Motif ID: Sox14

Z-value: 1.058


Transcription factors associated with Sox14:

Gene SymbolEntrez IDGene Name
Sox14 ENSMUSG00000053747.8 Sox14

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox14mm10_v2_chr9_-_99876147_998761930.019.2e-01Click!


Activity profile for motif Sox14.

activity profile for motif Sox14


Sorted Z-values histogram for motif Sox14

Sorted Z-values for motif Sox14



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox14

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 17.592 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr12_+_109546333 10.055 ENSMUST00000166636.2
 Meg3
maternally expressed 3
chr12_+_109546409 9.206 ENSMUST00000143847.1
 Meg3
maternally expressed 3
chr4_+_62965560 8.717 ENSMUST00000030043.6
ENSMUST00000107415.1
ENSMUST00000064814.5
 Zfp618


zinc finger protein 618


chr12_+_109545390 8.203 ENSMUST00000146701.1
 Meg3
maternally expressed 3
chr4_+_13751297 7.728 ENSMUST00000105566.2
 Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr10_-_6980376 7.152 ENSMUST00000105617.1
 Ipcef1
interaction protein for cytohesin exchange factors 1
chr4_+_102254739 6.192 ENSMUST00000106907.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr11_+_67586520 5.902 ENSMUST00000108682.2
 Gas7
growth arrest specific 7
chr13_-_58113592 5.793 ENSMUST00000160860.1
 Klhl3
kelch-like 3
chr11_+_67586675 5.411 ENSMUST00000108680.1
 Gas7
growth arrest specific 7
chr13_-_14523178 5.223 ENSMUST00000110516.2
 Hecw1
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
chrX_-_167209149 4.910 ENSMUST00000112176.1
 Tmsb4x
thymosin, beta 4, X chromosome
chr16_+_52031549 4.871 ENSMUST00000114471.1
 Cblb
Casitas B-lineage lymphoma b
chr14_-_98169542 4.562 ENSMUST00000069334.7
ENSMUST00000071533.6
 Dach1

dachshund 1 (Drosophila)

chr2_-_102186322 4.502 ENSMUST00000111222.1
ENSMUST00000058790.5
 Ldlrad3

low density lipoprotein receptor class A domain containing 3

chr12_-_32061221 4.307 ENSMUST00000003079.5
ENSMUST00000036497.9
 Prkar2b

protein kinase, cAMP dependent regulatory, type II beta

chr9_+_65265173 4.171 ENSMUST00000048762.1
 Cilp
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
chr1_-_12991109 4.055 ENSMUST00000115403.2
ENSMUST00000115402.1
 Slco5a1

solute carrier organic anion transporter family, member 5A1

chr14_-_104467984 4.020 ENSMUST00000053016.8
 Pou4f1
POU domain, class 4, transcription factor 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 141 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 27.9 GO:0008340 determination of adult lifespan(GO:0008340)
2.9 17.6 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 14.0 GO:0008360 regulation of cell shape(GO:0008360)
0.1 7.7 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.5 7.5 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.5 6.2 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.5 6.0 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
1.0 5.8 GO:0070294 renal sodium ion absorption(GO:0070294)
1.1 5.4 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.2 5.4 GO:0045063 T-helper 1 cell differentiation(GO:0045063)
1.6 4.9 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.5 4.9 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.5 4.7 GO:0061470 T follicular helper cell differentiation(GO:0061470)
0.6 4.6 GO:0010944 negative regulation of transcription by competitive promoter binding(GO:0010944)
0.1 4.5 GO:0070613 regulation of protein processing(GO:0070613)
0.0 4.3 GO:0048675 axon extension(GO:0048675)
0.0 4.2 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.3 4.1 GO:0043252 sodium-independent organic anion transport(GO:0043252)
1.3 4.0 GO:0030070 insulin processing(GO:0030070)
0.8 4.0 GO:0019230 proprioception(GO:0019230)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 65.4 GO:0005829 cytosol(GO:0005829)
0.1 12.6 GO:0005884 actin filament(GO:0005884)
0.1 7.8 GO:0016363 nuclear matrix(GO:0016363)
0.1 7.6 GO:0043204 perikaryon(GO:0043204)
0.2 7.5 GO:0043034 costamere(GO:0043034)
0.2 6.2 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 6.1 GO:0015629 actin cytoskeleton(GO:0015629)
0.1 5.9 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 5.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 5.5 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 4.8 GO:0014069 postsynaptic density(GO:0014069)
0.3 4.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 4.0 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.9 3.6 GO:0008623 CHRAC(GO:0008623)
0.2 3.6 GO:0035102 PRC1 complex(GO:0035102)
0.8 3.4 GO:0043259 laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259)
0.4 3.4 GO:0042382 paraspeckles(GO:0042382)
0.0 3.4 GO:0001650 fibrillar center(GO:0001650)
0.0 3.3 GO:0042641 actomyosin(GO:0042641)
0.7 3.0 GO:0090537 CERF complex(GO:0090537)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 96 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 16.2 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.1 15.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 10.4 GO:0051015 actin filament binding(GO:0051015)
0.2 9.7 GO:0001784 phosphotyrosine binding(GO:0001784)
0.7 7.5 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.1 7.4 GO:0035064 methylated histone binding(GO:0035064)
0.0 7.2 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1 6.6 GO:0005080 protein kinase C binding(GO:0005080)
0.1 6.3 GO:0001540 beta-amyloid binding(GO:0001540)
0.2 6.2 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 5.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 4.9 GO:0003785 actin monomer binding(GO:0003785)
0.6 4.6 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.4 4.3 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.1 4.3 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.4 4.1 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.1 4.0 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.2 3.9 GO:0070064 proline-rich region binding(GO:0070064)
0.2 3.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.4 3.4 GO:0043208 glycosphingolipid binding(GO:0043208)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.4 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1 6.0 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 4.9 PID_CD40_PATHWAY CD40/CD40L signaling
0.1 3.8 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.4 3.4 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 3.4 PID_IGF1_PATHWAY IGF1 pathway
0.0 3.4 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.1 3.3 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.2 3.0 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 2.4 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 2.2 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 2.1 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.0 1.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 1.6 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 1.6 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 1.4 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 1.4 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 1.3 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 1.2 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 1.1 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.5 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 6.0 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2 5.4 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.2 4.9 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.2 4.3 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.2 4.0 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 3.4 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.2 3.3 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.1 3.2 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 3.0 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.1 2.6 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.1 1.9 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 1.9 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.1 1.8 REACTOME_ACYL_CHAIN_REMODELLING_OF_PC Genes involved in Acyl chain remodelling of PC
0.0 1.8 REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES Genes involved in Transmission across Chemical Synapses
0.1 1.7 REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.0 1.7 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 1.6 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 1.6 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 1.5 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels