Motif ID: Sox5_Sry

Z-value: 1.991

Transcription factors associated with Sox5_Sry:

Gene SymbolEntrez IDGene Name
Sox5 ENSMUSG00000041540.10 Sox5
Sry ENSMUSG00000069036.3 Sry

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox5mm10_v2_chr6_-_143947092_1439471110.243.4e-02Click!


Activity profile for motif Sox5_Sry.

activity profile for motif Sox5_Sry


Sorted Z-values histogram for motif Sox5_Sry

Sorted Z-values for motif Sox5_Sry



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox5_Sry

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_115824699 44.057 ENSMUST00000169129.1
 Sox6
SRY-box containing gene 6
chr3_+_127633134 30.558 ENSMUST00000029587.7
 Neurog2
neurogenin 2
chr2_-_60125651 26.199 ENSMUST00000112550.1
 Baz2b
bromodomain adjacent to zinc finger domain, 2B
chr4_-_97584612 24.931 ENSMUST00000107068.2
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr1_+_6730051 24.900 ENSMUST00000043578.6
ENSMUST00000131467.1
ENSMUST00000150761.1
ENSMUST00000151281.1
 St18



suppression of tumorigenicity 18



chr18_-_84086379 24.820 ENSMUST00000060303.8
 Tshz1
teashirt zinc finger family member 1
chr4_-_97584605 24.625 ENSMUST00000107067.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr17_-_70849644 23.014 ENSMUST00000134654.1
ENSMUST00000172229.1
ENSMUST00000127719.1
 Tgif1


TGFB-induced factor homeobox 1


chr2_+_102658640 20.983 ENSMUST00000080210.3
 Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr4_+_109978004 20.533 ENSMUST00000061187.3
 Dmrta2
doublesex and mab-3 related transcription factor like family A2
chr13_-_56252163 19.445 ENSMUST00000058475.4
 Neurog1
neurogenin 1
chr10_-_130280218 19.110 ENSMUST00000061571.3
 Neurod4
neurogenic differentiation 4
chr6_+_15185456 18.081 ENSMUST00000115472.1
ENSMUST00000115474.1
ENSMUST00000031545.7
ENSMUST00000137628.1
 Foxp2



forkhead box P2



chr11_+_94044111 17.268 ENSMUST00000132079.1
 Spag9
sperm associated antigen 9
chr18_-_62756275 17.079 ENSMUST00000067450.1
ENSMUST00000048109.5
 2700046A07Rik

RIKEN cDNA 2700046A07 gene

chr6_+_128375456 17.013 ENSMUST00000100926.2
 4933413G19Rik
RIKEN cDNA 4933413G19 gene
chr1_+_6730135 16.709 ENSMUST00000155921.1
 St18
suppression of tumorigenicity 18
chr4_-_82505274 16.575 ENSMUST00000050872.8
ENSMUST00000064770.2
 Nfib

nuclear factor I/B

chr2_+_124610573 16.026 ENSMUST00000103239.3
ENSMUST00000103240.2
 Sema6d

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D

chr10_-_45470201 15.761 ENSMUST00000079390.6
 Lin28b
lin-28 homolog B (C. elegans)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 174 entries
Log-likelihood per target Total log-likelihoodTermDescription
7.0 56.3 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
13.0 52.0 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
3.2 50.8 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
4.4 48.5 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
3.2 38.3 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.3 29.8 GO:0043488 regulation of mRNA stability(GO:0043488)
3.0 27.1 GO:0010587 miRNA catabolic process(GO:0010587)
8.6 25.9 GO:0007290 spermatid nucleus elongation(GO:0007290)
8.3 24.8 GO:0060023 soft palate development(GO:0060023)
5.4 21.6 GO:0021603 cranial nerve formation(GO:0021603)
3.0 21.0 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
2.3 20.3 GO:0030035 microspike assembly(GO:0030035)
6.5 19.4 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
1.8 18.2 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
1.1 16.8 GO:0021796 cerebral cortex regionalization(GO:0021796)
4.2 16.7 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
1.2 15.4 GO:0035881 amacrine cell differentiation(GO:0035881)
0.3 15.4 GO:0006940 regulation of smooth muscle contraction(GO:0006940)
1.1 15.1 GO:0072189 ureter development(GO:0072189)
2.1 15.0 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 161.1 GO:0005634 nucleus(GO:0005634)
0.3 54.6 GO:0032993 protein-DNA complex(GO:0032993)
2.5 52.0 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.3 49.7 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.1 49.3 GO:0005815 microtubule organizing center(GO:0005815)
0.1 39.2 GO:0000785 chromatin(GO:0000785)
0.5 31.2 GO:0016459 myosin complex(GO:0016459)
0.2 27.4 GO:0005667 transcription factor complex(GO:0005667)
0.2 26.6 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
1.5 23.1 GO:0042788 polysomal ribosome(GO:0042788)
0.7 21.0 GO:0030673 axolemma(GO:0030673)
0.2 20.1 GO:0072562 blood microparticle(GO:0072562)
0.1 17.6 GO:0030027 lamellipodium(GO:0030027)
0.4 17.1 GO:0008180 COP9 signalosome(GO:0008180)
1.8 16.5 GO:0030478 actin cap(GO:0030478)
5.0 14.9 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.2 14.5 GO:0035097 histone methyltransferase complex(GO:0035097)
0.7 13.3 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
2.2 11.2 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.2 10.9 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 114 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 89.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
1.9 70.6 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
1.3 58.2 GO:0070888 E-box binding(GO:0070888)
3.6 53.7 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.2 36.9 GO:0001047 core promoter binding(GO:0001047)
0.9 32.4 GO:0017091 AU-rich element binding(GO:0017091)
0.6 32.3 GO:0030507 spectrin binding(GO:0030507)
0.1 32.0 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
1.3 29.5 GO:0070410 co-SMAD binding(GO:0070410)
1.4 27.3 GO:0030215 semaphorin receptor binding(GO:0030215)
1.4 25.9 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
1.7 24.2 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
3.5 21.0 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.2 20.8 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 19.7 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
1.3 19.6 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
1.0 19.4 GO:0001848 complement binding(GO:0001848)
2.4 16.8 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
3.3 16.7 GO:0043532 angiostatin binding(GO:0043532)
0.0 16.7 GO:0003677 DNA binding(GO:0003677)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 80.3 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.7 63.1 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.9 55.1 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.3 34.1 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.3 33.1 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.4 23.1 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.3 18.2 PID_PLK1_PATHWAY PLK1 signaling events
0.2 15.4 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.3 15.1 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
1.1 14.9 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 14.8 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3 14.3 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.3 13.7 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 10.1 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.4 9.8 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.3 8.5 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.3 7.8 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.1 7.3 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 6.0 PID_RHOA_PATHWAY RhoA signaling pathway
0.2 5.8 PID_HIF2PATHWAY HIF-2-alpha transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 52.0 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
1.1 40.4 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.6 31.4 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.3 30.5 REACTOME_MEIOSIS Genes involved in Meiosis
0.8 27.8 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.3 23.0 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
1.2 19.6 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.3 19.0 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.6 17.8 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.2 17.2 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.6 16.0 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 15.8 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.4 14.8 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.4 13.3 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 12.8 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.5 12.0 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.1 11.0 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
1.0 10.5 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
1.2 9.2 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.8 7.8 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter