Motif ID: Spi1

Z-value: 1.342


Transcription factors associated with Spi1:

Gene SymbolEntrez IDGene Name
Spi1 ENSMUSG00000002111.8 Spi1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Spi1mm10_v2_chr2_+_91082362_91082390-0.463.0e-05Click!


Activity profile for motif Spi1.

activity profile for motif Spi1


Sorted Z-values histogram for motif Spi1

Sorted Z-values for motif Spi1



Network of associatons between targets according to the STRING database.



First level regulatory network of Spi1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_127218303 16.018 ENSMUST00000106313.1
 Sept1
septin 1
chr7_-_127218390 15.404 ENSMUST00000142356.1
ENSMUST00000106314.1
 Sept1

septin 1

chr2_+_105675478 12.294 ENSMUST00000167211.2
ENSMUST00000111083.3
 Pax6

paired box gene 6

chr10_+_127725392 12.264 ENSMUST00000026466.3
 Tac2
tachykinin 2
chr1_-_172057573 12.113 ENSMUST00000059794.3
 Nhlh1
nescient helix loop helix 1
chr1_-_55226768 11.333 ENSMUST00000027121.8
ENSMUST00000114428.2
 Rftn2

raftlin family member 2

chr7_-_102250086 11.260 ENSMUST00000106923.1
ENSMUST00000098230.4
 Rhog

ras homolog gene family, member G

chr2_+_105682463 11.054 ENSMUST00000140173.1
ENSMUST00000135412.1
ENSMUST00000138365.1
ENSMUST00000145744.1
 Pax6



paired box gene 6



chr11_+_101468164 10.991 ENSMUST00000001347.6
 Rnd2
Rho family GTPase 2
chr3_-_95904683 10.194 ENSMUST00000147962.1
ENSMUST00000036181.8
 Car14

carbonic anhydrase 14

chr4_+_126556935 9.351 ENSMUST00000048391.8
 Clspn
claspin
chr9_-_94538075 9.026 ENSMUST00000113028.1
 1190002N15Rik
RIKEN cDNA 1190002N15 gene
chr11_+_61485431 8.912 ENSMUST00000064783.3
ENSMUST00000040522.6
 Mfap4

microfibrillar-associated protein 4

chr12_-_34528844 8.739 ENSMUST00000110819.2
 Hdac9
histone deacetylase 9
chr2_+_105675429 8.641 ENSMUST00000111085.1
 Pax6
paired box gene 6
chr5_+_64812336 8.619 ENSMUST00000166409.1
 Klf3
Kruppel-like factor 3 (basic)
chr7_+_51878967 8.483 ENSMUST00000051912.6
 Gas2
growth arrest specific 2
chr3_-_127780461 8.345 ENSMUST00000029662.5
ENSMUST00000161239.1
 Alpk1

alpha-kinase 1

chr4_+_8691303 8.311 ENSMUST00000051558.3
 Chd7
chromodomain helicase DNA binding protein 7
chr19_+_5740885 8.306 ENSMUST00000081496.5
 Ltbp3
latent transforming growth factor beta binding protein 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 715 entries
Log-likelihood per target Total log-likelihoodTermDescription
6.4 32.0 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
7.9 31.4 GO:0051311 spindle assembly involved in female meiosis(GO:0007056) meiotic metaphase plate congression(GO:0051311)
2.0 20.4 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.2 20.2 GO:0007050 cell cycle arrest(GO:0007050)
1.7 15.2 GO:0071493 cellular response to UV-B(GO:0071493)
2.5 14.7 GO:0021965 spinal cord ventral commissure morphogenesis(GO:0021965)
2.8 14.1 GO:0003213 cardiac right atrium morphogenesis(GO:0003213)
1.4 13.5 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.5 12.6 GO:0070207 protein homotrimerization(GO:0070207)
0.5 12.5 GO:1900027 regulation of ruffle assembly(GO:1900027)
2.1 12.4 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
3.1 12.3 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
1.7 12.0 GO:0044806 G-quadruplex DNA unwinding(GO:0044806)
0.3 12.0 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
1.5 11.9 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.4 11.8 GO:0035411 catenin import into nucleus(GO:0035411)
0.6 11.5 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.6 11.1 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.6 11.1 GO:0038092 nodal signaling pathway(GO:0038092)
0.7 11.0 GO:0048672 positive regulation of collateral sprouting(GO:0048672)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 262 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 121.0 GO:0005654 nucleoplasm(GO:0005654)
0.2 79.6 GO:0005667 transcription factor complex(GO:0005667)
3.5 31.6 GO:0072687 meiotic spindle(GO:0072687)
0.2 28.9 GO:0043296 apical junction complex(GO:0043296)
0.3 16.7 GO:0005871 kinesin complex(GO:0005871)
2.3 13.9 GO:0031262 Ndc80 complex(GO:0031262)
0.6 13.7 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.2 13.5 GO:0031985 Golgi cisterna(GO:0031985)
0.1 13.1 GO:0016363 nuclear matrix(GO:0016363)
1.1 12.3 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.1 12.2 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.6 12.1 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.2 12.0 GO:0005657 replication fork(GO:0005657)
2.3 11.5 GO:0097149 centralspindlin complex(GO:0097149)
0.1 10.8 GO:0000785 chromatin(GO:0000785)
2.4 9.6 GO:0008623 CHRAC(GO:0008623)
0.4 9.6 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 9.5 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 9.4 GO:0001650 fibrillar center(GO:0001650)
0.7 9.2 GO:0030126 COPI vesicle coat(GO:0030126)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 418 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 50.6 GO:0005525 GTP binding(GO:0005525)
0.0 43.1 GO:0003677 DNA binding(GO:0003677)
1.9 41.0 GO:0070410 co-SMAD binding(GO:0070410)
0.2 35.7 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 30.0 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.2 17.0 GO:0031490 chromatin DNA binding(GO:0031490)
2.7 16.5 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.5 15.9 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 14.1 GO:0003714 transcription corepressor activity(GO:0003714)
0.6 13.2 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.4 13.2 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.7 12.9 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
4.0 12.0 GO:0033680 ATP-dependent DNA/RNA helicase activity(GO:0033680)
0.3 11.5 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.2 11.3 GO:0001047 core promoter binding(GO:0001047)
0.6 11.2 GO:0035497 cAMP response element binding(GO:0035497)
0.8 11.0 GO:0017154 semaphorin receptor activity(GO:0017154)
1.1 10.6 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.3 10.6 GO:0032452 histone demethylase activity(GO:0032452)
0.2 10.5 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 84 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 41.3 PID_AURORA_B_PATHWAY Aurora B signaling
0.7 35.8 PID_PLK1_PATHWAY PLK1 signaling events
0.4 26.4 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.7 20.2 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.3 18.3 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.3 17.1 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.2 15.4 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.2 15.1 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.2 14.7 PID_CDC42_PATHWAY CDC42 signaling events
0.4 14.3 PID_ATM_PATHWAY ATM pathway
0.2 14.2 PID_E2F_PATHWAY E2F transcription factor network
0.5 12.4 PID_HIV_NEF_PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.3 12.3 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.4 12.1 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.5 11.2 PID_RHOA_PATHWAY RhoA signaling pathway
0.4 10.5 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.4 10.0 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.3 9.5 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.4 9.3 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.2 8.0 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 124 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.4 33.9 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.2 24.4 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.9 20.6 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.5 18.7 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Activation of the pre-replicative complex
0.7 14.7 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.4 14.1 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.3 14.1 REACTOME_PI3K_AKT_ACTIVATION Genes involved in PI3K/AKT activation
0.4 12.5 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.7 10.5 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.2 10.5 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.9 10.2 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.3 9.5 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.3 8.4 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.5 7.6 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.2 7.4 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.6 7.2 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.4 7.0 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.2 6.3 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.4 5.5 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 5.2 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions