Motif ID: Spib
Z-value: 2.326
Transcription factors associated with Spib:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Spib | ENSMUSG00000008193.7 | Spib |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 23.8 | 71.4 | GO:0001803 | type III hypersensitivity(GO:0001802) regulation of type III hypersensitivity(GO:0001803) positive regulation of type III hypersensitivity(GO:0001805) |
| 9.7 | 38.6 | GO:1904425 | negative regulation of GTP binding(GO:1904425) |
| 6.3 | 18.9 | GO:1902938 | regulation of intracellular calcium activated chloride channel activity(GO:1902938) |
| 6.2 | 18.6 | GO:0002865 | negative regulation of acute inflammatory response to antigenic stimulus(GO:0002865) |
| 6.2 | 31.0 | GO:0003105 | negative regulation of glomerular filtration(GO:0003105) |
| 6.2 | 24.7 | GO:0014846 | esophagus smooth muscle contraction(GO:0014846) |
| 6.1 | 36.8 | GO:1901164 | negative regulation of trophoblast cell migration(GO:1901164) |
| 5.7 | 39.9 | GO:0045650 | negative regulation of macrophage differentiation(GO:0045650) |
| 5.7 | 17.0 | GO:2001187 | positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187) |
| 4.1 | 16.4 | GO:0002322 | B cell proliferation involved in immune response(GO:0002322) |
| 3.9 | 81.5 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 3.7 | 18.5 | GO:0048133 | germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728) |
| 3.6 | 21.4 | GO:0032796 | uropod organization(GO:0032796) |
| 3.5 | 17.5 | GO:1902683 | regulation of receptor localization to synapse(GO:1902683) |
| 3.3 | 13.4 | GO:0010808 | positive regulation of synaptic vesicle priming(GO:0010808) |
| 3.3 | 9.8 | GO:1903538 | meiotic sister chromatid cohesion, centromeric(GO:0051754) meiotic cell cycle process involved in oocyte maturation(GO:1903537) regulation of meiotic cell cycle process involved in oocyte maturation(GO:1903538) |
| 2.8 | 13.8 | GO:1901843 | positive regulation of high voltage-gated calcium channel activity(GO:1901843) |
| 2.3 | 7.0 | GO:0045658 | regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659) |
| 2.3 | 11.3 | GO:0002667 | lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911) |
| 2.2 | 6.5 | GO:0016344 | meiotic chromosome movement towards spindle pole(GO:0016344) |
| 2.2 | 6.5 | GO:2000812 | regulation of barbed-end actin filament capping(GO:2000812) |
| 1.9 | 5.6 | GO:0070944 | neutrophil mediated killing of bacterium(GO:0070944) |
| 1.8 | 9.2 | GO:0030854 | positive regulation of granulocyte differentiation(GO:0030854) |
| 1.8 | 131.2 | GO:0038083 | peptidyl-tyrosine autophosphorylation(GO:0038083) |
| 1.7 | 10.5 | GO:0002710 | negative regulation of T cell mediated immunity(GO:0002710) |
| 1.7 | 5.1 | GO:0002538 | arachidonic acid metabolite production involved in inflammatory response(GO:0002538) |
| 1.7 | 8.4 | GO:0098706 | ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706) |
| 1.7 | 8.3 | GO:0045347 | negative regulation of MHC class II biosynthetic process(GO:0045347) |
| 1.6 | 11.1 | GO:1990573 | potassium ion import across plasma membrane(GO:1990573) |
| 1.6 | 14.0 | GO:0035887 | aortic smooth muscle cell differentiation(GO:0035887) |
| 1.5 | 11.9 | GO:0071361 | cellular response to ethanol(GO:0071361) |
| 1.5 | 7.4 | GO:0050861 | positive regulation of B cell receptor signaling pathway(GO:0050861) |
| 1.5 | 4.4 | GO:1904809 | dense core granule localization(GO:0032253) dense core granule transport(GO:1901950) regulation of dense core granule transport(GO:1904809) positive regulation of dense core granule transport(GO:1904811) |
| 1.5 | 11.7 | GO:1901844 | regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) |
| 1.4 | 36.0 | GO:0035641 | locomotory exploration behavior(GO:0035641) |
| 1.3 | 10.1 | GO:1990118 | sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118) |
| 1.0 | 3.1 | GO:0019676 | ammonia assimilation cycle(GO:0019676) |
| 1.0 | 9.1 | GO:0050908 | detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962) |
| 1.0 | 5.8 | GO:0042699 | follicle-stimulating hormone signaling pathway(GO:0042699) |
| 0.9 | 4.6 | GO:0019065 | receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509) |
| 0.9 | 4.3 | GO:0030644 | cellular chloride ion homeostasis(GO:0030644) |
| 0.8 | 15.2 | GO:0002091 | negative regulation of receptor internalization(GO:0002091) |
| 0.8 | 1.6 | GO:0001787 | natural killer cell proliferation(GO:0001787) |
| 0.8 | 20.4 | GO:0071353 | cellular response to interleukin-4(GO:0071353) |
| 0.7 | 4.5 | GO:0035469 | determination of pancreatic left/right asymmetry(GO:0035469) |
| 0.7 | 12.8 | GO:0007194 | negative regulation of adenylate cyclase activity(GO:0007194) |
| 0.7 | 3.4 | GO:0034162 | toll-like receptor 9 signaling pathway(GO:0034162) |
| 0.6 | 1.8 | GO:0035359 | negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359) cell proliferation involved in heart valve development(GO:2000793) |
| 0.6 | 9.0 | GO:0051639 | actin filament network formation(GO:0051639) |
| 0.6 | 5.7 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 0.5 | 1.6 | GO:1900149 | positive regulation of Schwann cell migration(GO:1900149) |
| 0.5 | 5.9 | GO:1903301 | positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301) |
| 0.5 | 2.6 | GO:0032497 | detection of lipopolysaccharide(GO:0032497) |
| 0.5 | 4.1 | GO:0019388 | galactose catabolic process(GO:0019388) |
| 0.5 | 5.2 | GO:0061299 | retina vasculature morphogenesis in camera-type eye(GO:0061299) |
| 0.5 | 29.1 | GO:0071277 | cellular response to calcium ion(GO:0071277) |
| 0.5 | 12.5 | GO:0015991 | ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662) |
| 0.5 | 3.2 | GO:0006621 | protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437) |
| 0.4 | 1.3 | GO:1905051 | regulation of base-excision repair(GO:1905051) positive regulation of base-excision repair(GO:1905053) |
| 0.4 | 1.3 | GO:1904154 | protein localization to endoplasmic reticulum exit site(GO:0070973) positive regulation of retrograde protein transport, ER to cytosol(GO:1904154) |
| 0.4 | 6.6 | GO:0045954 | positive regulation of natural killer cell mediated immunity(GO:0002717) positive regulation of natural killer cell mediated cytotoxicity(GO:0045954) |
| 0.4 | 11.1 | GO:0030903 | notochord development(GO:0030903) |
| 0.4 | 10.5 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.4 | 5.1 | GO:0006654 | phosphatidic acid biosynthetic process(GO:0006654) |
| 0.4 | 31.8 | GO:0032091 | negative regulation of protein binding(GO:0032091) |
| 0.4 | 2.5 | GO:1902255 | positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902255) |
| 0.3 | 13.2 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
| 0.3 | 13.0 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 0.3 | 0.9 | GO:0032532 | regulation of microvillus length(GO:0032532) |
| 0.3 | 1.1 | GO:2000383 | regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384) |
| 0.3 | 1.3 | GO:0032055 | negative regulation of translation in response to stress(GO:0032055) |
| 0.2 | 17.9 | GO:0003073 | regulation of systemic arterial blood pressure(GO:0003073) |
| 0.2 | 4.4 | GO:0006744 | ubiquinone biosynthetic process(GO:0006744) |
| 0.2 | 2.1 | GO:0033299 | secretion of lysosomal enzymes(GO:0033299) |
| 0.2 | 6.4 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.2 | 1.1 | GO:0060753 | regulation of mast cell chemotaxis(GO:0060753) |
| 0.2 | 5.1 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.2 | 1.0 | GO:1900095 | regulation of dosage compensation by inactivation of X chromosome(GO:1900095) |
| 0.2 | 2.6 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.2 | 1.0 | GO:2000623 | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623) |
| 0.2 | 1.3 | GO:0035372 | protein localization to microtubule(GO:0035372) |
| 0.2 | 1.7 | GO:0006105 | succinate metabolic process(GO:0006105) |
| 0.2 | 1.5 | GO:0000056 | ribosomal small subunit export from nucleus(GO:0000056) |
| 0.2 | 4.9 | GO:0030325 | adrenal gland development(GO:0030325) |
| 0.2 | 27.8 | GO:1990830 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
| 0.1 | 3.2 | GO:0006903 | vesicle targeting(GO:0006903) |
| 0.1 | 1.4 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
| 0.1 | 2.1 | GO:0007205 | protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205) |
| 0.1 | 2.4 | GO:0045761 | regulation of adenylate cyclase activity(GO:0045761) |
| 0.1 | 0.8 | GO:0060430 | lung saccule development(GO:0060430) |
| 0.1 | 3.8 | GO:0009299 | mRNA transcription(GO:0009299) |
| 0.1 | 3.5 | GO:0043966 | histone H3 acetylation(GO:0043966) |
| 0.1 | 2.7 | GO:0034314 | Arp2/3 complex-mediated actin nucleation(GO:0034314) |
| 0.1 | 0.3 | GO:0034058 | endosomal vesicle fusion(GO:0034058) |
| 0.1 | 0.5 | GO:0023035 | CD40 signaling pathway(GO:0023035) |
| 0.1 | 2.7 | GO:0030488 | tRNA methylation(GO:0030488) |
| 0.1 | 0.5 | GO:0036438 | maintenance of lens transparency(GO:0036438) |
| 0.1 | 1.8 | GO:0006308 | DNA catabolic process(GO:0006308) |
| 0.1 | 3.3 | GO:0008333 | endosome to lysosome transport(GO:0008333) |
| 0.1 | 2.2 | GO:0045026 | plasma membrane fusion(GO:0045026) |
| 0.1 | 4.1 | GO:0042255 | ribosome assembly(GO:0042255) |
| 0.1 | 1.2 | GO:0002115 | store-operated calcium entry(GO:0002115) |
| 0.1 | 0.3 | GO:0072383 | plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386) |
| 0.1 | 1.5 | GO:0031063 | regulation of histone deacetylation(GO:0031063) |
| 0.1 | 3.8 | GO:0051701 | interaction with host(GO:0051701) |
| 0.0 | 2.8 | GO:0015992 | proton transport(GO:0015992) |
| 0.0 | 0.1 | GO:0032792 | negative regulation of CREB transcription factor activity(GO:0032792) embryonic nail plate morphogenesis(GO:0035880) positive regulation of hair follicle maturation(GO:0048818) positive regulation of catagen(GO:0051795) |
| 0.0 | 0.6 | GO:0010216 | maintenance of DNA methylation(GO:0010216) |
| 0.0 | 6.8 | GO:0008654 | phospholipid biosynthetic process(GO:0008654) |
| 0.0 | 0.2 | GO:1990564 | protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592) |
| 0.0 | 0.6 | GO:0034244 | negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244) |
| 0.0 | 3.9 | GO:0016192 | vesicle-mediated transport(GO:0016192) |
| 0.0 | 0.5 | GO:0071712 | ER-associated misfolded protein catabolic process(GO:0071712) |
| 0.0 | 0.4 | GO:1902916 | positive regulation of protein polyubiquitination(GO:1902916) |
| 0.0 | 2.4 | GO:0046488 | phosphatidylinositol metabolic process(GO:0046488) |
| 0.0 | 0.0 | GO:0003219 | cardiac right ventricle formation(GO:0003219) |
| 0.0 | 4.5 | GO:0006898 | receptor-mediated endocytosis(GO:0006898) |
| 0.0 | 7.0 | GO:0006470 | protein dephosphorylation(GO:0006470) |
| 0.0 | 1.3 | GO:0006611 | protein export from nucleus(GO:0006611) |
| 0.0 | 4.8 | GO:0019221 | cytokine-mediated signaling pathway(GO:0019221) |
| 0.0 | 3.5 | GO:0018105 | peptidyl-serine phosphorylation(GO:0018105) |
| 0.0 | 1.2 | GO:0097190 | apoptotic signaling pathway(GO:0097190) |
| 0.0 | 0.1 | GO:0010616 | negative regulation of cardiac muscle adaptation(GO:0010616) |
| 0.0 | 0.0 | GO:0021747 | cochlear nucleus development(GO:0021747) |
| 0.0 | 0.9 | GO:0006367 | transcription initiation from RNA polymerase II promoter(GO:0006367) |
| 0.0 | 0.5 | GO:0090263 | positive regulation of canonical Wnt signaling pathway(GO:0090263) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.5 | 10.5 | GO:0099631 | postsynaptic endocytic zone cytoplasmic component(GO:0099631) |
| 3.3 | 13.2 | GO:0070436 | Grb2-EGFR complex(GO:0070436) |
| 2.7 | 13.4 | GO:0098831 | presynaptic active zone cytoplasmic component(GO:0098831) |
| 1.9 | 21.4 | GO:0032426 | stereocilium tip(GO:0032426) |
| 1.6 | 115.6 | GO:0005581 | collagen trimer(GO:0005581) |
| 1.4 | 8.4 | GO:0097443 | sorting endosome(GO:0097443) |
| 1.4 | 4.2 | GO:0071203 | WASH complex(GO:0071203) |
| 1.3 | 20.1 | GO:0097449 | astrocyte projection(GO:0097449) |
| 1.3 | 8.9 | GO:0000220 | vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) |
| 1.1 | 5.6 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.8 | 119.6 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.8 | 9.2 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 0.7 | 14.0 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.6 | 6.5 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 0.6 | 8.3 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.5 | 2.7 | GO:0043527 | tRNA methyltransferase complex(GO:0043527) |
| 0.5 | 2.6 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.5 | 3.5 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
| 0.5 | 9.0 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.5 | 10.9 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.5 | 20.8 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.4 | 109.8 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.4 | 2.6 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
| 0.4 | 1.7 | GO:0045283 | mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283) |
| 0.4 | 31.0 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.4 | 3.2 | GO:0000836 | ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836) |
| 0.4 | 36.0 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.4 | 5.8 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.4 | 4.3 | GO:0042581 | specific granule(GO:0042581) |
| 0.3 | 3.1 | GO:0097386 | glial cell projection(GO:0097386) |
| 0.3 | 4.6 | GO:0030122 | AP-2 adaptor complex(GO:0030122) |
| 0.3 | 1.3 | GO:0005784 | Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256) |
| 0.3 | 4.7 | GO:0033178 | proton-transporting two-sector ATPase complex, catalytic domain(GO:0033178) |
| 0.2 | 27.3 | GO:0043204 | perikaryon(GO:0043204) |
| 0.2 | 14.4 | GO:0030136 | clathrin-coated vesicle(GO:0030136) |
| 0.2 | 38.3 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.2 | 8.0 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.1 | 0.9 | GO:0070847 | core mediator complex(GO:0070847) |
| 0.1 | 2.2 | GO:0042788 | polysomal ribosome(GO:0042788) |
| 0.1 | 0.3 | GO:0033263 | CORVET complex(GO:0033263) |
| 0.1 | 0.5 | GO:0071797 | LUBAC complex(GO:0071797) |
| 0.1 | 2.2 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
| 0.1 | 3.6 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.1 | 2.1 | GO:0030904 | retromer complex(GO:0030904) |
| 0.1 | 1.5 | GO:0000124 | SAGA complex(GO:0000124) |
| 0.1 | 1.0 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.1 | 0.5 | GO:0036513 | Derlin-1 retrotranslocation complex(GO:0036513) |
| 0.1 | 17.8 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.1 | 48.1 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.1 | 29.3 | GO:0009986 | cell surface(GO:0009986) |
| 0.1 | 7.0 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.1 | 9.7 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.1 | 5.1 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.1 | 2.6 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.1 | 45.4 | GO:0043005 | neuron projection(GO:0043005) |
| 0.1 | 0.9 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
| 0.0 | 5.5 | GO:0030016 | myofibril(GO:0030016) |
| 0.0 | 4.3 | GO:0000784 | nuclear chromosome, telomeric region(GO:0000784) |
| 0.0 | 5.2 | GO:0005768 | endosome(GO:0005768) |
| 0.0 | 2.9 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 1.3 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.0 | 20.0 | GO:0005886 | plasma membrane(GO:0005886) |
| 0.0 | 0.0 | GO:0044449 | contractile fiber part(GO:0044449) |
| 0.0 | 1.1 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.0 | 0.6 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.0 | 1.0 | GO:0005930 | axoneme(GO:0005930) |
| 0.0 | 0.6 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 14.6 | 87.4 | GO:0019864 | immunoglobulin receptor activity(GO:0019763) IgG binding(GO:0019864) |
| 8.4 | 33.5 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 5.3 | 36.8 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 4.9 | 24.7 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 4.7 | 18.9 | GO:0001639 | PLC activating G-protein coupled glutamate receptor activity(GO:0001639) A2A adenosine receptor binding(GO:0031687) G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530) |
| 3.0 | 11.9 | GO:0031727 | CCR2 chemokine receptor binding(GO:0031727) |
| 2.6 | 131.2 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 2.2 | 11.1 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 1.9 | 21.4 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 1.9 | 5.8 | GO:0031896 | V2 vasopressin receptor binding(GO:0031896) |
| 1.8 | 12.8 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 1.5 | 22.5 | GO:0005537 | mannose binding(GO:0005537) |
| 1.4 | 5.6 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
| 1.4 | 7.0 | GO:0051425 | PTB domain binding(GO:0051425) |
| 1.4 | 8.3 | GO:0051525 | NFAT protein binding(GO:0051525) |
| 1.3 | 10.1 | GO:0015386 | potassium:proton antiporter activity(GO:0015386) |
| 1.1 | 4.6 | GO:0004609 | phosphatidylserine decarboxylase activity(GO:0004609) |
| 1.0 | 12.5 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
| 1.0 | 3.1 | GO:0016880 | acid-ammonia (or amide) ligase activity(GO:0016880) |
| 1.0 | 5.7 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 0.9 | 3.5 | GO:0010484 | H3 histone acetyltransferase activity(GO:0010484) |
| 0.9 | 10.5 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
| 0.9 | 2.6 | GO:0001875 | lipopolysaccharide receptor activity(GO:0001875) |
| 0.9 | 27.7 | GO:0017147 | Wnt-protein binding(GO:0017147) |
| 0.9 | 5.1 | GO:0050544 | arachidonic acid binding(GO:0050544) |
| 0.8 | 15.2 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.7 | 5.9 | GO:0003873 | 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331) |
| 0.6 | 9.1 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
| 0.6 | 13.8 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
| 0.6 | 4.1 | GO:0004614 | phosphoglucomutase activity(GO:0004614) |
| 0.6 | 1.7 | GO:0008177 | succinate dehydrogenase (ubiquinone) activity(GO:0008177) 3 iron, 4 sulfur cluster binding(GO:0051538) |
| 0.6 | 18.7 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.6 | 3.4 | GO:0008526 | phosphatidylinositol transporter activity(GO:0008526) |
| 0.4 | 1.3 | GO:0008534 | oxidized purine nucleobase lesion DNA N-glycosylase activity(GO:0008534) |
| 0.4 | 4.0 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.4 | 20.5 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.4 | 14.3 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.4 | 11.1 | GO:0005504 | fatty acid binding(GO:0005504) |
| 0.4 | 11.7 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.4 | 2.5 | GO:1990948 | ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948) |
| 0.3 | 2.7 | GO:0009019 | tRNA (guanine-N1-)-methyltransferase activity(GO:0009019) |
| 0.3 | 2.6 | GO:0051428 | peptide hormone receptor binding(GO:0051428) |
| 0.3 | 2.2 | GO:0016308 | 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308) |
| 0.3 | 8.3 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.2 | 4.4 | GO:0071949 | FAD binding(GO:0071949) |
| 0.2 | 3.2 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.2 | 5.1 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) |
| 0.2 | 4.4 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.2 | 17.0 | GO:0030295 | protein kinase activator activity(GO:0030295) |
| 0.2 | 13.4 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.2 | 6.4 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.2 | 2.1 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
| 0.2 | 0.8 | GO:0050220 | prostaglandin-E synthase activity(GO:0050220) |
| 0.2 | 3.4 | GO:0036312 | phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312) |
| 0.2 | 4.0 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.2 | 5.1 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.2 | 9.8 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.2 | 0.5 | GO:0008109 | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109) |
| 0.2 | 1.8 | GO:0016888 | endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888) |
| 0.2 | 45.1 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.1 | 2.1 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.1 | 2.4 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.1 | 13.4 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.1 | 0.8 | GO:0070180 | large ribosomal subunit rRNA binding(GO:0070180) |
| 0.1 | 0.3 | GO:0099609 | microtubule lateral binding(GO:0099609) |
| 0.1 | 9.2 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 4.2 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.1 | 1.3 | GO:0042288 | MHC class I protein binding(GO:0042288) |
| 0.1 | 1.2 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.1 | 4.6 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.1 | 4.3 | GO:0004497 | monooxygenase activity(GO:0004497) |
| 0.1 | 1.0 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.1 | 4.3 | GO:0042974 | retinoic acid receptor binding(GO:0042974) |
| 0.1 | 0.2 | GO:0071568 | UFM1 transferase activity(GO:0071568) |
| 0.1 | 14.2 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 0.1 | 1.6 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
| 0.1 | 10.2 | GO:0000287 | magnesium ion binding(GO:0000287) |
| 0.1 | 7.1 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.1 | 1.0 | GO:0008266 | poly(U) RNA binding(GO:0008266) |
| 0.1 | 0.5 | GO:1904264 | ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264) |
| 0.0 | 42.8 | GO:0042803 | protein homodimerization activity(GO:0042803) |
| 0.0 | 0.9 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.0 | 8.1 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 0.0 | 12.4 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.0 | 0.2 | GO:0030144 | alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144) |
| 0.0 | 2.2 | GO:0004714 | transmembrane receptor protein tyrosine kinase activity(GO:0004714) |
| 0.0 | 5.2 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 0.8 | GO:0001104 | RNA polymerase II transcription cofactor activity(GO:0001104) |
| 0.0 | 3.8 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 1.2 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.0 | 1.3 | GO:0036002 | pre-mRNA binding(GO:0036002) |
| 0.0 | 0.1 | GO:0004563 | beta-N-acetylhexosaminidase activity(GO:0004563) |
| 0.0 | 1.2 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 0.0 | 0.5 | GO:0043130 | ubiquitin binding(GO:0043130) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 53.7 | PID_FCER1_PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 1.0 | 44.9 | PID_RAS_PATHWAY | Regulation of Ras family activation |
| 1.0 | 29.9 | PID_IL12_STAT4_PATHWAY | IL12 signaling mediated by STAT4 |
| 1.0 | 61.9 | PID_KIT_PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.9 | 112.2 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.7 | 97.3 | PID_PDGFRB_PATHWAY | PDGFR-beta signaling pathway |
| 0.6 | 15.9 | ST_ERK1_ERK2_MAPK_PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.6 | 36.5 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
| 0.5 | 13.7 | PID_BCR_5PATHWAY | BCR signaling pathway |
| 0.5 | 12.7 | PID_ARF_3PATHWAY | Arf1 pathway |
| 0.4 | 11.1 | ST_ADRENERGIC | Adrenergic Pathway |
| 0.4 | 15.9 | PID_TRKR_PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.3 | 6.9 | PID_IL8_CXCR2_PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.3 | 5.6 | PID_RAC1_PATHWAY | RAC1 signaling pathway |
| 0.3 | 8.4 | SIG_CHEMOTAXIS | Genes related to chemotaxis |
| 0.2 | 2.8 | PID_EPHRINB_REV_PATHWAY | Ephrin B reverse signaling |
| 0.2 | 7.3 | PID_MET_PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| 0.2 | 4.6 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.1 | 3.2 | PID_HIF1A_PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.1 | 17.4 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 10.4 | PID_CMYB_PATHWAY | C-MYB transcription factor network |
| 0.1 | 3.2 | PID_TNF_PATHWAY | TNF receptor signaling pathway |
| 0.1 | 21.3 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 2.4 | SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES | Genes related to the insulin receptor pathway |
| 0.1 | 1.8 | PID_HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.1 | 1.1 | PID_SYNDECAN_4_PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 2.6 | PID_P53_DOWNSTREAM_PATHWAY | Direct p53 effectors |
| 0.0 | 1.3 | PID_MYC_ACTIV_PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 0.3 | PID_NCADHERIN_PATHWAY | N-cadherin signaling events |
| 0.0 | 0.3 | PID_VEGFR1_2_PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 20.2 | 121.5 | REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 2.4 | 31.2 | REACTOME_CD28_DEPENDENT_VAV1_PATHWAY | Genes involved in CD28 dependent Vav1 pathway |
| 2.2 | 28.7 | REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 1.4 | 12.8 | REACTOME_P2Y_RECEPTORS | Genes involved in P2Y receptors |
| 1.3 | 13.4 | REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |
| 1.2 | 21.1 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 1.0 | 33.8 | REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.8 | 9.8 | REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1 | Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| 0.8 | 16.0 | REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.7 | 14.4 | REACTOME_INSULIN_RECEPTOR_RECYCLING | Genes involved in Insulin receptor recycling |
| 0.6 | 10.5 | REACTOME_GAP_JUNCTION_DEGRADATION | Genes involved in Gap junction degradation |
| 0.5 | 11.9 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.4 | 14.3 | REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS | Genes involved in G alpha (z) signalling events |
| 0.4 | 69.3 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.4 | 20.4 | REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.3 | 10.3 | REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING | Genes involved in Sema4D in semaphorin signaling |
| 0.3 | 5.8 | REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS | Genes involved in Thrombin signalling through proteinase activated receptors (PARs) |
| 0.3 | 4.3 | REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.3 | 10.8 | REACTOME_DARPP_32_EVENTS | Genes involved in DARPP-32 events |
| 0.3 | 11.6 | REACTOME_GLYCOLYSIS | Genes involved in Glycolysis |
| 0.3 | 1.2 | REACTOME_CTLA4_INHIBITORY_SIGNALING | Genes involved in CTLA4 inhibitory signaling |
| 0.3 | 9.3 | REACTOME_SIGNALING_BY_SCF_KIT | Genes involved in Signaling by SCF-KIT |
| 0.3 | 2.6 | REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS | Genes involved in Glucagon-type ligand receptors |
| 0.3 | 11.1 | REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.3 | 4.1 | REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.2 | 6.0 | REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.2 | 2.6 | REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 | Genes involved in IKK complex recruitment mediated by RIP1 |
| 0.2 | 4.6 | REACTOME_EGFR_DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.2 | 2.3 | REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.2 | 17.7 | REACTOME_SIGNALING_BY_ERBB2 | Genes involved in Signaling by ERBB2 |
| 0.2 | 5.1 | REACTOME_SYNTHESIS_OF_PA | Genes involved in Synthesis of PA |
| 0.1 | 7.0 | REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 3.1 | REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.1 | 1.0 | REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 0.1 | 2.1 | REACTOME_LYSOSOME_VESICLE_BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.1 | 2.4 | REACTOME_SIGNALING_BY_ROBO_RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.1 | 8.3 | REACTOME_TOLL_RECEPTOR_CASCADES | Genes involved in Toll Receptor Cascades |
| 0.1 | 9.1 | REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES | Genes involved in Transmission across Chemical Synapses |
| 0.1 | 1.7 | REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.1 | 8.0 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.1 | 5.1 | REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.1 | 1.0 | REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.0 | 2.6 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 1.3 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.0 | 1.1 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 0.9 | REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 0.3 | REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.0 | 0.2 | REACTOME_N_GLYCAN_ANTENNAE_ELONGATION | Genes involved in N-Glycan antennae elongation |
