENSMUST00000137853.1
ENSMUST00000088102.5
ENSMUST00000113927.1
 Zfx


zinc finger protein X-linked


chr2_-_91950386 1.994 ENSMUST00000111303.1
 Dgkz
diacylglycerol kinase zeta
chr18_-_42579652 1.941 ENSMUST00000054738.3
 Gpr151
G protein-coupled receptor 151
chr7_-_45052865 1.893 ENSMUST00000057293.6
 Prr12
proline rich 12
chr4_+_11191354 1.759 ENSMUST00000170901.1
 Ccne2
cyclin E2
chr8_-_105637403 1.640 ENSMUST00000182046.1
 Gm5914
predicted gene 5914
chrX_-_20931520 1.627 ENSMUST00000001156.7
 Cfp
complement factor properdin
chr14_+_21500879 1.599 ENSMUST00000182964.1
 Kat6b
K(lysine) acetyltransferase 6B
chr18_+_40258361 1.596 ENSMUST00000091927.4
 Kctd16
potassium channel tetramerisation domain containing 16
chr2_-_128967725 1.578 ENSMUST00000099385.2
 Gm10762
predicted gene 10762
chr8_-_69184177 1.455 ENSMUST00000185176.1
 Lzts1
leucine zipper, putative tumor suppressor 1
chr18_+_11839220 1.307 ENSMUST00000171109.1
ENSMUST00000046948.8
 Cables1

CDK5 and Abl enzyme substrate 1

chr13_+_23752267 1.294 ENSMUST00000091703.2
 Hist1h3b
histone cluster 1, H3b
chr17_+_7925990 1.255 ENSMUST00000036370.7
 Tagap
T cell activation Rho GTPase activating protein
chr8_-_105637350 1.126 ENSMUST00000182863.1
 Gm5914
predicted gene 5914
chr10_+_80151154 1.101 ENSMUST00000146516.1
ENSMUST00000144526.1
 Midn

midnolin

chr13_+_104817171 1.070 ENSMUST00000022230.8
 Srek1ip1
splicing regulatory glutamine/lysine-rich protein 1interacting protein 1
chr11_+_69846610 1.005 ENSMUST00000152566.1
ENSMUST00000108633.2
 Plscr3

phospholipid scramblase 3

chr8_-_87959560 1.004 ENSMUST00000109655.2
 Zfp423
zinc finger protein 423
chr17_-_34615965 0.979 ENSMUST00000097345.3
ENSMUST00000015611.7
 Egfl8

EGF-like domain 8

chr14_-_20496780 0.898 ENSMUST00000022353.3
 Mss51
MSS51 mitochondrial translational activator
chr11_+_69846665 0.866 ENSMUST00000019605.2
 Plscr3
phospholipid scramblase 3
chr9_+_44107286 0.858 ENSMUST00000152956.1
ENSMUST00000114815.1
 C1qtnf5

C1q and tumor necrosis factor related protein 5

chrX_-_7947848 0.819 ENSMUST00000115642.1
ENSMUST00000033501.8
ENSMUST00000145675.1
 Hdac6


histone deacetylase 6


chr7_-_34654342 0.796 ENSMUST00000108069.1
 Kctd15
potassium channel tetramerisation domain containing 15
chr4_-_129261394 0.741 ENSMUST00000145261.1
 C77080
expressed sequence C77080
chr1_-_172297989 0.728 ENSMUST00000085913.4
ENSMUST00000097464.2
ENSMUST00000137679.1
 Atp1a2


ATPase, Na+/K+ transporting, alpha 2 polypeptide


chr15_-_103251465 0.705 ENSMUST00000133600.1
ENSMUST00000134554.1
ENSMUST00000156927.1
ENSMUST00000149111.1
ENSMUST00000132836.1
 Nfe2




nuclear factor, erythroid derived 2




chr17_-_25861456 0.703 ENSMUST00000079461.8
ENSMUST00000176923.1
 Wdr90

WD repeat domain 90

chr10_-_37138863 0.696 ENSMUST00000092584.5
 Marcks
myristoylated alanine rich protein kinase C substrate
chr10_+_80150448 0.687 ENSMUST00000153477.1
 Midn
midnolin
chr11_-_75190458 0.625 ENSMUST00000044949.4
 Dph1
DPH1 homolog (S. cerevisiae)
chr7_-_116237767 0.574 ENSMUST00000182834.1
 Plekha7
pleckstrin homology domain containing, family A member 7
chr6_+_125009665 0.555 ENSMUST00000046064.10
ENSMUST00000152752.1
ENSMUST00000088308.3
ENSMUST00000112425.1
ENSMUST00000084275.5
 Zfp384




zinc finger protein 384




chr2_-_148443543 0.540 ENSMUST00000099269.3
 Cd93
CD93 antigen
chr11_+_4135233 0.527 ENSMUST00000124670.1
 Rnf215
ring finger protein 215
chr13_-_104816908 0.512 ENSMUST00000022228.6
 Cwc27
CWC27 spliceosome-associated protein homolog (S. cerevisiae)
chr8_-_90908415 0.503 ENSMUST00000098517.1
 Gm6658
predicted gene 6658
chrX_+_99821021 0.489 ENSMUST00000096363.2
 Tmem28
transmembrane protein 28
chr16_+_32914094 0.472 ENSMUST00000023491.6
ENSMUST00000170899.1
ENSMUST00000171118.1
ENSMUST00000170201.1
ENSMUST00000165616.1
ENSMUST00000135193.2
 Lrch3





leucine-rich repeats and calponin homology (CH) domain containing 3





chr8_+_109705549 0.466 ENSMUST00000034163.8
 Zfp821
zinc finger protein 821
chr15_+_102102926 0.433 ENSMUST00000169627.1
ENSMUST00000046144.9
 Tenc1

tensin like C1 domain-containing phosphatase

chrX_-_94123087 0.417 ENSMUST00000113925.1
 Zfx
zinc finger protein X-linked
chr13_+_96542727 0.401 ENSMUST00000077672.4
ENSMUST00000109444.2
 Col4a3bp

collagen, type IV, alpha 3 (Goodpasture antigen) binding protein

chr2_+_177768044 0.395 ENSMUST00000108942.3
 Gm14322
predicted gene 14322
chrX_-_7947763 0.351 ENSMUST00000154244.1
 Hdac6
histone deacetylase 6
chr3_+_135438722 0.348 ENSMUST00000166033.1
 Ube2d3
ubiquitin-conjugating enzyme E2D 3
chrX_-_7947553 0.321 ENSMUST00000133349.1
 Hdac6
histone deacetylase 6
chr11_+_63131512 0.271 ENSMUST00000018361.3
 Pmp22
peripheral myelin protein 22
chr7_+_101321703 0.207 ENSMUST00000174291.1
ENSMUST00000167888.2
ENSMUST00000172662.1
ENSMUST00000173270.1
ENSMUST00000174083.1
 Stard10




START domain containing 10




chr11_+_101119938 0.205 ENSMUST00000043680.8
 Tubg1
tubulin, gamma 1
chr7_-_29180699 0.193 ENSMUST00000059642.10
 Psmd8
proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
chr7_-_29180454 0.179 ENSMUST00000182328.1
 Psmd8
proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
chr11_-_101119889 0.054 ENSMUST00000017946.5
 Fam134c
family with sequence similarity 134, member C
chr11_-_101119814 0.046 ENSMUST00000107295.3
 Fam134c
family with sequence similarity 134, member C

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.8 GO:0014877 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) membrane depolarization during Purkinje myocyte cell action potential(GO:0086047)
0.6 10.2 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.6 3.2 GO:0021764 amygdala development(GO:0021764)
0.5 1.5 GO:0070844 misfolded protein transport(GO:0070843) polyubiquitinated protein transport(GO:0070844) polyubiquitinated misfolded protein transport(GO:0070845) Hsp90 deacetylation(GO:0070846)
0.5 2.9 GO:1903012 positive regulation of bone development(GO:1903012)
0.4 4.5 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.3 2.3 GO:0072697 protein localization to cell cortex(GO:0072697)
0.3 1.8 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.3 1.6 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.2 0.7 GO:1903279 regulation of calcium:sodium antiporter activity(GO:1903279)
0.2 2.5 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.2 0.6 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.2 2.0 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.1 9.7 GO:0035019 somatic stem cell population maintenance(GO:0035019)
0.1 0.4 GO:0035621 ER to Golgi ceramide transport(GO:0035621) ceramide transport(GO:0035627)
0.1 4.6 GO:0007129 synapsis(GO:0007129)
0.1 0.6 GO:0045218 zonula adherens maintenance(GO:0045218)
0.1 0.7 GO:0034242 negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
0.1 0.5 GO:0098703 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.1 2.6 GO:0048599 oocyte development(GO:0048599)
0.1 1.5 GO:0016242 negative regulation of macroautophagy(GO:0016242)
0.0 1.3 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 7.9 GO:0008360 regulation of cell shape(GO:0008360)
0.0 0.2 GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.0 0.7 GO:0051764 actin crosslink formation(GO:0051764)
0.0 4.3 GO:0048469 cell maturation(GO:0048469)
0.0 1.9 GO:0042632 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.0 1.0 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 3.4 GO:0046488 phosphatidylinositol metabolic process(GO:0046488)
0.0 0.4 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.2 GO:0000212 meiotic spindle organization(GO:0000212)
0.0 1.6 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.3 GO:0032288 myelin assembly(GO:0032288)
0.0 0.5 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.9 GO:0070206 protein trimerization(GO:0070206)
0.0 1.6 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.6 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.4 2.5 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.2 0.7 GO:0042585 germinal vesicle(GO:0042585)
0.2 2.8 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 0.7 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.1 0.6 GO:0005915 zonula adherens(GO:0005915)
0.0 2.9 GO:0000786 nucleosome(GO:0000786)
0.0 0.4 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 1.5 GO:0016235 aggresome(GO:0016235)
0.0 0.2 GO:0005827 polar microtubule(GO:0005827)
0.0 1.6 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.2 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 6.0 GO:0043197 dendritic spine(GO:0043197)
0.0 0.9 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 4.5 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.3 GO:0043218 compact myelin(GO:0043218)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 4.4 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.5 4.5 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.4 2.5 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.4 2.8 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.4 1.5 GO:0042903 tubulin deacetylase activity(GO:0042903)
0.3 4.0 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.2 2.0 GO:0001727 lipid kinase activity(GO:0001727) diacylglycerol kinase activity(GO:0004143)
0.2 3.4 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.2 0.5 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.1 4.6 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 1.9 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.1 5.7 GO:0070888 E-box binding(GO:0070888)
0.1 2.3 GO:0032794 GTPase activating protein binding(GO:0032794)
0.1 0.7 GO:1990239 steroid hormone binding(GO:1990239)
0.1 0.5 GO:0001849 complement component C1q binding(GO:0001849)
0.1 0.4 GO:0097001 ceramide binding(GO:0097001)
0.0 3.2 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 0.6 GO:0070097 delta-catenin binding(GO:0070097)
0.0 9.7 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 1.3 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 1.6 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 0.7 GO:0050699 WW domain binding(GO:0050699)
0.0 0.5 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 0.7 GO:0005080 protein kinase C binding(GO:0005080)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.6 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 1.5 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 1.3 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.6 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.1 2.5 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 7.2 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 0.7 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 2.8 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 1.5 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 3.3 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.2 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 1.5 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.7 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.3 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases