Motif ID: Stat5a

Z-value: 0.984


Transcription factors associated with Stat5a:

Gene SymbolEntrez IDGene Name
Stat5a ENSMUSG00000004043.8 Stat5a



Activity profile for motif Stat5a.

activity profile for motif Stat5a


Sorted Z-values histogram for motif Stat5a

Sorted Z-values for motif Stat5a



Network of associatons between targets according to the STRING database.



First level regulatory network of Stat5a

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_61185558 13.185 ENSMUST00000166381.1
 Cdr1
cerebellar degeneration related antigen 1
chr17_+_22689771 12.902 ENSMUST00000055305.8
 Gm9805
predicted gene 9805
chr9_-_77347816 9.682 ENSMUST00000184138.1
ENSMUST00000184006.1
ENSMUST00000185144.1
ENSMUST00000034910.9
 Mlip



muscular LMNA-interacting protein



chr9_-_77347787 9.032 ENSMUST00000184848.1
ENSMUST00000184415.1
 Mlip

muscular LMNA-interacting protein

chr4_-_136898803 8.646 ENSMUST00000046285.5
 C1qa
complement component 1, q subcomponent, alpha polypeptide
chr4_-_64046925 6.296 ENSMUST00000107377.3
 Tnc
tenascin C
chr11_-_55419898 5.821 ENSMUST00000108858.1
ENSMUST00000141530.1
 Sparc

secreted acidic cysteine rich glycoprotein

chr13_+_83573577 5.612 ENSMUST00000185052.1
 Mef2c
myocyte enhancer factor 2C
chr8_-_71537402 5.612 ENSMUST00000051672.7
 Bst2
bone marrow stromal cell antigen 2
chr5_-_77408034 5.377 ENSMUST00000163898.1
ENSMUST00000046746.6
 Igfbp7

insulin-like growth factor binding protein 7

chr5_+_104435112 5.160 ENSMUST00000031243.8
ENSMUST00000086833.6
ENSMUST00000112748.1
ENSMUST00000112746.1
ENSMUST00000145084.1
ENSMUST00000132457.1
 Spp1





secreted phosphoprotein 1





chr11_+_78499087 5.066 ENSMUST00000017488.4
 Vtn
vitronectin
chr2_+_14229390 4.884 ENSMUST00000028045.2
 Mrc1
mannose receptor, C type 1
chr18_-_36726730 4.749 ENSMUST00000061829.6
 Cd14
CD14 antigen
chr19_+_12460749 4.687 ENSMUST00000081035.7
 Mpeg1
macrophage expressed gene 1
chr11_+_94936224 4.666 ENSMUST00000001547.7
 Col1a1
collagen, type I, alpha 1
chr6_+_96113146 4.646 ENSMUST00000122120.1
 Fam19a1
family with sequence similarity 19, member A1
chr11_-_100970887 4.587 ENSMUST00000060792.5
 Ptrf
polymerase I and transcript release factor
chr19_+_34217588 4.494 ENSMUST00000119603.1
 Stambpl1
STAM binding protein like 1
chr10_-_117282262 4.414 ENSMUST00000092163.7
 Lyz2
lysozyme 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 409 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 28.0 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.4 8.0 GO:0006958 complement activation, classical pathway(GO:0006958)
0.1 7.7 GO:0007416 synapse assembly(GO:0007416)
1.2 6.9 GO:0055091 phospholipid homeostasis(GO:0055091)
0.2 6.6 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.2 6.6 GO:0001937 negative regulation of endothelial cell proliferation(GO:0001937)
1.1 6.4 GO:0032346 positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349) leading edge cell differentiation(GO:0035026) regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)
1.6 6.3 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.6 6.2 GO:0097421 liver regeneration(GO:0097421)
0.2 5.9 GO:0060716 labyrinthine layer blood vessel development(GO:0060716)
1.9 5.6 GO:0007521 muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
1.4 5.6 GO:1901252 regulation of intracellular transport of viral material(GO:1901252)
1.8 5.4 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
1.3 5.4 GO:0071726 response to diacyl bacterial lipopeptide(GO:0071724) cellular response to diacyl bacterial lipopeptide(GO:0071726)
0.2 5.3 GO:0034340 response to type I interferon(GO:0034340)
1.3 5.2 GO:0035937 androgen catabolic process(GO:0006710) estrogen secretion(GO:0035937) estradiol secretion(GO:0035938) regulation of estrogen secretion(GO:2000861) regulation of estradiol secretion(GO:2000864)
1.6 4.8 GO:2000501 natural killer cell chemotaxis(GO:0035747) regulation of natural killer cell chemotaxis(GO:2000501)
0.3 4.8 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.8 4.7 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.4 4.7 GO:0030432 peristalsis(GO:0030432)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 185 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 29.0 GO:0005615 extracellular space(GO:0005615)
0.2 22.5 GO:0031225 anchored component of membrane(GO:0031225)
0.2 18.1 GO:0016605 PML body(GO:0016605)
0.2 16.6 GO:0005581 collagen trimer(GO:0005581)
2.5 12.7 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.5 8.3 GO:0005614 interstitial matrix(GO:0005614)
0.5 6.9 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
1.6 6.4 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1 6.0 GO:0055037 recycling endosome(GO:0055037)
1.5 5.8 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 5.4 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 5.4 GO:0008021 synaptic vesicle(GO:0008021)
0.1 4.8 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
1.6 4.7 GO:0005584 collagen type I trimer(GO:0005584)
0.0 4.6 GO:0044306 neuron projection terminus(GO:0044306)
0.7 4.3 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.1 4.3 GO:0009925 basal plasma membrane(GO:0009925)
0.2 4.0 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.3 3.7 GO:0044327 dendritic spine head(GO:0044327)
0.2 3.6 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 281 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 18.2 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.2 11.5 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 11.4 GO:0008237 metallopeptidase activity(GO:0008237)
0.5 8.0 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 7.7 GO:0003735 structural constituent of ribosome(GO:0003735)
1.9 7.6 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.8 7.0 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.4 6.6 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.9 6.5 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.5 6.4 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 6.4 GO:0003924 GTPase activity(GO:0003924)
1.0 5.9 GO:0045545 syndecan binding(GO:0045545)
0.4 5.6 GO:0003680 AT DNA binding(GO:0003680)
0.2 5.6 GO:0003785 actin monomer binding(GO:0003785)
1.8 5.4 GO:0003796 lysozyme activity(GO:0003796)
0.3 5.4 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.3 5.1 GO:0005537 mannose binding(GO:0005537)
0.3 5.1 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.4 4.9 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
1.6 4.7 GO:0071723 lipopeptide binding(GO:0071723)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 31.2 PID_INTEGRIN1_PATHWAY Beta1 integrin cell surface interactions
0.1 16.6 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 9.3 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 7.5 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 7.3 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 4.6 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.1 4.4 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.1 4.1 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 4.1 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 4.0 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.1 3.6 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.6 3.4 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.1 3.2 PID_TXA2PATHWAY Thromboxane A2 receptor signaling
0.2 3.1 PID_IL27_PATHWAY IL27-mediated signaling events
0.2 2.5 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 2.5 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.2 2.2 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.
0.1 1.9 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.9 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.2 1.8 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 94 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 15.1 REACTOME_ANTIGEN_PROCESSING_CROSS_PRESENTATION Genes involved in Antigen processing-Cross presentation
0.2 11.9 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.2 11.2 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.2 10.2 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
1.3 7.8 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.3 6.4 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.2 6.4 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 6.4 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 5.6 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.4 5.5 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.2 5.5 REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.2 5.1 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 5.1 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.1 4.8 REACTOME_IRON_UPTAKE_AND_TRANSPORT Genes involved in Iron uptake and transport
0.2 4.5 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.4 4.4 REACTOME_TRAF6_MEDIATED_INDUCTION_OF_TAK1_COMPLEX Genes involved in TRAF6 mediated induction of TAK1 complex
0.3 4.4 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 4.2 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.3 4.0 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 4.0 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation