Motif ID: Sox18_Sox12

Z-value: 0.913

Transcription factors associated with Sox18_Sox12:

Gene SymbolEntrez IDGene Name
Sox12 ENSMUSG00000051817.8 Sox12
Sox18 ENSMUSG00000046470.5 Sox18

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox18mm10_v2_chr2_-_181671622_181671645-0.225.7e-02Click!
Sox12mm10_v2_chr2_-_152398046_152398076-0.217.3e-02Click!


Activity profile for motif Sox18_Sox12.

activity profile for motif Sox18_Sox12


Sorted Z-values histogram for motif Sox18_Sox12

Sorted Z-values for motif Sox18_Sox12



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox18_Sox12

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_+_14063776 6.428 ENSMUST00000129488.1
ENSMUST00000110536.1
ENSMUST00000110534.1
ENSMUST00000039538.8
ENSMUST00000110533.1
 Arid4b




AT rich interactive domain 4B (RBP1-like)




chr10_-_62792243 4.953 ENSMUST00000020268.5
 Ccar1
cell division cycle and apoptosis regulator 1
chr2_+_176236860 4.909 ENSMUST00000166464.1
 2210418O10Rik
RIKEN cDNA 2210418O10 gene
chr2_+_55411790 4.781 ENSMUST00000155997.1
ENSMUST00000128307.1
 Gm14033

predicted gene 14033

chr6_-_23248264 4.761 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr1_+_55406163 4.683 ENSMUST00000042986.8
 Plcl1
phospholipase C-like 1
chr11_-_11970540 4.370 ENSMUST00000109653.1
 Grb10
growth factor receptor bound protein 10
chr8_-_67910911 4.319 ENSMUST00000093468.5
 Psd3
pleckstrin and Sec7 domain containing 3
chr18_-_88927447 4.121 ENSMUST00000147313.1
 Socs6
suppressor of cytokine signaling 6
chrX_+_106920618 4.022 ENSMUST00000060576.7
 Lpar4
lysophosphatidic acid receptor 4
chr16_-_63864114 3.767 ENSMUST00000064405.6
 Epha3
Eph receptor A3
chr2_+_102706356 3.630 ENSMUST00000123759.1
ENSMUST00000111212.1
ENSMUST00000005220.4
 Slc1a2


solute carrier family 1 (glial high affinity glutamate transporter), member 2


chr2_-_59948155 3.593 ENSMUST00000153136.1
 Baz2b
bromodomain adjacent to zinc finger domain, 2B
chr7_+_127800604 3.483 ENSMUST00000046863.5
ENSMUST00000106272.1
ENSMUST00000139068.1
 Hsd3b7


hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7


chr16_-_91618986 3.479 ENSMUST00000143058.1
ENSMUST00000049244.8
ENSMUST00000169982.1
ENSMUST00000133731.1
 Dnajc28



DnaJ (Hsp40) homolog, subfamily C, member 28



chr16_-_50330987 3.409 ENSMUST00000114488.1
 Bbx
bobby sox homolog (Drosophila)
chr14_+_62837679 3.315 ENSMUST00000014691.8
 Wdfy2
WD repeat and FYVE domain containing 2
chr14_-_100149764 3.309 ENSMUST00000097079.4
 Klf12
Kruppel-like factor 12
chr14_-_47418407 3.295 ENSMUST00000043296.3
 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr18_+_11633276 3.128 ENSMUST00000115861.2
 Rbbp8
retinoblastoma binding protein 8

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 112 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 6.7 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
1.1 6.4 GO:0034773 histone H4-K20 trimethylation(GO:0034773) establishment of Sertoli cell barrier(GO:0097368)
0.1 5.7 GO:0051028 mRNA transport(GO:0051028)
0.1 5.6 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.5 4.9 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.8 4.8 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.2 4.7 GO:0070207 protein homotrimerization(GO:0070207)
0.4 4.5 GO:0042118 endothelial cell activation(GO:0042118)
0.5 4.4 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.2 4.3 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 4.3 GO:0050868 negative regulation of T cell activation(GO:0050868)
1.3 3.8 GO:0097155 fasciculation of sensory neuron axon(GO:0097155)
0.8 3.8 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.7 3.7 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.5 3.5 GO:0035754 B cell chemotaxis(GO:0035754)
0.3 3.5 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.2 3.5 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.1 3.3 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.0 3.2 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.5 3.1 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.9 GO:0070469 respiratory chain(GO:0070469)
0.2 6.7 GO:0030673 axolemma(GO:0030673)
0.1 6.7 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.4 5.5 GO:0035631 CD40 receptor complex(GO:0035631)
0.3 4.9 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 4.9 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
1.2 4.7 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 4.6 GO:0032993 protein-DNA complex(GO:0032993)
0.1 4.0 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 4.0 GO:0005814 centriole(GO:0005814)
0.1 3.7 GO:0001772 immunological synapse(GO:0001772)
0.2 3.5 GO:0017119 Golgi transport complex(GO:0017119)
0.0 3.5 GO:0005884 actin filament(GO:0005884)
0.2 3.3 GO:0031616 spindle pole centrosome(GO:0031616)
0.7 3.0 GO:0099569 presynaptic cytoskeleton(GO:0099569)
0.1 2.9 GO:0051233 spindle midzone(GO:0051233)
0.2 2.8 GO:0005641 nuclear envelope lumen(GO:0005641)
0.1 2.8 GO:0035861 site of double-strand break(GO:0035861)
0.0 2.8 GO:0072686 mitotic spindle(GO:0072686)
0.2 2.6 GO:0042788 polysomal ribosome(GO:0042788)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 84 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 9.3 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 7.8 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
1.1 6.7 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 5.9 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 5.8 GO:0000975 regulatory region DNA binding(GO:0000975) transcription regulatory region DNA binding(GO:0044212)
0.8 5.7 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.4 4.7 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
1.1 4.5 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 4.5 GO:1990782 protein tyrosine kinase binding(GO:1990782)
0.1 4.4 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.2 4.3 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 3.9 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 3.9 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.5 3.8 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.5 3.6 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.6 3.5 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.0 3.5 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
1.0 3.1 GO:0016160 alpha-amylase activity(GO:0004556) amylase activity(GO:0016160)
0.3 3.1 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.2 3.1 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.6 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.2 5.5 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.2 4.7 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 4.5 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 4.1 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.2 4.0 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 3.8 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.1 3.2 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 3.1 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.1 2.8 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 2.7 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 2.4 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 2.2 ST_GA13_PATHWAY G alpha 13 Pathway
0.0 2.2 PID_LKB1_PATHWAY LKB1 signaling events
0.1 2.1 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.2 1.6 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 1.6 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 1.4 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.1 1.2 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 1.2 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.3 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.4 5.2 REACTOME_IRAK1_RECRUITS_IKK_COMPLEX Genes involved in IRAK1 recruits IKK complex
0.1 5.2 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 5.0 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.8 4.7 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.6 4.4 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.2 4.1 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.2 4.1 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.4 4.0 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 3.8 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 2.8 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.0 2.6 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.2 2.5 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.1 2.5 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 2.4 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.0 2.2 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.1 2.1 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.2 2.0 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 2.0 REACTOME_DIABETES_PATHWAYS Genes involved in Diabetes pathways
0.1 1.9 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle