Motif ID: Stat4_Stat3_Stat5b

Z-value: 0.883

Transcription factors associated with Stat4_Stat3_Stat5b:

Gene SymbolEntrez IDGene Name
Stat3 ENSMUSG00000004040.10 Stat3
Stat4 ENSMUSG00000062939.5 Stat4
Stat5b ENSMUSG00000020919.5 Stat5b

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Stat4mm10_v2_chr1_+_52008210_52008254-0.393.9e-04Click!
Stat5bmm10_v2_chr11_-_100850724_100850763-0.216.1e-02Click!
Stat3mm10_v2_chr11_-_100939457_1009394840.103.9e-01Click!


Activity profile for motif Stat4_Stat3_Stat5b.

activity profile for motif Stat4_Stat3_Stat5b


Sorted Z-values histogram for motif Stat4_Stat3_Stat5b

Sorted Z-values for motif Stat4_Stat3_Stat5b



Network of associatons between targets according to the STRING database.



First level regulatory network of Stat4_Stat3_Stat5b

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_80802789 13.549 ENSMUST00000107745.1
ENSMUST00000075316.4
 Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chrX_-_61185558 13.377 ENSMUST00000166381.1
 Cdr1
cerebellar degeneration related antigen 1
chr4_+_148602527 6.993 ENSMUST00000105701.2
ENSMUST00000052060.6
 Masp2

mannan-binding lectin serine peptidase 2

chr10_+_20312461 6.467 ENSMUST00000092678.3
ENSMUST00000043881.5
 Bclaf1

BCL2-associated transcription factor 1

chr10_-_95417099 6.452 ENSMUST00000135822.1
 Socs2
suppressor of cytokine signaling 2
chr10_-_95416850 6.191 ENSMUST00000020215.9
 Socs2
suppressor of cytokine signaling 2
chr12_+_11265867 6.063 ENSMUST00000020931.5
 Smc6
structural maintenance of chromosomes 6
chr13_-_67755132 6.038 ENSMUST00000091520.6
 Zfp85-rs1
zinc finger protein 85, related sequence 1
chr13_-_67755192 5.586 ENSMUST00000144183.1
 Zfp85-rs1
zinc finger protein 85, related sequence 1
chr17_+_26715644 4.994 ENSMUST00000062519.7
ENSMUST00000144221.1
ENSMUST00000142539.1
ENSMUST00000151681.1
 Crebrf



CREB3 regulatory factor



chr3_+_96576984 4.490 ENSMUST00000148290.1
 Gm16253
predicted gene 16253
chr19_-_5797410 4.335 ENSMUST00000173314.1
 Malat1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
chr2_+_3424123 3.956 ENSMUST00000061852.5
ENSMUST00000100463.3
ENSMUST00000102988.3
ENSMUST00000115066.1
 Dclre1c



DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae)



chr3_+_69004711 3.686 ENSMUST00000042901.8
 Smc4
structural maintenance of chromosomes 4
chr4_-_108031938 3.568 ENSMUST00000106708.1
 Podn
podocan
chr7_-_78577771 3.540 ENSMUST00000039438.7
 Ntrk3
neurotrophic tyrosine kinase, receptor, type 3
chr13_+_83738874 3.530 ENSMUST00000052354.4
 C130071C03Rik
RIKEN cDNA C130071C03 gene
chr16_-_74411776 3.405 ENSMUST00000116586.2
 Robo2
roundabout homolog 2 (Drosophila)
chr14_-_65833963 3.389 ENSMUST00000022613.9
 Esco2
establishment of cohesion 1 homolog 2 (S. cerevisiae)
chr16_-_74411292 3.269 ENSMUST00000117200.1
 Robo2
roundabout homolog 2 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 225 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 13.2 GO:0017145 stem cell division(GO:0017145)
0.7 13.1 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.4 11.3 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.7 8.1 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
1.1 7.5 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.2 6.9 GO:2000144 positive regulation of DNA-templated transcription, initiation(GO:2000144)
2.2 6.7 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.6 6.1 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.0 6.1 GO:0030336 negative regulation of cell migration(GO:0030336)
0.1 5.3 GO:0060612 adipose tissue development(GO:0060612)
1.0 5.0 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.9 4.3 GO:0035063 nuclear speck organization(GO:0035063)
0.6 4.0 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.4 4.0 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 4.0 GO:0061157 mRNA destabilization(GO:0061157)
0.1 4.0 GO:0006940 regulation of smooth muscle contraction(GO:0006940)
0.4 3.9 GO:0040016 embryonic cleavage(GO:0040016)
0.5 3.7 GO:0010032 meiotic chromosome condensation(GO:0010032)
1.2 3.5 GO:0048687 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)
0.7 3.4 GO:0034421 post-translational protein acetylation(GO:0034421)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 104 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 13.5 GO:0032279 asymmetric synapse(GO:0032279)
0.1 9.4 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.2 7.4 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 7.4 GO:0016607 nuclear speck(GO:0016607)
0.2 6.7 GO:0030673 axolemma(GO:0030673)
2.0 6.1 GO:0035061 interchromatin granule(GO:0035061)
0.2 5.4 GO:0043194 axon initial segment(GO:0043194)
0.6 5.3 GO:0030478 actin cap(GO:0030478)
0.2 4.3 GO:0034451 centriolar satellite(GO:0034451)
0.3 4.0 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.0 4.0 GO:0005814 centriole(GO:0005814)
0.0 3.9 GO:0001650 fibrillar center(GO:0001650)
0.9 3.7 GO:0090537 CERF complex(GO:0090537)
0.4 3.7 GO:0000796 condensin complex(GO:0000796)
0.1 3.6 GO:0005720 nuclear heterochromatin(GO:0005720)
0.3 3.4 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.1 3.1 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 3.0 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 2.7 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 2.6 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 157 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 16.6 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
2.7 13.7 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
2.3 13.5 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.3 10.6 GO:0017091 AU-rich element binding(GO:0017091)
0.7 6.7 GO:0008046 axon guidance receptor activity(GO:0008046)
0.5 6.2 GO:0001846 opsonin binding(GO:0001846)
0.9 4.5 GO:0016972 thiol oxidase activity(GO:0016972)
0.0 4.1 GO:0005096 GTPase activator activity(GO:0005096)
0.4 4.0 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.1 3.8 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
1.2 3.7 GO:0070615 nucleosome-dependent ATPase activity(GO:0070615)
0.7 3.5 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.6 3.4 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0 3.4 GO:0005518 collagen binding(GO:0005518)
0.1 3.2 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.8 3.1 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)
0.0 3.0 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 3.0 GO:0003697 single-stranded DNA binding(GO:0003697)
0.2 2.9 GO:0038191 neuropilin binding(GO:0038191)
0.2 2.9 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 12.6 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 9.1 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 8.0 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 5.3 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 4.2 PID_IL2_1PATHWAY IL2-mediated signaling events
0.1 4.0 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 3.2 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.1 3.2 PID_FOXO_PATHWAY FoxO family signaling
0.1 3.0 PID_AURORA_B_PATHWAY Aurora B signaling
0.5 2.7 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 2.5 PID_SHP2_PATHWAY SHP2 signaling
0.2 2.3 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 2.3 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 2.2 PID_P53_REGULATION_PATHWAY p53 pathway
0.1 1.8 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 1.7 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.1 1.6 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.1 1.4 PID_CXCR3_PATHWAY CXCR3-mediated signaling events
0.1 1.1 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 0.9 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 13.5 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.2 7.4 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling
0.2 6.8 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.1 6.1 REACTOME_MUSCLE_CONTRACTION Genes involved in Muscle contraction
1.0 5.7 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.3 4.0 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.0 3.9 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.1 3.7 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.1 3.5 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 3.3 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.4 3.2 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1 2.9 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.1 2.7 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 2.5 REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.2 2.2 REACTOME_SIGNALING_BY_ACTIVATED_POINT_MUTANTS_OF_FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.0 2.2 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 2.1 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 1.8 REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.1 1.8 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 1.8 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins