Motif ID: Sox3_Sox10
Z-value: 1.443
Transcription factors associated with Sox3_Sox10:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Sox10 | ENSMUSG00000033006.9 | Sox10 |
| Sox3 | ENSMUSG00000045179.8 | Sox3 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Sox3 | mm10_v2_chrX_-_60893430_60893440 | -0.17 | 1.5e-01 | Click! |
| Sox10 | mm10_v2_chr15_-_79164477_79164496 | 0.01 | 9.5e-01 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 388 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 54.9 | GO:0030041 | actin filament polymerization(GO:0030041) |
| 2.7 | 35.1 | GO:1901898 | negative regulation of relaxation of cardiac muscle(GO:1901898) |
| 3.3 | 29.7 | GO:1900034 | regulation of cellular response to heat(GO:1900034) |
| 0.2 | 28.3 | GO:0007416 | synapse assembly(GO:0007416) |
| 0.6 | 25.8 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 4.9 | 24.7 | GO:0043314 | negative regulation of neutrophil degranulation(GO:0043314) negative regulation of blood vessel remodeling(GO:0060313) |
| 3.5 | 24.4 | GO:0019532 | oxalate transport(GO:0019532) |
| 1.6 | 24.2 | GO:0048875 | chemical homeostasis within a tissue(GO:0048875) |
| 0.3 | 24.0 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 4.7 | 23.7 | GO:1902309 | negative regulation of peptidyl-serine dephosphorylation(GO:1902309) |
| 2.3 | 22.9 | GO:0061470 | interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619) |
| 2.0 | 21.9 | GO:0046543 | development of secondary female sexual characteristics(GO:0046543) |
| 0.6 | 20.5 | GO:0007026 | negative regulation of microtubule depolymerization(GO:0007026) |
| 1.1 | 20.0 | GO:0006054 | N-acetylneuraminate metabolic process(GO:0006054) |
| 0.8 | 19.3 | GO:0008340 | determination of adult lifespan(GO:0008340) |
| 4.3 | 17.0 | GO:0099566 | regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566) |
| 1.9 | 16.7 | GO:0098907 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) regulation of SA node cell action potential(GO:0098907) |
| 1.5 | 16.6 | GO:0051152 | positive regulation of smooth muscle cell differentiation(GO:0051152) |
| 1.1 | 15.8 | GO:0048672 | positive regulation of collateral sprouting(GO:0048672) |
| 1.9 | 15.5 | GO:0005513 | detection of calcium ion(GO:0005513) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 165 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 70.3 | GO:0005884 | actin filament(GO:0005884) |
| 0.1 | 60.1 | GO:0005768 | endosome(GO:0005768) |
| 1.4 | 56.7 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 2.1 | 51.7 | GO:0071565 | nBAF complex(GO:0071565) |
| 0.9 | 41.3 | GO:0043034 | costamere(GO:0043034) |
| 0.6 | 40.9 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 3.8 | 38.5 | GO:0045298 | tubulin complex(GO:0045298) |
| 0.4 | 33.8 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 1.7 | 26.6 | GO:1990635 | proximal dendrite(GO:1990635) |
| 0.2 | 25.9 | GO:0043204 | perikaryon(GO:0043204) |
| 2.7 | 24.6 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 1.0 | 18.7 | GO:0032279 | asymmetric synapse(GO:0032279) |
| 0.1 | 17.3 | GO:0000139 | Golgi membrane(GO:0000139) |
| 1.1 | 17.0 | GO:0043083 | synaptic cleft(GO:0043083) |
| 0.4 | 16.8 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 5.4 | 16.2 | GO:0002142 | stereocilia ankle link complex(GO:0002142) |
| 0.8 | 12.5 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.0 | 12.2 | GO:0005874 | microtubule(GO:0005874) |
| 0.7 | 11.2 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.1 | 10.2 | GO:0043195 | terminal bouton(GO:0043195) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 246 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 59.9 | GO:0015459 | potassium channel regulator activity(GO:0015459) |
| 0.2 | 51.6 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 1.2 | 38.5 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.2 | 38.5 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.2 | 38.1 | GO:0051015 | actin filament binding(GO:0051015) |
| 4.2 | 29.7 | GO:0099609 | microtubule lateral binding(GO:0099609) |
| 0.2 | 27.9 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 2.2 | 24.4 | GO:0031802 | type 5 metabotropic glutamate receptor binding(GO:0031802) |
| 2.2 | 24.4 | GO:0019531 | secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531) |
| 1.7 | 23.8 | GO:0031005 | filamin binding(GO:0031005) |
| 2.9 | 23.4 | GO:0005519 | cytoskeletal regulatory protein binding(GO:0005519) |
| 0.3 | 23.0 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.4 | 22.2 | GO:0036002 | pre-mRNA binding(GO:0036002) |
| 0.6 | 21.7 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.2 | 20.5 | GO:0008201 | heparin binding(GO:0008201) |
| 0.7 | 19.4 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.2 | 19.1 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 3.8 | 18.8 | GO:0003835 | beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835) |
| 0.1 | 17.8 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 2.1 | 17.0 | GO:0099583 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 54 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 31.5 | PID_LKB1_PATHWAY | LKB1 signaling events |
| 1.6 | 30.9 | PID_P38_GAMMA_DELTA_PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.4 | 30.9 | PID_RAC1_REG_PATHWAY | Regulation of RAC1 activity |
| 0.2 | 19.2 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.6 | 17.5 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
| 0.6 | 16.9 | PID_REELIN_PATHWAY | Reelin signaling pathway |
| 0.4 | 15.1 | PID_LIS1_PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.2 | 13.8 | PID_INSULIN_PATHWAY | Insulin Pathway |
| 0.2 | 13.6 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 13.6 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
| 0.3 | 13.0 | PID_TCPTP_PATHWAY | Signaling events mediated by TCPTP |
| 0.3 | 12.7 | PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.3 | 12.0 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
| 0.3 | 10.8 | PID_KIT_PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.4 | 10.6 | PID_IL3_PATHWAY | IL3-mediated signaling events |
| 0.1 | 10.0 | PID_P53_DOWNSTREAM_PATHWAY | Direct p53 effectors |
| 0.2 | 9.5 | PID_BMP_PATHWAY | BMP receptor signaling |
| 0.7 | 9.1 | PID_THROMBIN_PAR4_PATHWAY | PAR4-mediated thrombin signaling events |
| 0.2 | 8.3 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.2 | 8.2 | PID_TGFBR_PATHWAY | TGF-beta receptor signaling |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 95 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 43.7 | REACTOME_DARPP_32_EVENTS | Genes involved in DARPP-32 events |
| 1.2 | 27.9 | REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.3 | 26.3 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 1.3 | 25.8 | REACTOME_CRMPS_IN_SEMA3A_SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.3 | 25.5 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
| 0.2 | 24.9 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 1.0 | 21.5 | REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
| 0.3 | 17.0 | REACTOME_L1CAM_INTERACTIONS | Genes involved in L1CAM interactions |
| 0.2 | 16.9 | REACTOME_G_ALPHA_I_SIGNALLING_EVENTS | Genes involved in G alpha (i) signalling events |
| 1.1 | 16.8 | REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.6 | 16.8 | REACTOME_CGMP_EFFECTS | Genes involved in cGMP effects |
| 0.4 | 15.9 | REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.7 | 15.0 | REACTOME_TIE2_SIGNALING | Genes involved in Tie2 Signaling |
| 0.3 | 13.4 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.8 | 12.7 | REACTOME_GABA_A_RECEPTOR_ACTIVATION | Genes involved in GABA A receptor activation |
| 0.5 | 12.4 | REACTOME_OTHER_SEMAPHORIN_INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.4 | 11.0 | REACTOME_RAP1_SIGNALLING | Genes involved in Rap1 signalling |
| 0.3 | 11.0 | REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.8 | 10.8 | REACTOME_AMINE_LIGAND_BINDING_RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.2 | 10.4 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
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