Motif ID: Sox2

Z-value: 3.633


Transcription factors associated with Sox2:

Gene SymbolEntrez IDGene Name
Sox2 ENSMUSG00000074637.4 Sox2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox2mm10_v2_chr3_+_34649987_346500050.536.2e-07Click!


Activity profile for motif Sox2.

activity profile for motif Sox2


Sorted Z-values histogram for motif Sox2

Sorted Z-values for motif Sox2



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_45216671 85.409 ENSMUST00000134420.1
 Tead2
TEA domain family member 2
chr7_-_115824699 68.435 ENSMUST00000169129.1
 Sox6
SRY-box containing gene 6
chr1_-_138842429 67.044 ENSMUST00000112026.2
ENSMUST00000019374.7
 Lhx9

LIM homeobox protein 9

chr7_-_49636847 65.460 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr7_-_116038734 61.110 ENSMUST00000166877.1
 Sox6
SRY-box containing gene 6
chr11_+_119022962 55.239 ENSMUST00000026662.7
 Cbx2
chromobox 2
chr1_+_6734827 51.871 ENSMUST00000139838.1
 St18
suppression of tumorigenicity 18
chr9_+_118478851 51.115 ENSMUST00000150633.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr9_+_118478344 48.304 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)
chr5_-_98030727 44.629 ENSMUST00000031281.9
 Antxr2
anthrax toxin receptor 2
chr17_-_70851189 42.989 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr17_-_35704000 42.055 ENSMUST00000097333.3
ENSMUST00000003628.6
 Ddr1

discoidin domain receptor family, member 1

chr1_+_6487231 42.034 ENSMUST00000140079.1
ENSMUST00000131494.1
 St18

suppression of tumorigenicity 18

chr17_-_35703971 41.710 ENSMUST00000148065.1
 Ddr1
discoidin domain receptor family, member 1
chr7_+_45215753 41.646 ENSMUST00000033060.6
ENSMUST00000155313.1
ENSMUST00000107801.1
 Tead2


TEA domain family member 2


chr11_-_114795888 41.348 ENSMUST00000000206.3
 Btbd17
BTB (POZ) domain containing 17
chr2_+_181763315 40.836 ENSMUST00000081125.4
 Myt1
myelin transcription factor 1
chr2_+_156840966 40.477 ENSMUST00000109564.1
 Tgif2
TGFB-induced factor homeobox 2
chr15_+_25622525 39.983 ENSMUST00000110457.1
ENSMUST00000137601.1
 Myo10

myosin X

chr3_-_75956888 38.541 ENSMUST00000038563.7
ENSMUST00000167078.1
ENSMUST00000117242.1
 Golim4


