Motif ID: Sox21
Z-value: 0.586
Transcription factors associated with Sox21:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Sox21 | ENSMUSG00000061517.7 | Sox21 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Sox21 | mm10_v2_chr14_-_118237016_118237035 | 0.28 | 1.3e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 3.6 | GO:0043988 | histone H3-S28 phosphorylation(GO:0043988) |
| 0.9 | 2.7 | GO:0060489 | orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490) |
| 0.7 | 3.7 | GO:0033762 | response to glucagon(GO:0033762) |
| 0.6 | 5.4 | GO:0001842 | neural fold formation(GO:0001842) |
| 0.6 | 1.7 | GO:0009814 | defense response, incompatible interaction(GO:0009814) |
| 0.5 | 4.8 | GO:0098700 | neurotransmitter loading into synaptic vesicle(GO:0098700) |
| 0.4 | 3.9 | GO:0048934 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 0.3 | 1.0 | GO:0021649 | vestibulocochlear nerve structural organization(GO:0021649) ganglion morphogenesis(GO:0061552) dorsal root ganglion morphogenesis(GO:1904835) |
| 0.3 | 3.1 | GO:0071285 | cellular response to lithium ion(GO:0071285) |
| 0.3 | 1.9 | GO:1990564 | protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592) |
| 0.3 | 2.1 | GO:0070863 | positive regulation of protein exit from endoplasmic reticulum(GO:0070863) |
| 0.3 | 0.9 | GO:0070649 | formin-nucleated actin cable assembly(GO:0070649) |
| 0.2 | 2.0 | GO:0031914 | negative regulation of synaptic plasticity(GO:0031914) |
| 0.2 | 0.6 | GO:0044028 | DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029) |
| 0.2 | 1.0 | GO:0070295 | renal water absorption(GO:0070295) |
| 0.2 | 0.5 | GO:0045349 | regulation of dendritic cell cytokine production(GO:0002730) interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of interferon-beta biosynthetic process(GO:0045359) |
| 0.2 | 0.7 | GO:0070537 | histone H2A K63-linked deubiquitination(GO:0070537) |
| 0.2 | 1.0 | GO:0051461 | regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461) |
| 0.2 | 0.6 | GO:0045409 | negative regulation of interleukin-6 biosynthetic process(GO:0045409) |
| 0.1 | 0.4 | GO:0033364 | mast cell secretory granule organization(GO:0033364) |
| 0.1 | 0.3 | GO:0003345 | proepicardium cell migration involved in pericardium morphogenesis(GO:0003345) |
| 0.1 | 0.8 | GO:0032790 | ribosome disassembly(GO:0032790) |
| 0.1 | 0.6 | GO:0030950 | establishment or maintenance of actin cytoskeleton polarity(GO:0030950) |
| 0.1 | 0.4 | GO:0046909 | intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445) |
| 0.1 | 0.8 | GO:0032286 | central nervous system myelin maintenance(GO:0032286) |
| 0.1 | 1.4 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.1 | 3.1 | GO:0042773 | ATP synthesis coupled electron transport(GO:0042773) |
| 0.1 | 1.1 | GO:0045974 | miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974) |
| 0.1 | 0.9 | GO:0032460 | negative regulation of protein oligomerization(GO:0032460) negative regulation of protein homooligomerization(GO:0032463) |
| 0.1 | 0.2 | GO:0072425 | signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434) |
| 0.1 | 0.9 | GO:0006750 | glutathione biosynthetic process(GO:0006750) |
| 0.1 | 4.6 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.1 | 1.2 | GO:0045948 | positive regulation of translational initiation(GO:0045948) |
| 0.1 | 0.9 | GO:0033539 | fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539) |
| 0.0 | 0.6 | GO:2000381 | negative regulation of mesoderm development(GO:2000381) |
| 0.0 | 0.6 | GO:0015937 | coenzyme A biosynthetic process(GO:0015937) |
| 0.0 | 1.9 | GO:0006493 | protein O-linked glycosylation(GO:0006493) |
| 0.0 | 0.4 | GO:0021940 | positive regulation of cerebellar granule cell precursor proliferation(GO:0021940) |
| 0.0 | 0.1 | GO:0048014 | Tie signaling pathway(GO:0048014) |
| 0.0 | 1.0 | GO:0007271 | synaptic transmission, cholinergic(GO:0007271) |
| 0.0 | 0.1 | GO:0021529 | spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) |
| 0.0 | 1.2 | GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I(GO:0002474) |
| 0.0 | 0.4 | GO:0030539 | synaptonemal complex assembly(GO:0007130) male genitalia development(GO:0030539) |
| 0.0 | 0.5 | GO:0006491 | N-glycan processing(GO:0006491) |
| 0.0 | 3.9 | GO:0010466 | negative regulation of peptidase activity(GO:0010466) |
| 0.0 | 0.2 | GO:0045899 | positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899) |
| 0.0 | 0.7 | GO:0000132 | establishment of mitotic spindle orientation(GO:0000132) |
| 0.0 | 3.2 | GO:0002244 | hematopoietic progenitor cell differentiation(GO:0002244) |
| 0.0 | 0.1 | GO:0006621 | protein retention in ER lumen(GO:0006621) |
| 0.0 | 0.1 | GO:0015705 | iodide transport(GO:0015705) |
| 0.0 | 1.1 | GO:0007569 | cell aging(GO:0007569) |
| 0.0 | 0.1 | GO:2000096 | positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096) |
| 0.0 | 0.0 | GO:1903215 | negative regulation of protein targeting to mitochondrion(GO:1903215) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 5.4 | GO:0090537 | CERF complex(GO:0090537) |
| 0.7 | 3.6 | GO:0032133 | chromosome passenger complex(GO:0032133) |
| 0.7 | 2.7 | GO:0060187 | cell pole(GO:0060187) |
| 0.3 | 2.0 | GO:0044305 | calyx of Held(GO:0044305) |
| 0.3 | 3.7 | GO:0045275 | respiratory chain complex III(GO:0045275) |
| 0.2 | 1.0 | GO:0017071 | intracellular cyclic nucleotide activated cation channel complex(GO:0017071) |
| 0.2 | 0.6 | GO:0005943 | phosphatidylinositol 3-kinase complex, class IA(GO:0005943) |
| 0.2 | 4.8 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.2 | 11.4 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.1 | 0.7 | GO:0070531 | BRCA1-A complex(GO:0070531) |
| 0.1 | 1.1 | GO:0035068 | micro-ribonucleoprotein complex(GO:0035068) |
| 0.1 | 1.2 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.1 | 3.4 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.1 | 0.2 | GO:0070939 | Dsl1p complex(GO:0070939) |
| 0.1 | 1.2 | GO:0016460 | myosin II complex(GO:0016460) |
| 0.1 | 0.4 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.0 | 0.6 | GO:0031932 | TORC2 complex(GO:0031932) |
| 0.0 | 0.9 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 0.2 | GO:0031595 | nuclear proteasome complex(GO:0031595) |
| 0.0 | 0.7 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.0 | 0.7 | GO:0043034 | costamere(GO:0043034) |
| 0.0 | 0.2 | GO:0032797 | SMN complex(GO:0032797) |
| 0.0 | 0.9 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.0 | 1.0 | GO:0030315 | T-tubule(GO:0030315) |
| 0.0 | 1.0 | GO:0031225 | anchored component of membrane(GO:0031225) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 3.6 | GO:0035174 | histone serine kinase activity(GO:0035174) |
| 0.7 | 2.0 | GO:0001565 | phorbol ester receptor activity(GO:0001565) non-kinase phorbol ester receptor activity(GO:0001566) |
| 0.6 | 1.7 | GO:0071568 | UFM1 transferase activity(GO:0071568) |
| 0.5 | 3.7 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 0.4 | 11.4 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.3 | 0.9 | GO:0017099 | very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099) |
| 0.2 | 4.8 | GO:0005313 | L-glutamate transmembrane transporter activity(GO:0005313) |
| 0.2 | 1.0 | GO:0005052 | peroxisome matrix targeting signal-1 binding(GO:0005052) |
| 0.2 | 1.6 | GO:1990247 | N6-methyladenosine-containing RNA binding(GO:1990247) |
| 0.1 | 1.0 | GO:0015288 | porin activity(GO:0015288) |
| 0.1 | 1.0 | GO:0005021 | vascular endothelial growth factor-activated receptor activity(GO:0005021) |
| 0.1 | 1.9 | GO:0016805 | dipeptidase activity(GO:0016805) |
| 0.1 | 0.6 | GO:0004594 | pantothenate kinase activity(GO:0004594) |
| 0.1 | 1.0 | GO:0030550 | acetylcholine receptor inhibitor activity(GO:0030550) |
| 0.1 | 1.9 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.1 | 1.2 | GO:0030881 | beta-2-microglobulin binding(GO:0030881) |
| 0.1 | 3.9 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 0.6 | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813) |
| 0.1 | 3.1 | GO:0005504 | fatty acid binding(GO:0005504) |
| 0.1 | 0.5 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
| 0.1 | 0.9 | GO:0016594 | glycine binding(GO:0016594) |
| 0.0 | 1.9 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.0 | 0.7 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
| 0.0 | 1.0 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.0 | 0.6 | GO:0030247 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
| 0.0 | 0.2 | GO:0036402 | proteasome-activating ATPase activity(GO:0036402) |
| 0.0 | 0.1 | GO:0046923 | ER retention sequence binding(GO:0046923) |
| 0.0 | 0.7 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
| 0.0 | 1.1 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.0 | 0.3 | GO:0045499 | chemorepellent activity(GO:0045499) |
| 0.0 | 0.1 | GO:0015111 | iodide transmembrane transporter activity(GO:0015111) |
| 0.0 | 5.6 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.0 | 1.2 | GO:0035254 | glutamate receptor binding(GO:0035254) |
| 0.0 | 0.8 | GO:0020037 | heme binding(GO:0020037) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.9 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.1 | 3.6 | PID_AURORA_A_PATHWAY | Aurora A signaling |
| 0.1 | 1.0 | PID_VEGF_VEGFR_PATHWAY | VEGF and VEGFR signaling network |
| 0.0 | 3.0 | PID_AP1_PATHWAY | AP-1 transcription factor network |
| 0.0 | 0.6 | PID_IL5_PATHWAY | IL5-mediated signaling events |
| 0.0 | 1.1 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 3.8 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 0.5 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
| 0.0 | 0.6 | PID_PI3KCI_AKT_PATHWAY | Class I PI3K signaling events mediated by Akt |
| 0.0 | 2.3 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.1 | REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 4.6 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.1 | 1.0 | REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.1 | 4.8 | REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.1 | 1.0 | REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.1 | 0.5 | REACTOME_TRAF6_MEDIATED_INDUCTION_OF_TAK1_COMPLEX | Genes involved in TRAF6 mediated induction of TAK1 complex |
| 0.1 | 3.8 | REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 | Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| 0.0 | 1.9 | REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 0.6 | REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.0 | 1.1 | REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.0 | 1.3 | REACTOME_CD28_DEPENDENT_PI3K_AKT_SIGNALING | Genes involved in CD28 dependent PI3K/Akt signaling |
| 0.0 | 0.9 | REACTOME_GLUTATHIONE_CONJUGATION | Genes involved in Glutathione conjugation |
| 0.0 | 0.9 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 2.2 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 0.6 | REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_RAS | Genes involved in CREB phosphorylation through the activation of Ras |
