Motif ID: Smad2

Z-value: 0.607


Transcription factors associated with Smad2:

Gene SymbolEntrez IDGene Name
Smad2 ENSMUSG00000024563.9 Smad2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad2mm10_v2_chr18_+_76242135_76242174-0.047.4e-01Click!


Activity profile for motif Smad2.

activity profile for motif Smad2


Sorted Z-values histogram for motif Smad2

Sorted Z-values for motif Smad2



Network of associatons between targets according to the STRING database.



First level regulatory network of Smad2

PNG image of the network

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Top targets:


Showing 1 to 20 of 71 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_+_57694651 9.705 ENSMUST00000096430.4
 Zhx2
zinc fingers and homeoboxes 2
chr19_+_59458372 6.134 ENSMUST00000062216.3
 Emx2
empty spiracles homeobox 2
chr3_+_127633134 5.672 ENSMUST00000029587.7
 Neurog2
neurogenin 2
chr17_-_35700520 4.541 ENSMUST00000119825.1
 Ddr1
discoidin domain receptor family, member 1
chr6_+_83137089 4.441 ENSMUST00000121093.1
ENSMUST00000087938.4
 Rtkn

rhotekin

chr3_-_116968827 4.039 ENSMUST00000119557.1
 Palmd
palmdelphin
chr13_-_78199757 4.021 ENSMUST00000091458.6
 Nr2f1
nuclear receptor subfamily 2, group F, member 1
chr3_-_116968969 3.815 ENSMUST00000143611.1
ENSMUST00000040097.7
 Palmd

palmdelphin

chr4_-_155010984 3.436 ENSMUST00000105631.2
ENSMUST00000139976.2
ENSMUST00000145662.2
 Plch2


phospholipase C, eta 2


chr10_-_42583628 3.156 ENSMUST00000019938.4
 Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr5_-_113800356 2.882 ENSMUST00000160374.1
ENSMUST00000067853.5
 Tmem119

transmembrane protein 119

chr4_+_11191726 2.854 ENSMUST00000029866.9
ENSMUST00000108324.3
 Ccne2

cyclin E2

chr16_+_64851991 2.765 ENSMUST00000067744.7
 Cggbp1
CGG triplet repeat binding protein 1
chr9_-_119578981 2.755 ENSMUST00000117911.1
ENSMUST00000120420.1
 Scn5a

sodium channel, voltage-gated, type V, alpha

chr10_-_49788743 2.489 ENSMUST00000105483.1
ENSMUST00000105487.1
 Grik2

glutamate receptor, ionotropic, kainate 2 (beta 2)

chr7_+_82867327 2.323 ENSMUST00000082237.5
 Mex3b
mex3 homolog B (C. elegans)
chrX_-_94123359 2.133 ENSMUST00000137853.1
ENSMUST00000088102.5
ENSMUST00000113927.1
 Zfx


zinc finger protein X-linked


chr2_-_91950386 1.994 ENSMUST00000111303.1
 Dgkz
diacylglycerol kinase zeta
chr18_-_42579652 1.941 ENSMUST00000054738.3
 Gpr151
G protein-coupled receptor 151
chr7_-_45052865 1.893 ENSMUST00000057293.6
 Prr12
proline rich 12

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 10.2 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.1 9.7 GO:0035019 somatic stem cell population maintenance(GO:0035019)
0.0 7.9 GO:0008360 regulation of cell shape(GO:0008360)
0.1 4.6 GO:0007129 synapsis(GO:0007129)
0.4 4.5 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 4.3 GO:0048469 cell maturation(GO:0048469)
0.0 3.4 GO:0046488 phosphatidylinositol metabolic process(GO:0046488)
0.6 3.2 GO:0021764 amygdala development(GO:0021764)
0.5 2.9 GO:1903012 positive regulation of bone development(GO:1903012)
0.9 2.8 GO:0014877 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) membrane depolarization during Purkinje myocyte cell action potential(GO:0086047)
0.1 2.6 GO:0048599 oocyte development(GO:0048599)
0.2 2.5 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.3 2.3 GO:0072697 protein localization to cell cortex(GO:0072697)
0.2 2.0 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.0 1.9 GO:0042632 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.3 1.8 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.3 1.6 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 1.6 GO:0006334 nucleosome assembly(GO:0006334)
0.0 1.6 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.5 1.5 GO:0070844 misfolded protein transport(GO:0070843) polyubiquitinated protein transport(GO:0070844) polyubiquitinated misfolded protein transport(GO:0070845) Hsp90 deacetylation(GO:0070846)

Gene overrepresentation in cellular_component category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.0 GO:0043197 dendritic spine(GO:0043197)
1.5 4.6 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.0 4.5 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 2.9 GO:0000786 nucleosome(GO:0000786)
0.2 2.8 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.4 2.5 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 1.6 GO:0042734 presynaptic membrane(GO:0042734)
0.0 1.5 GO:0016235 aggresome(GO:0016235)
0.0 0.9 GO:0016328 lateral plasma membrane(GO:0016328)
0.2 0.7 GO:0042585 germinal vesicle(GO:0042585)
0.1 0.7 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.1 0.6 GO:0005915 zonula adherens(GO:0005915)
0.0 0.4 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.3 GO:0043218 compact myelin(GO:0043218)
0.0 0.2 GO:0005827 polar microtubule(GO:0005827)
0.0 0.2 GO:0046581 intercellular canaliculus(GO:0046581)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.7 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 5.7 GO:0070888 E-box binding(GO:0070888)
0.1 4.6 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.5 4.5 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.6 4.4 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.3 4.0 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.2 3.4 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 3.2 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.4 2.8 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.4 2.5 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 2.3 GO:0032794 GTPase activating protein binding(GO:0032794)
0.2 2.0 GO:0001727 lipid kinase activity(GO:0001727) diacylglycerol kinase activity(GO:0004143)
0.1 1.9 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 1.6 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.4 1.5 GO:0042903 tubulin deacetylase activity(GO:0042903)
0.0 1.3 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 0.7 GO:1990239 steroid hormone binding(GO:1990239)
0.0 0.7 GO:0050699 WW domain binding(GO:0050699)
0.0 0.7 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.6 GO:0070097 delta-catenin binding(GO:0070097)

Gene overrepresentation in C2:CP category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.6 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 1.5 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 1.3 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.2 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 4.6 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.0 3.3 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 2.8 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 2.5 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 1.5 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 1.5 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 1.3 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 0.7 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.7 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.2 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes