Motif ID: Snai1_Zeb1_Snai2
Z-value: 1.973



Transcription factors associated with Snai1_Zeb1_Snai2:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Snai1 | ENSMUSG00000042821.7 | Snai1 |
Snai2 | ENSMUSG00000022676.6 | Snai2 |
Zeb1 | ENSMUSG00000024238.7 | Zeb1 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Zeb1 | mm10_v2_chr18_+_5591860_5591902 | -0.78 | 1.1e-16 | Click! |
Snai2 | mm10_v2_chr16_+_14705832_14705858 | -0.21 | 6.2e-02 | Click! |
Snai1 | mm10_v2_chr2_+_167538192_167538210 | -0.01 | 9.1e-01 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 958 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.0 | 45.1 | GO:0034605 | cellular response to heat(GO:0034605) |
5.8 | 34.6 | GO:2000672 | negative regulation of motor neuron apoptotic process(GO:2000672) |
0.3 | 29.6 | GO:0016579 | protein deubiquitination(GO:0016579) |
9.7 | 29.1 | GO:0042323 | negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256) |
4.0 | 27.8 | GO:1990416 | cellular response to brain-derived neurotrophic factor stimulus(GO:1990416) |
1.3 | 27.7 | GO:0006491 | N-glycan processing(GO:0006491) |
0.4 | 27.2 | GO:1903749 | positive regulation of establishment of protein localization to mitochondrion(GO:1903749) |
3.7 | 26.1 | GO:0016185 | synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185) |
2.0 | 23.9 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
4.0 | 23.7 | GO:0060762 | regulation of branching involved in mammary gland duct morphogenesis(GO:0060762) |
1.1 | 23.7 | GO:1903861 | positive regulation of dendrite extension(GO:1903861) |
7.5 | 22.5 | GO:0099548 | trans-synaptic signaling by nitric oxide(GO:0099548) |
0.6 | 22.5 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
1.6 | 22.1 | GO:0007190 | activation of adenylate cyclase activity(GO:0007190) |
0.7 | 21.6 | GO:0061098 | positive regulation of protein tyrosine kinase activity(GO:0061098) |
4.3 | 21.5 | GO:0075136 | response to defenses of other organism involved in symbiotic interaction(GO:0052173) response to host defenses(GO:0052200) response to host(GO:0075136) |
2.4 | 21.3 | GO:0021894 | cerebral cortex GABAergic interneuron development(GO:0021894) |
2.9 | 20.5 | GO:0061092 | regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092) |
6.7 | 20.2 | GO:0071374 | cellular response to parathyroid hormone stimulus(GO:0071374) |
5.0 | 19.9 | GO:0051725 | protein de-ADP-ribosylation(GO:0051725) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 351 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.2 | 78.9 | GO:0005581 | collagen trimer(GO:0005581) |
0.1 | 74.0 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
0.3 | 72.0 | GO:0097060 | synaptic membrane(GO:0097060) |
0.6 | 58.4 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
0.7 | 52.1 | GO:0005604 | basement membrane(GO:0005604) |
2.2 | 42.2 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
0.4 | 35.0 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
11.3 | 34.0 | GO:0097058 | CRLF-CLCF1 complex(GO:0097058) |
1.6 | 33.1 | GO:0032279 | asymmetric synapse(GO:0032279) |
0.6 | 32.7 | GO:0034705 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
5.2 | 31.4 | GO:0008091 | spectrin(GO:0008091) |
1.7 | 29.3 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
0.7 | 28.3 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
2.0 | 25.9 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
0.5 | 25.5 | GO:0031594 | neuromuscular junction(GO:0031594) |
0.0 | 24.0 | GO:0016021 | integral component of membrane(GO:0016021) |
1.5 | 23.7 | GO:0005614 | interstitial matrix(GO:0005614) |
0.7 | 23.7 | GO:0048786 | presynaptic active zone(GO:0048786) |
0.2 | 23.6 | GO:0031225 | anchored component of membrane(GO:0031225) |
0.5 | 23.5 | GO:0030667 | secretory granule membrane(GO:0030667) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 586 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
7.6 | 52.9 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
4.3 | 51.9 | GO:0004016 | adenylate cyclase activity(GO:0004016) |
1.1 | 43.8 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
1.1 | 41.2 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
0.4 | 41.1 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
4.9 | 34.1 | GO:0005127 | ciliary neurotrophic factor receptor binding(GO:0005127) |
10.7 | 32.0 | GO:0005332 | gamma-aminobutyric acid:sodium symporter activity(GO:0005332) |
1.3 | 30.5 | GO:0030506 | ankyrin binding(GO:0030506) |
0.1 | 30.3 | GO:0005096 | GTPase activator activity(GO:0005096) |
4.0 | 28.0 | GO:0001609 | G-protein coupled adenosine receptor activity(GO:0001609) |
2.5 | 27.9 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
0.1 | 26.7 | GO:0003924 | GTPase activity(GO:0003924) |
2.4 | 26.4 | GO:0008603 | cAMP-dependent protein kinase regulator activity(GO:0008603) |
0.7 | 26.4 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
0.4 | 25.2 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
2.8 | 25.0 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
0.7 | 24.3 | GO:0030552 | cAMP binding(GO:0030552) |
0.8 | 23.1 | GO:0005227 | calcium activated cation channel activity(GO:0005227) |
0.9 | 21.6 | GO:0001968 | fibronectin binding(GO:0001968) |
2.1 | 21.3 | GO:0004972 | NMDA glutamate receptor activity(GO:0004972) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 98 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 108.9 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
0.8 | 58.1 | PID_RHOA_REG_PATHWAY | Regulation of RhoA activity |
0.9 | 56.3 | PID_ERBB1_INTERNALIZATION_PATHWAY | Internalization of ErbB1 |
0.4 | 45.2 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
0.7 | 39.6 | PID_TRKR_PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
0.5 | 37.1 | PID_PDGFRB_PATHWAY | PDGFR-beta signaling pathway |
0.8 | 30.4 | PID_REELIN_PATHWAY | Reelin signaling pathway |
0.8 | 28.0 | PID_ENDOTHELIN_PATHWAY | Endothelins |
1.0 | 27.9 | PID_INTEGRIN_A9B1_PATHWAY | Alpha9 beta1 integrin signaling events |
0.2 | 27.5 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
1.2 | 26.5 | PID_PDGFRA_PATHWAY | PDGFR-alpha signaling pathway |
1.4 | 24.4 | PID_LPA4_PATHWAY | LPA4-mediated signaling events |
0.5 | 19.3 | PID_INSULIN_PATHWAY | Insulin Pathway |
1.0 | 17.5 | PID_MAPK_TRK_PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
0.4 | 17.1 | PID_ATF2_PATHWAY | ATF-2 transcription factor network |
0.3 | 16.7 | PID_AP1_PATHWAY | AP-1 transcription factor network |
1.0 | 16.2 | PID_INTEGRIN5_PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
0.4 | 14.1 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
0.9 | 13.6 | PID_ERBB_NETWORK_PATHWAY | ErbB receptor signaling network |
0.1 | 13.6 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 180 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.7 | 46.4 | REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING | Genes involved in DCC mediated attractive signaling |
2.0 | 46.2 | REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB | Genes involved in PKA-mediated phosphorylation of CREB |
2.2 | 43.1 | REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
1.3 | 41.9 | REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
1.3 | 40.4 | REACTOME_BASIGIN_INTERACTIONS | Genes involved in Basigin interactions |
0.2 | 37.6 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
3.4 | 33.8 | REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
1.0 | 32.8 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
5.1 | 30.8 | REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
2.3 | 29.6 | REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS | Genes involved in Nucleotide-like (purinergic) receptors |
0.7 | 24.6 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
0.9 | 22.0 | REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
0.9 | 21.5 | REACTOME_ERK_MAPK_TARGETS | Genes involved in ERK/MAPK targets |
0.9 | 21.2 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
1.3 | 20.9 | REACTOME_GABA_A_RECEPTOR_ACTIVATION | Genes involved in GABA A receptor activation |
0.7 | 18.2 | REACTOME_RAP1_SIGNALLING | Genes involved in Rap1 signalling |
1.4 | 17.9 | REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
0.7 | 17.5 | REACTOME_CHOLESTEROL_BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
0.7 | 16.4 | REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
0.5 | 16.3 | REACTOME_SYNTHESIS_OF_PA | Genes involved in Synthesis of PA |