Motif ID: Sox1

Z-value: 0.476


Transcription factors associated with Sox1:

Gene SymbolEntrez IDGene Name
Sox1 ENSMUSG00000096014.1 Sox1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox1mm10_v2_chr8_+_12395287_123952950.171.4e-01Click!


Activity profile for motif Sox1.

activity profile for motif Sox1


Sorted Z-values histogram for motif Sox1

Sorted Z-values for motif Sox1



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_34287770 5.338 ENSMUST00000174751.1
ENSMUST00000040655.6
 H2-Aa

histocompatibility 2, class II antigen A, alpha

chr17_+_34263209 5.279 ENSMUST00000040828.5
 H2-Ab1
histocompatibility 2, class II antigen A, beta 1
chr15_-_75048837 5.110 ENSMUST00000179762.1
ENSMUST00000065408.9
 Ly6c1

lymphocyte antigen 6 complex, locus C1

chr15_-_74997634 4.734 ENSMUST00000023248.6
 Ly6a
lymphocyte antigen 6 complex, locus A
chr17_+_34969912 4.649 ENSMUST00000173680.1
 Gm20481
predicted gene 20481
chr17_+_47737030 1.746 ENSMUST00000086932.3
 Tfeb
transcription factor EB
chr9_-_114390633 1.684 ENSMUST00000084881.4
 Crtap
cartilage associated protein
chr3_-_34005490 1.671 ENSMUST00000060997.2
 Gm9791
predicted pseudogene 9791
chr17_-_47692466 1.464 ENSMUST00000113300.1
 Prickle4
prickle homolog 4 (Drosophila)
chr7_+_80343091 1.351 ENSMUST00000032747.5
 Hddc3
HD domain containing 3
chr6_+_117841174 1.226 ENSMUST00000112859.1
ENSMUST00000137224.1
ENSMUST00000164472.1
ENSMUST00000112861.1
ENSMUST00000035638.8
 Zfp637




zinc finger protein 637




chr16_-_37654408 1.114 ENSMUST00000023514.3
 Ndufb4
NADH dehydrogenase (ubiquinone) 1 beta subcomplex 4
chr8_+_13159135 1.088 ENSMUST00000033824.6
 Lamp1
lysosomal-associated membrane protein 1
chr6_+_114648811 0.869 ENSMUST00000182510.1
 Atg7
autophagy related 7
chr5_+_21737141 0.838 ENSMUST00000030882.5
 Pmpcb
peptidase (mitochondrial processing) beta
chr4_-_120747248 0.818 ENSMUST00000030376.7
 Kcnq4
potassium voltage-gated channel, subfamily Q, member 4
chrX_+_74297097 0.636 ENSMUST00000019231.5
ENSMUST00000147900.1
ENSMUST00000147275.1
ENSMUST00000114171.3
 Atp6ap1



ATPase, H+ transporting, lysosomal accessory protein 1



chr9_-_108305941 0.517 ENSMUST00000044725.7
 Tcta
T cell leukemia translocation altered gene
chr2_-_84650760 0.511 ENSMUST00000111691.1
 Ctnnd1
catenin (cadherin associated protein), delta 1
chr2_-_84650714 0.505 ENSMUST00000111697.2
ENSMUST00000111670.2
ENSMUST00000111696.1
ENSMUST00000111678.1
ENSMUST00000111690.1
ENSMUST00000111695.1
ENSMUST00000111677.1
ENSMUST00000111698.1
ENSMUST00000099941.2
ENSMUST00000111676.1
ENSMUST00000111694.1
ENSMUST00000111675.1
ENSMUST00000111689.1
ENSMUST00000111687.1
ENSMUST00000111692.1
ENSMUST00000111685.1
ENSMUST00000111686.1
ENSMUST00000111688.1
ENSMUST00000111693.1
ENSMUST00000111684.1
 Ctnnd1



















catenin (cadherin associated protein), delta 1



















chr5_+_21186267 0.477 ENSMUST00000036031.8
 Gsap
gamma-secretase activating protein
chr5_-_13121766 0.448 ENSMUST00000078246.4
 Gm10108
predicted pseudogene 10108
chr7_+_119690026 0.439 ENSMUST00000047045.8
 Acsm4
acyl-CoA synthetase medium-chain family member 4
chrX_+_101429555 0.321 ENSMUST00000033673.6
 Nono
non-POU-domain-containing, octamer binding protein
chr11_-_68853019 0.314 ENSMUST00000108672.1
 Ndel1
nuclear distribution gene E-like homolog 1 (A. nidulans)
chr7_-_46919915 0.290 ENSMUST00000143413.1
ENSMUST00000014546.8
 Tsg101

tumor susceptibility gene 101

chr7_-_57509995 0.232 ENSMUST00000068456.6
 Gabra5
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 5
chr6_+_121183667 0.179 ENSMUST00000118234.1
ENSMUST00000088561.3
ENSMUST00000137432.1
ENSMUST00000120066.1
 Pex26



peroxisomal biogenesis factor 26



chr11_-_68853119 0.173 ENSMUST00000018880.7
 Ndel1
nuclear distribution gene E-like homolog 1 (A. nidulans)
chr2_+_84798828 0.168 ENSMUST00000102642.2
ENSMUST00000150325.1
 Ube2l6

ubiquitin-conjugating enzyme E2L 6

chr2_+_34406845 0.159 ENSMUST00000124443.1
ENSMUST00000113124.1
 Mapkap1

mitogen-activated protein kinase associated protein 1

chr12_+_52097737 0.151 ENSMUST00000040090.9
 Nubpl
nucleotide binding protein-like
chr5_-_140649018 0.122 ENSMUST00000042661.3
 Ttyh3
tweety homolog 3 (Drosophila)
chr1_-_195131536 0.079 ENSMUST00000075451.6
 Cr1l
complement component (3b/4b) receptor 1-like
chr18_+_37496997 0.063 ENSMUST00000059571.5
 Pcdhb19
protocadherin beta 19
chr7_+_101896340 0.049 ENSMUST00000035395.7
ENSMUST00000106973.1
ENSMUST00000144207.1
 Anapc15


anaphase prompoting complex C subunit 15


chr10_+_84756055 0.049 ENSMUST00000060397.6
 Rfx4
regulatory factor X, 4 (influences HLA class II expression)
chr15_-_76918010 0.046 ENSMUST00000048854.7
 Zfp647
zinc finger protein 647
chr7_+_67655414 0.040 ENSMUST00000107470.1
 Ttc23
tetratricopeptide repeat domain 23

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 5.3 GO:0002339 B cell selection(GO:0002339)
0.6 1.7 GO:0009814 defense response, incompatible interaction(GO:0009814)
0.5 5.3 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.4 1.1 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626) positive regulation of natural killer cell degranulation(GO:0043323)
0.3 0.9 GO:0016237 lysosomal microautophagy(GO:0016237) piecemeal microautophagy of nucleus(GO:0034727) suppression by virus of host autophagy(GO:0039521) negative regulation of sphingolipid biosynthesis involved in cellular sphingolipid homeostasis(GO:0090157)
0.2 0.6 GO:2001206 positive regulation of osteoclast development(GO:2001206)
0.2 0.8 GO:0032227 negative regulation of synaptic transmission, dopaminergic(GO:0032227)
0.2 1.0 GO:0060690 epithelial cell differentiation involved in salivary gland development(GO:0060690)
0.2 1.7 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
0.1 0.5 GO:0072675 osteoclast fusion(GO:0072675)
0.1 0.3 GO:1903774 positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.1 0.8 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.0 0.5 GO:0030397 membrane disassembly(GO:0030397) nuclear envelope disassembly(GO:0051081)
0.0 0.3 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.0 0.5 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.0 1.3 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.2 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0 0.2 GO:0015919 peroxisomal membrane transport(GO:0015919) protein import into peroxisome membrane(GO:0045046)
0.0 0.2 GO:0032020 ISG15-protein conjugation(GO:0032020)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 10.6 GO:0042613 MHC class II protein complex(GO:0042613)
0.4 1.1 GO:0044194 cytolytic granule(GO:0044194)
0.1 1.0 GO:0005915 zonula adherens(GO:0005915)
0.1 0.8 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.1 9.8 GO:0031225 anchored component of membrane(GO:0031225)
0.1 0.6 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 0.5 GO:0060053 neurofilament cytoskeleton(GO:0060053)
0.0 0.3 GO:0042382 paraspeckles(GO:0042382)
0.0 0.3 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.9 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 1.1 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.2 GO:1902711 GABA-A receptor complex(GO:1902711)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 5.3 GO:1990405 protein antigen binding(GO:1990405)
0.3 0.9 GO:0019779 Atg12 activating enzyme activity(GO:0019778) Atg8 activating enzyme activity(GO:0019779)
0.2 5.3 GO:0042605 peptide antigen binding(GO:0042605)
0.1 0.4 GO:0003996 acyl-CoA ligase activity(GO:0003996)
0.1 0.5 GO:0070012 oligopeptidase activity(GO:0070012)
0.0 0.6 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.3 GO:0046790 virion binding(GO:0046790)
0.0 0.2 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 0.2 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.1 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.8 GO:0005249 voltage-gated potassium channel activity(GO:0005249)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.0 0.3 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.5 PID_AURORA_A_PATHWAY Aurora A signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.7 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 0.3 REACTOME_MEMBRANE_BINDING_AND_TARGETTING_OF_GAG_PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.8 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.1 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 0.8 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.2 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation