Motif ID: Sox4

Z-value: 0.947


Transcription factors associated with Sox4:

Gene SymbolEntrez IDGene Name
Sox4 ENSMUSG00000076431.4 Sox4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox4mm10_v2_chr13_-_28953690_289537130.065.9e-01Click!


Activity profile for motif Sox4.

activity profile for motif Sox4


Sorted Z-values histogram for motif Sox4

Sorted Z-values for motif Sox4



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox4

PNG image of the network

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Top targets:


Showing 1 to 20 of 109 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_75005523 13.668 ENSMUST00000001927.5
 Ltbp1
latent transforming growth factor beta binding protein 1
chr7_+_45216671 12.554 ENSMUST00000134420.1
 Tead2
TEA domain family member 2
chr2_-_33942111 12.073 ENSMUST00000130988.1
ENSMUST00000127936.1
ENSMUST00000134271.1
 Gm13403


predicted gene 13403


chr18_-_62756275 11.294 ENSMUST00000067450.1
ENSMUST00000048109.5
 2700046A07Rik

RIKEN cDNA 2700046A07 gene

chr13_-_97747373 9.792 ENSMUST00000123535.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr13_-_97747399 9.585 ENSMUST00000144993.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr1_+_135729147 8.585 ENSMUST00000027677.7
 Csrp1
cysteine and glycine-rich protein 1
chr7_+_99466004 8.313 ENSMUST00000037359.2
 Klhl35
kelch-like 35
chr17_-_35704000 7.372 ENSMUST00000097333.3
ENSMUST00000003628.6
 Ddr1

discoidin domain receptor family, member 1

chr3_+_131110350 7.366 ENSMUST00000066849.6
ENSMUST00000106341.2
ENSMUST00000029611.7
 Lef1


lymphoid enhancer binding factor 1


chr17_-_35704574 7.273 ENSMUST00000117301.1
ENSMUST00000134995.1
 Ddr1

discoidin domain receptor family, member 1

chr3_-_75956888 7.019 ENSMUST00000038563.7
ENSMUST00000167078.1
ENSMUST00000117242.1
 Golim4


golgi integral membrane protein 4


chr11_-_115813621 6.789 ENSMUST00000041684.4
ENSMUST00000156812.1
 Caskin2

CASK-interacting protein 2

chr4_+_41762309 6.640 ENSMUST00000108042.2
 Il11ra1
interleukin 11 receptor, alpha chain 1
chr4_-_91399984 5.995 ENSMUST00000102799.3
 Elavl2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr17_-_70851189 5.883 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr6_-_39557830 5.184 ENSMUST00000036877.3
ENSMUST00000154149.1
 Dennd2a

DENN/MADD domain containing 2A

chr1_+_165788681 5.162 ENSMUST00000161971.1
ENSMUST00000178336.1
ENSMUST00000005907.5
ENSMUST00000027849.4
 Cd247



CD247 antigen



chr12_-_54986363 5.158 ENSMUST00000173433.1
ENSMUST00000173803.1
 Baz1a
Gm20403
bromodomain adjacent to zinc finger domain 1A
predicted gene 20403
chr17_-_35697971 4.606 ENSMUST00000146472.1
 Ddr1
discoidin domain receptor family, member 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 19.3 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.5 13.7 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.5 12.6 GO:0048368 lateral mesoderm development(GO:0048368)
0.3 9.4 GO:0070207 protein homotrimerization(GO:0070207)
0.6 9.0 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1 7.9 GO:0006261 DNA-dependent DNA replication(GO:0006261)
2.5 7.4 GO:0032696 negative regulation of interleukin-13 production(GO:0032696) trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) odontoblast differentiation(GO:0071895) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
1.8 7.0 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
1.7 6.6 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
0.4 6.6 GO:0046697 decidualization(GO:0046697)
0.0 6.0 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
1.1 5.4 GO:0014834 skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration(GO:0014834)
0.1 5.2 GO:0070527 platelet aggregation(GO:0070527)
0.1 5.2 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
1.7 5.0 GO:0046671 negative regulation of retinal cell programmed cell death(GO:0046671)
0.8 4.9 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.1 4.9 GO:0042632 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.3 4.5 GO:0070307 lens fiber cell development(GO:0070307)
1.5 4.4 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.1 4.3 GO:0051965 positive regulation of synapse assembly(GO:0051965)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 17.1 GO:0016323 basolateral plasma membrane(GO:0016323)
4.6 13.7 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
4.2 12.6 GO:0071149 TEAD-2-YAP complex(GO:0071149)
2.3 9.4 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.1 8.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
2.0 7.9 GO:0008623 CHRAC(GO:0008623)
0.7 7.4 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 7.1 GO:0015629 actin cytoskeleton(GO:0015629)
0.1 6.6 GO:0008180 COP9 signalosome(GO:0008180)
0.1 4.4 GO:0005776 autophagosome(GO:0005776)
0.1 4.3 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 4.2 GO:0072686 mitotic spindle(GO:0072686)
0.1 3.6 GO:0031985 Golgi cisterna(GO:0031985)
0.4 3.4 GO:1990909 Wnt signalosome(GO:1990909)
0.0 3.0 GO:0016605 PML body(GO:0016605)
0.6 2.9 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.2 2.8 GO:1990023 mitotic spindle midzone(GO:1990023)
0.8 2.5 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.0 2.4 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 2.1 GO:0036038 MKS complex(GO:0036038)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 19.3 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
3.4 13.7 GO:0050436 microfibril binding(GO:0050436)
0.7 12.6 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.1 9.4 GO:1990782 protein tyrosine kinase binding(GO:1990782)
0.4 9.0 GO:0070410 co-SMAD binding(GO:0070410)
0.2 7.7 GO:0005109 frizzled binding(GO:0005109)
1.2 7.4 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 6.9 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
1.7 6.6 GO:0004921 interleukin-11 receptor activity(GO:0004921) interleukin-11 binding(GO:0019970)
1.3 6.6 GO:0043532 angiostatin binding(GO:0043532)
0.1 5.2 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.3 4.9 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.5 4.5 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 4.2 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 3.6 GO:0097110 scaffold protein binding(GO:0097110)
0.3 3.3 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 3.1 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.8 3.0 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.4 3.0 GO:0046790 virion binding(GO:0046790)
0.6 2.9 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)

Gene overrepresentation in C2:CP category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 17.6 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.3 9.4 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 9.2 PID_CMYB_PATHWAY C-MYB transcription factor network
0.1 9.1 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.2 7.8 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.1 3.6 PID_RHOA_PATHWAY RhoA signaling pathway
0.1 3.0 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 2.9 PID_E2F_PATHWAY E2F transcription factor network
0.0 2.1 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 1.1 PID_ATR_PATHWAY ATR signaling pathway
0.0 0.9 PID_FGF_PATHWAY FGF signaling pathway
0.0 0.5 PID_HNF3A_PATHWAY FOXA1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 12.6 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
1.6 9.4 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.3 9.0 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 6.8 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.2 6.6 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 3.5 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.5 3.3 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 2.9 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 2.4 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 2.4 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.1 1.8 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.1 1.5 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.8 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation