Motif ID: Spib
Z-value: 2.326
Transcription factors associated with Spib:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Spib | ENSMUSG00000008193.7 | Spib |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 126 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 131.2 | GO:0038083 | peptidyl-tyrosine autophosphorylation(GO:0038083) |
| 3.9 | 81.5 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 23.8 | 71.4 | GO:0001803 | type III hypersensitivity(GO:0001802) regulation of type III hypersensitivity(GO:0001803) positive regulation of type III hypersensitivity(GO:0001805) |
| 5.7 | 39.9 | GO:0045650 | negative regulation of macrophage differentiation(GO:0045650) |
| 9.7 | 38.6 | GO:1904425 | negative regulation of GTP binding(GO:1904425) |
| 6.1 | 36.8 | GO:1901164 | negative regulation of trophoblast cell migration(GO:1901164) |
| 1.4 | 36.0 | GO:0035641 | locomotory exploration behavior(GO:0035641) |
| 0.4 | 31.8 | GO:0032091 | negative regulation of protein binding(GO:0032091) |
| 6.2 | 31.0 | GO:0003105 | negative regulation of glomerular filtration(GO:0003105) |
| 0.5 | 29.1 | GO:0071277 | cellular response to calcium ion(GO:0071277) |
| 0.2 | 27.8 | GO:1990830 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
| 6.2 | 24.7 | GO:0014846 | esophagus smooth muscle contraction(GO:0014846) |
| 3.6 | 21.4 | GO:0032796 | uropod organization(GO:0032796) |
| 0.8 | 20.4 | GO:0071353 | cellular response to interleukin-4(GO:0071353) |
| 6.3 | 18.9 | GO:1902938 | regulation of intracellular calcium activated chloride channel activity(GO:1902938) |
| 6.2 | 18.6 | GO:0002865 | negative regulation of acute inflammatory response to antigenic stimulus(GO:0002865) |
| 3.7 | 18.5 | GO:0048133 | germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728) |
| 0.2 | 17.9 | GO:0003073 | regulation of systemic arterial blood pressure(GO:0003073) |
| 3.5 | 17.5 | GO:1902683 | regulation of receptor localization to synapse(GO:1902683) |
| 5.7 | 17.0 | GO:2001187 | positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 67 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 119.6 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 1.6 | 115.6 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.4 | 109.8 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.1 | 48.1 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.1 | 45.4 | GO:0043005 | neuron projection(GO:0043005) |
| 0.2 | 38.3 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.4 | 36.0 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.4 | 31.0 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.1 | 29.3 | GO:0009986 | cell surface(GO:0009986) |
| 0.2 | 27.3 | GO:0043204 | perikaryon(GO:0043204) |
| 1.9 | 21.4 | GO:0032426 | stereocilium tip(GO:0032426) |
| 0.5 | 20.8 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 1.3 | 20.1 | GO:0097449 | astrocyte projection(GO:0097449) |
| 0.0 | 20.0 | GO:0005886 | plasma membrane(GO:0005886) |
| 0.1 | 17.8 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.2 | 14.4 | GO:0030136 | clathrin-coated vesicle(GO:0030136) |
| 0.7 | 14.0 | GO:0071564 | npBAF complex(GO:0071564) |
| 2.7 | 13.4 | GO:0098831 | presynaptic active zone cytoplasmic component(GO:0098831) |
| 3.3 | 13.2 | GO:0070436 | Grb2-EGFR complex(GO:0070436) |
| 0.5 | 10.9 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 94 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 131.2 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 14.6 | 87.4 | GO:0019864 | immunoglobulin receptor activity(GO:0019763) IgG binding(GO:0019864) |
| 0.2 | 45.1 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 42.8 | GO:0042803 | protein homodimerization activity(GO:0042803) |
| 5.3 | 36.8 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 8.4 | 33.5 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 0.9 | 27.7 | GO:0017147 | Wnt-protein binding(GO:0017147) |
| 4.9 | 24.7 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 1.5 | 22.5 | GO:0005537 | mannose binding(GO:0005537) |
| 1.9 | 21.4 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.4 | 20.5 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 4.7 | 18.9 | GO:0001639 | PLC activating G-protein coupled glutamate receptor activity(GO:0001639) A2A adenosine receptor binding(GO:0031687) G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530) |
| 0.6 | 18.7 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.2 | 17.0 | GO:0030295 | protein kinase activator activity(GO:0030295) |
| 0.8 | 15.2 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.4 | 14.3 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.1 | 14.2 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 0.6 | 13.8 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
| 0.2 | 13.4 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.1 | 13.4 | GO:0017137 | Rab GTPase binding(GO:0017137) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 30 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 112.2 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.7 | 97.3 | PID_PDGFRB_PATHWAY | PDGFR-beta signaling pathway |
| 1.0 | 61.9 | PID_KIT_PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 1.1 | 53.7 | PID_FCER1_PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 1.0 | 44.9 | PID_RAS_PATHWAY | Regulation of Ras family activation |
| 0.6 | 36.5 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
| 1.0 | 29.9 | PID_IL12_STAT4_PATHWAY | IL12 signaling mediated by STAT4 |
| 0.1 | 21.3 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 17.4 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.6 | 15.9 | ST_ERK1_ERK2_MAPK_PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.4 | 15.9 | PID_TRKR_PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.5 | 13.7 | PID_BCR_5PATHWAY | BCR signaling pathway |
| 0.5 | 12.7 | PID_ARF_3PATHWAY | Arf1 pathway |
| 0.4 | 11.1 | ST_ADRENERGIC | Adrenergic Pathway |
| 0.1 | 10.4 | PID_CMYB_PATHWAY | C-MYB transcription factor network |
| 0.3 | 8.4 | SIG_CHEMOTAXIS | Genes related to chemotaxis |
| 0.2 | 7.3 | PID_MET_PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| 0.3 | 6.9 | PID_IL8_CXCR2_PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.3 | 5.6 | PID_RAC1_PATHWAY | RAC1 signaling pathway |
| 0.2 | 4.6 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 48 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 20.2 | 121.5 | REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.4 | 69.3 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 1.0 | 33.8 | REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 2.4 | 31.2 | REACTOME_CD28_DEPENDENT_VAV1_PATHWAY | Genes involved in CD28 dependent Vav1 pathway |
| 2.2 | 28.7 | REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 1.2 | 21.1 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.4 | 20.4 | REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.2 | 17.7 | REACTOME_SIGNALING_BY_ERBB2 | Genes involved in Signaling by ERBB2 |
| 0.8 | 16.0 | REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.7 | 14.4 | REACTOME_INSULIN_RECEPTOR_RECYCLING | Genes involved in Insulin receptor recycling |
| 0.4 | 14.3 | REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS | Genes involved in G alpha (z) signalling events |
| 1.3 | 13.4 | REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |
| 1.4 | 12.8 | REACTOME_P2Y_RECEPTORS | Genes involved in P2Y receptors |
| 0.5 | 11.9 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.3 | 11.6 | REACTOME_GLYCOLYSIS | Genes involved in Glycolysis |
| 0.3 | 11.1 | REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.3 | 10.8 | REACTOME_DARPP_32_EVENTS | Genes involved in DARPP-32 events |
| 0.6 | 10.5 | REACTOME_GAP_JUNCTION_DEGRADATION | Genes involved in Gap junction degradation |
| 0.3 | 10.3 | REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING | Genes involved in Sema4D in semaphorin signaling |
| 0.8 | 9.8 | REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1 | Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
