Motif ID: Spic
Z-value: 1.636
Transcription factors associated with Spic:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Spic | ENSMUSG00000004359.10 | Spic |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Spic | mm10_v2_chr10_-_88683021_88683025 | -0.03 | 7.7e-01 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 182 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 15.7 | 47.2 | GO:0001803 | type III hypersensitivity(GO:0001802) regulation of type III hypersensitivity(GO:0001803) positive regulation of type III hypersensitivity(GO:0001805) |
| 5.3 | 36.8 | GO:0045650 | negative regulation of macrophage differentiation(GO:0045650) |
| 1.6 | 32.8 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.2 | 31.8 | GO:1990830 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
| 5.7 | 28.6 | GO:0003105 | negative regulation of glomerular filtration(GO:0003105) |
| 2.2 | 24.7 | GO:2000580 | positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582) |
| 4.1 | 24.5 | GO:1901164 | negative regulation of trophoblast cell migration(GO:1901164) |
| 1.6 | 24.5 | GO:0010447 | response to acidic pH(GO:0010447) |
| 1.4 | 20.7 | GO:0021902 | commitment of neuronal cell to specific neuron type in forebrain(GO:0021902) |
| 0.3 | 17.1 | GO:0038083 | peptidyl-tyrosine autophosphorylation(GO:0038083) |
| 4.5 | 13.6 | GO:0016998 | cell wall macromolecule catabolic process(GO:0016998) |
| 2.0 | 12.2 | GO:0032796 | uropod organization(GO:0032796) |
| 2.4 | 11.9 | GO:2000561 | CD4-positive, alpha-beta T cell proliferation(GO:0035739) regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000561) |
| 3.9 | 11.8 | GO:0002865 | negative regulation of acute inflammatory response to antigenic stimulus(GO:0002865) |
| 3.7 | 11.2 | GO:0048611 | ectodermal digestive tract development(GO:0007439) embryonic ectodermal digestive tract development(GO:0048611) |
| 0.3 | 11.1 | GO:0034314 | Arp2/3 complex-mediated actin nucleation(GO:0034314) |
| 0.8 | 10.4 | GO:0033008 | positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of mast cell degranulation(GO:0043306) |
| 3.2 | 9.6 | GO:2001187 | positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187) |
| 3.2 | 9.5 | GO:0060785 | regulation of apoptosis involved in tissue homeostasis(GO:0060785) |
| 0.1 | 9.5 | GO:0008643 | carbohydrate transport(GO:0008643) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 102 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 74.0 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.3 | 70.2 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 48.0 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.2 | 34.4 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.1 | 27.3 | GO:0005764 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
| 8.2 | 24.7 | GO:1990257 | piccolo-bassoon transport vesicle(GO:1990257) |
| 3.8 | 18.9 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.2 | 17.1 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.1 | 17.1 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.5 | 16.9 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.2 | 15.8 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 2.7 | 13.6 | GO:0048237 | rough endoplasmic reticulum lumen(GO:0048237) |
| 1.1 | 12.2 | GO:0032426 | stereocilium tip(GO:0032426) |
| 2.2 | 11.2 | GO:1990745 | EARP complex(GO:1990745) |
| 0.2 | 10.4 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.9 | 10.3 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 0.4 | 10.2 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.8 | 10.1 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.1 | 9.5 | GO:0030863 | cortical cytoskeleton(GO:0030863) |
| 0.1 | 9.3 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 139 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.8 | 59.0 | GO:0019864 | immunoglobulin receptor activity(GO:0019763) IgG binding(GO:0019864) |
| 1.5 | 24.7 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 3.5 | 24.5 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 0.7 | 20.1 | GO:0001968 | fibronectin binding(GO:0001968) |
| 0.5 | 19.8 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 4.7 | 18.9 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
| 0.2 | 18.9 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 18.8 | GO:0042803 | protein homodimerization activity(GO:0042803) |
| 2.3 | 18.3 | GO:0070290 | N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290) |
| 0.2 | 17.0 | GO:0019905 | syntaxin binding(GO:0019905) |
| 0.5 | 15.8 | GO:0017147 | Wnt-protein binding(GO:0017147) |
| 1.5 | 14.8 | GO:0004972 | NMDA glutamate receptor activity(GO:0004972) |
| 4.5 | 13.6 | GO:0003796 | lysozyme activity(GO:0003796) |
| 1.1 | 12.2 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 1.6 | 11.0 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.2 | 10.6 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.1 | 10.3 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 3.2 | 9.5 | GO:0072541 | peroxynitrite reductase activity(GO:0072541) |
| 2.4 | 9.5 | GO:0005459 | UDP-galactose transmembrane transporter activity(GO:0005459) |
| 1.4 | 8.6 | GO:0004920 | interleukin-10 receptor activity(GO:0004920) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 36 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 78.9 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.8 | 70.3 | PID_FCER1_PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.5 | 29.8 | PID_RAC1_PATHWAY | RAC1 signaling pathway |
| 0.3 | 23.8 | PID_RHOA_REG_PATHWAY | Regulation of RhoA activity |
| 0.1 | 20.2 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.5 | 18.7 | PID_KIT_PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.2 | 16.2 | PID_PDGFRB_PATHWAY | PDGFR-beta signaling pathway |
| 0.3 | 11.5 | PID_INTEGRIN3_PATHWAY | Beta3 integrin cell surface interactions |
| 0.1 | 10.0 | NABA_MATRISOME_ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
| 1.2 | 8.6 | PID_TCR_JNK_PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.2 | 7.9 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
| 0.3 | 6.6 | PID_ARF_3PATHWAY | Arf1 pathway |
| 0.1 | 5.8 | WNT_SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.7 | 5.5 | PID_ANTHRAX_PATHWAY | Cellular roles of Anthrax toxin |
| 0.3 | 4.5 | PID_LPA4_PATHWAY | LPA4-mediated signaling events |
| 0.2 | 3.9 | PID_SYNDECAN_4_PATHWAY | Syndecan-4-mediated signaling events |
| 0.1 | 3.1 | PID_FGF_PATHWAY | FGF signaling pathway |
| 0.0 | 2.6 | PID_MYC_REPRESS_PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.2 | 2.5 | PID_EPO_PATHWAY | EPO signaling pathway |
| 0.2 | 2.5 | PID_ERB_GENOMIC_PATHWAY | Validated nuclear estrogen receptor beta network |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 53 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 12.2 | 73.4 | REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.2 | 42.7 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 2.2 | 29.0 | REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 8.2 | 24.5 | REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.9 | 24.2 | REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.2 | 17.9 | REACTOME_PEPTIDE_CHAIN_ELONGATION | Genes involved in Peptide chain elongation |
| 0.2 | 16.4 | REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.6 | 11.8 | REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 1.2 | 11.0 | REACTOME_P2Y_RECEPTORS | Genes involved in P2Y receptors |
| 0.3 | 10.8 | REACTOME_SYNTHESIS_OF_PA | Genes involved in Synthesis of PA |
| 0.1 | 9.6 | REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM | Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism |
| 0.2 | 9.5 | REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.1 | 8.8 | REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 0.2 | 8.4 | REACTOME_EGFR_DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.2 | 8.3 | REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.2 | 7.7 | REACTOME_GLYCOLYSIS | Genes involved in Glycolysis |
| 0.4 | 7.3 | REACTOME_PLATELET_SENSITIZATION_BY_LDL | Genes involved in Platelet sensitization by LDL |
| 0.3 | 7.3 | REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
| 0.5 | 6.3 | REACTOME_POL_SWITCHING | Genes involved in Polymerase switching |
| 0.2 | 5.9 | REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
