Motif ID: Sox17
Z-value: 0.537
Transcription factors associated with Sox17:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Sox17 | ENSMUSG00000025902.7 | Sox17 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Sox17 | mm10_v2_chr1_-_4496400_4496420 | -0.10 | 3.7e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 9.6 | GO:0007217 | tachykinin receptor signaling pathway(GO:0007217) |
| 1.6 | 4.8 | GO:0006553 | lysine metabolic process(GO:0006553) |
| 1.4 | 8.3 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
| 1.3 | 3.9 | GO:0046122 | purine deoxyribonucleoside metabolic process(GO:0046122) |
| 1.2 | 3.6 | GO:2000373 | regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373) |
| 1.0 | 6.8 | GO:0070779 | D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
| 0.8 | 7.1 | GO:0070874 | negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874) |
| 0.3 | 0.9 | GO:0048239 | negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695) |
| 0.2 | 2.1 | GO:0045086 | positive regulation of interleukin-2 biosynthetic process(GO:0045086) |
| 0.2 | 1.8 | GO:1902741 | type I interferon secretion(GO:0072641) interferon-alpha secretion(GO:0072642) regulation of interferon-alpha secretion(GO:1902739) positive regulation of interferon-alpha secretion(GO:1902741) |
| 0.2 | 1.6 | GO:0048625 | myoblast fate commitment(GO:0048625) |
| 0.2 | 0.8 | GO:0038108 | negative regulation of appetite by leptin-mediated signaling pathway(GO:0038108) |
| 0.2 | 3.3 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
| 0.2 | 1.4 | GO:0080184 | response to stilbenoid(GO:0035634) response to phenylpropanoid(GO:0080184) |
| 0.1 | 3.4 | GO:0030866 | cortical actin cytoskeleton organization(GO:0030866) |
| 0.1 | 0.6 | GO:0098734 | protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734) |
| 0.1 | 0.8 | GO:0002361 | CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361) |
| 0.1 | 1.6 | GO:0030813 | positive regulation of nucleotide catabolic process(GO:0030813) positive regulation of glycolytic process(GO:0045821) positive regulation of cofactor metabolic process(GO:0051194) positive regulation of coenzyme metabolic process(GO:0051197) |
| 0.1 | 1.1 | GO:0006264 | mitochondrial DNA replication(GO:0006264) |
| 0.1 | 0.5 | GO:0019370 | leukotriene biosynthetic process(GO:0019370) |
| 0.1 | 4.7 | GO:0070527 | platelet aggregation(GO:0070527) |
| 0.1 | 7.7 | GO:0001824 | blastocyst development(GO:0001824) |
| 0.1 | 0.6 | GO:0002098 | tRNA wobble uridine modification(GO:0002098) |
| 0.1 | 0.5 | GO:0019227 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
| 0.0 | 0.9 | GO:0045947 | negative regulation of translational initiation(GO:0045947) |
| 0.0 | 0.7 | GO:0046855 | inositol phosphate dephosphorylation(GO:0046855) |
| 0.0 | 3.1 | GO:0009063 | cellular amino acid catabolic process(GO:0009063) |
| 0.0 | 4.1 | GO:0001578 | microtubule bundle formation(GO:0001578) |
| 0.0 | 0.8 | GO:0035493 | SNARE complex assembly(GO:0035493) |
| 0.0 | 0.1 | GO:0046341 | CDP-diacylglycerol metabolic process(GO:0046341) |
| 0.0 | 2.2 | GO:0000245 | spliceosomal complex assembly(GO:0000245) |
| 0.0 | 0.3 | GO:0050957 | equilibrioception(GO:0050957) |
| 0.0 | 2.4 | GO:0006635 | fatty acid beta-oxidation(GO:0006635) |
| 0.0 | 0.1 | GO:0097026 | dendritic cell dendrite assembly(GO:0097026) |
| 0.0 | 0.5 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.0 | 0.1 | GO:0000973 | posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973) |
| 0.0 | 0.5 | GO:0010758 | regulation of macrophage chemotaxis(GO:0010758) |
| 0.0 | 0.8 | GO:0006406 | mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427) |
| 0.0 | 3.3 | GO:0030336 | negative regulation of cell migration(GO:0030336) |
| 0.0 | 0.2 | GO:0006895 | Golgi to endosome transport(GO:0006895) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 3.6 | GO:0000799 | nuclear condensin complex(GO:0000799) |
| 0.7 | 3.3 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
| 0.5 | 4.1 | GO:0097427 | microtubule bundle(GO:0097427) |
| 0.2 | 1.6 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) |
| 0.2 | 2.1 | GO:0031462 | Cul2-RING ubiquitin ligase complex(GO:0031462) |
| 0.2 | 0.8 | GO:0070820 | tertiary granule(GO:0070820) |
| 0.2 | 3.3 | GO:0016580 | Sin3 complex(GO:0016580) |
| 0.1 | 1.8 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 0.1 | 2.4 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.1 | 0.9 | GO:0000783 | telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783) |
| 0.1 | 6.8 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.1 | 0.8 | GO:0034464 | BBSome(GO:0034464) |
| 0.1 | 1.1 | GO:0042575 | DNA polymerase complex(GO:0042575) |
| 0.0 | 0.8 | GO:0005686 | U2 snRNP(GO:0005686) |
| 0.0 | 0.2 | GO:1990462 | omegasome(GO:1990462) |
| 0.0 | 0.5 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.0 | 4.8 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 2.6 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.0 | 0.1 | GO:0044614 | nuclear pore cytoplasmic filaments(GO:0044614) |
| 0.0 | 0.4 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
| 0.0 | 4.7 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.0 | 0.5 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 3.9 | GO:0004731 | purine-nucleoside phosphorylase activity(GO:0004731) |
| 1.2 | 4.8 | GO:0016647 | oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647) |
| 1.1 | 6.8 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 1.0 | 3.1 | GO:0001716 | L-amino-acid oxidase activity(GO:0001716) |
| 0.7 | 2.1 | GO:0005171 | hepatocyte growth factor receptor binding(GO:0005171) |
| 0.7 | 3.3 | GO:0061731 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 0.6 | 1.8 | GO:0008384 | IkappaB kinase activity(GO:0008384) |
| 0.6 | 3.6 | GO:0044547 | DNA topoisomerase binding(GO:0044547) |
| 0.5 | 2.4 | GO:0004165 | dodecenoyl-CoA delta-isomerase activity(GO:0004165) |
| 0.3 | 1.6 | GO:0004382 | guanosine-diphosphatase activity(GO:0004382) |
| 0.2 | 0.7 | GO:0016314 | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314) |
| 0.2 | 3.0 | GO:0008253 | 5'-nucleotidase activity(GO:0008253) |
| 0.2 | 7.1 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.1 | 0.9 | GO:0010521 | telomerase inhibitor activity(GO:0010521) |
| 0.1 | 0.6 | GO:0016300 | tRNA (uracil) methyltransferase activity(GO:0016300) |
| 0.1 | 0.5 | GO:0004301 | epoxide hydrolase activity(GO:0004301) |
| 0.1 | 0.5 | GO:0008494 | translation activator activity(GO:0008494) |
| 0.1 | 1.6 | GO:0070016 | gamma-catenin binding(GO:0045295) armadillo repeat domain binding(GO:0070016) |
| 0.1 | 0.6 | GO:0008474 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.1 | 0.9 | GO:0090079 | translation repressor activity, nucleic acid binding(GO:0000900) translation regulator activity, nucleic acid binding(GO:0090079) |
| 0.0 | 8.3 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 1.1 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.0 | 0.8 | GO:0004623 | phospholipase A2 activity(GO:0004623) |
| 0.0 | 0.5 | GO:0031402 | sodium ion binding(GO:0031402) |
| 0.0 | 0.8 | GO:0001103 | RNA polymerase II repressing transcription factor binding(GO:0001103) |
| 0.0 | 6.6 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.0 | 0.2 | GO:0008329 | signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187) |
| 0.0 | 1.3 | GO:0004004 | RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) |
| 0.0 | 0.1 | GO:0017169 | CDP-alcohol phosphatidyltransferase activity(GO:0017169) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.1 | PID_IGF1_PATHWAY | IGF1 pathway |
| 0.1 | 3.6 | PID_AURORA_B_PATHWAY | Aurora B signaling |
| 0.1 | 1.8 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
| 0.0 | 3.3 | PID_E2F_PATHWAY | E2F transcription factor network |
| 0.0 | 0.7 | PID_IL27_PATHWAY | IL27-mediated signaling events |
| 0.0 | 1.6 | PID_AP1_PATHWAY | AP-1 transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 3.9 | REACTOME_PURINE_CATABOLISM | Genes involved in Purine catabolism |
| 0.3 | 7.1 | REACTOME_SIGNAL_ATTENUATION | Genes involved in Signal attenuation |
| 0.2 | 1.8 | REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 | Genes involved in IKK complex recruitment mediated by RIP1 |
| 0.2 | 3.3 | REACTOME_G1_S_SPECIFIC_TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.1 | 6.8 | REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.1 | 1.4 | REACTOME_REGULATION_OF_IFNA_SIGNALING | Genes involved in Regulation of IFNA signaling |
| 0.1 | 0.8 | REACTOME_ACYL_CHAIN_REMODELLING_OF_PI | Genes involved in Acyl chain remodelling of PI |
| 0.1 | 0.8 | REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.0 | 0.7 | REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS | Genes involved in Amine compound SLC transporters |
| 0.0 | 0.7 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |
| 0.0 | 0.3 | REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.0 | 0.6 | REACTOME_MRNA_3_END_PROCESSING | Genes involved in mRNA 3'-end processing |
