Motif ID: Smad4

Z-value: 1.202


Transcription factors associated with Smad4:

Gene SymbolEntrez IDGene Name
Smad4 ENSMUSG00000024515.7 Smad4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad4mm10_v2_chr18_-_73703739_737038060.379.4e-04Click!


Activity profile for motif Smad4.

activity profile for motif Smad4


Sorted Z-values histogram for motif Smad4

Sorted Z-values for motif Smad4



Network of associatons between targets according to the STRING database.



First level regulatory network of Smad4

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 192 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_127534540 23.288 ENSMUST00000095266.2
 Nxph4
neurexophilin 4
chr19_+_5740885 16.346 ENSMUST00000081496.5
 Ltbp3
latent transforming growth factor beta binding protein 3
chr4_-_117178726 13.222 ENSMUST00000153953.1
ENSMUST00000106436.1
 Kif2c

kinesin family member 2C

chr7_+_45216671 12.433 ENSMUST00000134420.1
 Tead2
TEA domain family member 2
chr7_+_45215753 12.095 ENSMUST00000033060.6
ENSMUST00000155313.1
ENSMUST00000107801.1
 Tead2


TEA domain family member 2


chr14_+_50944499 10.447 ENSMUST00000178092.1
 Pnp
purine-nucleoside phosphorylase
chr18_-_84086379 10.434 ENSMUST00000060303.8
 Tshz1
teashirt zinc finger family member 1
chr7_-_70360593 10.342 ENSMUST00000032768.7
 Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr3_+_127633134 10.147 ENSMUST00000029587.7
 Neurog2
neurogenin 2
chr10_-_92164666 9.590 ENSMUST00000183123.1
ENSMUST00000182033.1
 Rmst

rhabdomyosarcoma 2 associated transcript (non-coding RNA)

chr10_-_42583628 9.162 ENSMUST00000019938.4
 Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr14_-_104467984 9.012 ENSMUST00000053016.8
 Pou4f1
POU domain, class 4, transcription factor 1
chr17_+_75178797 8.719 ENSMUST00000112516.1
ENSMUST00000135447.1
 Ltbp1

latent transforming growth factor beta binding protein 1

chr5_+_92683625 8.717 ENSMUST00000168878.1
 Shroom3
shroom family member 3
chr17_+_75178911 7.892 ENSMUST00000112514.1
 Ltbp1
latent transforming growth factor beta binding protein 1
chr11_-_5261558 7.391 ENSMUST00000020662.8
 Kremen1
kringle containing transmembrane protein 1
chr13_-_21832194 7.108 ENSMUST00000102979.1
 Hist1h4n
histone cluster 1, H4n
chr11_-_3931960 7.107 ENSMUST00000109990.1
ENSMUST00000020710.4
ENSMUST00000109989.3
ENSMUST00000109991.1
ENSMUST00000109993.2
 Tcn2




transcobalamin 2




chr14_+_12189943 6.603 ENSMUST00000119888.1
 Ptprg
protein tyrosine phosphatase, receptor type, G
chr5_+_64803513 6.142 ENSMUST00000165536.1
 Klf3
Kruppel-like factor 3 (basic)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 110 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 24.5 GO:0048368 lateral mesoderm development(GO:0048368)
1.2 23.6 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.7 16.6 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
5.4 16.3 GO:1902460 transforming growth factor beta activation(GO:0036363) regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
2.6 13.2 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
3.3 13.1 GO:0015889 cobalamin transport(GO:0015889)
0.7 11.2 GO:0035090 maintenance of apical/basal cell polarity(GO:0035090)
3.5 10.4 GO:0046122 purine deoxyribonucleoside metabolic process(GO:0046122)
3.5 10.4 GO:0060023 soft palate development(GO:0060023)
2.1 10.3 GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.1 10.1 GO:0021954 central nervous system neuron development(GO:0021954)
1.8 9.2 GO:0021764 amygdala development(GO:0021764)
1.8 9.0 GO:0019230 proprioception(GO:0019230)
0.1 8.7 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)
0.1 6.6 GO:1901998 toxin transport(GO:1901998)
1.2 6.0 GO:0006447 regulation of translational initiation by iron(GO:0006447) positive regulation of translational initiation by iron(GO:0045994)
0.1 5.9 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
1.1 5.7 GO:1904672 regulation of somatic stem cell population maintenance(GO:1904672)
0.4 5.7 GO:0038092 nodal signaling pathway(GO:0038092)
0.4 5.4 GO:0072189 ureter development(GO:0072189)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
8.2 24.5 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.0 22.1 GO:0005667 transcription factor complex(GO:0005667)
5.5 16.6 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.5 16.6 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 13.0 GO:0005874 microtubule(GO:0005874)
1.0 11.2 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 11.2 GO:0000790 nuclear chromatin(GO:0000790)
0.3 10.4 GO:0000786 nucleosome(GO:0000786)
0.2 8.5 GO:0035371 microtubule plus-end(GO:0035371)
0.1 6.2 GO:0005581 collagen trimer(GO:0005581)
0.3 5.8 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.1 5.1 GO:0032809 neuronal cell body membrane(GO:0032809)
0.2 4.8 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 4.5 GO:0001650 fibrillar center(GO:0001650)
0.2 4.3 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.2 4.3 GO:0001891 phagocytic cup(GO:0001891)
0.3 3.9 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.2 3.6 GO:0035102 PRC1 complex(GO:0035102)
0.1 3.3 GO:0002102 podosome(GO:0002102)
0.1 3.1 GO:0005680 anaphase-promoting complex(GO:0005680)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 77 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 24.5 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.1 23.7 GO:0042393 histone binding(GO:0042393)
4.2 16.8 GO:0050436 microfibril binding(GO:0050436)
1.3 16.4 GO:0001972 retinoic acid binding(GO:0001972)
0.7 16.3 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.1 16.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
1.9 13.1 GO:0031419 cobalamin binding(GO:0031419)
0.1 12.4 GO:0051015 actin filament binding(GO:0051015)
0.0 11.7 GO:0003677 DNA binding(GO:0003677)
3.5 10.4 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.2 10.1 GO:0070888 E-box binding(GO:0070888)
0.2 9.2 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.2 9.0 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1 9.0 GO:0017137 Rab GTPase binding(GO:0017137)
0.3 8.8 GO:0008432 JUN kinase binding(GO:0008432)
0.5 8.5 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 6.6 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.3 5.7 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.2 5.6 GO:0070182 DNA polymerase binding(GO:0070182)
0.4 5.2 GO:0045294 alpha-catenin binding(GO:0045294)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 42.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.3 16.4 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.3 14.4 PID_AURORA_B_PATHWAY Aurora B signaling
0.4 11.5 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.2 9.6 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 9.5 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.2 6.0 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 5.7 PID_LKB1_PATHWAY LKB1 signaling events
0.1 5.7 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 5.6 ST_FAS_SIGNALING_PATHWAY Fas Signaling Pathway
0.1 5.2 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.1 4.5 NABA_COLLAGENS Genes encoding collagen proteins
0.1 4.3 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.0 4.0 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.1 3.9 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.1 3.7 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 3.2 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.1 3.2 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 3.0 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.1 2.4 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 31.1 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.6 22.2 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.5 13.2 REACTOME_KINESINS Genes involved in Kinesins
0.2 13.0 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.9 10.4 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.2 10.3 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 7.0 REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE Genes involved in Cell death signalling via NRAGE, NRIF and NADE
0.2 5.7 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 4.5 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.4 4.3 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 4.2 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.2 4.0 REACTOME_DESTABILIZATION_OF_MRNA_BY_TRISTETRAPROLIN_TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.0 4.0 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.2 3.0 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.1 2.7 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.2 2.5 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 2.5 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.1 2.5 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 2.5 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 2.0 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis