Motif ID: Sox18_Sox12
Z-value: 0.913
Transcription factors associated with Sox18_Sox12:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Sox12 | ENSMUSG00000051817.8 | Sox12 |
| Sox18 | ENSMUSG00000046470.5 | Sox18 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Sox18 | mm10_v2_chr2_-_181671622_181671645 | -0.22 | 5.7e-02 | Click! |
| Sox12 | mm10_v2_chr2_-_152398046_152398076 | -0.21 | 7.3e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 3.8 | GO:0097155 | fasciculation of sensory neuron axon(GO:0097155) |
| 1.1 | 6.4 | GO:0034773 | histone H4-K20 trimethylation(GO:0034773) establishment of Sertoli cell barrier(GO:0097368) |
| 1.0 | 3.0 | GO:0098928 | presynaptic signal transduction(GO:0098928) presynapse to nucleus signaling pathway(GO:0099526) |
| 1.0 | 6.7 | GO:0070779 | D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
| 0.8 | 4.8 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
| 0.8 | 3.8 | GO:1900122 | positive regulation of receptor binding(GO:1900122) |
| 0.7 | 3.7 | GO:0010792 | DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) |
| 0.7 | 2.9 | GO:0021698 | cerebellar cortex structural organization(GO:0021698) |
| 0.7 | 2.1 | GO:0021972 | corticospinal neuron axon guidance through spinal cord(GO:0021972) positive regulation of negative chemotaxis(GO:0050924) induction of negative chemotaxis(GO:0050929) negative regulation of mononuclear cell migration(GO:0071676) negative regulation of retinal ganglion cell axon guidance(GO:0090260) |
| 0.7 | 2.0 | GO:0001869 | regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869) |
| 0.6 | 2.5 | GO:0072362 | regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter(GO:0072362) |
| 0.6 | 1.7 | GO:0042320 | regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938) |
| 0.5 | 4.9 | GO:0098789 | pre-mRNA cleavage required for polyadenylation(GO:0098789) |
| 0.5 | 2.7 | GO:1903347 | negative regulation of bicellular tight junction assembly(GO:1903347) |
| 0.5 | 3.1 | GO:0071883 | activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883) |
| 0.5 | 3.5 | GO:0035754 | B cell chemotaxis(GO:0035754) |
| 0.5 | 1.5 | GO:0045410 | positive regulation of interleukin-6 biosynthetic process(GO:0045410) |
| 0.5 | 2.4 | GO:0071894 | histone H2B conserved C-terminal lysine ubiquitination(GO:0071894) |
| 0.5 | 4.4 | GO:0070874 | negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874) |
| 0.5 | 1.8 | GO:0006742 | NADP catabolic process(GO:0006742) pyridine nucleotide catabolic process(GO:0019364) |
| 0.4 | 1.3 | GO:1902527 | positive regulation of protein K48-linked ubiquitination(GO:1902524) positive regulation of protein monoubiquitination(GO:1902527) |
| 0.4 | 2.5 | GO:0048840 | otolith development(GO:0048840) |
| 0.4 | 4.5 | GO:0042118 | endothelial cell activation(GO:0042118) |
| 0.4 | 1.2 | GO:0060743 | epithelial cell maturation involved in prostate gland development(GO:0060743) |
| 0.4 | 1.6 | GO:0021812 | neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812) |
| 0.4 | 1.9 | GO:0006537 | glutamate biosynthetic process(GO:0006537) glutamine catabolic process(GO:0006543) |
| 0.4 | 1.1 | GO:0046381 | CMP-N-acetylneuraminate metabolic process(GO:0046381) |
| 0.3 | 2.4 | GO:1902965 | regulation of protein localization to early endosome(GO:1902965) positive regulation of protein localization to early endosome(GO:1902966) |
| 0.3 | 1.7 | GO:0021764 | amygdala development(GO:0021764) |
| 0.3 | 0.9 | GO:0097089 | methyl-branched fatty acid metabolic process(GO:0097089) |
| 0.3 | 1.2 | GO:1904694 | negative regulation of vascular smooth muscle contraction(GO:1904694) |
| 0.3 | 3.5 | GO:0000301 | retrograde transport, vesicle recycling within Golgi(GO:0000301) |
| 0.3 | 1.4 | GO:0018076 | N-terminal peptidyl-lysine acetylation(GO:0018076) |
| 0.3 | 2.0 | GO:0060903 | positive regulation of meiosis I(GO:0060903) |
| 0.3 | 2.4 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.3 | 0.8 | GO:2000409 | positive regulation of T cell extravasation(GO:2000409) |
| 0.3 | 1.3 | GO:0033762 | response to glucagon(GO:0033762) |
| 0.2 | 2.2 | GO:0000729 | DNA double-strand break processing(GO:0000729) |
| 0.2 | 1.1 | GO:1902995 | apolipoprotein A-I-mediated signaling pathway(GO:0038027) regulation of phospholipid efflux(GO:1902994) positive regulation of phospholipid efflux(GO:1902995) positive regulation of apoptotic cell clearance(GO:2000427) |
| 0.2 | 2.0 | GO:0030035 | microspike assembly(GO:0030035) |
| 0.2 | 1.3 | GO:0030643 | cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502) |
| 0.2 | 1.1 | GO:0046684 | response to pyrethroid(GO:0046684) |
| 0.2 | 0.8 | GO:0033326 | cerebrospinal fluid secretion(GO:0033326) |
| 0.2 | 1.6 | GO:0097264 | self proteolysis(GO:0097264) |
| 0.2 | 4.7 | GO:0070207 | protein homotrimerization(GO:0070207) |
| 0.2 | 1.1 | GO:0034145 | positive regulation of toll-like receptor 4 signaling pathway(GO:0034145) |
| 0.2 | 0.9 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.2 | 0.7 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.2 | 4.3 | GO:0032011 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
| 0.2 | 1.8 | GO:0060575 | intestinal epithelial cell differentiation(GO:0060575) |
| 0.2 | 3.5 | GO:0051482 | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482) |
| 0.2 | 1.0 | GO:0003406 | retinal pigment epithelium development(GO:0003406) |
| 0.2 | 1.4 | GO:0006020 | inositol metabolic process(GO:0006020) |
| 0.1 | 2.2 | GO:0033129 | positive regulation of histone phosphorylation(GO:0033129) |
| 0.1 | 2.5 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.1 | 5.6 | GO:0042773 | ATP synthesis coupled electron transport(GO:0042773) |
| 0.1 | 0.7 | GO:1903361 | protein localization to basolateral plasma membrane(GO:1903361) |
| 0.1 | 0.5 | GO:0090126 | protein complex assembly involved in synapse maturation(GO:0090126) |
| 0.1 | 0.7 | GO:0071267 | amino acid salvage(GO:0043102) L-methionine salvage(GO:0071267) |
| 0.1 | 2.3 | GO:0015693 | magnesium ion transport(GO:0015693) |
| 0.1 | 1.2 | GO:0031118 | rRNA pseudouridine synthesis(GO:0031118) |
| 0.1 | 0.8 | GO:0048702 | embryonic neurocranium morphogenesis(GO:0048702) axis elongation involved in somitogenesis(GO:0090245) |
| 0.1 | 0.6 | GO:0071947 | protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947) |
| 0.1 | 0.4 | GO:0072137 | condensed mesenchymal cell proliferation(GO:0072137) |
| 0.1 | 0.3 | GO:0060382 | regulation of DNA strand elongation(GO:0060382) |
| 0.1 | 0.8 | GO:0090400 | stress-induced premature senescence(GO:0090400) |
| 0.1 | 1.0 | GO:0019368 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
| 0.1 | 0.7 | GO:0010825 | positive regulation of centrosome duplication(GO:0010825) |
| 0.1 | 0.4 | GO:0036518 | chemorepulsion of dopaminergic neuron axon(GO:0036518) |
| 0.1 | 0.5 | GO:0071699 | olfactory placode formation(GO:0030910) diencephalon morphogenesis(GO:0048852) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699) |
| 0.1 | 2.5 | GO:0032467 | positive regulation of cytokinesis(GO:0032467) |
| 0.1 | 2.9 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.1 | 0.7 | GO:0002318 | myeloid progenitor cell differentiation(GO:0002318) |
| 0.1 | 1.6 | GO:0043984 | histone H4-K16 acetylation(GO:0043984) |
| 0.1 | 2.0 | GO:0031954 | positive regulation of protein autophosphorylation(GO:0031954) |
| 0.1 | 0.8 | GO:0045066 | regulatory T cell differentiation(GO:0045066) regulation of regulatory T cell differentiation(GO:0045589) |
| 0.1 | 0.6 | GO:1990845 | adaptive thermogenesis(GO:1990845) |
| 0.1 | 0.4 | GO:1900246 | positive regulation of RIG-I signaling pathway(GO:1900246) |
| 0.1 | 1.1 | GO:0016973 | poly(A)+ mRNA export from nucleus(GO:0016973) |
| 0.1 | 1.7 | GO:0015985 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 0.1 | 3.3 | GO:0045600 | positive regulation of fat cell differentiation(GO:0045600) |
| 0.1 | 0.5 | GO:1902916 | positive regulation of protein polyubiquitination(GO:1902916) |
| 0.1 | 4.3 | GO:0050868 | negative regulation of T cell activation(GO:0050868) |
| 0.1 | 0.3 | GO:0038032 | termination of G-protein coupled receptor signaling pathway(GO:0038032) |
| 0.1 | 5.7 | GO:0051028 | mRNA transport(GO:0051028) |
| 0.0 | 0.6 | GO:0045723 | positive regulation of fatty acid biosynthetic process(GO:0045723) |
| 0.0 | 3.2 | GO:0051489 | regulation of filopodium assembly(GO:0051489) |
| 0.0 | 1.0 | GO:0006308 | DNA catabolic process(GO:0006308) |
| 0.0 | 0.3 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.0 | 0.2 | GO:1902775 | mitochondrial large ribosomal subunit assembly(GO:1902775) |
| 0.0 | 0.7 | GO:0009083 | branched-chain amino acid catabolic process(GO:0009083) |
| 0.0 | 0.8 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.0 | 1.9 | GO:0002066 | columnar/cuboidal epithelial cell development(GO:0002066) |
| 0.0 | 0.7 | GO:0008090 | retrograde axonal transport(GO:0008090) |
| 0.0 | 0.7 | GO:0033194 | response to hydroperoxide(GO:0033194) |
| 0.0 | 1.2 | GO:2000279 | negative regulation of DNA biosynthetic process(GO:2000279) |
| 0.0 | 2.6 | GO:0043488 | regulation of mRNA stability(GO:0043488) |
| 0.0 | 1.0 | GO:0000186 | activation of MAPKK activity(GO:0000186) |
| 0.0 | 0.1 | GO:0045852 | regulation of integrin biosynthetic process(GO:0045113) pH elevation(GO:0045852) intracellular pH elevation(GO:0051454) |
| 0.0 | 0.4 | GO:0047497 | establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497) |
| 0.0 | 0.1 | GO:2000659 | regulation of interleukin-1-mediated signaling pathway(GO:2000659) |
| 0.0 | 3.1 | GO:0016052 | carbohydrate catabolic process(GO:0016052) |
| 0.0 | 0.9 | GO:0006284 | base-excision repair(GO:0006284) |
| 0.0 | 1.4 | GO:0043966 | histone H3 acetylation(GO:0043966) |
| 0.0 | 0.8 | GO:0050919 | negative chemotaxis(GO:0050919) |
| 0.0 | 1.7 | GO:0001578 | microtubule bundle formation(GO:0001578) |
| 0.0 | 0.5 | GO:0034508 | centromere complex assembly(GO:0034508) |
| 0.0 | 0.1 | GO:1900169 | regulation of glucocorticoid mediated signaling pathway(GO:1900169) |
| 0.0 | 0.3 | GO:0071157 | negative regulation of cell cycle arrest(GO:0071157) |
| 0.0 | 0.2 | GO:0045653 | negative regulation of megakaryocyte differentiation(GO:0045653) |
| 0.0 | 0.3 | GO:0046677 | response to antibiotic(GO:0046677) |
| 0.0 | 0.1 | GO:0017121 | phospholipid scrambling(GO:0017121) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 4.7 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 0.7 | 3.0 | GO:0099569 | presynaptic cytoskeleton(GO:0099569) |
| 0.4 | 1.6 | GO:0043259 | laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259) |
| 0.4 | 5.5 | GO:0035631 | CD40 receptor complex(GO:0035631) |
| 0.3 | 1.6 | GO:0072487 | MSL complex(GO:0072487) |
| 0.3 | 4.9 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
| 0.2 | 2.2 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.2 | 2.8 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.2 | 3.5 | GO:0017119 | Golgi transport complex(GO:0017119) |
| 0.2 | 2.4 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.2 | 0.7 | GO:0031673 | H zone(GO:0031673) |
| 0.2 | 2.6 | GO:0042788 | polysomal ribosome(GO:0042788) |
| 0.2 | 6.7 | GO:0030673 | axolemma(GO:0030673) |
| 0.2 | 3.3 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.2 | 2.1 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.1 | 6.7 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.1 | 2.5 | GO:0016580 | Sin3 complex(GO:0016580) |
| 0.1 | 1.3 | GO:0045275 | respiratory chain complex III(GO:0045275) |
| 0.1 | 4.0 | GO:0044298 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
| 0.1 | 7.9 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.1 | 1.0 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 0.1 | 1.4 | GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671) |
| 0.1 | 2.9 | GO:0051233 | spindle midzone(GO:0051233) |
| 0.1 | 0.7 | GO:0097025 | MPP7-DLG1-LIN7 complex(GO:0097025) |
| 0.1 | 3.7 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.1 | 1.4 | GO:0000124 | SAGA complex(GO:0000124) |
| 0.1 | 2.8 | GO:0035861 | site of double-strand break(GO:0035861) |
| 0.1 | 1.1 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.1 | 0.2 | GO:0030934 | collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934) |
| 0.1 | 1.1 | GO:0000346 | transcription export complex(GO:0000346) |
| 0.1 | 0.8 | GO:0032156 | septin cytoskeleton(GO:0032156) |
| 0.0 | 2.4 | GO:0000922 | spindle pole(GO:0000922) |
| 0.0 | 0.3 | GO:0070187 | telosome(GO:0070187) |
| 0.0 | 2.8 | GO:0072686 | mitotic spindle(GO:0072686) |
| 0.0 | 1.6 | GO:0016592 | mediator complex(GO:0016592) |
| 0.0 | 4.0 | GO:0005814 | centriole(GO:0005814) |
| 0.0 | 1.2 | GO:0032420 | stereocilium(GO:0032420) |
| 0.0 | 1.7 | GO:0016459 | myosin complex(GO:0016459) |
| 0.0 | 0.5 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.0 | 0.9 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) |
| 0.0 | 1.3 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 4.9 | GO:0009898 | cytoplasmic side of plasma membrane(GO:0009898) |
| 0.0 | 4.6 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.0 | 3.5 | GO:0005884 | actin filament(GO:0005884) |
| 0.0 | 1.9 | GO:0030496 | midbody(GO:0030496) |
| 0.0 | 0.1 | GO:0071438 | invadopodium membrane(GO:0071438) |
| 0.0 | 0.7 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.0 | 0.7 | GO:0097546 | ciliary base(GO:0097546) |
| 0.0 | 0.7 | GO:0019897 | extrinsic component of plasma membrane(GO:0019897) |
| 0.0 | 0.4 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
| 0.0 | 1.1 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 1.2 | GO:0000776 | kinetochore(GO:0000776) |
| 0.0 | 0.8 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.0 | 0.9 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 4.5 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 1.1 | 6.7 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 1.0 | 3.1 | GO:0016160 | alpha-amylase activity(GO:0004556) amylase activity(GO:0016160) |
| 0.9 | 2.7 | GO:0008384 | IkappaB kinase activity(GO:0008384) |
| 0.8 | 5.7 | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity(GO:0004726) |
| 0.6 | 3.5 | GO:0003854 | 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854) |
| 0.5 | 3.6 | GO:0035727 | lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915) |
| 0.5 | 3.8 | GO:0005004 | GPI-linked ephrin receptor activity(GO:0005004) |
| 0.5 | 1.8 | GO:0035529 | NADH pyrophosphatase activity(GO:0035529) |
| 0.4 | 1.3 | GO:0098770 | FBXO family protein binding(GO:0098770) |
| 0.4 | 1.2 | GO:0038052 | RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052) |
| 0.4 | 1.1 | GO:0030226 | apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556) |
| 0.4 | 1.9 | GO:0004359 | glutaminase activity(GO:0004359) |
| 0.4 | 4.7 | GO:0070679 | inositol 1,4,5 trisphosphate binding(GO:0070679) |
| 0.4 | 1.1 | GO:0016716 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716) |
| 0.3 | 1.4 | GO:0000832 | inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724) |
| 0.3 | 1.7 | GO:0004839 | ubiquitin activating enzyme activity(GO:0004839) |
| 0.3 | 1.3 | GO:0047389 | glycerophosphocholine phosphodiesterase activity(GO:0047389) |
| 0.3 | 9.3 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.3 | 2.5 | GO:0035033 | histone deacetylase regulator activity(GO:0035033) |
| 0.3 | 3.1 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.3 | 2.2 | GO:0005519 | cytoskeletal regulatory protein binding(GO:0005519) |
| 0.3 | 2.1 | GO:0048495 | GTPase inhibitor activity(GO:0005095) Roundabout binding(GO:0048495) |
| 0.2 | 1.4 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
| 0.2 | 0.9 | GO:0000700 | mismatch base pair DNA N-glycosylase activity(GO:0000700) |
| 0.2 | 1.1 | GO:0004719 | protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719) |
| 0.2 | 3.1 | GO:0000014 | single-stranded DNA endodeoxyribonuclease activity(GO:0000014) |
| 0.2 | 1.6 | GO:0043208 | glycosphingolipid binding(GO:0043208) |
| 0.2 | 1.2 | GO:0061649 | ubiquitinated histone binding(GO:0061649) |
| 0.2 | 1.4 | GO:0001075 | transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075) |
| 0.2 | 1.3 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 0.2 | 2.5 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.2 | 4.3 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.2 | 0.8 | GO:0070330 | aromatase activity(GO:0070330) |
| 0.1 | 0.6 | GO:0017077 | oxidative phosphorylation uncoupler activity(GO:0017077) |
| 0.1 | 5.9 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.1 | 0.7 | GO:0008172 | S-methyltransferase activity(GO:0008172) |
| 0.1 | 1.5 | GO:0031996 | thioesterase binding(GO:0031996) |
| 0.1 | 2.3 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.1 | 4.4 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.1 | 0.7 | GO:0097016 | L27 domain binding(GO:0097016) |
| 0.1 | 0.4 | GO:0005522 | profilin binding(GO:0005522) |
| 0.1 | 0.3 | GO:1990955 | G-rich single-stranded DNA binding(GO:1990955) |
| 0.1 | 1.0 | GO:0009922 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
| 0.1 | 2.9 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.1 | 1.7 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.1 | 1.0 | GO:0016888 | endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888) |
| 0.1 | 1.7 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.1 | 0.9 | GO:0031957 | fatty acid transporter activity(GO:0015245) very long-chain fatty acid-CoA ligase activity(GO:0031957) |
| 0.1 | 2.4 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
| 0.1 | 1.5 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.1 | 4.5 | GO:1990782 | protein tyrosine kinase binding(GO:1990782) |
| 0.1 | 2.4 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.1 | 2.6 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.1 | 1.2 | GO:0009982 | pseudouridine synthase activity(GO:0009982) |
| 0.1 | 0.6 | GO:1990380 | Lys48-specific deubiquitinase activity(GO:1990380) |
| 0.1 | 3.9 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.1 | 0.8 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
| 0.1 | 1.1 | GO:0031402 | sodium ion binding(GO:0031402) |
| 0.0 | 2.8 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.0 | 0.5 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 0.0 | 0.5 | GO:0035198 | miRNA binding(GO:0035198) |
| 0.0 | 1.0 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 0.2 | GO:0047184 | 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184) |
| 0.0 | 1.3 | GO:0008028 | monocarboxylic acid transmembrane transporter activity(GO:0008028) |
| 0.0 | 0.8 | GO:0046966 | thyroid hormone receptor binding(GO:0046966) |
| 0.0 | 0.3 | GO:0004128 | cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128) |
| 0.0 | 2.0 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.0 | 0.1 | GO:0030171 | voltage-gated proton channel activity(GO:0030171) |
| 0.0 | 0.8 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.0 | 0.7 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.0 | 5.8 | GO:0000975 | regulatory region DNA binding(GO:0000975) transcription regulatory region DNA binding(GO:0044212) |
| 0.0 | 7.8 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.0 | 2.1 | GO:0015078 | hydrogen ion transmembrane transporter activity(GO:0015078) |
| 0.0 | 1.1 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 2.1 | GO:0051117 | ATPase binding(GO:0051117) |
| 0.0 | 3.9 | GO:0004721 | phosphoprotein phosphatase activity(GO:0004721) |
| 0.0 | 2.0 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 0.4 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.0 | 1.6 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
| 0.0 | 0.6 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.0 | 3.5 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.0 | 0.5 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.0 | 0.2 | GO:0004385 | guanylate kinase activity(GO:0004385) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.0 | PID_LPA4_PATHWAY | LPA4-mediated signaling events |
| 0.2 | 1.6 | PID_INTEGRIN4_PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.2 | 5.5 | PID_NFKAPPAB_CANONICAL_PATHWAY | Canonical NF-kappaB pathway |
| 0.2 | 4.7 | PID_IL12_STAT4_PATHWAY | IL12 signaling mediated by STAT4 |
| 0.1 | 3.8 | PID_EPHA_FWDPATHWAY | EPHA forward signaling |
| 0.1 | 2.1 | PID_GLYPICAN_1PATHWAY | Glypican 1 network |
| 0.1 | 5.6 | PID_HES_HEY_PATHWAY | Notch-mediated HES/HEY network |
| 0.1 | 4.1 | PID_RET_PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.1 | 1.2 | PID_ERB_GENOMIC_PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.1 | 2.8 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
| 0.1 | 3.2 | PID_AURORA_A_PATHWAY | Aurora A signaling |
| 0.1 | 1.6 | SA_PTEN_PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.1 | 0.8 | PID_SMAD2_3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.1 | 2.2 | ST_GA13_PATHWAY | G alpha 13 Pathway |
| 0.1 | 3.1 | PID_THROMBIN_PAR1_PATHWAY | PAR1-mediated thrombin signaling events |
| 0.1 | 4.5 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 2.7 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 1.4 | PID_RETINOIC_ACID_PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.0 | 1.0 | ST_JNK_MAPK_PATHWAY | JNK MAPK Pathway |
| 0.0 | 0.8 | SIG_CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.0 | 2.2 | PID_LKB1_PATHWAY | LKB1 signaling events |
| 0.0 | 0.4 | PID_INSULIN_GLUCOSE_PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 0.9 | PID_AURORA_B_PATHWAY | Aurora B signaling |
| 0.0 | 2.4 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 0.7 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 0.7 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 0.4 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
| 0.0 | 1.2 | PID_PDGFRB_PATHWAY | PDGFR-beta signaling pathway |
| 0.0 | 0.8 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 4.7 | REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.6 | 4.4 | REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.4 | 4.0 | REACTOME_P2Y_RECEPTORS | Genes involved in P2Y receptors |
| 0.4 | 5.2 | REACTOME_IRAK1_RECRUITS_IKK_COMPLEX | Genes involved in IRAK1 recruits IKK complex |
| 0.2 | 4.1 | REACTOME_REGULATION_OF_KIT_SIGNALING | Genes involved in Regulation of KIT signaling |
| 0.2 | 2.0 | REACTOME_INTRINSIC_PATHWAY | Genes involved in Intrinsic Pathway |
| 0.2 | 4.1 | REACTOME_SIGNAL_ATTENUATION | Genes involved in Signal attenuation |
| 0.2 | 2.5 | REACTOME_PLATELET_CALCIUM_HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.2 | 6.3 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 2.1 | REACTOME_ACTIVATION_OF_RAC | Genes involved in Activation of Rac |
| 0.1 | 1.9 | REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.1 | 1.8 | REACTOME_NOD1_2_SIGNALING_PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.1 | 5.2 | REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.1 | 2.5 | REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.1 | 1.4 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.1 | 0.9 | REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 0.1 | 1.8 | REACTOME_HS_GAG_DEGRADATION | Genes involved in HS-GAG degradation |
| 0.1 | 2.8 | REACTOME_NETRIN1_SIGNALING | Genes involved in Netrin-1 signaling |
| 0.1 | 1.1 | REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.1 | 2.4 | REACTOME_RECYCLING_PATHWAY_OF_L1 | Genes involved in Recycling pathway of L1 |
| 0.0 | 3.8 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 1.2 | REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.0 | 1.0 | REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.0 | 1.5 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 5.0 | REACTOME_MRNA_SPLICING | Genes involved in mRNA Splicing |
| 0.0 | 2.6 | REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.0 | 0.7 | REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 2.2 | REACTOME_MEIOTIC_RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.0 | 1.7 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.0 | 1.6 | REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.0 | 2.0 | REACTOME_DIABETES_PATHWAYS | Genes involved in Diabetes pathways |
| 0.0 | 1.9 | REACTOME_GENERIC_TRANSCRIPTION_PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.0 | 1.2 | REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 0.3 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 1.1 | REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
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