Motif ID: Srf

Z-value: 1.186


Transcription factors associated with Srf:

Gene SymbolEntrez IDGene Name
Srf ENSMUSG00000015605.5 Srf

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Srfmm10_v2_chr17_-_46556158_465561880.066.2e-01Click!


Activity profile for motif Srf.

activity profile for motif Srf


Sorted Z-values histogram for motif Srf

Sorted Z-values for motif Srf



Network of associatons between targets according to the STRING database.



First level regulatory network of Srf

PNG image of the network

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Top targets:


Showing 1 to 20 of 108 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_34861200 25.446 ENSMUST00000165033.1
 Egr1
early growth response 1
chr6_-_23248264 15.845 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr14_+_5071040 7.981 ENSMUST00000163719.1
 Gm8281
predicted gene, 8281
chr4_+_43957678 7.552 ENSMUST00000107855.1
 Glipr2
GLI pathogenesis-related 2
chr4_+_43957401 7.046 ENSMUST00000030202.7
 Glipr2
GLI pathogenesis-related 2
chr14_+_4415448 6.931 ENSMUST00000168866.1
 Gm3164
predicted gene 3164
chr14_+_4334763 6.716 ENSMUST00000165466.1
 2610042L04Rik
RIKEN cDNA 2610042L04 gene
chr14_+_4726775 6.659 ENSMUST00000165619.1
 Gm3252
predicted gene 3252
chr14_+_3652030 6.439 ENSMUST00000167430.1
 Gm3020
predicted gene 3020
chr14_+_4182576 6.181 ENSMUST00000164512.1
 Gm2974
predicted gene 2974
chr14_+_3412614 6.168 ENSMUST00000170123.1
 Gm10409
predicted gene 10409
chr14_-_6889962 6.137 ENSMUST00000171906.1
 Gm3667
predicted gene 3667
chr14_+_3572023 6.025 ENSMUST00000178728.1
 Gm3005
predicted gene 3005
chr14_-_7568566 5.998 ENSMUST00000163790.1
 Gm3558
predicted gene 3558
chr14_+_3332627 5.913 ENSMUST00000177786.1
 Gm2956
predicted gene 2956
chr12_+_85473883 5.759 ENSMUST00000021674.6
 Fos
FBJ osteosarcoma oncogene
chr7_-_142661305 5.747 ENSMUST00000105936.1
 Igf2
insulin-like growth factor 2
chr5_-_24329556 5.631 ENSMUST00000115098.2
 Kcnh2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr7_-_19310035 5.516 ENSMUST00000003640.2
 Fosb
FBJ osteosarcoma oncogene B
chr14_-_5961745 5.345 ENSMUST00000163885.1
 Gm3248
predicted gene 3248

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
8.5 25.4 GO:0072223 metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
2.6 15.8 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.2 10.7 GO:0010718 positive regulation of epithelial to mesenchymal transition(GO:0010718)
1.0 8.0 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
1.1 7.7 GO:1902302 regulation of potassium ion export(GO:1902302)
1.7 6.7 GO:0060025 regulation of synaptic activity(GO:0060025)
0.8 5.9 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.3 5.8 GO:0035994 response to muscle stretch(GO:0035994)
0.1 5.5 GO:0071277 cellular response to calcium ion(GO:0071277)
0.4 5.3 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.2 5.2 GO:0001706 endoderm formation(GO:0001706)
0.1 5.0 GO:0045214 sarcomere organization(GO:0045214)
0.2 4.9 GO:0050765 negative regulation of phagocytosis(GO:0050765)
1.2 4.7 GO:0030091 protein repair(GO:0030091)
2.1 4.2 GO:0035793 negative regulation of phosphatidylinositol biosynthetic process(GO:0010512) cell migration involved in metanephros development(GO:0035788) metanephric mesenchymal cell migration(GO:0035789) positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:0035793) regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:1900238) regulation of metanephric mesenchymal cell migration(GO:2000589) positive regulation of metanephric mesenchymal cell migration(GO:2000591)
1.4 4.2 GO:0010814 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.3 3.9 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.6 3.1 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.3 3.1 GO:0030322 stabilization of membrane potential(GO:0030322)
0.2 3.1 GO:0001553 luteinization(GO:0001553)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 14.6 GO:0000139 Golgi membrane(GO:0000139)
1.0 5.8 GO:0035976 AP1 complex(GO:0035976)
1.4 5.6 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.0 4.7 GO:0031965 nuclear membrane(GO:0031965)
0.8 4.2 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 4.2 GO:0005902 microvillus(GO:0005902)
0.2 3.9 GO:0005680 anaphase-promoting complex(GO:0005680)
0.5 3.1 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.3 2.0 GO:0042629 mast cell granule(GO:0042629)
0.0 2.0 GO:0030496 midbody(GO:0030496)
0.1 1.8 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 1.7 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.5 1.6 GO:0005927 muscle tendon junction(GO:0005927)
0.1 1.6 GO:0043034 costamere(GO:0043034)
0.1 1.5 GO:0031430 M band(GO:0031430)
0.1 1.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 1.1 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.1 1.0 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 1.0 GO:0000124 SAGA complex(GO:0000124)
0.0 1.0 GO:0032587 ruffle membrane(GO:0032587)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
6.4 25.4 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.1 13.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.7 10.5 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.3 8.0 GO:0043539 insulin-like growth factor receptor binding(GO:0005159) protein serine/threonine kinase activator activity(GO:0043539)
0.7 5.9 GO:0048495 Roundabout binding(GO:0048495)
0.1 5.8 GO:0070412 R-SMAD binding(GO:0070412)
1.1 5.6 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.8 4.7 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.1 4.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.3 4.2 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 4.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.3 3.1 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 3.1 GO:0035064 methylated histone binding(GO:0035064)
0.1 2.6 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.2 2.5 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 2.2 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 2.1 GO:0071837 HMG box domain binding(GO:0071837)
0.1 2.1 GO:0008307 structural constituent of muscle(GO:0008307)
0.7 2.0 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.2 2.0 GO:0051428 peptide hormone receptor binding(GO:0051428)

Gene overrepresentation in C2:CP category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 25.4 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.1 7.7 PID_AP1_PATHWAY AP-1 transcription factor network
0.4 5.8 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.1 5.3 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.1 4.2 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.1 3.5 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 2.6 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 2.5 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 2.3 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.1 2.1 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 1.9 PID_IFNG_PATHWAY IFN-gamma pathway
0.0 1.8 PID_RAC1_PATHWAY RAC1 signaling pathway
0.1 1.5 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 1.3 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 0.7 PID_IGF1_PATHWAY IGF1 pathway
0.0 0.4 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 24.3 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.5 8.0 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.3 5.8 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 5.6 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 5.1 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 4.2 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION Genes involved in Downstream signal transduction
0.4 3.1 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 2.1 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 1.3 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 1.2 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 1.0 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.8 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.7 REACTOME_DESTABILIZATION_OF_MRNA_BY_KSRP Genes involved in Destabilization of mRNA by KSRP
0.0 0.5 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation