Motif ID: T
Z-value: 0.624
Transcription factors associated with T:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| T | ENSMUSG00000062327.4 | T |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 4.7 | GO:0003349 | epicardium-derived cardiac endothelial cell differentiation(GO:0003349) |
| 0.7 | 3.5 | GO:0015871 | choline transport(GO:0015871) |
| 0.7 | 4.0 | GO:0032196 | regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) transposition(GO:0032196) |
| 0.5 | 1.5 | GO:0015866 | ADP transport(GO:0015866) |
| 0.5 | 4.0 | GO:0090074 | negative regulation of protein homodimerization activity(GO:0090074) |
| 0.4 | 1.5 | GO:0048633 | positive regulation of skeletal muscle tissue growth(GO:0048633) |
| 0.3 | 1.3 | GO:0008078 | zygotic determination of anterior/posterior axis, embryo(GO:0007354) mesodermal cell migration(GO:0008078) |
| 0.3 | 3.1 | GO:1903351 | response to dopamine(GO:1903350) cellular response to dopamine(GO:1903351) |
| 0.3 | 0.9 | GO:0002669 | positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913) protein K29-linked ubiquitination(GO:0035519) |
| 0.3 | 0.9 | GO:1902524 | interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of protein K48-linked ubiquitination(GO:1902524) |
| 0.3 | 0.9 | GO:0014063 | negative regulation of serotonin secretion(GO:0014063) |
| 0.3 | 4.5 | GO:0021902 | commitment of neuronal cell to specific neuron type in forebrain(GO:0021902) |
| 0.3 | 3.6 | GO:0061072 | iris morphogenesis(GO:0061072) |
| 0.2 | 0.7 | GO:0048859 | formation of anatomical boundary(GO:0048859) |
| 0.2 | 0.9 | GO:0007066 | female meiosis sister chromatid cohesion(GO:0007066) |
| 0.2 | 0.9 | GO:0060745 | positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335) mammary gland branching involved in pregnancy(GO:0060745) positive regulation of G0 to G1 transition(GO:0070318) |
| 0.2 | 1.0 | GO:0071267 | amino acid salvage(GO:0043102) L-methionine salvage(GO:0071267) |
| 0.2 | 2.4 | GO:0051574 | positive regulation of histone H3-K9 methylation(GO:0051574) |
| 0.2 | 0.9 | GO:0002457 | T cell antigen processing and presentation(GO:0002457) |
| 0.2 | 1.1 | GO:0043569 | negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569) |
| 0.2 | 0.5 | GO:0045004 | DNA replication proofreading(GO:0045004) |
| 0.1 | 0.9 | GO:0051790 | short-chain fatty acid biosynthetic process(GO:0051790) |
| 0.1 | 0.7 | GO:0090070 | positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234) |
| 0.1 | 0.7 | GO:0015074 | DNA integration(GO:0015074) |
| 0.1 | 0.7 | GO:0051987 | positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987) |
| 0.1 | 0.9 | GO:0060575 | intestinal epithelial cell differentiation(GO:0060575) |
| 0.1 | 4.5 | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading(GO:1900026) |
| 0.1 | 1.1 | GO:1902018 | negative regulation of cilium assembly(GO:1902018) |
| 0.1 | 0.7 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 0.1 | 0.7 | GO:1901162 | serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162) |
| 0.1 | 1.5 | GO:1904262 | negative regulation of TORC1 signaling(GO:1904262) |
| 0.1 | 1.8 | GO:0030033 | microvillus assembly(GO:0030033) |
| 0.1 | 1.8 | GO:0021819 | layer formation in cerebral cortex(GO:0021819) |
| 0.1 | 1.9 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.1 | 0.8 | GO:0010826 | negative regulation of centrosome duplication(GO:0010826) negative regulation of centrosome cycle(GO:0046606) |
| 0.1 | 0.2 | GO:0046416 | D-amino acid metabolic process(GO:0046416) |
| 0.1 | 0.7 | GO:2000381 | negative regulation of mesoderm development(GO:2000381) |
| 0.1 | 0.7 | GO:0001672 | regulation of chromatin assembly or disassembly(GO:0001672) |
| 0.1 | 1.0 | GO:0090161 | Golgi ribbon formation(GO:0090161) |
| 0.0 | 0.4 | GO:0034983 | peptidyl-lysine deacetylation(GO:0034983) |
| 0.0 | 0.1 | GO:0031335 | regulation of sulfur amino acid metabolic process(GO:0031335) |
| 0.0 | 0.8 | GO:0070536 | protein K63-linked deubiquitination(GO:0070536) |
| 0.0 | 0.2 | GO:2000643 | positive regulation of early endosome to late endosome transport(GO:2000643) |
| 0.0 | 0.2 | GO:0051256 | mitotic spindle midzone assembly(GO:0051256) |
| 0.0 | 0.8 | GO:0070232 | regulation of T cell apoptotic process(GO:0070232) |
| 0.0 | 1.3 | GO:0032088 | negative regulation of NF-kappaB transcription factor activity(GO:0032088) |
| 0.0 | 0.4 | GO:2000001 | regulation of DNA damage checkpoint(GO:2000001) |
| 0.0 | 0.3 | GO:0042178 | xenobiotic catabolic process(GO:0042178) |
| 0.0 | 0.1 | GO:0001574 | ganglioside biosynthetic process(GO:0001574) |
| 0.0 | 1.0 | GO:0030500 | regulation of bone mineralization(GO:0030500) |
| 0.0 | 0.6 | GO:0051220 | cytoplasmic sequestering of protein(GO:0051220) |
| 0.0 | 0.6 | GO:0061003 | positive regulation of dendritic spine morphogenesis(GO:0061003) |
| 0.0 | 1.5 | GO:0098656 | anion transmembrane transport(GO:0098656) |
| 0.0 | 0.1 | GO:0071763 | nuclear membrane organization(GO:0071763) |
| 0.0 | 1.9 | GO:0030308 | negative regulation of cell growth(GO:0030308) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.5 | GO:0042581 | specific granule(GO:0042581) |
| 0.3 | 0.9 | GO:0000802 | transverse filament(GO:0000802) |
| 0.2 | 1.2 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
| 0.1 | 4.7 | GO:0090544 | BAF-type complex(GO:0090544) |
| 0.1 | 1.3 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.1 | 2.4 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.1 | 1.4 | GO:0097539 | ciliary transition fiber(GO:0097539) |
| 0.1 | 0.5 | GO:0008622 | epsilon DNA polymerase complex(GO:0008622) |
| 0.1 | 0.6 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.1 | 0.7 | GO:0030688 | preribosome, small subunit precursor(GO:0030688) |
| 0.1 | 1.4 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.1 | 0.7 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.0 | 0.8 | GO:0036038 | MKS complex(GO:0036038) |
| 0.0 | 4.5 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 2.2 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 1.0 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
| 0.0 | 0.2 | GO:1990357 | terminal web(GO:1990357) |
| 0.0 | 1.6 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.0 | 2.7 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 2.1 | GO:0005776 | autophagosome(GO:0005776) |
| 0.0 | 0.9 | GO:0016592 | mediator complex(GO:0016592) |
| 0.0 | 3.4 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 4.0 | GO:0047844 | deoxycytidine deaminase activity(GO:0047844) |
| 0.9 | 3.5 | GO:0015220 | choline transmembrane transporter activity(GO:0015220) |
| 0.5 | 1.5 | GO:0004711 | ribosomal protein S6 kinase activity(GO:0004711) |
| 0.4 | 1.1 | GO:0015228 | coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122) |
| 0.3 | 4.0 | GO:0048273 | mitogen-activated protein kinase p38 binding(GO:0048273) |
| 0.2 | 0.7 | GO:0004510 | tryptophan 5-monooxygenase activity(GO:0004510) |
| 0.2 | 1.1 | GO:0008172 | S-methyltransferase activity(GO:0008172) |
| 0.2 | 0.9 | GO:0004315 | 3-oxoacyl-[acyl-carrier-protein] synthase activity(GO:0004315) |
| 0.2 | 0.9 | GO:0036033 | mediator complex binding(GO:0036033) |
| 0.2 | 1.2 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
| 0.2 | 0.5 | GO:0008310 | single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310) |
| 0.1 | 0.7 | GO:0043515 | kinetochore binding(GO:0043515) |
| 0.1 | 0.9 | GO:0032453 | histone demethylase activity (H3-K4 specific)(GO:0032453) |
| 0.1 | 1.5 | GO:0005225 | volume-sensitive anion channel activity(GO:0005225) |
| 0.1 | 0.9 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.1 | 0.9 | GO:0008227 | G-protein coupled amine receptor activity(GO:0008227) |
| 0.1 | 1.4 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.1 | 2.4 | GO:0032452 | histone demethylase activity(GO:0032452) |
| 0.1 | 0.2 | GO:0036361 | racemase and epimerase activity, acting on amino acids and derivatives(GO:0016855) racemase activity, acting on amino acids and derivatives(GO:0036361) amino-acid racemase activity(GO:0047661) |
| 0.1 | 0.8 | GO:0031005 | filamin binding(GO:0031005) |
| 0.0 | 1.9 | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity(GO:0003755) |
| 0.0 | 0.1 | GO:0016206 | catechol O-methyltransferase activity(GO:0016206) |
| 0.0 | 0.8 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.0 | 0.4 | GO:0031078 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
| 0.0 | 3.1 | GO:0033613 | activating transcription factor binding(GO:0033613) |
| 0.0 | 0.5 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.0 | 5.3 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 0.2 | GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629) |
| 0.0 | 0.8 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.0 | 1.9 | GO:0019905 | syntaxin binding(GO:0019905) |
| 0.0 | 0.1 | GO:0001665 | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665) |
| 0.0 | 0.9 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.0 | 0.7 | GO:0005160 | transforming growth factor beta receptor binding(GO:0005160) |
| 0.0 | 1.3 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.0 | 9.4 | GO:0003682 | chromatin binding(GO:0003682) |
| 0.0 | 1.9 | GO:0003774 | motor activity(GO:0003774) |
| 0.0 | 0.1 | GO:0043423 | 3-phosphoinositide-dependent protein kinase binding(GO:0043423) |
| 0.0 | 4.5 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.0 | 2.2 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.0 | 0.3 | GO:1900750 | glutathione binding(GO:0043295) oligopeptide binding(GO:1900750) |
| 0.0 | 0.5 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.0 | PID_ARF6_TRAFFICKING_PATHWAY | Arf6 trafficking events |
| 0.1 | 2.3 | PID_RXR_VDR_PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 1.8 | PID_LIS1_PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 1.4 | PID_ER_NONGENOMIC_PATHWAY | Plasma membrane estrogen receptor signaling |
| 0.0 | 1.3 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 1.3 | PID_ECADHERIN_NASCENT_AJ_PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 0.9 | PID_NFAT_TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 0.4 | PID_HDAC_CLASSIII_PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 0.7 | PID_PLK1_PATHWAY | PLK1 signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.5 | REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS | Genes involved in Amine compound SLC transporters |
| 0.1 | 1.5 | REACTOME_MTORC1_MEDIATED_SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.1 | 0.9 | REACTOME_AMINE_LIGAND_BINDING_RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.1 | 0.7 | REACTOME_AMINE_DERIVED_HORMONES | Genes involved in Amine-derived hormones |
| 0.0 | 1.3 | REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.0 | 0.5 | REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER | Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER |
| 0.0 | 0.9 | REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.0 | 2.5 | REACTOME_L1CAM_INTERACTIONS | Genes involved in L1CAM interactions |
| 0.0 | 0.9 | REACTOME_MEIOTIC_SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.0 | 0.2 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.0 | 0.3 | REACTOME_GLUTATHIONE_CONJUGATION | Genes involved in Glutathione conjugation |
