Motif ID: Sp1

Z-value: 1.820


Transcription factors associated with Sp1:

Gene SymbolEntrez IDGene Name
Sp1 ENSMUSG00000001280.6 Sp1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sp1mm10_v2_chr15_+_102406143_102406380-0.281.5e-02Click!


Activity profile for motif Sp1.

activity profile for motif Sp1


Sorted Z-values histogram for motif Sp1

Sorted Z-values for motif Sp1



Network of associatons between targets according to the STRING database.



First level regulatory network of Sp1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_56971762 28.592 ENSMUST00000114415.3
 Satb2
special AT-rich sequence binding protein 2
chr5_+_134986191 24.912 ENSMUST00000094245.2
 Cldn3
claudin 3
chr16_-_22439719 22.432 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr2_+_172345565 22.375 ENSMUST00000028995.4
 Fam210b
family with sequence similarity 210, member B
chr8_-_84800024 19.982 ENSMUST00000126806.1
ENSMUST00000076715.6
 Nfix

nuclear factor I/X

chr5_-_109558957 19.770 ENSMUST00000044579.7
 Crlf2
cytokine receptor-like factor 2
chr1_-_56972437 19.506 ENSMUST00000042857.7
 Satb2
special AT-rich sequence binding protein 2
chr9_+_44043384 17.634 ENSMUST00000114840.1
 Thy1
thymus cell antigen 1, theta
chr5_-_134747241 17.128 ENSMUST00000015138.9
 Eln
elastin
chr12_-_4841583 16.382 ENSMUST00000020964.5
 Fkbp1b
FK506 binding protein 1b
chr12_+_70825492 16.263 ENSMUST00000057859.7
 Frmd6
FERM domain containing 6
chr14_-_25769033 15.935 ENSMUST00000069180.7
 Zcchc24
zinc finger, CCHC domain containing 24
chrX_+_99975570 15.825 ENSMUST00000113779.1
ENSMUST00000113776.1
ENSMUST00000113775.1
ENSMUST00000113780.1
ENSMUST00000113778.1
ENSMUST00000113781.1
ENSMUST00000113783.1
ENSMUST00000071453.2
ENSMUST00000113777.1
 Eda








ectodysplasin-A








chr18_+_24709436 15.697 ENSMUST00000037097.7
 Fhod3
formin homology 2 domain containing 3
chr17_+_83215271 15.691 ENSMUST00000170794.1
 Pkdcc
protein kinase domain containing, cytoplasmic
chr16_-_22439570 15.575 ENSMUST00000170393.1
 Etv5
ets variant gene 5
chr4_-_133498538 14.434 ENSMUST00000125541.1
 Trnp1
TMF1-regulated nuclear protein 1
chr9_+_50752758 14.091 ENSMUST00000034562.7
 Cryab
crystallin, alpha B
chr2_-_33130565 14.087 ENSMUST00000124000.1
 Garnl3
GTPase activating RANGAP domain-like 3
chr1_+_42697146 13.874 ENSMUST00000054883.2
 Pou3f3
POU domain, class 3, transcription factor 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,192 entries
Log-likelihood per target Total log-likelihoodTermDescription
7.5 52.8 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
1.0 45.2 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
2.8 44.2 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
3.2 32.1 GO:0010459 negative regulation of heart rate(GO:0010459)
0.6 29.9 GO:0031338 regulation of vesicle fusion(GO:0031338)
1.3 28.7 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
3.3 26.5 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
3.3 26.4 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
1.7 25.3 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
5.0 24.8 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
2.6 23.4 GO:2000467 positive regulation of glycogen (starch) synthase activity(GO:2000467)
1.9 22.7 GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus(GO:0097011)
5.6 22.4 GO:2000525 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
3.1 21.7 GO:0003096 renal sodium ion transport(GO:0003096)
2.7 21.4 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
1.9 20.9 GO:0055003 cardiac myofibril assembly(GO:0055003)
1.2 20.7 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
2.9 20.1 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
1.3 20.0 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
2.8 19.3 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 395 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 393.3 GO:0016021 integral component of membrane(GO:0016021)
0.5 112.7 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.4 94.8 GO:0016323 basolateral plasma membrane(GO:0016323)
0.3 89.4 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.2 67.0 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.3 64.3 GO:0000139 Golgi membrane(GO:0000139)
0.6 59.3 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 50.6 GO:0005739 mitochondrion(GO:0005739)
0.3 43.1 GO:0070382 exocytic vesicle(GO:0070382)
0.8 41.1 GO:0031901 early endosome membrane(GO:0031901)
0.2 34.3 GO:0097060 synaptic membrane(GO:0097060)
1.8 34.1 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 32.7 GO:0005615 extracellular space(GO:0005615)
1.3 27.3 GO:0005581 collagen trimer(GO:0005581)
0.3 26.8 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
1.8 25.3 GO:0043083 synaptic cleft(GO:0043083)
0.7 23.9 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.2 22.8 GO:0005802 trans-Golgi network(GO:0005802)
0.4 22.6 GO:0043195 terminal bouton(GO:0043195)
1.8 21.5 GO:0044327 dendritic spine head(GO:0044327)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 668 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 63.3 GO:0005096 GTPase activator activity(GO:0005096)
0.8 49.1 GO:0005179 hormone activity(GO:0005179)
0.6 46.8 GO:0005178 integrin binding(GO:0005178)
0.3 44.2 GO:0003735 structural constituent of ribosome(GO:0003735)
0.5 40.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
1.3 40.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
1.0 38.4 GO:0070412 R-SMAD binding(GO:0070412)
0.9 34.3 GO:0005484 SNAP receptor activity(GO:0005484)
0.5 32.4 GO:0005080 protein kinase C binding(GO:0005080)
2.4 31.2 GO:0019855 calcium channel inhibitor activity(GO:0019855)
1.7 29.8 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.8 29.6 GO:0050840 extracellular matrix binding(GO:0050840)
0.5 28.5 GO:0008201 heparin binding(GO:0008201)
0.5 26.4 GO:0015485 cholesterol binding(GO:0015485)
1.5 26.2 GO:0005003 ephrin receptor activity(GO:0005003)
2.8 25.5 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.3 25.1 GO:0005125 cytokine activity(GO:0005125)
1.0 23.4 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.9 23.4 GO:0071837 HMG box domain binding(GO:0071837)
1.2 22.7 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 120 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 98.7 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.3 52.7 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.4 51.0 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
1.1 48.0 PID_SHP2_PATHWAY SHP2 signaling
1.5 46.0 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
1.2 38.9 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
2.0 33.4 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.9 32.4 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.9 30.4 PID_RAS_PATHWAY Regulation of Ras family activation
1.1 30.3 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
1.2 26.7 ST_GA12_PATHWAY G alpha 12 Pathway
0.4 23.5 PID_ERBB1_DOWNSTREAM_PATHWAY ErbB1 downstream signaling
1.2 23.1 PID_IL23_PATHWAY IL23-mediated signaling events
1.5 20.9 ST_JAK_STAT_PATHWAY Jak-STAT Pathway
0.8 20.3 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
1.2 20.0 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.8 20.0 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.5 20.0 PID_INSULIN_PATHWAY Insulin Pathway
0.6 19.8 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.7 19.1 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 206 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 68.1 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.7 44.3 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.3 43.4 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
1.3 40.7 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
1.8 35.6 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.3 34.6 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
2.1 31.7 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
1.0 31.2 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.5 30.1 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
1.0 24.0 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.6 23.8 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.4 23.3 REACTOME_CELL_JUNCTION_ORGANIZATION Genes involved in Cell junction organization
0.7 23.1 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.2 21.2 REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism
1.5 20.5 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.8 20.4 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
1.6 20.3 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.6 19.7 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.8 19.6 REACTOME_KERATAN_SULFATE_KERATIN_METABOLISM Genes involved in Keratan sulfate/keratin metabolism
1.0 18.1 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis