Motif ID: Sox21

Z-value: 0.586


Transcription factors associated with Sox21:

Gene SymbolEntrez IDGene Name
Sox21 ENSMUSG00000061517.7 Sox21

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox21mm10_v2_chr14_-_118237016_1182370350.281.3e-02Click!


Activity profile for motif Sox21.

activity profile for motif Sox21


Sorted Z-values histogram for motif Sox21

Sorted Z-values for motif Sox21



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox21

PNG image of the network

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Top targets:


Showing 1 to 20 of 109 entries
PromoterScoreRefseqGene SymbolGene Name
chrM_-_14060 6.968 ENSMUST00000082419.1
 mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chr6_+_120666388 5.418 ENSMUST00000112686.1
 Cecr2
cat eye syndrome chromosome region, candidate 2
chr7_+_51621830 4.789 ENSMUST00000032710.5
 Slc17a6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr1_+_109993982 4.560 ENSMUST00000027542.6
 Cdh7
cadherin 7, type 2
chr12_+_38783503 3.905 ENSMUST00000159334.1
 Etv1
ets variant gene 1
chr1_+_107511416 3.848 ENSMUST00000009356.4
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chrM_+_14138 3.732 ENSMUST00000082421.1
 mt-Cytb
mitochondrially encoded cytochrome b
chr11_+_69045640 3.584 ENSMUST00000108666.1
ENSMUST00000021277.5
 Aurkb

aurora kinase B

chr18_-_34007206 3.431 ENSMUST00000025234.5
 Epb4.1l4a
erythrocyte protein band 4.1-like 4a
chr3_-_10208569 3.136 ENSMUST00000029041.4
 Fabp4
fatty acid binding protein 4, adipocyte
chrM_+_11734 3.052 ENSMUST00000082418.1
 mt-Nd5
mitochondrially encoded NADH dehydrogenase 5
chr10_-_116972609 2.578 ENSMUST00000092165.4
 Gm10271
predicted gene 10271
chr4_+_116708467 2.470 ENSMUST00000030452.6
 Ccdc163
coiled-coil domain containing 163
chr2_-_72986716 2.436 ENSMUST00000112062.1
 Gm11084
predicted gene 11084
chr19_+_44493472 2.177 ENSMUST00000041163.4
 Wnt8b
wingless related MMTV integration site 8b
chr7_-_25675047 2.107 ENSMUST00000108404.1
ENSMUST00000108405.1
ENSMUST00000079439.3
 Tmem91


transmembrane protein 91


chr13_-_85127514 2.054 ENSMUST00000179230.1
 Gm4076
predicted gene 4076
chr9_-_73968901 2.036 ENSMUST00000184666.1
 Unc13c
unc-13 homolog C (C. elegans)
chr1_-_24612700 2.036 ENSMUST00000088336.1
 Gm10222
predicted gene 10222
chr2_+_73312601 1.932 ENSMUST00000090811.4
ENSMUST00000112050.1
 Scrn3

secernin 3


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 5.4 GO:0001842 neural fold formation(GO:0001842)
0.5 4.8 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.1 4.6 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.4 3.9 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 3.9 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.7 3.7 GO:0033762 response to glucagon(GO:0033762)
1.2 3.6 GO:0043988 histone H3-S28 phosphorylation(GO:0043988)
0.0 3.2 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.3 3.1 GO:0071285 cellular response to lithium ion(GO:0071285)
0.1 3.1 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.9 2.7 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.3 2.1 GO:0070863 positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
0.2 2.0 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.3 1.9 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.0 1.9 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.6 1.7 GO:0009814 defense response, incompatible interaction(GO:0009814)
0.1 1.4 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 1.2 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.0 1.2 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.1 1.1 GO:0045974 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 11.4 GO:0070469 respiratory chain(GO:0070469)
1.4 5.4 GO:0090537 CERF complex(GO:0090537)
0.2 4.8 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.3 3.7 GO:0045275 respiratory chain complex III(GO:0045275)
0.7 3.6 GO:0032133 chromosome passenger complex(GO:0032133)
0.1 3.4 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.7 2.7 GO:0060187 cell pole(GO:0060187)
0.3 2.0 GO:0044305 calyx of Held(GO:0044305)
0.1 1.2 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 1.2 GO:0016460 myosin II complex(GO:0016460)
0.1 1.1 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.2 1.0 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.0 1.0 GO:0030315 T-tubule(GO:0030315)
0.0 1.0 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.9 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.9 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 0.7 GO:0070531 BRCA1-A complex(GO:0070531)
0.0 0.7 GO:0043194 axon initial segment(GO:0043194)
0.0 0.7 GO:0043034 costamere(GO:0043034)
0.2 0.6 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 11.4 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 5.6 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.2 4.8 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.1 3.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.5 3.7 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.7 3.6 GO:0035174 histone serine kinase activity(GO:0035174)
0.1 3.1 GO:0005504 fatty acid binding(GO:0005504)
0.7 2.0 GO:0001565 phorbol ester receptor activity(GO:0001565) non-kinase phorbol ester receptor activity(GO:0001566)
0.1 1.9 GO:0016805 dipeptidase activity(GO:0016805)
0.1 1.9 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 1.9 GO:0005109 frizzled binding(GO:0005109)
0.6 1.7 GO:0071568 UFM1 transferase activity(GO:0071568)
0.2 1.6 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.1 1.2 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.0 1.2 GO:0035254 glutamate receptor binding(GO:0035254)
0.0 1.1 GO:0030332 cyclin binding(GO:0030332)
0.2 1.0 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.1 1.0 GO:0015288 porin activity(GO:0015288)
0.1 1.0 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.1 1.0 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.9 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 3.8 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 3.6 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 3.0 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 2.3 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 1.1 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 1.0 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 0.6 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.6 PID_PI3KCI_AKT_PATHWAY Class I PI3K signaling events mediated by Akt
0.0 0.5 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.8 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 4.6 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 3.8 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.1 3.1 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 2.2 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.9 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 1.3 REACTOME_CD28_DEPENDENT_PI3K_AKT_SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.0 1.1 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 1.0 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 1.0 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.9 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 0.9 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 0.6 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.6 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_RAS Genes involved in CREB phosphorylation through the activation of Ras
0.1 0.5 REACTOME_TRAF6_MEDIATED_INDUCTION_OF_TAK1_COMPLEX Genes involved in TRAF6 mediated induction of TAK1 complex