golgi integral membrane protein 4



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 439 entries
Log-likelihood per target Total log-likelihoodTermDescription
15.9 175.1 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
7.5 165.6 GO:0048368 lateral mesoderm development(GO:0048368)
11.7 140.8 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
11.4 136.9 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
8.4 134.4 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
33.1 99.4 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
8.8 97.2 GO:0060539 diaphragm development(GO:0060539)
4.0 83.0 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
13.4 67.0 GO:0035262 gonad morphogenesis(GO:0035262)
0.5 65.7 GO:0006261 DNA-dependent DNA replication(GO:0006261)
5.5 65.5 GO:0035881 amacrine cell differentiation(GO:0035881)
4.4 65.5 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
9.1 54.8 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
2.9 48.9 GO:0071850 mitotic cell cycle arrest(GO:0071850)
2.7 48.7 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
3.8 46.2 GO:0070933 histone H4 deacetylation(GO:0070933)
15.0 45.0 GO:0003349 epicardium-derived cardiac endothelial cell differentiation(GO:0003349)
11.1 44.4 GO:0090235 regulation of metaphase plate congression(GO:0090235)
6.2 43.2 GO:0038092 nodal signaling pathway(GO:0038092)
1.8 42.4 GO:0042462 eye photoreceptor cell development(GO:0042462)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 178 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 345.3 GO:0005667 transcription factor complex(GO:0005667)
0.1 205.2 GO:0005654 nucleoplasm(GO:0005654)
0.1 205.2 GO:0005634 nucleus(GO:0005634)
1.3 198.1 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
1.3 178.7 GO:0032993 protein-DNA complex(GO:0032993)
42.4 127.1 GO:0071149 TEAD-2-YAP complex(GO:0071149)
4.5 80.3 GO:0035102 PRC1 complex(GO:0035102)
1.2 73.0 GO:0017053 transcriptional repressor complex(GO:0017053)
0.3 70.2 GO:0043235 receptor complex(GO:0043235)
1.0 63.6 GO:0016459 myosin complex(GO:0016459)
15.9 63.4 GO:0008623 CHRAC(GO:0008623)
0.6 61.4 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 59.7 GO:0005730 nucleolus(GO:0005730)
0.3 56.8 GO:0005815 microtubule organizing center(GO:0005815)
4.3 55.3 GO:0043219 lateral loop(GO:0043219)
0.7 53.6 GO:0001669 acrosomal vesicle(GO:0001669)
0.9 53.0 GO:0005871 kinesin complex(GO:0005871)
4.7 51.6 GO:1990907 beta-catenin-TCF complex(GO:1990907)
2.7 47.8 GO:0032156 septin cytoskeleton(GO:0032156)
9.3 46.6 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 269 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 378.0 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.3 376.8 GO:0003677 DNA binding(GO:0003677)
1.5 245.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
3.4 202.3 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
8.9 168.4 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
16.8 151.1 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.9 98.6 GO:0003774 motor activity(GO:0003774)
1.0 74.1 GO:0035064 methylated histone binding(GO:0035064)
3.7 70.4 GO:0035497 cAMP response element binding(GO:0035497)
3.8 64.6 GO:0070410 co-SMAD binding(GO:0070410)
5.2 57.0 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
2.4 48.4 GO:0030215 semaphorin receptor binding(GO:0030215)
9.3 46.6 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
7.1 42.9 GO:0070644 vitamin D response element binding(GO:0070644)
2.4 40.3 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
1.5 39.8 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
1.1 39.5 GO:0031492 nucleosomal DNA binding(GO:0031492)
1.1 38.6 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
2.1 38.4 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
1.4 38.4 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 74 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 117.3 PID_IL12_2PATHWAY IL12-mediated signaling events
1.0 83.7 PID_E2F_PATHWAY E2F transcription factor network
1.1 81.6 PID_CMYB_PATHWAY C-MYB transcription factor network
1.3 59.4 PID_AURORA_B_PATHWAY Aurora B signaling
1.3 58.8 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.9 56.4 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
1.0 54.6 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.8 52.8 PID_NOTCH_PATHWAY Notch signaling pathway
0.9 47.5 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.3 44.6 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
1.0 40.6 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
2.6 37.0 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.6 34.7 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
1.3 33.2 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
2.0 32.7 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.6 31.6 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.7 29.5 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.9 29.4 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.8 28.3 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.9 27.9 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 102 entries
Log-likelihood per target Total log-likelihoodTermDescription
6.3 193.8 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
3.0 114.1 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.7 80.8 REACTOME_MEIOSIS Genes involved in Meiosis
1.5 50.4 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.2 49.2 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
3.1 46.6 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
1.8 46.5 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
1.1 42.4 REACTOME_MYOGENESIS Genes involved in Myogenesis
1.9 40.4 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
1.8 36.5 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
4.3 34.5 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.8 33.3 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
3.6 32.3 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
1.1 29.8 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
2.5 29.7 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
1.9 26.9 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules
0.4 26.5 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
1.0 26.4 REACTOME_KINESINS Genes involved in Kinesins
0.3 26.1 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
2.1 25.8 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling