Motif ID: Sox4

Z-value: 0.947


Transcription factors associated with Sox4:

Gene SymbolEntrez IDGene Name
Sox4 ENSMUSG00000076431.4 Sox4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox4mm10_v2_chr13_-_28953690_289537130.065.9e-01Click!


Activity profile for motif Sox4.

activity profile for motif Sox4


Sorted Z-values histogram for motif Sox4

Sorted Z-values for motif Sox4



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_75005523 13.668 ENSMUST00000001927.5
 Ltbp1
latent transforming growth factor beta binding protein 1
chr7_+_45216671 12.554 ENSMUST00000134420.1
 Tead2
TEA domain family member 2
chr2_-_33942111 12.073 ENSMUST00000130988.1
ENSMUST00000127936.1
ENSMUST00000134271.1
 Gm13403


predicted gene 13403


chr18_-_62756275 11.294 ENSMUST00000067450.1
ENSMUST00000048109.5
 2700046A07Rik

RIKEN cDNA 2700046A07 gene

chr13_-_97747373 9.792 ENSMUST00000123535.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr13_-_97747399 9.585 ENSMUST00000144993.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr1_+_135729147 8.585 ENSMUST00000027677.7
 Csrp1
cysteine and glycine-rich protein 1
chr7_+_99466004 8.313 ENSMUST00000037359.2
 Klhl35
kelch-like 35
chr17_-_35704000 7.372 ENSMUST00000097333.3
ENSMUST00000003628.6
 Ddr1

discoidin domain receptor family, member 1

chr3_+_131110350 7.366 ENSMUST00000066849.6
ENSMUST00000106341.2
ENSMUST00000029611.7
 Lef1


lymphoid enhancer binding factor 1


chr17_-_35704574 7.273 ENSMUST00000117301.1
ENSMUST00000134995.1
 Ddr1

discoidin domain receptor family, member 1

chr3_-_75956888 7.019 ENSMUST00000038563.7
ENSMUST00000167078.1
ENSMUST00000117242.1
 Golim4


golgi integral membrane protein 4


chr11_-_115813621 6.789 ENSMUST00000041684.4
ENSMUST00000156812.1
 Caskin2

CASK-interacting protein 2

chr4_+_41762309 6.640 ENSMUST00000108042.2
 Il11ra1
interleukin 11 receptor, alpha chain 1
chr4_-_91399984 5.995 ENSMUST00000102799.3
 Elavl2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr17_-_70851189 5.883 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr6_-_39557830 5.184 ENSMUST00000036877.3
ENSMUST00000154149.1
 Dennd2a

DENN/MADD domain containing 2A

chr1_+_165788681 5.162 ENSMUST00000161971.1
ENSMUST00000178336.1
ENSMUST00000005907.5
ENSMUST00000027849.4
 Cd247



CD247 antigen



chr12_-_54986363 5.158 ENSMUST00000173433.1
ENSMUST00000173803.1
 Baz1a
Gm20403
bromodomain adjacent to zinc finger domain 1A
predicted gene 20403
chr17_-_35697971 4.606 ENSMUST00000146472.1
 Ddr1
discoidin domain receptor family, member 1
chr9_-_103480328 4.545 ENSMUST00000124310.2
 Bfsp2
beaded filament structural protein 2, phakinin
chrX_-_10117597 4.419 ENSMUST00000115543.2
ENSMUST00000044789.3
ENSMUST00000115544.2
 Srpx


sushi-repeat-containing protein


chr1_+_59482133 4.290 ENSMUST00000114246.2
ENSMUST00000037105.6
 Fzd7

frizzled homolog 7 (Drosophila)

chr9_+_85842852 4.260 ENSMUST00000098500.3
 Tpbg
trophoblast glycoprotein
chr1_+_165788746 4.207 ENSMUST00000161559.2
 Cd247
CD247 antigen
chr15_+_102296256 4.194 ENSMUST00000064924.4
 Espl1
extra spindle poles-like 1 (S. cerevisiae)
chr7_-_105787544 4.191 ENSMUST00000078482.5
ENSMUST00000154659.1
 Dchs1

dachsous 1 (Drosophila)

chr11_+_88068242 4.003 ENSMUST00000018521.4
 Vezf1
vascular endothelial zinc finger 1
chr5_+_115908644 3.641 ENSMUST00000141101.1
 Cit
citron
chrX_-_145505136 3.370 ENSMUST00000112835.1
 Amot
angiomotin
chr12_-_98577940 3.325 ENSMUST00000110113.1
 Kcnk10
potassium channel, subfamily K, member 10
chrX_-_145505175 3.279 ENSMUST00000143610.1
 Amot
angiomotin
chr17_-_70853482 3.163 ENSMUST00000118283.1
 Tgif1
TGFB-induced factor homeobox 1
chr12_-_79296266 3.132 ENSMUST00000021547.6
 Zfyve26
zinc finger, FYVE domain containing 26
chr2_-_180776900 3.123 ENSMUST00000108878.1
 Bhlhe23
basic helix-loop-helix family, member e23
chr10_+_80151154 3.044 ENSMUST00000146516.1
ENSMUST00000144526.1
 Midn

midnolin

chr6_-_38875965 2.959 ENSMUST00000160360.1
 Hipk2
homeodomain interacting protein kinase 2
chr12_+_24708984 2.887 ENSMUST00000154588.1
 Rrm2
ribonucleotide reductase M2
chr14_+_54936456 2.856 ENSMUST00000037814.6
 Cmtm5
CKLF-like MARVEL transmembrane domain containing 5
chr7_-_105787567 2.854 ENSMUST00000144189.1
 Dchs1
dachsous 1 (Drosophila)
chr19_+_34922351 2.798 ENSMUST00000087341.5
 Kif20b
kinesin family member 20B
chr12_-_54986328 2.719 ENSMUST00000038926.6
 Baz1a
bromodomain adjacent to zinc finger domain 1A
chr3_+_146500071 2.522 ENSMUST00000119130.1
 Gng5
guanine nucleotide binding protein (G protein), gamma 5
chr11_+_69846374 2.491 ENSMUST00000108632.1
 Plscr3
phospholipid scramblase 3
chr7_-_105752193 2.445 ENSMUST00000033184.4
 Tpp1
tripeptidyl peptidase I
chr16_+_20516962 2.382 ENSMUST00000003318.5
 Dvl3
dishevelled 3, dsh homolog (Drosophila)
chr8_-_84773381 2.183 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr17_-_79020816 2.072 ENSMUST00000168887.1
ENSMUST00000119284.1
 Prkd3

protein kinase D3

chr5_-_31291026 2.064 ENSMUST00000041565.7
 Ift172
intraflagellar transport 172
chr5_-_122050102 1.923 ENSMUST00000154139.1
 Cux2
cut-like homeobox 2
chr12_+_49385174 1.863 ENSMUST00000110746.1
 3110039M20Rik
RIKEN cDNA 3110039M20 gene
chr18_-_15063560 1.854 ENSMUST00000168989.1
 Kctd1
potassium channel tetramerisation domain containing 1
chr2_-_180776749 1.848 ENSMUST00000061098.2
 Bhlhe23
basic helix-loop-helix family, member e23
chr10_+_80150448 1.842 ENSMUST00000153477.1
 Midn
midnolin
chr3_+_135826075 1.780 ENSMUST00000029810.5
 Slc39a8
solute carrier family 39 (metal ion transporter), member 8
chr7_+_100493795 1.637 ENSMUST00000129324.1
 Ucp2
uncoupling protein 2 (mitochondrial, proton carrier)
chr13_+_117220584 1.579 ENSMUST00000022242.7
 Emb
embigin
chr3_+_89164790 1.485 ENSMUST00000121212.2
ENSMUST00000152205.1
ENSMUST00000090927.5
ENSMUST00000148265.1
ENSMUST00000121931.1
 Clk2




CDC-like kinase 2




chr9_+_13765970 1.467 ENSMUST00000152532.1
 Mtmr2
myotubularin related protein 2
chr11_-_100650693 1.432 ENSMUST00000103119.3
 Zfp385c
zinc finger protein 385C
chr7_+_100494044 1.391 ENSMUST00000153287.1
 Ucp2
uncoupling protein 2 (mitochondrial, proton carrier)
chr11_+_69846610 1.320 ENSMUST00000152566.1
ENSMUST00000108633.2
 Plscr3

phospholipid scramblase 3

chr11_-_49187159 1.291 ENSMUST00000046522.6
 Btnl9
butyrophilin-like 9
chr1_+_158362330 1.233 ENSMUST00000170718.1
 Astn1
astrotactin 1
chr11_+_101442440 1.232 ENSMUST00000107249.1
 Rpl27
ribosomal protein L27
chr9_+_104002546 1.206 ENSMUST00000035167.8
ENSMUST00000117054.1
 Nphp3

nephronophthisis 3 (adolescent)

chr7_+_127233227 1.197 ENSMUST00000056232.6
 Zfp553
zinc finger protein 553
chr11_+_101442298 1.161 ENSMUST00000077856.6
 Rpl27
ribosomal protein L27
chr7_-_100514800 1.155 ENSMUST00000054923.7
 Dnajb13
DnaJ (Hsp40) related, subfamily B, member 13
chr5_-_138155694 1.140 ENSMUST00000132318.1
ENSMUST00000049393.8
 Zfp113

zinc finger protein 113

chr14_+_47298260 1.132 ENSMUST00000166743.1
 Mapk1ip1l
mitogen-activated protein kinase 1 interacting protein 1-like
chr18_-_43059418 1.104 ENSMUST00000025377.7
 Ppp2r2b
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr5_-_131538687 1.087 ENSMUST00000161374.1
 Auts2
autism susceptibility candidate 2
chr11_+_69846665 1.082 ENSMUST00000019605.2
 Plscr3
phospholipid scramblase 3
chr8_-_11635745 1.079 ENSMUST00000033905.5
ENSMUST00000169782.1
 Ankrd10

ankyrin repeat domain 10

chr6_-_47594967 1.078 ENSMUST00000081721.6
ENSMUST00000114618.1
ENSMUST00000114616.1
 Ezh2


enhancer of zeste homolog 2 (Drosophila)


chr2_-_121806988 1.016 ENSMUST00000110592.1
 Frmd5
FERM domain containing 5
chr16_+_20517000 1.009 ENSMUST00000171572.1
 Dvl3
dishevelled 3, dsh homolog (Drosophila)
chr5_-_114380459 0.952 ENSMUST00000001125.5
 Kctd10
potassium channel tetramerisation domain containing 10
chr1_+_181150926 0.934 ENSMUST00000134115.1
ENSMUST00000111059.1
 Cnih4

cornichon homolog 4 (Drosophila)

chr14_+_27039001 0.899 ENSMUST00000035336.3
 Il17rd
interleukin 17 receptor D
chr3_-_95133989 0.888 ENSMUST00000172572.2
ENSMUST00000173462.2
 Scnm1

sodium channel modifier 1

chr6_-_47813512 0.846 ENSMUST00000077290.7
 Pdia4
protein disulfide isomerase associated 4
chrX_+_71556874 0.825 ENSMUST00000123100.1
 Hmgb3
high mobility group box 3
chr2_-_26910569 0.798 ENSMUST00000015920.5
ENSMUST00000139815.1
ENSMUST00000102899.3
 Med22


mediator complex subunit 22


chr5_-_114380505 0.785 ENSMUST00000102581.4
 Kctd10
potassium channel tetramerisation domain containing 10
chr11_-_106160101 0.755 ENSMUST00000045923.3
 Limd2
LIM domain containing 2
chr2_-_168206875 0.752 ENSMUST00000057793.4
 Adnp
activity-dependent neuroprotective protein
chr2_-_101649501 0.744 ENSMUST00000160722.1
ENSMUST00000160037.1
ENSMUST00000078494.5
 B230118H07Rik

Rag1
RIKEN cDNA B230118H07 gene

recombination activating gene 1
chr17_+_37193889 0.716 ENSMUST00000038844.6
 Ubd
ubiquitin D
chr7_+_127233044 0.679 ENSMUST00000106312.3
 Zfp553
zinc finger protein 553
chr11_-_98625661 0.644 ENSMUST00000104933.1
 Gm12355
predicted gene 12355
chr15_-_76656905 0.641 ENSMUST00000176274.1
 Cyhr1
cysteine and histidine rich 1
chr5_-_24445166 0.626 ENSMUST00000115043.1
ENSMUST00000115041.1
 Fastk

Fas-activated serine/threonine kinase

chr9_-_32541589 0.592 ENSMUST00000016231.7
 Fli1
Friend leukemia integration 1
chr5_-_134456702 0.555 ENSMUST00000073161.5
ENSMUST00000171794.2
ENSMUST00000111245.2
ENSMUST00000100654.3
ENSMUST00000167084.2
ENSMUST00000100652.3
ENSMUST00000100650.3
ENSMUST00000074114.5
 Gtf2ird1







general transcription factor II I repeat domain-containing 1







chr5_-_24445254 0.548 ENSMUST00000030800.6
 Fastk
Fas-activated serine/threonine kinase
chr12_-_112674193 0.526 ENSMUST00000001780.3
 Akt1
thymoma viral proto-oncogene 1
chr1_+_158362261 0.517 ENSMUST00000046110.9
 Astn1
astrotactin 1
chr2_+_78869009 0.464 ENSMUST00000028398.7
 Ube2e3
ubiquitin-conjugating enzyme E2E 3
chr4_+_129513581 0.430 ENSMUST00000062356.6
 Marcksl1
MARCKS-like 1
chr16_-_84835557 0.411 ENSMUST00000138279.1
ENSMUST00000023608.7
 Atp5j

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F

chr11_+_22512088 0.402 ENSMUST00000059319.7
 Tmem17
transmembrane protein 17
chr16_+_84834901 0.299 ENSMUST00000114184.1
 Gabpa
GA repeat binding protein, alpha
chr11_-_106159902 0.251 ENSMUST00000064545.4
 Limd2
LIM domain containing 2
chr10_-_17947997 0.175 ENSMUST00000037879.6
 Heca
headcase homolog (Drosophila)
chr11_+_70432627 0.162 ENSMUST00000084954.6
ENSMUST00000108568.3
ENSMUST00000079056.2
ENSMUST00000102564.4
ENSMUST00000124943.1
ENSMUST00000150076.1
ENSMUST00000102563.1
 Arrb2






arrestin, beta 2






chr19_+_40831248 0.099 ENSMUST00000025983.6
ENSMUST00000120057.1
 Ccnj

cyclin J

chr16_-_84835484 0.081 ENSMUST00000114191.1
 Atp5j
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 7.4 GO:0032696 negative regulation of interleukin-13 production(GO:0032696) trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) odontoblast differentiation(GO:0071895) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
1.8 7.0 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
1.7 6.6 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
1.7 5.0 GO:0046671 negative regulation of retinal cell programmed cell death(GO:0046671)
1.6 19.3 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
1.5 4.4 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
1.1 5.4 GO:0014834 skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration(GO:0014834)
0.9 2.8 GO:1903490 regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490)
0.8 4.9 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.6 9.0 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.6 3.4 GO:1904953 Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation(GO:1904953)
0.5 12.6 GO:0048368 lateral mesoderm development(GO:0048368)
0.5 13.7 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.4 6.6 GO:0046697 decidualization(GO:0046697)
0.4 2.5 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.4 1.2 GO:0048496 maintenance of organ identity(GO:0048496)
0.4 1.1 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
0.3 3.0 GO:1990845 adaptive thermogenesis(GO:1990845)
0.3 3.3 GO:0030322 stabilization of membrane potential(GO:0030322)
0.3 3.0 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.3 9.4 GO:0070207 protein homotrimerization(GO:0070207)
0.3 2.1 GO:0089700 protein kinase D signaling(GO:0089700)
0.3 4.5 GO:0070307 lens fiber cell development(GO:0070307)
0.3 0.8 GO:1903334 positive regulation of protein folding(GO:1903334)
0.3 4.2 GO:0000212 meiotic spindle organization(GO:0000212)
0.2 0.7 GO:0002331 pre-B cell allelic exclusion(GO:0002331)
0.2 2.2 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.2 1.8 GO:0007158 neuron cell-cell adhesion(GO:0007158)
0.2 1.5 GO:0031642 negative regulation of myelination(GO:0031642)
0.2 3.6 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.2 1.8 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.2 2.9 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.2 1.5 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.2 0.8 GO:0045578 negative regulation of B cell differentiation(GO:0045578)
0.2 1.6 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.1 2.1 GO:0070986 left/right axis specification(GO:0070986)
0.1 2.7 GO:0007614 short-term memory(GO:0007614)
0.1 0.6 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.1 1.1 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.1 1.7 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.1 2.4 GO:0043171 peptide catabolic process(GO:0043171)
0.1 4.9 GO:0042632 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.1 5.2 GO:0070527 platelet aggregation(GO:0070527)
0.1 5.2 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.1 7.9 GO:0006261 DNA-dependent DNA replication(GO:0006261)
0.1 0.7 GO:0070842 aggresome assembly(GO:0070842)
0.1 4.0 GO:0001885 endothelial cell development(GO:0001885)
0.1 4.3 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 1.7 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 0.2 GO:0034392 negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.0 6.0 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.0 1.2 GO:0035082 axoneme assembly(GO:0035082)
0.0 3.1 GO:0000910 cytokinesis(GO:0000910)
0.0 0.5 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.1 GO:0060709 glycogen cell differentiation involved in embryonic placenta development(GO:0060709)
0.0 0.3 GO:0035855 megakaryocyte development(GO:0035855)
0.0 0.5 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 1.4 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.0 2.4 GO:0006364 rRNA processing(GO:0006364)
0.0 0.9 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
4.6 13.7 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
4.2 12.6 GO:0071149 TEAD-2-YAP complex(GO:0071149)
2.3 9.4 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
2.0 7.9 GO:0008623 CHRAC(GO:0008623)
0.8 2.5 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.7 7.4 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.6 2.9 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.4 1.2 GO:0097543 ciliary inversin compartment(GO:0097543)
0.4 3.4 GO:1990909 Wnt signalosome(GO:1990909)
0.2 2.8 GO:1990023 mitotic spindle midzone(GO:1990023)
0.1 6.6 GO:0008180 COP9 signalosome(GO:0008180)
0.1 2.1 GO:0036038 MKS complex(GO:0036038)
0.1 8.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 4.3 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 2.1 GO:0097225 sperm midpiece(GO:0097225)
0.1 0.8 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 17.1 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 1.1 GO:0045120 pronucleus(GO:0045120)
0.1 4.4 GO:0005776 autophagosome(GO:0005776)
0.1 3.6 GO:0031985 Golgi cisterna(GO:0031985)
0.1 4.2 GO:0072686 mitotic spindle(GO:0072686)
0.1 1.1 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.5 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 2.4 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 3.0 GO:0016605 PML body(GO:0016605)
0.0 1.6 GO:0005882 intermediate filament(GO:0005882)
0.0 0.8 GO:0016592 mediator complex(GO:0016592)
0.0 0.7 GO:0016235 aggresome(GO:0016235)
0.0 1.2 GO:0036126 sperm flagellum(GO:0036126)
0.0 1.8 GO:0031090 organelle membrane(GO:0031090)
0.0 1.5 GO:0005774 vacuolar membrane(GO:0005774)
0.0 0.9 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 7.1 GO:0015629 actin cytoskeleton(GO:0015629)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.4 13.7 GO:0050436 microfibril binding(GO:0050436)
2.1 19.3 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
1.7 6.6 GO:0004921 interleukin-11 receptor activity(GO:0004921) interleukin-11 binding(GO:0019970)
1.3 6.6 GO:0043532 angiostatin binding(GO:0043532)
1.2 7.4 GO:0030284 estrogen receptor activity(GO:0030284)
0.8 3.0 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.7 12.6 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.6 2.4 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.6 2.9 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.5 4.5 GO:0005212 structural constituent of eye lens(GO:0005212)
0.4 9.0 GO:0070410 co-SMAD binding(GO:0070410)
0.4 3.0 GO:0046790 virion binding(GO:0046790)
0.3 4.9 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.3 3.3 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.3 0.9 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.2 1.5 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.2 7.7 GO:0005109 frizzled binding(GO:0005109)
0.2 1.1 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.1 9.4 GO:1990782 protein tyrosine kinase binding(GO:1990782)
0.1 5.2 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 0.9 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.1 2.8 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 2.1 GO:0004697 protein kinase C activity(GO:0004697)
0.1 0.8 GO:0015037 peptide disulfide oxidoreductase activity(GO:0015037)
0.1 3.1 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 1.8 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 4.2 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.1 0.2 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.0 3.6 GO:0097110 scaffold protein binding(GO:0097110)
0.0 0.7 GO:0070628 proteasome binding(GO:0070628)
0.0 1.5 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 2.9 GO:0005125 cytokine activity(GO:0005125)
0.0 2.5 GO:0030165 PDZ domain binding(GO:0030165)
0.0 1.4 GO:0002039 p53 binding(GO:0002039)
0.0 1.1 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.8 GO:0005507 copper ion binding(GO:0005507)
0.0 0.2 GO:0005112 Notch binding(GO:0005112)
0.0 1.2 GO:0051082 unfolded protein binding(GO:0051082)
0.0 6.9 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 2.4 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 1.0 GO:0005200 structural constituent of cytoskeleton(GO:0005200)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 9.4 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.2 7.8 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.1 17.6 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 9.2 PID_CMYB_PATHWAY C-MYB transcription factor network
0.1 9.1 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 3.0 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 3.6 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 2.9 PID_E2F_PATHWAY E2F transcription factor network
0.0 2.1 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 1.1 PID_ATR_PATHWAY ATR signaling pathway
0.0 0.5 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 0.9 PID_FGF_PATHWAY FGF signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 9.4 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.5 3.3 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.4 12.6 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.3 9.0 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.2 6.6 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.1 2.9 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 1.8 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.1 1.5 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 6.8 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 2.4 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 3.5 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.0 2.4 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.0 0.8 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation