Motif ID: Sox8

Z-value: 0.465


Transcription factors associated with Sox8:

Gene SymbolEntrez IDGene Name
Sox8 ENSMUSG00000024176.4 Sox8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox8mm10_v2_chr17_-_25570678_25570694-0.481.0e-05Click!


Activity profile for motif Sox8.

activity profile for motif Sox8


Sorted Z-values histogram for motif Sox8

Sorted Z-values for motif Sox8



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox8

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_110095937 4.869 ENSMUST00000106664.3
ENSMUST00000046223.7
ENSMUST00000106662.1
 Abca8a


ATP-binding cassette, sub-family A (ABC1), member 8a


chr11_+_97415527 3.349 ENSMUST00000121799.1
 Arhgap23
Rho GTPase activating protein 23
chr11_-_110095974 2.965 ENSMUST00000100287.2
 Abca8a
ATP-binding cassette, sub-family A (ABC1), member 8a
chr3_+_65109343 2.540 ENSMUST00000159525.1
ENSMUST00000049230.8
 Kcnab1

potassium voltage-gated channel, shaker-related subfamily, beta member 1

chrX_+_134404780 2.526 ENSMUST00000113224.2
ENSMUST00000113226.1
 Drp2

dystrophin related protein 2

chr18_+_36952621 2.464 ENSMUST00000115661.2
 Pcdha2
protocadherin alpha 2
chr18_-_62741387 2.413 ENSMUST00000097557.3
 Spink13
serine peptidase inhibitor, Kazal type 13
chr13_-_66227573 2.298 ENSMUST00000167981.2
 Gm10772
predicted gene 10772
chr13_-_19395728 2.190 ENSMUST00000039694.7
 Stard3nl
STARD3 N-terminal like
chrX_-_162643575 2.169 ENSMUST00000101102.1
 Reps2
RALBP1 associated Eps domain containing protein 2
chrX_-_162643629 2.167 ENSMUST00000112334.1
 Reps2
RALBP1 associated Eps domain containing protein 2
chr11_+_32286946 2.001 ENSMUST00000101387.3
 Hbq1b
hemoglobin, theta 1B
chr13_+_93304799 1.935 ENSMUST00000080127.5
 Homer1
homer homolog 1 (Drosophila)
chr13_-_66852017 1.882 ENSMUST00000059329.6
 Gm17449
predicted gene, 17449
chr17_+_70561739 1.821 ENSMUST00000097288.2
 Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr13_+_65512678 1.789 ENSMUST00000081471.2
 Gm10139
predicted gene 10139
chr4_+_43401232 1.634 ENSMUST00000125399.1
 Rusc2
RUN and SH3 domain containing 2
chr14_-_49783327 1.328 ENSMUST00000118129.1
ENSMUST00000036972.6
 3632451O06Rik

RIKEN cDNA 3632451O06 gene

chr15_-_97020322 1.214 ENSMUST00000166223.1
 Slc38a4
solute carrier family 38, member 4
chr19_+_24875679 1.136 ENSMUST00000073080.5
 Gm10053
predicted gene 10053
chr13_+_93304066 1.070 ENSMUST00000109493.1
 Homer1
homer homolog 1 (Drosophila)
chr4_-_134245579 0.961 ENSMUST00000030644.7
 Zfp593
zinc finger protein 593
chr7_-_126800354 0.895 ENSMUST00000106348.1
 Aldoa
aldolase A, fructose-bisphosphate
chr1_+_109983737 0.766 ENSMUST00000172005.1
 Cdh7
cadherin 7, type 2
chr11_+_69991061 0.705 ENSMUST00000018711.8
 Gabarap
gamma-aminobutyric acid receptor associated protein
chr11_-_26591729 0.704 ENSMUST00000109504.1
 Vrk2
vaccinia related kinase 2
chr7_-_126800036 0.694 ENSMUST00000133514.1
ENSMUST00000151137.1
 Aldoa

aldolase A, fructose-bisphosphate

chr11_+_69991633 0.690 ENSMUST00000108592.1
 Gabarap
gamma-aminobutyric acid receptor associated protein
chr15_-_103215285 0.629 ENSMUST00000122182.1
ENSMUST00000108813.3
ENSMUST00000127191.1
 Cbx5


chromobox 5


chr13_-_66851513 0.589 ENSMUST00000169322.1
 Gm17404
predicted gene, 17404
chr16_-_29541483 0.541 ENSMUST00000057018.8
ENSMUST00000182627.1
 Atp13a4

ATPase type 13A4

chr1_+_109993982 0.520 ENSMUST00000027542.6
 Cdh7
cadherin 7, type 2
chr2_-_84715160 0.460 ENSMUST00000035840.5
 Zdhhc5
zinc finger, DHHC domain containing 5
chr10_+_82378593 0.422 ENSMUST00000165906.1
 Gm4924
predicted gene 4924
chr15_-_89149557 0.404 ENSMUST00000088823.3
 Mapk11
mitogen-activated protein kinase 11
chr4_+_154142363 0.401 ENSMUST00000030895.5
 Wrap73
WD repeat containing, antisense to Trp73
chr4_-_129578535 0.324 ENSMUST00000052835.8
 Fam167b
family with sequence similarity 167, member B
chr13_-_30950298 0.291 ENSMUST00000102946.1
 Exoc2
exocyst complex component 2
chr3_-_8667033 0.290 ENSMUST00000042412.3
 Hey1
hairy/enhancer-of-split related with YRPW motif 1
chr4_-_58553553 0.281 ENSMUST00000107575.2
ENSMUST00000107574.1
ENSMUST00000147354.1
 Lpar1


lysophosphatidic acid receptor 1


chr9_-_4309432 0.279 ENSMUST00000051589.7
 Aasdhppt
aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
chr9_-_95815389 0.279 ENSMUST00000119760.1
 Pls1
plastin 1 (I-isoform)
chr8_-_33747724 0.276 ENSMUST00000179364.1
 Smim18
small integral membrane protein 18
chrX_-_72918284 0.254 ENSMUST00000152200.1
 Cetn2
centrin 2
chr7_-_42578588 0.212 ENSMUST00000179470.1
 Gm21028
predicted gene, 21028
chr2_-_37647199 0.125 ENSMUST00000028279.3
 Strbp
spermatid perinuclear RNA binding protein
chr2_+_176236860 0.102 ENSMUST00000166464.1
 2210418O10Rik
RIKEN cDNA 2210418O10 gene
chr2_+_69789647 0.096 ENSMUST00000112266.1
 Phospho2
phosphatase, orphan 2
chr2_+_69789621 0.007 ENSMUST00000151298.1
ENSMUST00000028494.2
 Phospho2

phosphatase, orphan 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.4 GO:0060467 negative regulation of fertilization(GO:0060467)
0.2 0.7 GO:2000659 regulation of interleukin-1-mediated signaling pathway(GO:2000659)
0.2 3.0 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.2 2.5 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.2 1.6 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.1 1.8 GO:0070842 aggresome assembly(GO:0070842)
0.1 1.0 GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
0.1 1.4 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.1 0.3 GO:0006553 lysine metabolic process(GO:0006553)
0.1 0.3 GO:0001951 intestinal D-glucose absorption(GO:0001951) terminal web assembly(GO:1902896)
0.1 0.3 GO:2000820 negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000820)
0.1 0.3 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.1 0.4 GO:2001184 regulation of interleukin-12 secretion(GO:2001182) positive regulation of interleukin-12 secretion(GO:2001184)
0.0 0.3 GO:0001927 exocyst assembly(GO:0001927)
0.0 1.2 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 7.8 GO:0006869 lipid transport(GO:0006869)
0.0 0.5 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.4 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.0 3.3 GO:0043547 positive regulation of GTPase activity(GO:0043547)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.5 GO:1990635 proximal dendrite(GO:1990635)
0.1 2.2 GO:0044232 organelle membrane contact site(GO:0044232)
0.1 1.6 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 1.4 GO:0097225 sperm midpiece(GO:0097225)
0.1 0.3 GO:1990357 terminal web(GO:1990357)
0.1 3.0 GO:0043034 costamere(GO:0043034)
0.1 0.3 GO:0071942 XPC complex(GO:0071942)
0.0 0.6 GO:0010369 chromocenter(GO:0010369)
0.0 1.0 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 2.4 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 7.3 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 0.3 GO:0000145 exocyst(GO:0000145)
0.0 4.3 GO:0045211 postsynaptic membrane(GO:0045211)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.0 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.3 1.6 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.2 2.5 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.1 1.0 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.1 0.3 GO:0035939 microsatellite binding(GO:0035939)
0.1 1.4 GO:0050811 GABA receptor binding(GO:0050811)
0.1 2.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 5.6 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 2.2 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.3 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.3 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.0 0.1 GO:0033883 pyridoxal phosphatase activity(GO:0033883)
0.0 0.4 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.5 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 1.6 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 1.2 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.0 0.3 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 0.3 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.0 3.3 GO:0005096 GTPase activator activity(GO:0005096)
0.0 5.5 GO:0005509 calcium ion binding(GO:0005509)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.6 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.4 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.5 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.6 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 1.3 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.2 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.4 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.0 0.3 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.3 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing