Motif ID: Sox17

Z-value: 0.537


Transcription factors associated with Sox17:

Gene SymbolEntrez IDGene Name
Sox17 ENSMUSG00000025902.7 Sox17

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox17mm10_v2_chr1_-_4496400_4496420-0.103.7e-01Click!


Activity profile for motif Sox17.

activity profile for motif Sox17


Sorted Z-values histogram for motif Sox17

Sorted Z-values for motif Sox17



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox17

PNG image of the network

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Top targets:


Showing 1 to 20 of 70 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_127725392 9.617 ENSMUST00000026466.3
 Tac2
tachykinin 2
chr6_-_23248264 8.264 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr11_-_11970540 7.083 ENSMUST00000109653.1
 Grb10
growth factor receptor bound protein 10
chr2_+_102659213 6.759 ENSMUST00000111213.1
 Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr11_-_77894096 4.800 ENSMUST00000017597.4
 Pipox
pipecolic acid oxidase
chr1_+_135729147 4.741 ENSMUST00000027677.7
 Csrp1
cysteine and glycine-rich protein 1
chr8_-_105471481 4.129 ENSMUST00000014990.6
 Tppp3
tubulin polymerization-promoting protein family member 3
chr14_+_50944499 3.869 ENSMUST00000178092.1
 Pnp
purine-nucleoside phosphorylase
chr10_-_128176568 3.663 ENSMUST00000092033.2
 Rbms2
RNA binding motif, single stranded interacting protein 2
chr2_-_127133909 3.600 ENSMUST00000110387.3
 Ncaph
non-SMC condensin I complex, subunit H
chr2_+_52857844 3.399 ENSMUST00000090952.4
ENSMUST00000049483.6
ENSMUST00000050719.6
 Fmnl2


formin-like 2


chr6_-_148944750 3.333 ENSMUST00000111562.1
ENSMUST00000081956.5
 Fam60a

family with sequence similarity 60, member A

chr12_+_24708241 3.282 ENSMUST00000020980.5
 Rrm2
ribonucleotide reductase M2
chr2_-_180889660 3.258 ENSMUST00000137629.1
 Gm14342
predicted gene 14342
chr4_+_118961578 3.110 ENSMUST00000058651.4
 Lao1
L-amino acid oxidase 1
chr14_+_31134853 3.035 ENSMUST00000090212.4
 Nt5dc2
5'-nucleotidase domain containing 2
chr12_+_51348265 2.637 ENSMUST00000119211.1
 G2e3
G2/M-phase specific E3 ubiquitin ligase
chr12_+_51348370 2.557 ENSMUST00000121521.1
 G2e3
G2/M-phase specific E3 ubiquitin ligase
chr12_+_51348019 2.501 ENSMUST00000054308.6
 G2e3
G2/M-phase specific E3 ubiquitin ligase
chr13_-_35027077 2.429 ENSMUST00000170538.1
ENSMUST00000163280.1
 Eci2

enoyl-Coenzyme A delta isomerase 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.4 9.6 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
1.4 8.3 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 7.7 GO:0001824 blastocyst development(GO:0001824)
0.8 7.1 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
1.0 6.8 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
1.6 4.8 GO:0006553 lysine metabolic process(GO:0006553)
0.1 4.7 GO:0070527 platelet aggregation(GO:0070527)
0.0 4.1 GO:0001578 microtubule bundle formation(GO:0001578)
1.3 3.9 GO:0046122 purine deoxyribonucleoside metabolic process(GO:0046122)
1.2 3.6 GO:2000373 regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
0.1 3.4 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.2 3.3 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.0 3.3 GO:0030336 negative regulation of cell migration(GO:0030336)
0.0 3.1 GO:0009063 cellular amino acid catabolic process(GO:0009063)
0.0 2.4 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.0 2.2 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.2 2.1 GO:0045086 positive regulation of interleukin-2 biosynthetic process(GO:0045086)
0.2 1.8 GO:1902741 type I interferon secretion(GO:0072641) interferon-alpha secretion(GO:0072642) regulation of interferon-alpha secretion(GO:1902739) positive regulation of interferon-alpha secretion(GO:1902741)
0.2 1.6 GO:0048625 myoblast fate commitment(GO:0048625)
0.1 1.6 GO:0030813 positive regulation of nucleotide catabolic process(GO:0030813) positive regulation of glycolytic process(GO:0045821) positive regulation of cofactor metabolic process(GO:0051194) positive regulation of coenzyme metabolic process(GO:0051197)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.8 GO:0042734 presynaptic membrane(GO:0042734)
0.0 4.8 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 4.7 GO:0005925 focal adhesion(GO:0005925)
0.5 4.1 GO:0097427 microtubule bundle(GO:0097427)
1.2 3.6 GO:0000799 nuclear condensin complex(GO:0000799)
0.7 3.3 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.2 3.3 GO:0016580 Sin3 complex(GO:0016580)
0.0 2.6 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 2.4 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.2 2.1 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.1 1.8 GO:0008385 IkappaB kinase complex(GO:0008385)
0.2 1.6 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 1.1 GO:0042575 DNA polymerase complex(GO:0042575)
0.1 0.9 GO:0000783 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.2 0.8 GO:0070820 tertiary granule(GO:0070820)
0.1 0.8 GO:0034464 BBSome(GO:0034464)
0.0 0.8 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.5 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.5 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.4 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 7.1 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
1.1 6.8 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 6.6 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
1.2 4.8 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
1.3 3.9 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.6 3.6 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.7 3.3 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
1.0 3.1 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.2 3.0 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.5 2.4 GO:0004165 dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.7 2.1 GO:0005171 hepatocyte growth factor receptor binding(GO:0005171)
0.6 1.8 GO:0008384 IkappaB kinase activity(GO:0008384)
0.3 1.6 GO:0004382 guanosine-diphosphatase activity(GO:0004382)
0.1 1.6 GO:0070016 gamma-catenin binding(GO:0045295) armadillo repeat domain binding(GO:0070016)
0.0 1.3 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.0 1.1 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 0.9 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.1 0.9 GO:0090079 translation repressor activity, nucleic acid binding(GO:0000900) translation regulator activity, nucleic acid binding(GO:0090079)
0.0 0.8 GO:0004623 phospholipase A2 activity(GO:0004623)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.1 PID_IGF1_PATHWAY IGF1 pathway
0.1 3.6 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 3.3 PID_E2F_PATHWAY E2F transcription factor network
0.1 1.8 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 1.6 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 0.7 PID_IL27_PATHWAY IL27-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 7.1 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.1 6.8 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.4 3.9 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.2 3.3 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.2 1.8 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.1 1.4 REACTOME_REGULATION_OF_IFNA_SIGNALING Genes involved in Regulation of IFNA signaling
0.1 0.8 REACTOME_ACYL_CHAIN_REMODELLING_OF_PI Genes involved in Acyl chain remodelling of PI
0.1 0.8 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.7 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 0.7 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.6 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.0 0.3 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation