Motif ID: Spdef
Z-value: 0.541
Transcription factors associated with Spdef:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Spdef | ENSMUSG00000024215.7 | Spdef |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Spdef | mm10_v2_chr17_-_27728889_27728956 | -0.17 | 1.5e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 2.6 | GO:0061349 | Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) hypophysis morphogenesis(GO:0048850) cervix development(GO:0060067) planar cell polarity pathway involved in outflow tract morphogenesis(GO:0061347) planar cell polarity pathway involved in ventricular septum morphogenesis(GO:0061348) planar cell polarity pathway involved in cardiac right atrium morphogenesis(GO:0061349) planar cell polarity pathway involved in cardiac muscle tissue morphogenesis(GO:0061350) planar cell polarity pathway involved in pericardium morphogenesis(GO:0061354) |
| 0.8 | 3.2 | GO:0044565 | dendritic cell proliferation(GO:0044565) |
| 0.5 | 1.6 | GO:0043323 | positive regulation of natural killer cell degranulation(GO:0043323) |
| 0.4 | 1.2 | GO:0019085 | early viral transcription(GO:0019085) |
| 0.3 | 1.7 | GO:0034421 | post-translational protein acetylation(GO:0034421) |
| 0.3 | 1.7 | GO:0044314 | protein K27-linked ubiquitination(GO:0044314) |
| 0.3 | 1.3 | GO:0061428 | embryonic heart tube left/right pattern formation(GO:0060971) negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428) |
| 0.3 | 1.3 | GO:0032275 | luteinizing hormone secretion(GO:0032275) |
| 0.3 | 1.0 | GO:1902915 | negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915) |
| 0.3 | 4.2 | GO:0071257 | cellular response to electrical stimulus(GO:0071257) |
| 0.3 | 0.9 | GO:0071921 | establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922) |
| 0.3 | 2.5 | GO:0070236 | negative regulation of activation-induced cell death of T cells(GO:0070236) |
| 0.3 | 1.3 | GO:0046864 | retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865) alveolar primary septum development(GO:0061143) |
| 0.2 | 1.4 | GO:0036438 | maintenance of lens transparency(GO:0036438) |
| 0.2 | 0.7 | GO:0060244 | negative regulation of cell proliferation involved in contact inhibition(GO:0060244) |
| 0.2 | 0.9 | GO:0086046 | membrane depolarization during SA node cell action potential(GO:0086046) |
| 0.2 | 1.7 | GO:0035743 | CD4-positive, alpha-beta T cell cytokine production(GO:0035743) |
| 0.2 | 1.4 | GO:1904217 | regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) regulation of serine C-palmitoyltransferase activity(GO:1904220) positive regulation of serine C-palmitoyltransferase activity(GO:1904222) |
| 0.2 | 1.6 | GO:0070317 | negative regulation of G0 to G1 transition(GO:0070317) |
| 0.2 | 0.8 | GO:2000256 | endomitotic cell cycle(GO:0007113) thrombopoietin-mediated signaling pathway(GO:0038163) positive regulation of male germ cell proliferation(GO:2000256) |
| 0.2 | 0.6 | GO:0002447 | eosinophil activation involved in immune response(GO:0002278) eosinophil mediated immunity(GO:0002447) eosinophil degranulation(GO:0043308) regulation of eosinophil activation(GO:1902566) |
| 0.2 | 1.1 | GO:0090070 | positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234) |
| 0.2 | 0.7 | GO:0019355 | nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process(GO:0034627) 'de novo' NAD biosynthetic process from aspartate(GO:0034628) |
| 0.2 | 0.8 | GO:1901668 | regulation of superoxide dismutase activity(GO:1901668) |
| 0.2 | 1.2 | GO:1903551 | regulation of extracellular exosome assembly(GO:1903551) |
| 0.1 | 1.5 | GO:0006691 | leukotriene metabolic process(GO:0006691) |
| 0.1 | 0.6 | GO:0006776 | vitamin A metabolic process(GO:0006776) |
| 0.1 | 2.9 | GO:0006044 | N-acetylglucosamine metabolic process(GO:0006044) |
| 0.1 | 0.4 | GO:0035526 | retrograde transport, plasma membrane to Golgi(GO:0035526) |
| 0.1 | 0.6 | GO:0009212 | dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212) dTTP metabolic process(GO:0046075) |
| 0.1 | 1.4 | GO:0070574 | cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574) |
| 0.1 | 1.2 | GO:0071397 | cellular response to cholesterol(GO:0071397) |
| 0.1 | 0.6 | GO:0021506 | anterior neuropore closure(GO:0021506) neuropore closure(GO:0021995) |
| 0.1 | 1.4 | GO:1904153 | negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153) |
| 0.1 | 0.7 | GO:2000623 | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623) |
| 0.1 | 0.3 | GO:0006546 | glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464) |
| 0.1 | 0.4 | GO:0070537 | histone H2A K63-linked deubiquitination(GO:0070537) |
| 0.1 | 0.7 | GO:2000483 | negative regulation of interleukin-8 secretion(GO:2000483) |
| 0.1 | 0.5 | GO:0032485 | regulation of Ral protein signal transduction(GO:0032485) |
| 0.1 | 0.5 | GO:0018125 | peptidyl-cysteine methylation(GO:0018125) |
| 0.1 | 0.5 | GO:0031022 | nuclear migration along microfilament(GO:0031022) |
| 0.1 | 0.4 | GO:0021764 | amygdala development(GO:0021764) |
| 0.1 | 0.6 | GO:0006741 | NADP biosynthetic process(GO:0006741) |
| 0.1 | 0.8 | GO:0031848 | protection from non-homologous end joining at telomere(GO:0031848) |
| 0.1 | 0.3 | GO:2000850 | negative regulation of corticosteroid hormone secretion(GO:2000847) negative regulation of glucocorticoid secretion(GO:2000850) |
| 0.1 | 1.4 | GO:0060693 | regulation of branching involved in salivary gland morphogenesis(GO:0060693) |
| 0.1 | 0.3 | GO:2000016 | negative regulation of determination of dorsal identity(GO:2000016) |
| 0.1 | 0.5 | GO:0097473 | cellular response to light intensity(GO:0071484) cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473) |
| 0.1 | 2.6 | GO:0060749 | mammary gland alveolus development(GO:0060749) mammary gland lobule development(GO:0061377) |
| 0.1 | 0.8 | GO:0019227 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
| 0.1 | 0.2 | GO:1902277 | negative regulation of pancreatic amylase secretion(GO:1902277) |
| 0.1 | 0.5 | GO:0098535 | de novo centriole assembly(GO:0098535) |
| 0.1 | 0.2 | GO:0018214 | peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214) |
| 0.1 | 0.7 | GO:0051256 | mitotic spindle midzone assembly(GO:0051256) |
| 0.1 | 0.4 | GO:0071955 | recycling endosome to Golgi transport(GO:0071955) |
| 0.1 | 1.5 | GO:0034315 | regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315) |
| 0.1 | 0.1 | GO:0006041 | glucosamine metabolic process(GO:0006041) |
| 0.1 | 0.7 | GO:0032471 | negative regulation of endoplasmic reticulum calcium ion concentration(GO:0032471) |
| 0.1 | 0.7 | GO:0097151 | positive regulation of inhibitory postsynaptic potential(GO:0097151) |
| 0.1 | 0.7 | GO:0060836 | lymphatic endothelial cell differentiation(GO:0060836) |
| 0.1 | 0.3 | GO:0043353 | enucleate erythrocyte differentiation(GO:0043353) |
| 0.1 | 0.7 | GO:0060501 | positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) |
| 0.1 | 0.4 | GO:1901098 | positive regulation of autophagosome maturation(GO:1901098) |
| 0.1 | 0.2 | GO:0039533 | regulation of MDA-5 signaling pathway(GO:0039533) |
| 0.1 | 1.4 | GO:1902857 | positive regulation of nonmotile primary cilium assembly(GO:1902857) |
| 0.1 | 0.6 | GO:0018342 | protein prenylation(GO:0018342) prenylation(GO:0097354) |
| 0.1 | 0.4 | GO:0031584 | activation of phospholipase D activity(GO:0031584) |
| 0.0 | 2.1 | GO:0071526 | semaphorin-plexin signaling pathway(GO:0071526) |
| 0.0 | 0.3 | GO:0051418 | interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418) |
| 0.0 | 0.1 | GO:1904211 | membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211) |
| 0.0 | 0.4 | GO:0006104 | succinyl-CoA metabolic process(GO:0006104) |
| 0.0 | 0.3 | GO:0032264 | IMP salvage(GO:0032264) |
| 0.0 | 0.3 | GO:0097039 | protein linear polyubiquitination(GO:0097039) |
| 0.0 | 1.4 | GO:0034724 | DNA replication-independent nucleosome organization(GO:0034724) |
| 0.0 | 0.6 | GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977) |
| 0.0 | 0.7 | GO:0045742 | positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742) |
| 0.0 | 0.1 | GO:0051388 | positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) |
| 0.0 | 0.2 | GO:0002756 | MyD88-independent toll-like receptor signaling pathway(GO:0002756) |
| 0.0 | 0.3 | GO:2001185 | regulation of CD8-positive, alpha-beta T cell activation(GO:2001185) |
| 0.0 | 0.7 | GO:0033539 | fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539) |
| 0.0 | 0.3 | GO:0043029 | T cell homeostasis(GO:0043029) |
| 0.0 | 1.6 | GO:0030520 | intracellular estrogen receptor signaling pathway(GO:0030520) |
| 0.0 | 0.2 | GO:0036015 | response to interleukin-3(GO:0036015) cellular response to interleukin-3(GO:0036016) |
| 0.0 | 0.5 | GO:1901898 | regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898) |
| 0.0 | 1.5 | GO:1902476 | chloride transmembrane transport(GO:1902476) |
| 0.0 | 0.6 | GO:0060218 | hematopoietic stem cell differentiation(GO:0060218) |
| 0.0 | 0.1 | GO:1900060 | negative regulation of ceramide biosynthetic process(GO:1900060) |
| 0.0 | 0.4 | GO:0035721 | intraciliary retrograde transport(GO:0035721) |
| 0.0 | 0.1 | GO:0044313 | protein K6-linked deubiquitination(GO:0044313) |
| 0.0 | 0.4 | GO:0060213 | regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213) |
| 0.0 | 0.4 | GO:0060363 | cranial suture morphogenesis(GO:0060363) |
| 0.0 | 0.6 | GO:0010996 | response to auditory stimulus(GO:0010996) |
| 0.0 | 0.2 | GO:0007016 | cytoskeletal anchoring at plasma membrane(GO:0007016) |
| 0.0 | 0.7 | GO:0002063 | chondrocyte development(GO:0002063) |
| 0.0 | 0.3 | GO:0032463 | negative regulation of protein homooligomerization(GO:0032463) |
| 0.0 | 0.5 | GO:0072673 | lamellipodium morphogenesis(GO:0072673) |
| 0.0 | 0.4 | GO:0016558 | protein import into peroxisome matrix(GO:0016558) |
| 0.0 | 0.1 | GO:0036508 | protein deglycosylation involved in glycoprotein catabolic process(GO:0035977) protein demannosylation(GO:0036507) protein alpha-1,2-demannosylation(GO:0036508) glycoprotein ERAD pathway(GO:0097466) mannose trimming involved in glycoprotein ERAD pathway(GO:1904382) |
| 0.0 | 0.0 | GO:1900226 | negative regulation of NLRP3 inflammasome complex assembly(GO:1900226) |
| 0.0 | 0.1 | GO:1903588 | negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588) |
| 0.0 | 0.3 | GO:0007250 | activation of NF-kappaB-inducing kinase activity(GO:0007250) |
| 0.0 | 0.1 | GO:0046855 | inositol phosphate dephosphorylation(GO:0046855) |
| 0.0 | 0.1 | GO:0007296 | vitellogenesis(GO:0007296) |
| 0.0 | 1.4 | GO:0030968 | endoplasmic reticulum unfolded protein response(GO:0030968) |
| 0.0 | 0.2 | GO:0099590 | neurotransmitter receptor internalization(GO:0099590) |
| 0.0 | 0.2 | GO:0090148 | membrane fission(GO:0090148) |
| 0.0 | 0.1 | GO:0045903 | positive regulation of translational fidelity(GO:0045903) |
| 0.0 | 0.6 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
| 0.0 | 0.7 | GO:0050982 | detection of mechanical stimulus(GO:0050982) |
| 0.0 | 0.1 | GO:1903361 | protein localization to basolateral plasma membrane(GO:1903361) |
| 0.0 | 0.2 | GO:0007220 | Notch receptor processing(GO:0007220) |
| 0.0 | 0.1 | GO:0006398 | mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398) |
| 0.0 | 0.3 | GO:0006353 | DNA-templated transcription, termination(GO:0006353) |
| 0.0 | 0.5 | GO:0044030 | regulation of DNA methylation(GO:0044030) |
| 0.0 | 0.3 | GO:0006744 | ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663) |
| 0.0 | 0.0 | GO:0015712 | hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760) |
| 0.0 | 0.0 | GO:0002946 | tRNA C5-cytosine methylation(GO:0002946) |
| 0.0 | 0.8 | GO:0030835 | negative regulation of actin filament depolymerization(GO:0030835) |
| 0.0 | 0.2 | GO:0031145 | anaphase-promoting complex-dependent catabolic process(GO:0031145) |
| 0.0 | 0.2 | GO:0031937 | positive regulation of chromatin silencing(GO:0031937) |
| 0.0 | 0.3 | GO:0046856 | phosphatidylinositol dephosphorylation(GO:0046856) |
| 0.0 | 0.4 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.0 | 0.3 | GO:0005980 | polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247) |
| 0.0 | 0.5 | GO:0006891 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) intra-Golgi vesicle-mediated transport(GO:0006891) |
| 0.0 | 0.6 | GO:0060612 | adipose tissue development(GO:0060612) |
| 0.0 | 0.3 | GO:0015991 | ATP hydrolysis coupled proton transport(GO:0015991) |
| 0.0 | 0.1 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
| 0.0 | 0.5 | GO:0050688 | regulation of defense response to virus(GO:0050688) |
| 0.0 | 0.1 | GO:0045650 | negative regulation of macrophage differentiation(GO:0045650) |
| 0.0 | 0.2 | GO:0030238 | male sex determination(GO:0030238) |
| 0.0 | 0.1 | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) |
| 0.0 | 1.0 | GO:0098656 | anion transmembrane transport(GO:0098656) |
| 0.0 | 0.0 | GO:0016256 | N-glycan processing to lysosome(GO:0016256) |
| 0.0 | 1.5 | GO:0006261 | DNA-dependent DNA replication(GO:0006261) |
| 0.0 | 0.4 | GO:0007212 | dopamine receptor signaling pathway(GO:0007212) |
| 0.0 | 0.8 | GO:0030148 | sphingolipid biosynthetic process(GO:0030148) |
| 0.0 | 0.6 | GO:0060395 | SMAD protein signal transduction(GO:0060395) |
| 0.0 | 0.2 | GO:0021902 | commitment of neuronal cell to specific neuron type in forebrain(GO:0021902) |
| 0.0 | 0.5 | GO:0007029 | endoplasmic reticulum organization(GO:0007029) |
| 0.0 | 0.1 | GO:0006172 | ADP biosynthetic process(GO:0006172) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.5 | GO:0008623 | CHRAC(GO:0008623) |
| 0.2 | 0.6 | GO:0035101 | FACT complex(GO:0035101) |
| 0.2 | 0.7 | GO:0045251 | mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251) |
| 0.2 | 0.8 | GO:1990130 | Iml1 complex(GO:1990130) |
| 0.1 | 1.5 | GO:0033179 | proton-transporting V-type ATPase, V0 domain(GO:0033179) |
| 0.1 | 3.8 | GO:0045334 | clathrin-coated endocytic vesicle(GO:0045334) |
| 0.1 | 0.5 | GO:0032444 | activin responsive factor complex(GO:0032444) |
| 0.1 | 0.4 | GO:0070552 | BRISC complex(GO:0070552) |
| 0.1 | 0.7 | GO:0005964 | phosphorylase kinase complex(GO:0005964) |
| 0.1 | 0.3 | GO:0097543 | ciliary inversin compartment(GO:0097543) |
| 0.1 | 0.3 | GO:0036488 | CHOP-C/EBP complex(GO:0036488) |
| 0.1 | 0.6 | GO:0000322 | storage vacuole(GO:0000322) |
| 0.1 | 2.5 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.1 | 0.3 | GO:1990415 | Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429) |
| 0.1 | 0.3 | GO:0071797 | LUBAC complex(GO:0071797) |
| 0.1 | 0.4 | GO:0030062 | mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062) |
| 0.1 | 0.8 | GO:0070419 | nonhomologous end joining complex(GO:0070419) |
| 0.1 | 0.5 | GO:0034993 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 0.1 | 0.4 | GO:0070847 | core mediator complex(GO:0070847) |
| 0.1 | 0.3 | GO:0000839 | Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839) |
| 0.1 | 1.7 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.1 | 0.2 | GO:0030688 | preribosome, small subunit precursor(GO:0030688) |
| 0.1 | 0.8 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.1 | 0.5 | GO:0097427 | microtubule bundle(GO:0097427) |
| 0.0 | 0.4 | GO:0030991 | intraciliary transport particle A(GO:0030991) |
| 0.0 | 0.4 | GO:1990316 | ATG1/ULK1 kinase complex(GO:1990316) |
| 0.0 | 0.3 | GO:0000923 | equatorial microtubule organizing center(GO:0000923) |
| 0.0 | 0.4 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
| 0.0 | 0.5 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.0 | 1.2 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
| 0.0 | 0.7 | GO:0031105 | septin complex(GO:0031105) |
| 0.0 | 0.8 | GO:0032433 | filopodium tip(GO:0032433) |
| 0.0 | 2.0 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 0.2 | GO:0005672 | transcription factor TFIIA complex(GO:0005672) |
| 0.0 | 0.7 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.0 | 0.5 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
| 0.0 | 0.7 | GO:0030904 | retromer complex(GO:0030904) |
| 0.0 | 1.2 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.0 | 0.4 | GO:0017119 | Golgi transport complex(GO:0017119) |
| 0.0 | 0.2 | GO:0070765 | gamma-secretase complex(GO:0070765) |
| 0.0 | 0.1 | GO:0071556 | integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553) |
| 0.0 | 1.1 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.0 | 4.4 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 1.2 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.0 | 0.1 | GO:0035339 | SPOTS complex(GO:0035339) |
| 0.0 | 0.3 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 0.0 | 0.2 | GO:0090543 | Flemming body(GO:0090543) |
| 0.0 | 0.6 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.0 | 0.7 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.0 | 1.0 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.0 | 0.1 | GO:0000801 | central element(GO:0000801) |
| 0.0 | 4.5 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.0 | 0.7 | GO:0035869 | ciliary transition zone(GO:0035869) |
| 0.0 | 0.3 | GO:0071004 | U2-type prespliceosome(GO:0071004) |
| 0.0 | 0.3 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 0.7 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.0 | 0.1 | GO:0016593 | Cdc73/Paf1 complex(GO:0016593) |
| 0.0 | 0.5 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.0 | 1.0 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.0 | 1.7 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 0.3 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
| 0.0 | 0.2 | GO:0005682 | U5 snRNP(GO:0005682) |
| 0.0 | 0.2 | GO:0005689 | U12-type spliceosomal complex(GO:0005689) |
| 0.0 | 0.8 | GO:0000118 | histone deacetylase complex(GO:0000118) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 2.6 | GO:0005110 | frizzled-2 binding(GO:0005110) |
| 0.5 | 2.5 | GO:0004342 | glucosamine-6-phosphate deaminase activity(GO:0004342) |
| 0.5 | 1.4 | GO:0008109 | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109) |
| 0.3 | 1.4 | GO:0008269 | JAK pathway signal transduction adaptor activity(GO:0008269) |
| 0.3 | 0.8 | GO:0047256 | beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256) |
| 0.3 | 1.6 | GO:0016300 | tRNA (uracil) methyltransferase activity(GO:0016300) |
| 0.3 | 0.8 | GO:0031752 | D5 dopamine receptor binding(GO:0031752) |
| 0.2 | 0.9 | GO:0008332 | low voltage-gated calcium channel activity(GO:0008332) |
| 0.2 | 1.1 | GO:0004095 | carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416) |
| 0.2 | 0.6 | GO:0016501 | prostacyclin receptor activity(GO:0016501) |
| 0.2 | 0.7 | GO:0004174 | electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649) |
| 0.2 | 2.4 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.2 | 0.7 | GO:0004515 | nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515) |
| 0.2 | 0.8 | GO:0008427 | calcium-dependent protein kinase inhibitor activity(GO:0008427) |
| 0.1 | 0.6 | GO:0016230 | sphingomyelin phosphodiesterase activator activity(GO:0016230) |
| 0.1 | 0.7 | GO:0052833 | inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834) |
| 0.1 | 0.4 | GO:0004774 | succinate-CoA ligase activity(GO:0004774) |
| 0.1 | 1.2 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.1 | 0.4 | GO:0001888 | glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0001888) |
| 0.1 | 0.6 | GO:0050265 | RNA uridylyltransferase activity(GO:0050265) |
| 0.1 | 1.3 | GO:0050693 | LBD domain binding(GO:0050693) |
| 0.1 | 0.3 | GO:0004534 | transcription termination site sequence-specific DNA binding(GO:0001147) transcription termination site DNA binding(GO:0001160) 5'-3' exoribonuclease activity(GO:0004534) |
| 0.1 | 0.6 | GO:0051185 | coenzyme transporter activity(GO:0051185) |
| 0.1 | 0.7 | GO:0004689 | phosphorylase kinase activity(GO:0004689) |
| 0.1 | 0.3 | GO:1990450 | linear polyubiquitin binding(GO:1990450) |
| 0.1 | 1.0 | GO:0004445 | inositol-polyphosphate 5-phosphatase activity(GO:0004445) inositol trisphosphate phosphatase activity(GO:0046030) |
| 0.1 | 0.4 | GO:0032422 | purine-rich negative regulatory element binding(GO:0032422) |
| 0.1 | 0.4 | GO:0051377 | mannose-ethanolamine phosphotransferase activity(GO:0051377) |
| 0.1 | 0.8 | GO:0035312 | 5'-3' exodeoxyribonuclease activity(GO:0035312) |
| 0.1 | 0.7 | GO:0001075 | transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075) |
| 0.1 | 1.2 | GO:0022889 | L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889) |
| 0.1 | 0.6 | GO:0008318 | protein prenyltransferase activity(GO:0008318) |
| 0.1 | 1.0 | GO:0005225 | volume-sensitive anion channel activity(GO:0005225) |
| 0.1 | 0.7 | GO:0034711 | inhibin binding(GO:0034711) |
| 0.1 | 1.4 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.1 | 0.5 | GO:0043199 | sulfate binding(GO:0043199) |
| 0.1 | 2.0 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.1 | 0.3 | GO:0043812 | phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812) |
| 0.1 | 1.8 | GO:0030742 | GTP-dependent protein binding(GO:0030742) |
| 0.1 | 0.2 | GO:0031871 | proteinase activated receptor binding(GO:0031871) |
| 0.1 | 1.6 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.1 | 2.5 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.1 | 0.4 | GO:0031821 | G-protein coupled serotonin receptor binding(GO:0031821) |
| 0.1 | 1.4 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.1 | 1.7 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
| 0.0 | 0.9 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.0 | 0.8 | GO:0031402 | sodium ion binding(GO:0031402) |
| 0.0 | 0.3 | GO:0003876 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
| 0.0 | 0.6 | GO:0070513 | death domain binding(GO:0070513) |
| 0.0 | 1.3 | GO:0046966 | thyroid hormone receptor binding(GO:0046966) |
| 0.0 | 0.3 | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity(GO:0004726) |
| 0.0 | 1.3 | GO:0051183 | vitamin transporter activity(GO:0051183) |
| 0.0 | 0.5 | GO:0030296 | protein tyrosine kinase activator activity(GO:0030296) |
| 0.0 | 0.9 | GO:0031078 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
| 0.0 | 0.7 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.0 | 1.3 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 0.0 | 0.3 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.0 | 1.3 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.0 | 0.3 | GO:0090599 | alpha-glucosidase activity(GO:0090599) |
| 0.0 | 0.2 | GO:0005131 | growth hormone receptor binding(GO:0005131) |
| 0.0 | 0.2 | GO:0045131 | pre-mRNA branch point binding(GO:0045131) |
| 0.0 | 0.8 | GO:0034237 | protein kinase A regulatory subunit binding(GO:0034237) |
| 0.0 | 0.6 | GO:0003951 | NAD+ kinase activity(GO:0003951) |
| 0.0 | 0.3 | GO:0030550 | acetylcholine receptor inhibitor activity(GO:0030550) |
| 0.0 | 4.8 | GO:0003774 | motor activity(GO:0003774) |
| 0.0 | 0.3 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
| 0.0 | 0.5 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.0 | 0.7 | GO:0008143 | poly(A) binding(GO:0008143) |
| 0.0 | 1.4 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.0 | 0.9 | GO:0030515 | snoRNA binding(GO:0030515) |
| 0.0 | 0.2 | GO:0089720 | caspase binding(GO:0089720) |
| 0.0 | 0.3 | GO:0045125 | bioactive lipid receptor activity(GO:0045125) |
| 0.0 | 0.5 | GO:0050321 | tau-protein kinase activity(GO:0050321) |
| 0.0 | 0.7 | GO:0031435 | mitogen-activated protein kinase kinase kinase binding(GO:0031435) |
| 0.0 | 0.5 | GO:0008483 | transaminase activity(GO:0008483) |
| 0.0 | 1.5 | GO:0005254 | chloride channel activity(GO:0005254) |
| 0.0 | 0.1 | GO:0008409 | 5'-3' exonuclease activity(GO:0008409) |
| 0.0 | 1.3 | GO:0061733 | peptide-lysine-N-acetyltransferase activity(GO:0061733) |
| 0.0 | 0.2 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
| 0.0 | 0.9 | GO:0051879 | Hsp90 protein binding(GO:0051879) |
| 0.0 | 0.1 | GO:0046899 | nucleoside triphosphate adenylate kinase activity(GO:0046899) |
| 0.0 | 0.3 | GO:1904264 | ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264) |
| 0.0 | 0.2 | GO:0048038 | quinone binding(GO:0048038) |
| 0.0 | 0.8 | GO:0004177 | aminopeptidase activity(GO:0004177) |
| 0.0 | 0.1 | GO:0042500 | aspartic endopeptidase activity, intramembrane cleaving(GO:0042500) |
| 0.0 | 1.3 | GO:0043022 | ribosome binding(GO:0043022) |
| 0.0 | 0.3 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.0 | 0.3 | GO:0071949 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) FAD binding(GO:0071949) |
| 0.0 | 0.3 | GO:0046961 | proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
| 0.0 | 0.5 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.0 | 0.1 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
| 0.0 | 0.0 | GO:0010385 | double-stranded methylated DNA binding(GO:0010385) |
| 0.0 | 0.4 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.0 | 0.1 | GO:0004839 | ubiquitin activating enzyme activity(GO:0004839) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.8 | PID_ECADHERIN_STABILIZATION_PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.1 | 2.4 | PID_WNT_CANONICAL_PATHWAY | Canonical Wnt signaling pathway |
| 0.1 | 2.6 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
| 0.1 | 1.2 | PID_S1P_S1P4_PATHWAY | S1P4 pathway |
| 0.1 | 1.6 | PID_HDAC_CLASSIII_PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 0.5 | PID_ALK2_PATHWAY | ALK2 signaling events |
| 0.0 | 0.8 | PID_DNA_PK_PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 0.2 | ST_IL_13_PATHWAY | Interleukin 13 (IL-13) Pathway |
| 0.0 | 0.7 | PID_ALK1_PATHWAY | ALK1 signaling events |
| 0.0 | 0.5 | SA_TRKA_RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.0 | 3.3 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 2.0 | PID_IL2_1PATHWAY | IL2-mediated signaling events |
| 0.0 | 0.8 | PID_PS1_PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.0 | 0.9 | PID_HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 0.8 | PID_AJDISS_2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 0.2 | PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY | EGF receptor (ErbB1) signaling pathway |
| 0.0 | 1.4 | PID_HDAC_CLASSI_PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 0.8 | PID_TRKR_PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 0.9 | PID_TCR_PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.0 | 0.5 | PID_CERAMIDE_PATHWAY | Ceramide signaling pathway |
| 0.0 | 0.4 | PID_THROMBIN_PAR1_PATHWAY | PAR1-mediated thrombin signaling events |
| 0.0 | 0.9 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 0.8 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.2 | REACTOME_GAP_JUNCTION_DEGRADATION | Genes involved in Gap junction degradation |
| 0.2 | 2.2 | REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.1 | 0.4 | REACTOME_THROMBOXANE_SIGNALLING_THROUGH_TP_RECEPTOR | Genes involved in Thromboxane signalling through TP receptor |
| 0.1 | 1.4 | REACTOME_ZINC_TRANSPORTERS | Genes involved in Zinc transporters |
| 0.1 | 1.2 | REACTOME_SIGNALING_BY_NODAL | Genes involved in Signaling by NODAL |
| 0.0 | 0.4 | REACTOME_G_ALPHA1213_SIGNALLING_EVENTS | Genes involved in G alpha (12/13) signalling events |
| 0.0 | 1.0 | REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.0 | 2.1 | REACTOME_PIP3_ACTIVATES_AKT_SIGNALING | Genes involved in PIP3 activates AKT signaling |
| 0.0 | 1.0 | REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
| 0.0 | 0.4 | REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS | Genes involved in Thrombin signalling through proteinase activated receptors (PARs) |
| 0.0 | 0.3 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.0 | 0.3 | REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 | Genes involved in IKK complex recruitment mediated by RIP1 |
| 0.0 | 0.3 | REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.0 | 0.7 | REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.0 | 0.6 | REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.0 | 0.4 | REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY | Genes involved in Adenylate cyclase inhibitory pathway |
| 0.0 | 0.8 | REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.0 | 0.9 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 0.7 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
| 0.0 | 0.2 | REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
| 0.0 | 0.2 | REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR | Genes involved in Regulated proteolysis of p75NTR |
| 0.0 | 0.5 | REACTOME_SMOOTH_MUSCLE_CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 0.2 | REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.0 | 0.4 | REACTOME_REGULATORY_RNA_PATHWAYS | Genes involved in Regulatory RNA pathways |
| 0.0 | 0.9 | REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 0.2 | REACTOME_IL_6_SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.0 | 0.3 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 0.1 | REACTOME_CALNEXIN_CALRETICULIN_CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.0 | 0.5 | REACTOME_G_ALPHA_S_SIGNALLING_EVENTS | Genes involved in G alpha (s) signalling events |
