Motif ID: Sp2
Z-value: 0.588
Transcription factors associated with Sp2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Sp2 | ENSMUSG00000018678.6 | Sp2 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Sp2 | mm10_v2_chr11_-_96977660_96977711 | 0.19 | 9.7e-02 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 221 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 12.9 | GO:0048672 | positive regulation of collateral sprouting(GO:0048672) |
| 0.7 | 5.3 | GO:0010032 | meiotic chromosome condensation(GO:0010032) |
| 1.5 | 4.5 | GO:0007290 | spermatid nucleus elongation(GO:0007290) |
| 1.5 | 4.5 | GO:0001869 | regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869) |
| 1.0 | 4.2 | GO:1902724 | positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728) |
| 0.2 | 4.1 | GO:0021978 | telencephalon regionalization(GO:0021978) |
| 0.2 | 3.7 | GO:0043567 | regulation of insulin-like growth factor receptor signaling pathway(GO:0043567) |
| 0.5 | 3.5 | GO:1903690 | negative regulation of wound healing, spreading of epidermal cells(GO:1903690) |
| 0.4 | 3.2 | GO:0001842 | neural fold formation(GO:0001842) |
| 0.4 | 3.1 | GO:0006477 | protein sulfation(GO:0006477) |
| 0.6 | 2.9 | GO:0060266 | negative regulation of respiratory burst involved in inflammatory response(GO:0060266) |
| 0.2 | 2.7 | GO:0048843 | negative regulation of axon extension involved in axon guidance(GO:0048843) |
| 0.1 | 2.6 | GO:0006493 | protein O-linked glycosylation(GO:0006493) |
| 0.1 | 2.4 | GO:0003334 | keratinocyte development(GO:0003334) |
| 0.3 | 2.3 | GO:0010745 | negative regulation of macrophage derived foam cell differentiation(GO:0010745) |
| 0.1 | 2.3 | GO:0099517 | anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517) |
| 0.0 | 2.3 | GO:0007093 | mitotic cell cycle checkpoint(GO:0007093) |
| 0.3 | 2.2 | GO:1904217 | regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) regulation of serine C-palmitoyltransferase activity(GO:1904220) positive regulation of serine C-palmitoyltransferase activity(GO:1904222) |
| 0.3 | 2.0 | GO:0044829 | positive regulation by host of viral genome replication(GO:0044829) |
| 0.1 | 1.9 | GO:0050873 | brown fat cell differentiation(GO:0050873) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 97 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.2 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 7.2 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.1 | 6.7 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.5 | 5.3 | GO:0000796 | condensin complex(GO:0000796) |
| 0.8 | 3.2 | GO:0090537 | CERF complex(GO:0090537) |
| 0.2 | 2.9 | GO:0045180 | basal cortex(GO:0045180) |
| 0.1 | 2.4 | GO:0002102 | podosome(GO:0002102) |
| 0.1 | 2.3 | GO:1904115 | axon cytoplasm(GO:1904115) |
| 0.7 | 2.1 | GO:1990423 | RZZ complex(GO:1990423) |
| 0.0 | 1.9 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.1 | 1.6 | GO:0032156 | septin cytoskeleton(GO:0032156) |
| 0.0 | 1.5 | GO:1990391 | DNA repair complex(GO:1990391) |
| 0.0 | 1.5 | GO:0060170 | ciliary membrane(GO:0060170) |
| 0.0 | 1.5 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 1.5 | GO:0000922 | spindle pole(GO:0000922) |
| 0.0 | 1.3 | GO:0043235 | receptor complex(GO:0043235) |
| 0.0 | 1.3 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.2 | 1.2 | GO:1990726 | Lsm1-7-Pat1 complex(GO:1990726) |
| 0.1 | 1.2 | GO:0045120 | pronucleus(GO:0045120) |
| 0.0 | 1.2 | GO:0045178 | basal part of cell(GO:0045178) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 149 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 9.2 | GO:0019841 | retinol binding(GO:0019841) |
| 0.1 | 5.8 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.8 | 5.0 | GO:0008467 | [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467) |
| 0.0 | 4.7 | GO:0000987 | core promoter proximal region sequence-specific DNA binding(GO:0000987) |
| 0.2 | 4.5 | GO:0032454 | histone demethylase activity (H3-K9 specific)(GO:0032454) |
| 0.2 | 4.5 | GO:0001848 | complement binding(GO:0001848) |
| 0.5 | 4.2 | GO:0031730 | CCR5 chemokine receptor binding(GO:0031730) |
| 0.2 | 3.1 | GO:0048273 | mitogen-activated protein kinase p38 binding(GO:0048273) |
| 0.0 | 3.1 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 3.1 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.2 | 3.0 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.3 | 2.5 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 0.0 | 2.5 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.2 | 2.2 | GO:0022889 | L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889) |
| 0.6 | 1.9 | GO:0003979 | UDP-glucose 6-dehydrogenase activity(GO:0003979) |
| 0.0 | 1.8 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.0 | 1.7 | GO:0002039 | p53 binding(GO:0002039) |
| 0.0 | 1.6 | GO:0070063 | RNA polymerase binding(GO:0070063) |
| 0.2 | 1.5 | GO:0030911 | TPR domain binding(GO:0030911) |
| 0.1 | 1.5 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 27 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.4 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 6.1 | PID_AURORA_B_PATHWAY | Aurora B signaling |
| 0.0 | 4.4 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
| 0.2 | 4.2 | PID_IL27_PATHWAY | IL27-mediated signaling events |
| 0.1 | 3.1 | PID_P38_ALPHA_BETA_PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.1 | 2.9 | PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 2.8 | PID_HIF1A_PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.1 | 2.7 | PID_S1P_META_PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.0 | 2.5 | PID_HES_HEY_PATHWAY | Notch-mediated HES/HEY network |
| 0.2 | 1.8 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 1.5 | PID_HEDGEHOG_GLI_PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 1.4 | PID_RB_1PATHWAY | Regulation of retinoblastoma protein |
| 0.0 | 1.4 | PID_CMYB_PATHWAY | C-MYB transcription factor network |
| 0.0 | 1.2 | SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 0.1 | 0.9 | ST_G_ALPHA_I_PATHWAY | G alpha i Pathway |
| 0.0 | 0.9 | PID_RET_PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 0.9 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 0.9 | PID_BMP_PATHWAY | BMP receptor signaling |
| 0.1 | 0.8 | PID_INTEGRIN4_PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 0.8 | SA_PROGRAMMED_CELL_DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 61 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.9 | REACTOME_HS_GAG_BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.4 | 4.5 | REACTOME_INTRINSIC_PATHWAY | Genes involved in Intrinsic Pathway |
| 0.3 | 4.2 | REACTOME_IL_6_SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.1 | 2.6 | REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.1 | 2.6 | REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 2.2 | REACTOME_MRNA_3_END_PROCESSING | Genes involved in mRNA 3'-end processing |
| 0.0 | 2.2 | REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 0.0 | 2.1 | REACTOME_NETRIN1_SIGNALING | Genes involved in Netrin-1 signaling |
| 0.0 | 2.1 | REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS | Genes involved in Class A/1 (Rhodopsin-like receptors) |
| 0.2 | 1.9 | REACTOME_GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.0 | 1.9 | REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.0 | 1.8 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 1.7 | REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
| 0.1 | 1.6 | REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.0 | 1.6 | REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 1.5 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
| 0.0 | 1.4 | REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 1.3 | REACTOME_KINESINS | Genes involved in Kinesins |
| 0.1 | 1.2 | REACTOME_IL_RECEPTOR_SHC_SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.0 | 1.2 | REACTOME_PEPTIDE_CHAIN_ELONGATION | Genes involved in Peptide chain elongation |
