Motif ID: Stat6

Z-value: 0.653


Transcription factors associated with Stat6:

Gene SymbolEntrez IDGene Name
Stat6 ENSMUSG00000002147.12 Stat6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Stat6mm10_v2_chr10_+_127642975_127643034-0.009.9e-01Click!


Activity profile for motif Stat6.

activity profile for motif Stat6


Sorted Z-values histogram for motif Stat6

Sorted Z-values for motif Stat6



Network of associatons between targets according to the STRING database.



First level regulatory network of Stat6

PNG image of the network

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Top targets:


Showing 1 to 20 of 133 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_139543889 10.100 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr14_-_21989475 9.105 ENSMUST00000043409.7
 Zfp503
zinc finger protein 503
chr3_-_86548268 8.020 ENSMUST00000077524.3
 Mab21l2
mab-21-like 2 (C. elegans)
chr5_-_106574706 7.819 ENSMUST00000131029.1
ENSMUST00000124394.2
 RP24-421H18.1

RP24-421H18.1

chr3_+_102010138 7.452 ENSMUST00000066187.4
 Nhlh2
nescient helix loop helix 2
chr9_-_70421533 6.843 ENSMUST00000034742.6
 Ccnb2
cyclin B2
chr17_+_29090969 6.531 ENSMUST00000119901.1
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr18_+_50053282 6.456 ENSMUST00000148159.2
 Tnfaip8
tumor necrosis factor, alpha-induced protein 8
chr4_+_116708467 6.389 ENSMUST00000030452.6
 Ccdc163
coiled-coil domain containing 163
chr2_-_113848655 5.941 ENSMUST00000102545.1
ENSMUST00000110948.1
 Arhgap11a

Rho GTPase activating protein 11A

chr2_-_113848601 5.489 ENSMUST00000110949.2
 Arhgap11a
Rho GTPase activating protein 11A
chr7_-_70366735 5.461 ENSMUST00000089565.5
 Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr4_+_116708571 5.436 ENSMUST00000106462.2
ENSMUST00000138305.1
ENSMUST00000125671.1
ENSMUST00000130828.1
 Ccdc163



coiled-coil domain containing 163



chr4_+_116708687 4.542 ENSMUST00000135499.1
 Ccdc163
coiled-coil domain containing 163
chr4_+_116708624 4.388 ENSMUST00000106463.1
 Ccdc163
coiled-coil domain containing 163
chr1_+_146497614 4.197 ENSMUST00000132847.1
ENSMUST00000166814.1
 Brinp3

bone morphogenetic protein/retinoic acid inducible neural specific 3

chr17_-_89910449 4.149 ENSMUST00000086423.4
 Gm10184
predicted pseudogene 10184
chr11_-_102579461 3.846 ENSMUST00000107081.1
 Gm11627
predicted gene 11627
chr1_+_146495621 3.409 ENSMUST00000074622.4
 Brinp3
bone morphogenetic protein/retinoic acid inducible neural specific 3
chr15_-_82244716 3.135 ENSMUST00000089155.4
ENSMUST00000089157.3
 Cenpm

centromere protein M


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 10.1 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
3.0 9.1 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
0.3 8.0 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.1 7.6 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.3 7.5 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.7 6.5 GO:0071493 cellular response to UV-B(GO:0071493)
0.1 6.5 GO:0050830 defense response to Gram-positive bacterium(GO:0050830)
1.1 5.5 GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.5 5.3 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.1 4.9 GO:0043029 T cell homeostasis(GO:0043029)
0.4 2.9 GO:0003062 regulation of heart rate by chemical signal(GO:0003062)
0.0 2.9 GO:0019827 stem cell population maintenance(GO:0019827)
0.1 2.3 GO:0007271 synaptic transmission, cholinergic(GO:0007271)
0.4 2.1 GO:0036151 phosphatidylcholine acyl-chain remodeling(GO:0036151)
0.0 2.1 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.5 2.0 GO:2000383 regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384)
0.0 2.0 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.4 1.9 GO:0010701 positive regulation of norepinephrine secretion(GO:0010701) positive regulation of inositol trisphosphate biosynthetic process(GO:0032962)
0.3 1.8 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.1 1.8 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.2 6.5 GO:0070557 PCNA-p21 complex(GO:0070557)
0.4 5.3 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 3.1 GO:0000776 kinetochore(GO:0000776)
0.1 2.2 GO:0016592 mediator complex(GO:0016592)
0.1 2.1 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 2.1 GO:0014069 postsynaptic density(GO:0014069)
0.2 2.0 GO:0045298 tubulin complex(GO:0045298)
0.0 2.0 GO:0016459 myosin complex(GO:0016459)
0.0 1.7 GO:0005884 actin filament(GO:0005884)
0.0 1.4 GO:0005801 cis-Golgi network(GO:0005801)
0.0 1.4 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.3 1.2 GO:1990111 spermatoproteasome complex(GO:1990111)
0.2 1.2 GO:0034750 Scrib-APC-beta-catenin complex(GO:0034750)
0.1 1.2 GO:0005677 chromatin silencing complex(GO:0005677)
0.1 1.1 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.1 1.1 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 1.0 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.6 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 0.6 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 0.5 GO:0031932 TORC2 complex(GO:0031932)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.3 GO:0005096 GTPase activator activity(GO:0005096)
0.1 8.7 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 7.2 GO:0045296 cadherin binding(GO:0045296)
2.2 6.5 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.2 6.5 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.4 5.5 GO:0001972 retinoic acid binding(GO:0001972)
0.9 5.3 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 2.9 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.2 2.6 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.3 2.3 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.7 2.1 GO:0030156 benzodiazepine receptor binding(GO:0030156)
0.0 2.1 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 2.0 GO:0030507 spectrin binding(GO:0030507)
0.1 1.9 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.1 1.9 GO:0004697 protein kinase C activity(GO:0004697)
0.4 1.8 GO:0036468 aromatic-L-amino-acid decarboxylase activity(GO:0004058) L-dopa decarboxylase activity(GO:0036468)
0.1 1.8 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 1.6 GO:0005179 hormone activity(GO:0005179)
0.0 1.5 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 1.4 GO:0019905 syntaxin binding(GO:0019905)

Gene overrepresentation in C2:CP category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.4 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.2 6.8 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.7 6.5 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 5.5 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 5.3 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 2.9 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 2.0 PID_PLK1_PATHWAY PLK1 signaling events
0.0 1.4 PID_BCR_5PATHWAY BCR signaling pathway
0.0 1.3 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.0 1.2 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.0 1.1 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 0.5 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 0.5 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.0 0.3 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.3 PID_IL4_2PATHWAY IL4-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.3 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 10.5 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.4 6.8 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.2 6.5 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.1 5.3 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 3.1 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 2.7 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 2.0 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.2 1.8 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 1.6 REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.0 1.5 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.4 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 1.4 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.2 1.2 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 1.2 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 1.0 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 1.0 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 0.9 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.7 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.1 0.6 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins