Motif ID: Stat1

Z-value: 0.546


Transcription factors associated with Stat1:

Gene SymbolEntrez IDGene Name
Stat1 ENSMUSG00000026104.8 Stat1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Stat1mm10_v2_chr1_+_52119438_52119499-0.511.7e-06Click!


Activity profile for motif Stat1.

activity profile for motif Stat1


Sorted Z-values histogram for motif Stat1

Sorted Z-values for motif Stat1



Network of associatons between targets according to the STRING database.



First level regulatory network of Stat1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 162 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_93519499 8.916 ENSMUST00000109255.2
 Prickle1
prickle homolog 1 (Drosophila)
chr11_+_78499087 7.430 ENSMUST00000017488.4
 Vtn
vitronectin
chr12_+_74297474 5.657 ENSMUST00000072100.3
 Dbpht2
DNA binding protein with his-thr domain
chrX_-_61185558 4.872 ENSMUST00000166381.1
 Cdr1
cerebellar degeneration related antigen 1
chr17_-_68004075 4.342 ENSMUST00000024840.5
 Arhgap28
Rho GTPase activating protein 28
chr15_-_37459327 4.268 ENSMUST00000119730.1
ENSMUST00000120746.1
 Ncald

neurocalcin delta

chr15_-_37458523 4.194 ENSMUST00000116445.2
 Ncald
neurocalcin delta
chr4_-_136886187 3.906 ENSMUST00000046384.8
 C1qb
complement component 1, q subcomponent, beta polypeptide
chr9_+_20868628 3.844 ENSMUST00000043911.7
 A230050P20Rik
RIKEN cDNA A230050P20 gene
chr3_-_80802789 3.801 ENSMUST00000107745.1
ENSMUST00000075316.4
 Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chr11_+_101245996 3.697 ENSMUST00000129680.1
 Ramp2
receptor (calcitonin) activity modifying protein 2
chr4_-_64046925 3.135 ENSMUST00000107377.3
 Tnc
tenascin C
chr7_-_78577771 3.109 ENSMUST00000039438.7
 Ntrk3
neurotrophic tyrosine kinase, receptor, type 3
chr3_-_10440054 2.980 ENSMUST00000099223.4
ENSMUST00000029047.6
 Snx16

sorting nexin 16

chr7_+_45783686 2.871 ENSMUST00000118564.1
ENSMUST00000133428.1
 Lmtk3

lemur tyrosine kinase 3

chr11_+_82035569 2.862 ENSMUST00000000193.5
 Ccl2
chemokine (C-C motif) ligand 2
chr16_-_42340595 2.775 ENSMUST00000102817.4
 Gap43
growth associated protein 43
chr4_+_43401232 2.748 ENSMUST00000125399.1
 Rusc2
RUN and SH3 domain containing 2
chr7_+_45783883 2.724 ENSMUST00000072580.5
 Lmtk3
lemur tyrosine kinase 3
chr7_+_24134148 2.436 ENSMUST00000056549.7
 Zfp235
zinc finger protein 235

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.0 8.9 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
0.1 8.5 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.7 7.4 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302) liver regeneration(GO:0097421)
0.2 7.3 GO:0034340 response to type I interferon(GO:0034340)
0.1 5.6 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
1.1 4.3 GO:1904425 negative regulation of GTP binding(GO:1904425)
1.0 4.1 GO:0046967 cytosol to ER transport(GO:0046967)
0.1 3.8 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.6 3.7 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.4 3.7 GO:0016198 axon choice point recognition(GO:0016198)
0.5 3.5 GO:0015862 uridine transport(GO:0015862)
0.5 3.2 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) phosphate ion transmembrane transport(GO:0035435) cellular trivalent inorganic anion homeostasis(GO:0072502)
1.0 3.1 GO:0048687 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)
0.8 3.1 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.1 3.0 GO:0006622 protein targeting to lysosome(GO:0006622)
0.6 2.9 GO:2000427 eosinophil chemotaxis(GO:0048245) T cell extravasation(GO:0072683) positive regulation of apoptotic cell clearance(GO:2000427)
0.2 2.4 GO:1901898 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 2.4 GO:0032026 response to magnesium ion(GO:0032026)
0.8 2.3 GO:2000501 natural killer cell chemotaxis(GO:0035747) negative regulation of lymphocyte migration(GO:2000402) regulation of natural killer cell chemotaxis(GO:2000501)
0.3 2.3 GO:2000394 positive regulation of lamellipodium morphogenesis(GO:2000394)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 15.1 GO:0031226 intrinsic component of plasma membrane(GO:0031226)
0.0 7.6 GO:0031965 nuclear membrane(GO:0031965)
1.5 7.4 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.1 6.1 GO:0005581 collagen trimer(GO:0005581)
0.6 4.1 GO:0042825 TAP complex(GO:0042825)
0.2 3.8 GO:0032279 asymmetric synapse(GO:0032279)
0.7 3.7 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.2 3.1 GO:0005614 interstitial matrix(GO:0005614)
0.4 3.0 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
1.0 2.9 GO:0044299 C-fiber(GO:0044299)
0.0 2.7 GO:0097708 cytoplasmic vesicle(GO:0031410) intracellular vesicle(GO:0097708)
0.1 2.4 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 2.2 GO:0031527 filopodium membrane(GO:0031527)
0.0 2.0 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 1.9 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 1.6 GO:0005688 U6 snRNP(GO:0005688)
0.4 1.5 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.3 1.4 GO:0005796 Golgi lumen(GO:0005796)
0.1 1.3 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.3 1.2 GO:0031673 H zone(GO:0031673)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 10.1 GO:0008270 zinc ion binding(GO:0008270)
0.5 8.5 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.2 8.5 GO:0043014 alpha-tubulin binding(GO:0043014)
1.3 5.1 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
1.0 4.1 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)
0.0 4.1 GO:0005096 GTPase activator activity(GO:0005096)
0.0 4.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.6 3.8 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.7 3.7 GO:0097643 amylin receptor activity(GO:0097643)
0.9 3.5 GO:0019962 interferon receptor activity(GO:0004904) type I interferon receptor activity(GO:0004905) type I interferon binding(GO:0019962)
0.1 3.5 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
1.1 3.2 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.6 3.1 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.5 3.1 GO:0045545 syndecan binding(GO:0045545)
0.0 2.9 GO:0017137 Rab GTPase binding(GO:0017137)
0.4 2.8 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.0 2.6 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.1 2.4 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.5 2.2 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 2.1 GO:0030507 spectrin binding(GO:0030507)

Gene overrepresentation in C2:CP category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 7.4 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 6.6 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 3.1 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.1 2.9 PID_IL23_PATHWAY IL23-mediated signaling events
0.1 2.9 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.1 2.8 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.1 2.8 PID_SHP2_PATHWAY SHP2 signaling
0.1 2.7 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.6 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 1.5 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.
0.1 1.4 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.1 1.2 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.0 1.2 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.8 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 0.8 ST_INTEGRIN_SIGNALING_PATHWAY Integrin Signaling Pathway
0.0 0.6 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.6 PID_IL2_1PATHWAY IL2-mediated signaling events
0.0 0.3 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.2 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.5 8.5 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.8 4.7 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 4.6 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.2 4.1 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.2 3.8 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 3.7 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.3 3.5 REACTOME_REGULATION_OF_IFNA_SIGNALING Genes involved in Regulation of IFNA signaling
0.1 3.5 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 3.3 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling
0.1 2.9 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4
0.0 2.9 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 2.4 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 2.3 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 1.9 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.0 1.9 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY Genes involved in Generic Transcription Pathway
0.2 1.7 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.1 1.6 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 1.1 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.9 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor