Motif ID: Spib

Z-value: 2.326


Transcription factors associated with Spib:

Gene SymbolEntrez IDGene Name
Spib ENSMUSG00000008193.7 Spib



Activity profile for motif Spib.

activity profile for motif Spib


Sorted Z-values histogram for motif Spib

Sorted Z-values for motif Spib



Network of associatons between targets according to the STRING database.



First level regulatory network of Spib

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_66812593 92.490 ENSMUST00000100572.3
Sla
src-like adaptor
chr4_-_136898803 42.099 ENSMUST00000046285.5
C1qa
complement component 1, q subcomponent, alpha polypeptide
chr4_-_136892867 39.940 ENSMUST00000046332.5
C1qc
complement component 1, q subcomponent, C chain
chr4_-_136886187 39.432 ENSMUST00000046384.8
C1qb
complement component 1, q subcomponent, beta polypeptide
chr16_+_41532851 36.015 ENSMUST00000078873.4
Lsamp
limbic system-associated membrane protein
chr3_-_87263518 32.731 ENSMUST00000090986.4
Fcrls
Fc receptor-like S, scavenger receptor
chr1_-_171059390 32.238 ENSMUST00000164044.1
ENSMUST00000169017.1
Fcgr3

Fc receptor, IgG, low affinity III

chr6_+_137410721 31.004 ENSMUST00000167002.1
Ptpro
protein tyrosine phosphatase, receptor type, O
chr1_-_171234290 28.707 ENSMUST00000079957.6
Fcer1g
Fc receptor, IgE, high affinity I, gamma polypeptide
chr3_-_87263703 26.129 ENSMUST00000146512.1
Fcrls
Fc receptor-like S, scavenger receptor
chr10_+_81257277 24.253 ENSMUST00000117488.1
ENSMUST00000105328.3
ENSMUST00000121205.1
Matk


megakaryocyte-associated tyrosine kinase


chr4_+_130913120 23.634 ENSMUST00000151698.1
Laptm5
lysosomal-associated protein transmembrane 5
chr4_+_130913264 22.857 ENSMUST00000156225.1
ENSMUST00000156742.1
Laptm5

lysosomal-associated protein transmembrane 5

chr6_-_136941694 21.723 ENSMUST00000032344.5
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr5_+_81021202 21.500 ENSMUST00000117253.1
ENSMUST00000120128.1
Lphn3

latrophilin 3

chr15_-_37458523 21.108 ENSMUST00000116445.2
Ncald
neurocalcin delta
chr19_+_12460749 20.529 ENSMUST00000081035.7
Mpeg1
macrophage expressed gene 1
chr2_+_14229390 20.435 ENSMUST00000028045.2
Mrc1
mannose receptor, C type 1
chr2_+_121357714 19.697 ENSMUST00000125812.1
ENSMUST00000078222.2
ENSMUST00000125221.1
ENSMUST00000150271.1
Ckmt1



creatine kinase, mitochondrial 1, ubiquitous



chr17_-_68004075 19.448 ENSMUST00000024840.5
Arhgap28
Rho GTPase activating protein 28
chr17_-_67950908 19.191 ENSMUST00000164647.1
Arhgap28
Rho GTPase activating protein 28
chr7_+_87602544 18.853 ENSMUST00000167164.1
ENSMUST00000107263.2
Grm5

glutamate receptor, metabotropic 5

chr19_+_6399857 18.584 ENSMUST00000146601.1
ENSMUST00000150713.1
Rasgrp2

RAS, guanyl releasing protein 2

chr19_-_11336107 18.569 ENSMUST00000056035.2
ENSMUST00000067532.4
Ms4a7

membrane-spanning 4-domains, subfamily A, member 7

chr16_-_22439719 18.523 ENSMUST00000079601.6
Etv5
ets variant gene 5
chr12_-_86988676 17.638 ENSMUST00000095521.2
Zdhhc22
zinc finger, DHHC-type containing 22
chr7_-_19118357 17.474 ENSMUST00000141380.1
Gm4969
predicted gene 4969
chr15_+_103453782 17.046 ENSMUST00000047405.7
Nckap1l
NCK associated protein 1 like
chrX_-_43167817 16.093 ENSMUST00000115058.1
ENSMUST00000115059.1
Tenm1

teneurin transmembrane protein 1

chr1_-_170976112 16.048 ENSMUST00000027966.7
ENSMUST00000081103.5
ENSMUST00000159688.1
Fcgr2b


Fc receptor, IgG, low affinity IIb


chr18_-_35215008 15.220 ENSMUST00000091636.3
Lrrtm2
leucine rich repeat transmembrane neuronal 2
chr6_-_136941494 15.075 ENSMUST00000111892.1
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr13_+_5861489 14.149 ENSMUST00000000080.6
Klf6
Kruppel-like factor 6
chr19_+_26623419 13.979 ENSMUST00000176584.1
Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr14_-_124677089 13.777 ENSMUST00000095529.3
Fgf14
fibroblast growth factor 14
chr2_+_121358591 13.764 ENSMUST00000000317.6
ENSMUST00000129130.1
Ckmt1

creatine kinase, mitochondrial 1, ubiquitous

chr2_-_166155624 13.745 ENSMUST00000109249.2
Sulf2
sulfatase 2
chr1_-_22315792 13.358 ENSMUST00000164877.1
Rims1
regulating synaptic membrane exocytosis 1
chr19_+_6399746 13.095 ENSMUST00000113468.1
Rasgrp2
RAS, guanyl releasing protein 2
chr3_-_59210881 12.817 ENSMUST00000040622.1
P2ry13
purinergic receptor P2Y, G-protein coupled 13
chr11_+_82045705 11.912 ENSMUST00000021011.2
Ccl7
chemokine (C-C motif) ligand 7
chr13_+_109903089 11.704 ENSMUST00000120664.1
Pde4d
phosphodiesterase 4D, cAMP specific
chr16_-_36666067 11.344 ENSMUST00000089620.4
Cd86
CD86 antigen
chr4_+_136143497 11.122 ENSMUST00000008016.2
Id3
inhibitor of DNA binding 3
chr2_+_55437100 11.059 ENSMUST00000112633.2
ENSMUST00000112632.1
Kcnj3

potassium inwardly-rectifying channel, subfamily J, member 3

chr2_-_166155272 10.990 ENSMUST00000088086.3
Sulf2
sulfatase 2
chr13_+_102693522 10.916 ENSMUST00000022124.3
ENSMUST00000171267.1
ENSMUST00000167144.1
ENSMUST00000170878.1
Cd180



CD180 antigen



chr13_+_30659999 10.477 ENSMUST00000091672.6
ENSMUST00000110310.1
ENSMUST00000095914.5
Dusp22


dual specificity phosphatase 22


chr2_+_169633517 10.454 ENSMUST00000109157.1
Tshz2
teashirt zinc finger family member 2
chr3_-_96293953 10.443 ENSMUST00000029748.3
Fcgr1
Fc receptor, IgG, high affinity I
chr13_-_103334429 10.209 ENSMUST00000167058.1
ENSMUST00000164111.1
Mast4

microtubule associated serine/threonine kinase family member 4

chr9_+_94669876 10.083 ENSMUST00000033463.9
Slc9a9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr10_-_61383523 10.049 ENSMUST00000020289.8
Pald1
phosphatase domain containing, paladin 1
chr17_+_20945311 9.767 ENSMUST00000007708.7
Ppp2r1a
protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform
chr9_+_58582240 9.455 ENSMUST00000177292.1
ENSMUST00000085651.5
Nptn

neuroplastin

chr11_+_61653259 9.290 ENSMUST00000004959.2
Grap
GRB2-related adaptor protein
chr4_+_36952930 9.242 ENSMUST00000144029.1
Gm12371
predicted gene 12371
chr16_+_36934976 9.200 ENSMUST00000023531.8
Hcls1
hematopoietic cell specific Lyn substrate 1
chr2_-_52558539 9.076 ENSMUST00000102760.3
ENSMUST00000102761.2
Cacnb4

calcium channel, voltage-dependent, beta 4 subunit

chr4_+_57434247 9.057 ENSMUST00000102905.1
Palm2
paralemmin 2
chr14_+_75131499 8.969 ENSMUST00000125833.1
ENSMUST00000124499.1
Lcp1

lymphocyte cytosolic protein 1

chr2_-_181691771 8.912 ENSMUST00000108778.1
ENSMUST00000165416.1
Rgs19

regulator of G-protein signaling 19

chr7_-_126704736 8.808 ENSMUST00000131415.1
Coro1a
coronin, actin binding protein 1A
chr15_-_12592556 8.750 ENSMUST00000075317.5
Pdzd2
PDZ domain containing 2
chr2_+_91096744 8.323 ENSMUST00000132741.2
Spi1
spleen focus forming virus (SFFV) proviral integration oncogene
chr9_+_58582397 8.088 ENSMUST00000176557.1
ENSMUST00000114121.4
ENSMUST00000177064.1
Nptn


neuroplastin


chr2_-_6721890 7.789 ENSMUST00000114927.2
Celf2
CUGBP, Elav-like family member 2
chr15_-_83033294 7.443 ENSMUST00000100377.4
Nfam1
Nfat activating molecule with ITAM motif 1
chr2_+_169632996 7.322 ENSMUST00000109159.2
Tshz2
teashirt zinc finger family member 2
chr1_+_135147615 7.232 ENSMUST00000125774.1
Arl8a
ADP-ribosylation factor-like 8A
chr4_+_119195496 7.216 ENSMUST00000097908.3
Ccdc23
coiled-coil domain containing 23
chr1_+_87620334 6.986 ENSMUST00000042275.8
ENSMUST00000168783.1
Inpp5d

inositol polyphosphate-5-phosphatase D

chr4_+_119195279 6.975 ENSMUST00000030395.2
Ccdc23
coiled-coil domain containing 23
chr4_+_119195353 6.943 ENSMUST00000106345.2
Ccdc23
coiled-coil domain containing 23
chr12_-_78980758 6.798 ENSMUST00000174072.1
Tmem229b
transmembrane protein 229B
chr17_+_57279094 6.647 ENSMUST00000169220.2
ENSMUST00000005889.9
ENSMUST00000112870.4
Vav1


vav 1 oncogene


chr11_-_115699307 6.647 ENSMUST00000106499.1
Grb2
growth factor receptor bound protein 2
chr11_-_115699461 6.576 ENSMUST00000106497.1
Grb2
growth factor receptor bound protein 2
chr11_-_20112876 6.505 ENSMUST00000000137.7
Actr2
ARP2 actin-related protein 2
chr6_-_35539765 6.465 ENSMUST00000031866.5
Mtpn
myotrophin
chr7_-_126704179 6.450 ENSMUST00000106364.1
Coro1a
coronin, actin binding protein 1A
chr7_+_45896941 6.153 ENSMUST00000069772.7
ENSMUST00000107716.1
Tmem143

transmembrane protein 143

chr7_-_126704522 6.144 ENSMUST00000135087.1
Coro1a
coronin, actin binding protein 1A
chr1_-_130729249 5.933 ENSMUST00000171479.1
Pfkfb2
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
chr7_-_126897424 5.838 ENSMUST00000120007.1
Tmem219
transmembrane protein 219
chr7_+_99535439 5.827 ENSMUST00000098266.2
ENSMUST00000179755.1
Arrb1

arrestin, beta 1

chr11_+_78324200 5.707 ENSMUST00000102478.3
Aldoc
aldolase C, fructose-bisphosphate
chr2_+_145934800 5.622 ENSMUST00000138774.1
ENSMUST00000152515.1
ENSMUST00000130168.1
ENSMUST00000133433.1
ENSMUST00000118002.1
4930529M08Rik




RIKEN cDNA 4930529M08 gene




chr5_-_134229581 5.620 ENSMUST00000111275.1
ENSMUST00000016094.6
ENSMUST00000144086.1
Ncf1


neutrophil cytosolic factor 1


chr4_+_44012661 5.588 ENSMUST00000107849.3
ENSMUST00000107851.3
ENSMUST00000107845.3
Clta


clathrin, light polypeptide (Lca)


chr17_+_50509518 5.517 ENSMUST00000043938.6
Plcl2
phospholipase C-like 2
chr2_-_181693810 5.381 ENSMUST00000108776.1
ENSMUST00000108771.1
ENSMUST00000108779.1
ENSMUST00000108769.1
ENSMUST00000108772.1
ENSMUST00000002532.2
Rgs19





regulator of G-protein signaling 19





chr2_-_6721606 5.248 ENSMUST00000150624.2
ENSMUST00000142941.1
ENSMUST00000100429.4
ENSMUST00000182879.1
Celf2



CUGBP, Elav-like family member 2



chr1_-_168431695 5.246 ENSMUST00000176790.1
Pbx1
pre B cell leukemia homeobox 1
chr12_+_75308308 5.158 ENSMUST00000118602.1
ENSMUST00000118966.1
ENSMUST00000055390.5
Rhoj


ras homolog gene family, member J


chr5_+_149265035 5.130 ENSMUST00000130144.1
ENSMUST00000071130.3
Alox5ap

arachidonate 5-lipoxygenase activating protein

chr3_-_69127098 5.058 ENSMUST00000029353.2
Kpna4
karyopherin (importin) alpha 4
chr4_+_44012638 4.908 ENSMUST00000107847.3
ENSMUST00000170241.1
Clta

clathrin, light polypeptide (Lca)

chr1_-_183297008 4.842 ENSMUST00000057062.5
Brox
BRO1 domain and CAAX motif containing
chr4_-_117887292 4.791 ENSMUST00000150204.1
ENSMUST00000147845.1
ENSMUST00000036380.7
ENSMUST00000136596.1
Atp6v0b



ATPase, H+ transporting, lysosomal V0 subunit B



chr4_+_109343029 4.632 ENSMUST00000030281.5
Eps15
epidermal growth factor receptor pathway substrate 15
chr2_+_91650169 4.587 ENSMUST00000090614.4
Arhgap1
Rho GTPase activating protein 1
chr11_-_103344651 4.476 ENSMUST00000041385.7
Arhgap27
Rho GTPase activating protein 27
chr3_-_33844255 4.458 ENSMUST00000029222.5
Ccdc39
coiled-coil domain containing 39
chr7_-_100856289 4.438 ENSMUST00000139604.1
Relt
RELT tumor necrosis factor receptor
chr12_+_28751798 4.417 ENSMUST00000035657.7
Tssc1
tumor suppressing subtransferable candidate 1
chr14_+_80000292 4.311 ENSMUST00000088735.3
Olfm4
olfactomedin 4
chr6_+_38918969 4.291 ENSMUST00000003017.6
Tbxas1
thromboxane A synthase 1, platelet
chr4_-_43454600 4.244 ENSMUST00000098105.3
ENSMUST00000098104.3
ENSMUST00000030179.4
Cd72


CD72 antigen


chr5_-_123141067 4.187 ENSMUST00000162697.1
ENSMUST00000160321.1
ENSMUST00000159637.1
AI480526


expressed sequence AI480526


chr3_-_94582716 4.179 ENSMUST00000029783.9
Snx27
sorting nexin family member 27
chr4_+_99955715 4.134 ENSMUST00000102783.4
Pgm2
phosphoglucomutase 2
chr3_-_97868242 4.065 ENSMUST00000107038.3
Pde4dip
phosphodiesterase 4D interacting protein (myomegalin)
chr4_-_117887279 4.062 ENSMUST00000132073.1
Atp6v0b
ATPase, H+ transporting, lysosomal V0 subunit B
chrX_+_20848543 4.035 ENSMUST00000001155.4
ENSMUST00000122312.1
ENSMUST00000120356.1
ENSMUST00000122850.1
Araf



v-raf murine sarcoma 3611 viral oncogene homolog



chr2_+_32721055 3.999 ENSMUST00000074248.4
Sh2d3c
SH2 domain containing 3C
chr17_+_34604262 3.927 ENSMUST00000174041.1
Agpat1
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
chr2_+_91650116 3.797 ENSMUST00000111331.2
Arhgap1
Rho GTPase activating protein 1
chr2_-_104494400 3.752 ENSMUST00000028600.7
Hipk3
homeodomain interacting protein kinase 3
chr4_-_124850670 3.721 ENSMUST00000163946.1
ENSMUST00000106190.3
1110065P20Rik

RIKEN cDNA 1110065P20 gene

chr6_-_120822680 3.690 ENSMUST00000019354.8
Atp6v1e1
ATPase, H+ transporting, lysosomal V1 subunit E1
chr8_+_107056870 3.586 ENSMUST00000034392.5
ENSMUST00000170962.1
Nip7

nuclear import 7 homolog (S. cerevisiae)

chr11_-_120457936 3.539 ENSMUST00000137632.1
ENSMUST00000044007.2
Oxld1

oxidoreductase like domain containing 1

chr14_-_65593079 3.536 ENSMUST00000022609.5
Elp3
elongator acetyltransferase complex subunit 3
chr19_-_6084873 3.450 ENSMUST00000160977.1
ENSMUST00000159859.1
Zfpl1

zinc finger like protein 1

chr19_-_41385070 3.352 ENSMUST00000059672.7
Pik3ap1
phosphoinositide-3-kinase adaptor protein 1
chr11_-_107470699 3.352 ENSMUST00000103064.3
Pitpnc1
phosphatidylinositol transfer protein, cytoplasmic 1
chr15_-_13173607 3.196 ENSMUST00000036439.4
Cdh6
cadherin 6
chr10_-_127121125 3.194 ENSMUST00000164259.1
ENSMUST00000080975.4
Os9

amplified in osteosarcoma

chr19_+_6341121 3.189 ENSMUST00000025897.6
ENSMUST00000130382.1
Map4k2

mitogen-activated protein kinase kinase kinase kinase 2

chr1_+_153899937 3.131 ENSMUST00000086199.5
Glul
glutamate-ammonia ligase (glutamine synthetase)
chr4_-_43454563 3.097 ENSMUST00000107926.1
Cd72
CD72 antigen
chr4_-_43454582 2.988 ENSMUST00000107925.1
Cd72
CD72 antigen
chr5_-_138263942 2.986 ENSMUST00000048421.7
ENSMUST00000164203.1
BC037034
BC037034
cDNA sequence BC037034
cDNA sequence BC037034
chr8_-_106573461 2.938 ENSMUST00000073722.5
Gm10073
predicted pseudogene 10073
chr4_+_62663620 2.822 ENSMUST00000126338.1
Rgs3
regulator of G-protein signaling 3
chr19_-_6084941 2.798 ENSMUST00000025707.2
ENSMUST00000160712.1
Zfpl1

zinc finger like protein 1

chr6_+_113378113 2.735 ENSMUST00000171058.1
ENSMUST00000156898.1
Arpc4

actin related protein 2/3 complex, subunit 4

chr3_-_95142346 2.731 ENSMUST00000013851.3
Tnfaip8l2
tumor necrosis factor, alpha-induced protein 8-like 2
chr19_-_27429807 2.724 ENSMUST00000076219.4
D19Bwg1357e
DNA segment, Chr 19, Brigham & Women's Genetics 1357 expressed
chr2_-_132815978 2.708 ENSMUST00000039554.6
Trmt6
tRNA methyltransferase 6
chr4_+_45297127 2.699 ENSMUST00000044673.2
ENSMUST00000144781.1
Trmt10b

tRNA methyltransferase 10B

chrX_+_159708593 2.647 ENSMUST00000080394.6
Sh3kbp1
SH3-domain kinase binding protein 1
chr18_+_40258361 2.621 ENSMUST00000091927.4
Kctd16
potassium channel tetramerisation domain containing 16
chr1_+_16688405 2.601 ENSMUST00000026881.4
Ly96
lymphocyte antigen 96
chr15_+_58933774 2.600 ENSMUST00000022980.3
Ndufb9
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9
chr4_-_120815703 2.594 ENSMUST00000120779.1
Nfyc
nuclear transcription factor-Y gamma
chr19_-_6084679 2.585 ENSMUST00000161548.1
Zfpl1
zinc finger like protein 1
chr17_+_93199348 2.571 ENSMUST00000064775.6
Adcyap1
adenylate cyclase activating polypeptide 1
chr2_-_93046053 2.536 ENSMUST00000111272.1
ENSMUST00000178666.1
ENSMUST00000147339.1
Prdm11


PR domain containing 11


chr3_+_106721672 2.468 ENSMUST00000098750.2
ENSMUST00000130105.1
Lrif1

ligand dependent nuclear receptor interacting factor 1

chr4_-_122886044 2.448 ENSMUST00000106255.1
ENSMUST00000106257.3
Cap1

CAP, adenylate cyclase-associated protein 1 (yeast)

chr5_-_32746272 2.418 ENSMUST00000120591.1
Pisd
phosphatidylserine decarboxylase
chr12_-_28635914 2.404 ENSMUST00000074267.3
Rps7
ribosomal protein S7
chr7_-_80387935 2.310 ENSMUST00000080932.6
Fes
feline sarcoma oncogene
chr5_-_138264013 2.271 ENSMUST00000161604.1
ENSMUST00000163268.1
BC037034
BC037034
cDNA sequence BC037034
cDNA sequence BC037034
chr13_+_9093893 2.174 ENSMUST00000091829.2
Larp4b
La ribonucleoprotein domain family, member 4B
chr4_-_118489755 2.172 ENSMUST00000184261.1
Tie1
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
chr13_+_77135513 2.165 ENSMUST00000168779.1
2210408I21Rik
RIKEN cDNA 2210408I21 gene
chr5_-_32746317 2.142 ENSMUST00000135248.1
Pisd
phosphatidylserine decarboxylase
chr16_-_22657165 2.118 ENSMUST00000089925.3
Dgkg
diacylglycerol kinase, gamma
chr9_+_46273064 2.092 ENSMUST00000156440.1
ENSMUST00000034583.6
ENSMUST00000114552.3
Zfp259


zinc finger protein 259


chr6_+_122308684 2.053 ENSMUST00000007602.8
ENSMUST00000112610.1
M6pr

mannose-6-phosphate receptor, cation dependent

chr10_+_128748455 1.914 ENSMUST00000065210.8
Wibg
within bgcn homolog (Drosophila)
chr12_+_33957645 1.840 ENSMUST00000049089.5
Twist1
twist basic helix-loop-helix transcription factor 1
chr15_-_58933688 1.828 ENSMUST00000110155.1
Tatdn1
TatD DNase domain containing 1
chr12_-_78861636 1.809 ENSMUST00000021536.7
Atp6v1d
ATPase, H+ transporting, lysosomal V1 subunit D
chrX_-_107816238 1.797 ENSMUST00000120722.1
2610002M06Rik
RIKEN cDNA 2610002M06 gene
chr3_+_106721893 1.790 ENSMUST00000106736.2
ENSMUST00000154973.1
ENSMUST00000131330.1
ENSMUST00000150513.1
Lrif1



ligand dependent nuclear receptor interacting factor 1



chr2_-_26640230 1.723 ENSMUST00000181621.1
ENSMUST00000180659.1
Snhg7

small nucleolar RNA host gene (non-protein coding) 7

chr4_+_140961203 1.723 ENSMUST00000010007.8
Sdhb
succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
chr12_+_84361968 1.705 ENSMUST00000021661.6
Coq6
coenzyme Q6 homolog (yeast)
chr16_-_89960815 1.640 ENSMUST00000002588.3
Tiam1
T cell lymphoma invasion and metastasis 1
chr10_+_81393610 1.604 ENSMUST00000118206.1
2210404O07Rik
RIKEN cDNA 2210404O07 gene
chrX_-_48454152 1.600 ENSMUST00000114958.1
Elf4
E74-like factor 4 (ets domain transcription factor)
chr10_+_80292453 1.454 ENSMUST00000068408.7
ENSMUST00000062674.6
Rps15

ribosomal protein S15

chr12_+_84362029 1.433 ENSMUST00000110278.1
ENSMUST00000145522.1
Coq6

coenzyme Q6 homolog (yeast)

chr3_-_95106779 1.430 ENSMUST00000005768.7
ENSMUST00000107232.2
ENSMUST00000107236.2
Pip5k1a


phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha


chr7_-_81345189 1.414 ENSMUST00000080813.4
Rps17
ribosomal protein S17
chr2_-_130424242 1.375 ENSMUST00000089581.4
Pced1a
PC-esterase domain containing 1A
chrX_+_169685191 1.342 ENSMUST00000112104.1
ENSMUST00000112107.1
Mid1

midline 1

chr7_-_99483645 1.335 ENSMUST00000107096.1
ENSMUST00000032998.6
Rps3

ribosomal protein S3

chrX_-_73716145 1.333 ENSMUST00000002091.5
Bcap31
B cell receptor associated protein 31
chr9_+_21526144 1.333 ENSMUST00000086361.5
ENSMUST00000179459.1
ENSMUST00000173769.2
AB124611


cDNA sequence AB124611


chr8_+_72219726 1.320 ENSMUST00000003123.8
Fam32a
family with sequence similarity 32, member A
chr17_+_35517100 1.301 ENSMUST00000164242.2
ENSMUST00000045956.7
Cchcr1

coiled-coil alpha-helical rod protein 1

chr6_-_113377866 1.295 ENSMUST00000032410.7
Tada3
transcriptional adaptor 3
chr12_+_84361636 1.292 ENSMUST00000110276.1
Coq6
coenzyme Q6 homolog (yeast)
chr12_+_78861693 1.267 ENSMUST00000071230.7
Eif2s1
eukaryotic translation initiation factor 2, subunit 1 alpha
chrX_-_136741155 1.237 ENSMUST00000166930.1
ENSMUST00000113095.1
ENSMUST00000155207.1
ENSMUST00000080411.6
ENSMUST00000169418.1
Morf4l2




mortality factor 4 like 2




chr2_-_26604267 1.215 ENSMUST00000028286.5
Agpat2
1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)
chr4_-_98383232 1.204 ENSMUST00000143116.1
ENSMUST00000030292.5
ENSMUST00000102793.4
Tm2d1


TM2 domain containing 1


chr7_+_127769809 1.171 ENSMUST00000118865.1
ENSMUST00000061587.6
ENSMUST00000121504.1
Orai3


ORAI calcium release-activated calcium modulator 3


chr12_+_110485710 1.168 ENSMUST00000084985.3
ENSMUST00000109832.1
Ppp2r5c

protein phosphatase 2, regulatory subunit B (B56), gamma isoform

chr1_+_59482133 1.106 ENSMUST00000114246.2
ENSMUST00000037105.6
Fzd7

frizzled homolog 7 (Drosophila)

chr15_-_78572754 1.078 ENSMUST00000043214.6
Rac2
RAS-related C3 botulinum substrate 2
chr4_-_154160632 1.051 ENSMUST00000105639.3
ENSMUST00000030896.8
Tprgl

transformation related protein 63 regulated like

chrX_-_103981242 1.017 ENSMUST00000121153.1
ENSMUST00000070705.4
Rlim

ring finger protein, LIM domain interacting

chr2_+_112284561 0.970 ENSMUST00000053666.7
Slc12a6
solute carrier family 12, member 6
chr15_-_36608959 0.968 ENSMUST00000001809.8
Pabpc1
poly(A) binding protein, cytoplasmic 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
23.8 71.4 GO:0001803 type III hypersensitivity(GO:0001802) regulation of type III hypersensitivity(GO:0001803) positive regulation of type III hypersensitivity(GO:0001805)
9.7 38.6 GO:1904425 negative regulation of GTP binding(GO:1904425)
6.3 18.9 GO:1902938 regulation of intracellular calcium activated chloride channel activity(GO:1902938)
6.2 18.6 GO:0002865 negative regulation of acute inflammatory response to antigenic stimulus(GO:0002865)
6.2 31.0 GO:0003105 negative regulation of glomerular filtration(GO:0003105)
6.2 24.7 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
6.1 36.8 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
5.7 39.9 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
5.7 17.0 GO:2001187 positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
4.1 16.4 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
3.9 81.5 GO:0006958 complement activation, classical pathway(GO:0006958)
3.7 18.5 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
3.6 21.4 GO:0032796 uropod organization(GO:0032796)
3.5 17.5 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
3.3 13.4 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
3.3 9.8 GO:1903538 meiotic sister chromatid cohesion, centromeric(GO:0051754) meiotic cell cycle process involved in oocyte maturation(GO:1903537) regulation of meiotic cell cycle process involved in oocyte maturation(GO:1903538)
2.8 13.8 GO:1901843 positive regulation of high voltage-gated calcium channel activity(GO:1901843)
2.3 7.0 GO:0045658 regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
2.3 11.3 GO:0002667 lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911)
2.2 6.5 GO:0016344 meiotic chromosome movement towards spindle pole(GO:0016344)
2.2 6.5 GO:2000812 regulation of barbed-end actin filament capping(GO:2000812)
1.9 5.6 GO:0070944 neutrophil mediated killing of bacterium(GO:0070944)
1.8 9.2 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
1.8 131.2 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
1.7 10.5 GO:0002710 negative regulation of T cell mediated immunity(GO:0002710)
1.7 5.1 GO:0002538 arachidonic acid metabolite production involved in inflammatory response(GO:0002538)
1.7 8.4 GO:0098706 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
1.7 8.3 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
1.6 11.1 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
1.6 14.0 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
1.5 11.9 GO:0071361 cellular response to ethanol(GO:0071361)
1.5 7.4 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
1.5 4.4 GO:1904809 dense core granule localization(GO:0032253) dense core granule transport(GO:1901950) regulation of dense core granule transport(GO:1904809) positive regulation of dense core granule transport(GO:1904811)
1.5 11.7 GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844)
1.4 36.0 GO:0035641 locomotory exploration behavior(GO:0035641)
1.3 10.1 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
1.0 3.1 GO:0019676 ammonia assimilation cycle(GO:0019676)
1.0 9.1 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
1.0 5.8 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.9 4.6 GO:0019065 receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509)
0.9 4.3 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.8 15.2 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.8 1.6 GO:0001787 natural killer cell proliferation(GO:0001787)
0.8 20.4 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.7 4.5 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.7 12.8 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.7 3.4 GO:0034162 toll-like receptor 9 signaling pathway(GO:0034162)
0.6 1.8 GO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359) cell proliferation involved in heart valve development(GO:2000793)
0.6 9.0 GO:0051639 actin filament network formation(GO:0051639)
0.6 5.7 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.5 1.6 GO:1900149 positive regulation of Schwann cell migration(GO:1900149)
0.5 5.9 GO:1903301 positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301)
0.5 2.6 GO:0032497 detection of lipopolysaccharide(GO:0032497)
0.5 4.1 GO:0019388 galactose catabolic process(GO:0019388)
0.5 5.2 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.5 29.1 GO:0071277 cellular response to calcium ion(GO:0071277)
0.5 12.5 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.5 3.2 GO:0006621 protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.4 1.3 GO:1905051 regulation of base-excision repair(GO:1905051) positive regulation of base-excision repair(GO:1905053)
0.4 1.3 GO:1904154 protein localization to endoplasmic reticulum exit site(GO:0070973) positive regulation of retrograde protein transport, ER to cytosol(GO:1904154)
0.4 6.6 GO:0045954 positive regulation of natural killer cell mediated immunity(GO:0002717) positive regulation of natural killer cell mediated cytotoxicity(GO:0045954)
0.4 11.1 GO:0030903 notochord development(GO:0030903)
0.4 10.5 GO:0048268 clathrin coat assembly(GO:0048268)
0.4 5.1 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
0.4 31.8 GO:0032091 negative regulation of protein binding(GO:0032091)
0.4 2.5 GO:1902255 positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902255)
0.3 13.2 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.3 13.0 GO:0006376 mRNA splice site selection(GO:0006376)
0.3 0.9 GO:0032532 regulation of microvillus length(GO:0032532)
0.3 1.1 GO:2000383 regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384)
0.3 1.3 GO:0032055 negative regulation of translation in response to stress(GO:0032055)
0.2 17.9 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.2 4.4 GO:0006744 ubiquinone biosynthetic process(GO:0006744)
0.2 2.1 GO:0033299 secretion of lysosomal enzymes(GO:0033299)
0.2 6.4 GO:0018345 protein palmitoylation(GO:0018345)
0.2 1.1 GO:0060753 regulation of mast cell chemotaxis(GO:0060753)
0.2 5.1 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.2 1.0 GO:1900095 regulation of dosage compensation by inactivation of X chromosome(GO:1900095)
0.2 2.6 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.2 1.0 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.2 1.3 GO:0035372 protein localization to microtubule(GO:0035372)
0.2 1.7 GO:0006105 succinate metabolic process(GO:0006105)
0.2 1.5 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.2 4.9 GO:0030325 adrenal gland development(GO:0030325)
0.2 27.8 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.1 3.2 GO:0006903 vesicle targeting(GO:0006903)
0.1 1.4 GO:0002227 innate immune response in mucosa(GO:0002227)
0.1 2.1 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.1 2.4 GO:0045761 regulation of adenylate cyclase activity(GO:0045761)
0.1 0.8 GO:0060430 lung saccule development(GO:0060430)
0.1 3.8 GO:0009299 mRNA transcription(GO:0009299)
0.1 3.5 GO:0043966 histone H3 acetylation(GO:0043966)
0.1 2.7 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.1 0.3 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.1 0.5 GO:0023035 CD40 signaling pathway(GO:0023035)
0.1 2.7 GO:0030488 tRNA methylation(GO:0030488)
0.1 0.5 GO:0036438 maintenance of lens transparency(GO:0036438)
0.1 1.8 GO:0006308 DNA catabolic process(GO:0006308)
0.1 3.3 GO:0008333 endosome to lysosome transport(GO:0008333)
0.1 2.2 GO:0045026 plasma membrane fusion(GO:0045026)
0.1 4.1 GO:0042255 ribosome assembly(GO:0042255)
0.1 1.2 GO:0002115 store-operated calcium entry(GO:0002115)
0.1 0.3 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.1 1.5 GO:0031063 regulation of histone deacetylation(GO:0031063)
0.1 3.8 GO:0051701 interaction with host(GO:0051701)
0.0 2.8 GO:0015992 proton transport(GO:0015992)
0.0 0.1 GO:0032792 negative regulation of CREB transcription factor activity(GO:0032792) embryonic nail plate morphogenesis(GO:0035880) positive regulation of hair follicle maturation(GO:0048818) positive regulation of catagen(GO:0051795)
0.0 0.6 GO:0010216 maintenance of DNA methylation(GO:0010216)
0.0 6.8 GO:0008654 phospholipid biosynthetic process(GO:0008654)
0.0 0.2 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.0 0.6 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.0 3.9 GO:0016192 vesicle-mediated transport(GO:0016192)
0.0 0.5 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.0 0.4 GO:1902916 positive regulation of protein polyubiquitination(GO:1902916)
0.0 2.4 GO:0046488 phosphatidylinositol metabolic process(GO:0046488)
0.0 0.0 GO:0003219 cardiac right ventricle formation(GO:0003219)
0.0 4.5 GO:0006898 receptor-mediated endocytosis(GO:0006898)
0.0 7.0 GO:0006470 protein dephosphorylation(GO:0006470)
0.0 1.3 GO:0006611 protein export from nucleus(GO:0006611)
0.0 4.8 GO:0019221 cytokine-mediated signaling pathway(GO:0019221)
0.0 3.5 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.0 1.2 GO:0097190 apoptotic signaling pathway(GO:0097190)
0.0 0.1 GO:0010616 negative regulation of cardiac muscle adaptation(GO:0010616)
0.0 0.0 GO:0021747 cochlear nucleus development(GO:0021747)
0.0 0.9 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 0.5 GO:0090263 positive regulation of canonical Wnt signaling pathway(GO:0090263)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 10.5 GO:0099631 postsynaptic endocytic zone cytoplasmic component(GO:0099631)
3.3 13.2 GO:0070436 Grb2-EGFR complex(GO:0070436)
2.7 13.4 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)
1.9 21.4 GO:0032426 stereocilium tip(GO:0032426)
1.6 115.6 GO:0005581 collagen trimer(GO:0005581)
1.4 8.4 GO:0097443 sorting endosome(GO:0097443)
1.4 4.2 GO:0071203 WASH complex(GO:0071203)
1.3 20.1 GO:0097449 astrocyte projection(GO:0097449)
1.3 8.9 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
1.1 5.6 GO:0043020 NADPH oxidase complex(GO:0043020)
0.8 119.6 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.8 9.2 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.7 14.0 GO:0071564 npBAF complex(GO:0071564)
0.6 6.5 GO:0008290 F-actin capping protein complex(GO:0008290)
0.6 8.3 GO:0031209 SCAR complex(GO:0031209)
0.5 2.7 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.5 2.6 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.5 3.5 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.5 9.0 GO:0001891 phagocytic cup(GO:0001891)
0.5 10.9 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.5 20.8 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.4 109.8 GO:0009897 external side of plasma membrane(GO:0009897)
0.4 2.6 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.4 1.7 GO:0045283 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.4 31.0 GO:0016328 lateral plasma membrane(GO:0016328)
0.4 3.2 GO:0000836 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.4 36.0 GO:0031225 anchored component of membrane(GO:0031225)
0.4 5.8 GO:0031143 pseudopodium(GO:0031143)
0.4 4.3 GO:0042581 specific granule(GO:0042581)
0.3 3.1 GO:0097386 glial cell projection(GO:0097386)
0.3 4.6 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.3 1.3 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.3 4.7 GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain(GO:0033178)
0.2 27.3 GO:0043204 perikaryon(GO:0043204)
0.2 14.4 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.2 38.3 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.2 8.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 0.9 GO:0070847 core mediator complex(GO:0070847)
0.1 2.2 GO:0042788 polysomal ribosome(GO:0042788)
0.1 0.3 GO:0033263 CORVET complex(GO:0033263)
0.1 0.5 GO:0071797 LUBAC complex(GO:0071797)
0.1 2.2 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.1 3.6 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.1 2.1 GO:0030904 retromer complex(GO:0030904)
0.1 1.5 GO:0000124 SAGA complex(GO:0000124)
0.1 1.0 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 0.5 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
0.1 17.8 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 48.1 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 29.3 GO:0009986 cell surface(GO:0009986)
0.1 7.0 GO:0055037 recycling endosome(GO:0055037)
0.1 9.7 GO:0001650 fibrillar center(GO:0001650)
0.1 5.1 GO:0005643 nuclear pore(GO:0005643)
0.1 2.6 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 45.4 GO:0043005 neuron projection(GO:0043005)
0.1 0.9 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 5.5 GO:0030016 myofibril(GO:0030016)
0.0 4.3 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.0 5.2 GO:0005768 endosome(GO:0005768)
0.0 2.9 GO:0016605 PML body(GO:0016605)
0.0 1.3 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 20.0 GO:0005886 plasma membrane(GO:0005886)
0.0 0.0 GO:0044449 contractile fiber part(GO:0044449)
0.0 1.1 GO:0030027 lamellipodium(GO:0030027)
0.0 0.6 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 1.0 GO:0005930 axoneme(GO:0005930)
0.0 0.6 GO:0005720 nuclear heterochromatin(GO:0005720)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
14.6 87.4 GO:0019864 immunoglobulin receptor activity(GO:0019763) IgG binding(GO:0019864)
8.4 33.5 GO:0004111 creatine kinase activity(GO:0004111)
5.3 36.8 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
4.9 24.7 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
4.7 18.9 GO:0001639 PLC activating G-protein coupled glutamate receptor activity(GO:0001639) A2A adenosine receptor binding(GO:0031687) G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
3.0 11.9 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
2.6 131.2 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
2.2 11.1 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
1.9 21.4 GO:0032036 myosin heavy chain binding(GO:0032036)
1.9 5.8 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
1.8 12.8 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
1.5 22.5 GO:0005537 mannose binding(GO:0005537)
1.4 5.6 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
1.4 7.0 GO:0051425 PTB domain binding(GO:0051425)
1.4 8.3 GO:0051525 NFAT protein binding(GO:0051525)
1.3 10.1 GO:0015386 potassium:proton antiporter activity(GO:0015386)
1.1 4.6 GO:0004609 phosphatidylserine decarboxylase activity(GO:0004609)
1.0 12.5 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
1.0 3.1 GO:0016880 acid-ammonia (or amide) ligase activity(GO:0016880)
1.0 5.7 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.9 3.5 GO:0010484 H3 histone acetyltransferase activity(GO:0010484)
0.9 10.5 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.9 2.6 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.9 27.7 GO:0017147 Wnt-protein binding(GO:0017147)
0.9 5.1 GO:0050544 arachidonic acid binding(GO:0050544)
0.8 15.2 GO:0042043 neurexin family protein binding(GO:0042043)
0.7 5.9 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.6 9.1 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.6 13.8 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.6 4.1 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.6 1.7 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177) 3 iron, 4 sulfur cluster binding(GO:0051538)
0.6 18.7 GO:0043014 alpha-tubulin binding(GO:0043014)
0.6 3.4 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.4 1.3 GO:0008534 oxidized purine nucleobase lesion DNA N-glycosylase activity(GO:0008534)
0.4 4.0 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.4 20.5 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.4 14.3 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.4 11.1 GO:0005504 fatty acid binding(GO:0005504)
0.4 11.7 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.4 2.5 GO:1990948 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
0.3 2.7 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.3 2.6 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.3 2.2 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.3 8.3 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.2 4.4 GO:0071949 FAD binding(GO:0071949)
0.2 3.2 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.2 5.1 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171)
0.2 4.4 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.2 17.0 GO:0030295 protein kinase activator activity(GO:0030295)
0.2 13.4 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.2 6.4 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.2 2.1 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.2 0.8 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.2 3.4 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.2 4.0 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.2 5.1 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.2 9.8 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.2 0.5 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.2 1.8 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.2 45.1 GO:0005096 GTPase activator activity(GO:0005096)
0.1 2.1 GO:0050811 GABA receptor binding(GO:0050811)
0.1 2.4 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 13.4 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 0.8 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.1 0.3 GO:0099609 microtubule lateral binding(GO:0099609)
0.1 9.2 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 4.2 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 1.3 GO:0042288 MHC class I protein binding(GO:0042288)
0.1 1.2 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 4.6 GO:0031593 polyubiquitin binding(GO:0031593)
0.1 4.3 GO:0004497 monooxygenase activity(GO:0004497)
0.1 1.0 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 4.3 GO:0042974 retinoic acid receptor binding(GO:0042974)
0.1 0.2 GO:0071568 UFM1 transferase activity(GO:0071568)
0.1 14.2 GO:0030246 carbohydrate binding(GO:0030246)
0.1 1.6 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.1 10.2 GO:0000287 magnesium ion binding(GO:0000287)
0.1 7.1 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 1.0 GO:0008266 poly(U) RNA binding(GO:0008266)
0.1 0.5 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0 42.8 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 0.9 GO:0003785 actin monomer binding(GO:0003785)
0.0 8.1 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 12.4 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 0.2 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.0 2.2 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0 5.2 GO:0051015 actin filament binding(GO:0051015)
0.0 0.8 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.0 3.8 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 1.2 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 1.3 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.1 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.0 1.2 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 0.5 GO:0043130 ubiquitin binding(GO:0043130)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 53.7 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells
1.0 44.9 PID_RAS_PATHWAY Regulation of Ras family activation
1.0 29.9 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
1.0 61.9 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.9 112.2 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.7 97.3 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.6 15.9 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.6 36.5 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.5 13.7 PID_BCR_5PATHWAY BCR signaling pathway
0.5 12.7 PID_ARF_3PATHWAY Arf1 pathway
0.4 11.1 ST_ADRENERGIC Adrenergic Pathway
0.4 15.9 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.3 6.9 PID_IL8_CXCR2_PATHWAY IL8- and CXCR2-mediated signaling events
0.3 5.6 PID_RAC1_PATHWAY RAC1 signaling pathway
0.3 8.4 SIG_CHEMOTAXIS Genes related to chemotaxis
0.2 2.8 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.2 7.3 PID_MET_PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.2 4.6 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 3.2 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.1 17.4 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 10.4 PID_CMYB_PATHWAY C-MYB transcription factor network
0.1 3.2 PID_TNF_PATHWAY TNF receptor signaling pathway
0.1 21.3 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 2.4 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.1 1.8 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.1 1.1 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 2.6 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.0 1.3 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.3 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 0.3 PID_VEGFR1_2_PATHWAY Signaling events mediated by VEGFR1 and VEGFR2

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
20.2 121.5 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
2.4 31.2 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway
2.2 28.7 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
1.4 12.8 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
1.3 13.4 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
1.2 21.1 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
1.0 33.8 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.8 9.8 REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.8 16.0 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.7 14.4 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.6 10.5 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.5 11.9 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.4 14.3 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.4 69.3 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.4 20.4 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.3 10.3 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.3 5.8 REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.3 4.3 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.3 10.8 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.3 11.6 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.3 1.2 REACTOME_CTLA4_INHIBITORY_SIGNALING Genes involved in CTLA4 inhibitory signaling
0.3 9.3 REACTOME_SIGNALING_BY_SCF_KIT Genes involved in Signaling by SCF-KIT
0.3 2.6 REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS Genes involved in Glucagon-type ligand receptors
0.3 11.1 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.3 4.1 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.2 6.0 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.2 2.6 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.2 4.6 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.2 2.3 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.2 17.7 REACTOME_SIGNALING_BY_ERBB2 Genes involved in Signaling by ERBB2
0.2 5.1 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.1 7.0 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 3.1 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 1.0 REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.1 2.1 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 2.4 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.1 8.3 REACTOME_TOLL_RECEPTOR_CASCADES Genes involved in Toll Receptor Cascades
0.1 9.1 REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES Genes involved in Transmission across Chemical Synapses
0.1 1.7 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 8.0 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 5.1 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 1.0 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 2.6 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 1.3 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 1.1 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.9 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.3 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.2 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation