Motif ID: Stat2

Z-value: 2.664


Transcription factors associated with Stat2:

Gene SymbolEntrez IDGene Name
Stat2 ENSMUSG00000040033.9 Stat2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Stat2mm10_v2_chr10_+_128270546_1282705770.234.4e-02Click!


Activity profile for motif Stat2.

activity profile for motif Stat2


Sorted Z-values histogram for motif Stat2

Sorted Z-values for motif Stat2



Network of associatons between targets according to the STRING database.



First level regulatory network of Stat2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_173942445 46.262 ENSMUST00000042228.8
ENSMUST00000081216.5
ENSMUST00000129829.1
ENSMUST00000123708.1
ENSMUST00000111210.2
 Ifi203



Mndal
interferon activated gene 203



myeloid nuclear differentiation antigen like
chr7_-_141010759 42.380 ENSMUST00000026565.6
 Ifitm3
interferon induced transmembrane protein 3
chr4_-_154636831 31.534 ENSMUST00000030902.6
ENSMUST00000105637.1
ENSMUST00000070313.7
ENSMUST00000105636.1
ENSMUST00000105638.2
ENSMUST00000097759.2
ENSMUST00000124771.1
 Prdm16






PR domain containing 16






chr12_+_103434211 30.301 ENSMUST00000079294.5
ENSMUST00000076788.5
ENSMUST00000076702.5
ENSMUST00000066701.6
ENSMUST00000085065.5
ENSMUST00000140838.1
 Ifi27





interferon, alpha-inducible protein 27





chr3_-_107760221 28.442 ENSMUST00000153114.1
ENSMUST00000118593.1
ENSMUST00000120243.1
 Csf1


colony stimulating factor 1 (macrophage)


chr1_-_156674290 27.528 ENSMUST00000079625.4
 Tor3a
torsin family 3, member A
chr6_+_121245903 26.103 ENSMUST00000032198.9
 Usp18
ubiquitin specific peptidase 18
chr16_+_42907563 22.608 ENSMUST00000151244.1
ENSMUST00000114694.2
 Zbtb20

zinc finger and BTB domain containing 20

chr16_+_43363855 20.795 ENSMUST00000156367.1
 Zbtb20
zinc finger and BTB domain containing 20
chr14_+_28511344 20.758 ENSMUST00000112272.1
 Wnt5a
wingless-related MMTV integration site 5A
chr11_+_119393060 20.246 ENSMUST00000131035.2
ENSMUST00000093902.5
 Rnf213

ring finger protein 213

chr8_-_71537402 19.851 ENSMUST00000051672.7
 Bst2
bone marrow stromal cell antigen 2
chr16_+_23609895 19.742 ENSMUST00000038423.5
 Rtp4
receptor transporter protein 4
chr6_-_39118211 19.363 ENSMUST00000038398.6
 Parp12
poly (ADP-ribose) polymerase family, member 12
chr16_+_43235856 18.713 ENSMUST00000146708.1
 Zbtb20
zinc finger and BTB domain containing 20
chr16_+_43364145 18.219 ENSMUST00000148775.1
 Zbtb20
zinc finger and BTB domain containing 20
chr16_-_22439719 17.590 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr2_-_51972990 17.254 ENSMUST00000145481.1
ENSMUST00000112705.2
 Nmi

N-myc (and STAT) interactor

chr1_-_170110491 16.835 ENSMUST00000027985.2
 Ddr2
discoidin domain receptor family, member 2
chr8_-_84773381 16.591 ENSMUST00000109764.1
 Nfix
nuclear factor I/X

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 109 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.3 119.2 GO:0045071 negative regulation of viral genome replication(GO:0045071)
2.4 82.9 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
2.1 65.4 GO:0035458 cellular response to interferon-beta(GO:0035458)
3.9 31.5 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
7.8 31.4 GO:0060332 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
0.7 30.3 GO:0046825 regulation of protein export from nucleus(GO:0046825)
4.7 28.5 GO:0032196 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) transposition(GO:0032196)
8.9 26.8 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
3.3 26.1 GO:0080184 response to stilbenoid(GO:0035634) response to phenylpropanoid(GO:0080184)
4.2 25.0 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
4.3 21.6 GO:0035547 interferon-beta secretion(GO:0035546) regulation of interferon-beta secretion(GO:0035547) positive regulation of interferon-beta secretion(GO:0035549)
6.9 20.8 GO:0061349 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) hypophysis morphogenesis(GO:0048850) cervix development(GO:0060067) planar cell polarity pathway involved in outflow tract morphogenesis(GO:0061347) planar cell polarity pathway involved in ventricular septum morphogenesis(GO:0061348) planar cell polarity pathway involved in cardiac right atrium morphogenesis(GO:0061349) planar cell polarity pathway involved in cardiac muscle tissue morphogenesis(GO:0061350) planar cell polarity pathway involved in pericardium morphogenesis(GO:0061354)
2.2 20.2 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
5.0 19.9 GO:1901252 regulation of intracellular transport of viral material(GO:1901252)
6.6 19.7 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
3.5 17.6 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
3.5 17.6 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
5.8 17.3 GO:1902524 interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of protein K48-linked ubiquitination(GO:1902524)
2.1 16.8 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
1.1 16.6 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 216.0 GO:0005634 nucleus(GO:0005634)
0.2 81.3 GO:0045177 apical part of cell(GO:0045177)
0.5 55.3 GO:0016363 nuclear matrix(GO:0016363)
0.1 48.6 GO:0005730 nucleolus(GO:0005730)
0.8 35.1 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 32.2 GO:0005615 extracellular space(GO:0005615)
0.3 31.9 GO:0005923 bicellular tight junction(GO:0005923)
0.7 31.5 GO:0016235 aggresome(GO:0016235)
0.0 31.5 GO:0005739 mitochondrion(GO:0005739)
0.7 30.3 GO:0005637 nuclear inner membrane(GO:0005637)
9.5 28.4 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.1 27.7 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
1.7 25.6 GO:0044754 autolysosome(GO:0044754)
0.0 19.4 GO:0009986 cell surface(GO:0009986)
1.4 17.8 GO:0020003 symbiont-containing vacuole(GO:0020003)
0.1 15.5 GO:0043235 receptor complex(GO:0043235)
1.0 15.2 GO:0043083 synaptic cleft(GO:0043083)
1.6 14.6 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
1.3 13.3 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.9 10.3 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 93 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 124.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.7 55.3 GO:0019843 rRNA binding(GO:0019843)
0.1 53.5 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
2.5 52.5 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 41.5 GO:0005525 GTP binding(GO:0005525)
0.4 40.9 GO:0033613 activating transcription factor binding(GO:0033613)
1.3 30.3 GO:0005521 lamin binding(GO:0005521)
7.1 28.5 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.3 28.4 GO:0008083 growth factor activity(GO:0008083)
0.5 27.5 GO:0016836 hydro-lyase activity(GO:0016836)
0.2 25.7 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.3 22.6 GO:0003725 double-stranded RNA binding(GO:0003725)
6.9 20.8 GO:0005110 frizzled-2 binding(GO:0005110)
1.6 18.8 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
4.4 17.6 GO:0038049 glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.1 17.3 GO:0003712 transcription cofactor activity(GO:0003712)
1.9 16.8 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
2.2 15.2 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.7 14.6 GO:0070016 gamma-catenin binding(GO:0045295) armadillo repeat domain binding(GO:0070016)
0.1 14.5 GO:0001664 G-protein coupled receptor binding(GO:0001664)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 32.3 PID_AP1_PATHWAY AP-1 transcription factor network
2.8 28.4 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.5 28.4 PID_SHP2_PATHWAY SHP2 signaling
0.6 25.0 PID_IL12_2PATHWAY IL12-mediated signaling events
0.2 21.4 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.7 20.8 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.6 17.6 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.3 12.7 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.4 12.1 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 11.9 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 10.7 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.3 9.5 PID_MYC_PATHWAY C-MYC pathway
0.3 9.4 PID_IL1_PATHWAY IL1-mediated signaling events
0.3 7.8 PID_TCPTP_PATHWAY Signaling events mediated by TCPTP
0.1 5.1 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 5.1 PID_PLK1_PATHWAY PLK1 signaling events
0.3 5.0 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 4.6 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 3.6 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.4 3.5 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY PI3K Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.6 182.2 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
2.5 34.7 REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.4 17.6 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.6 15.2 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.2 12.6 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.4 12.2 REACTOME_INTERFERON_GAMMA_SIGNALING Genes involved in Interferon gamma signaling
0.3 10.7 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 10.2 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 9.9 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION Genes involved in Downstream signal transduction
0.1 9.5 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
3.1 9.4 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.2 7.9 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.4 7.4 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.2 5.2 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.1 5.1 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.2 5.0 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 4.4 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.4 3.5 REACTOME_PD1_SIGNALING Genes involved in PD-1 signaling
0.1 2.9 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 2.3 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling