Motif ID: Snai1_Zeb1_Snai2

Z-value: 1.973

Transcription factors associated with Snai1_Zeb1_Snai2:

Gene SymbolEntrez IDGene Name
Snai1 ENSMUSG00000042821.7 Snai1
Snai2 ENSMUSG00000022676.6 Snai2
Zeb1 ENSMUSG00000024238.7 Zeb1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zeb1mm10_v2_chr18_+_5591860_5591902-0.781.1e-16Click!
Snai2mm10_v2_chr16_+_14705832_14705858-0.216.2e-02Click!
Snai1mm10_v2_chr2_+_167538192_167538210-0.019.1e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Snai1_Zeb1_Snai2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_67922136 47.289 ENSMUST00000021288.3
ENSMUST00000108677.1
Usp43

ubiquitin specific peptidase 43

chr6_+_114131229 33.909 ENSMUST00000032451.7
Slc6a11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr12_+_82616885 29.192 ENSMUST00000161801.1
Rgs6
regulator of G-protein signaling 6
chr15_-_66831625 28.120 ENSMUST00000164163.1
Sla
src-like adaptor
chr8_+_70493156 23.114 ENSMUST00000008032.7
Crlf1
cytokine receptor-like factor 1
chr17_-_26201363 21.479 ENSMUST00000121959.1
Arhgdig
Rho GDP dissociation inhibitor (GDI) gamma
chr19_-_57314896 19.860 ENSMUST00000111524.1
Ablim1
actin-binding LIM protein 1
chr13_-_57907587 19.265 ENSMUST00000172326.1
Spock1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1
chr7_-_4789541 18.946 ENSMUST00000168578.1
Tmem238
transmembrane protein 238
chr15_+_54571358 18.909 ENSMUST00000025356.2
Mal2
mal, T cell differentiation protein 2
chr1_-_134234492 18.688 ENSMUST00000169927.1
Adora1
adenosine A1 receptor
chr10_+_81257277 17.345 ENSMUST00000117488.1
ENSMUST00000105328.3
ENSMUST00000121205.1
Matk


megakaryocyte-associated tyrosine kinase


chr13_+_83504032 17.204 ENSMUST00000163888.1
ENSMUST00000005722.7
Mef2c

myocyte enhancer factor 2C

chr4_-_136892867 16.480 ENSMUST00000046332.5
C1qc
complement component 1, q subcomponent, C chain
chr18_-_61911783 16.467 ENSMUST00000049378.8
ENSMUST00000166783.1
Ablim3

actin binding LIM protein family, member 3

chr4_+_85205417 16.401 ENSMUST00000030212.8
ENSMUST00000107189.1
ENSMUST00000107184.1
Sh3gl2


SH3-domain GRB2-like 2


chr3_-_82074639 16.399 ENSMUST00000029635.8
Gucy1b3
guanylate cyclase 1, soluble, beta 3
chr6_-_148444336 15.366 ENSMUST00000060095.8
ENSMUST00000100772.3
Tmtc1

transmembrane and tetratricopeptide repeat containing 1

chr18_-_66291770 15.100 ENSMUST00000130300.1
Ccbe1
collagen and calcium binding EGF domains 1
chr8_-_70439557 15.087 ENSMUST00000076615.5
Crtc1
CREB regulated transcription coactivator 1

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 958 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 45.1 GO:0034605 cellular response to heat(GO:0034605)
5.8 34.6 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.3 29.6 GO:0016579 protein deubiquitination(GO:0016579)
9.7 29.1 GO:0042323 negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256)
4.0 27.8 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
1.3 27.7 GO:0006491 N-glycan processing(GO:0006491)
0.4 27.2 GO:1903749 positive regulation of establishment of protein localization to mitochondrion(GO:1903749)
3.7 26.1 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
2.0 23.9 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
4.0 23.7 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
1.1 23.7 GO:1903861 positive regulation of dendrite extension(GO:1903861)
7.5 22.5 GO:0099548 trans-synaptic signaling by nitric oxide(GO:0099548)
0.6 22.5 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
1.6 22.1 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.7 21.6 GO:0061098 positive regulation of protein tyrosine kinase activity(GO:0061098)
4.3 21.5 GO:0075136 response to defenses of other organism involved in symbiotic interaction(GO:0052173) response to host defenses(GO:0052200) response to host(GO:0075136)
2.4 21.3 GO:0021894 cerebral cortex GABAergic interneuron development(GO:0021894)
2.9 20.5 GO:0061092 regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
6.7 20.2 GO:0071374 cellular response to parathyroid hormone stimulus(GO:0071374)
5.0 19.9 GO:0051725 protein de-ADP-ribosylation(GO:0051725)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 351 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 78.9 GO:0005581 collagen trimer(GO:0005581)
0.1 74.0 GO:0005887 integral component of plasma membrane(GO:0005887)
0.3 72.0 GO:0097060 synaptic membrane(GO:0097060)
0.6 58.4 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.7 52.1 GO:0005604 basement membrane(GO:0005604)
2.2 42.2 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.4 35.0 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
11.3 34.0 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
1.6 33.1 GO:0032279 asymmetric synapse(GO:0032279)
0.6 32.7 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
5.2 31.4 GO:0008091 spectrin(GO:0008091)
1.7 29.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.7 28.3 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
2.0 25.9 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.5 25.5 GO:0031594 neuromuscular junction(GO:0031594)
0.0 24.0 GO:0016021 integral component of membrane(GO:0016021)
1.5 23.7 GO:0005614 interstitial matrix(GO:0005614)
0.7 23.7 GO:0048786 presynaptic active zone(GO:0048786)
0.2 23.6 GO:0031225 anchored component of membrane(GO:0031225)
0.5 23.5 GO:0030667 secretory granule membrane(GO:0030667)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 586 entries
Log-likelihood per target Total log-likelihoodTermDescription
7.6 52.9 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
4.3 51.9 GO:0004016 adenylate cyclase activity(GO:0004016)
1.1 43.8 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
1.1 41.2 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.4 41.1 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
4.9 34.1 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
10.7 32.0 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
1.3 30.5 GO:0030506 ankyrin binding(GO:0030506)
0.1 30.3 GO:0005096 GTPase activator activity(GO:0005096)
4.0 28.0 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
2.5 27.9 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 26.7 GO:0003924 GTPase activity(GO:0003924)
2.4 26.4 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.7 26.4 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.4 25.2 GO:0048306 calcium-dependent protein binding(GO:0048306)
2.8 25.0 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.7 24.3 GO:0030552 cAMP binding(GO:0030552)
0.8 23.1 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.9 21.6 GO:0001968 fibronectin binding(GO:0001968)
2.1 21.3 GO:0004972 NMDA glutamate receptor activity(GO:0004972)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 98 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 108.9 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.8 58.1 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.9 56.3 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.4 45.2 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.7 39.6 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.5 37.1 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.8 30.4 PID_REELIN_PATHWAY Reelin signaling pathway
0.8 28.0 PID_ENDOTHELIN_PATHWAY Endothelins
1.0 27.9 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.2 27.5 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
1.2 26.5 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
1.4 24.4 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.5 19.3 PID_INSULIN_PATHWAY Insulin Pathway
1.0 17.5 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.4 17.1 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.3 16.7 PID_AP1_PATHWAY AP-1 transcription factor network
1.0 16.2 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.4 14.1 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.9 13.6 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 13.6 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 180 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 46.4 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
2.0 46.2 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
2.2 43.1 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
1.3 41.9 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
1.3 40.4 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.2 37.6 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
3.4 33.8 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
1.0 32.8 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
5.1 30.8 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
2.3 29.6 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.7 24.6 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.9 22.0 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.9 21.5 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.9 21.2 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
1.3 20.9 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.7 18.2 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
1.4 17.9 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.7 17.5 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.7 16.4 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.5 16.3 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA