Motif ID: Taf1

Z-value: 3.780


Transcription factors associated with Taf1:

Gene SymbolEntrez IDGene Name
Taf1 ENSMUSG00000031314.11 Taf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Taf1mm10_v2_chrX_+_101532734_1015327770.765.9e-16Click!


Activity profile for motif Taf1.

activity profile for motif Taf1


Sorted Z-values histogram for motif Taf1

Sorted Z-values for motif Taf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Taf1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_119047116 38.782 ENSMUST00000152380.1
ENSMUST00000099542.2
Casc5

cancer susceptibility candidate 5

chr2_+_119047129 33.549 ENSMUST00000153300.1
ENSMUST00000028799.5
Casc5

cancer susceptibility candidate 5

chr5_-_123749393 33.267 ENSMUST00000057795.5
ENSMUST00000111515.1
ENSMUST00000182309.1
Rsrc2


arginine/serine-rich coiled-coil 2


chr5_-_123749371 32.891 ENSMUST00000182955.1
ENSMUST00000182489.1
ENSMUST00000050827.7
Rsrc2


arginine/serine-rich coiled-coil 2


chr3_+_69004969 31.401 ENSMUST00000136502.1
ENSMUST00000107803.1
Smc4

structural maintenance of chromosomes 4

chr3_+_69004711 29.711 ENSMUST00000042901.8
Smc4
structural maintenance of chromosomes 4
chr10_+_79854618 25.877 ENSMUST00000165704.1
Ptbp1
polypyrimidine tract binding protein 1
chr7_+_59228743 24.770 ENSMUST00000107537.1
Ube3a
ubiquitin protein ligase E3A
chr10_+_79854658 22.463 ENSMUST00000171599.1
ENSMUST00000095457.4
Ptbp1

polypyrimidine tract binding protein 1

chr9_+_80067452 21.087 ENSMUST00000165607.2
Senp6
SUMO/sentrin specific peptidase 6
chr5_+_23434435 20.558 ENSMUST00000094962.2
ENSMUST00000115128.1
Kmt2e

lysine (K)-specific methyltransferase 2E

chr6_+_38433913 20.466 ENSMUST00000160583.1
Ubn2
ubinuclein 2
chr12_-_101083653 20.422 ENSMUST00000048305.8
ENSMUST00000163095.1
Smek1

SMEK homolog 1, suppressor of mek1 (Dictyostelium)

chrX_-_103483205 20.274 ENSMUST00000127786.2
Xist
inactive X specific transcripts
chr19_+_34922351 19.026 ENSMUST00000087341.5
Kif20b
kinesin family member 20B
chr12_+_83632208 18.075 ENSMUST00000048155.9
ENSMUST00000182618.1
ENSMUST00000183154.1
ENSMUST00000182036.1
ENSMUST00000182347.1
Rbm25




RNA binding motif protein 25




chr7_+_123123870 17.870 ENSMUST00000094053.5
Tnrc6a
trinucleotide repeat containing 6a
chrX_-_103981242 17.624 ENSMUST00000121153.1
ENSMUST00000070705.4
Rlim

ring finger protein, LIM domain interacting

chr3_-_84220853 17.538 ENSMUST00000154152.1
ENSMUST00000107693.2
ENSMUST00000107695.2
Trim2


tripartite motif-containing 2


chr18_-_6241486 17.367 ENSMUST00000025083.7
Kif5b
kinesin family member 5B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 454 entries
Log-likelihood per target Total log-likelihoodTermDescription
7.6 61.1 GO:0010032 meiotic chromosome condensation(GO:0010032)
5.3 53.1 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
0.2 48.4 GO:0006397 mRNA processing(GO:0006397)
4.5 45.4 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
8.8 44.1 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.9 38.2 GO:0006376 mRNA splice site selection(GO:0006376)
0.3 37.0 GO:0043484 regulation of RNA splicing(GO:0043484)
2.6 35.9 GO:0060009 Sertoli cell development(GO:0060009)
3.1 34.1 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
4.8 33.9 GO:0090234 regulation of kinetochore assembly(GO:0090234)
6.7 33.3 GO:0034421 post-translational protein acetylation(GO:0034421)
3.3 33.0 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
6.3 31.3 GO:2001032 regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.2 30.9 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
7.5 29.9 GO:0097393 post-embryonic appendage morphogenesis(GO:0035120) post-embryonic limb morphogenesis(GO:0035127) post-embryonic forelimb morphogenesis(GO:0035128) telomeric repeat-containing RNA transcription(GO:0097393) telomeric repeat-containing RNA transcription from RNA pol II promoter(GO:0097394) regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901580) negative regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901581) positive regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901582)
5.8 28.9 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
1.1 28.7 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
7.1 28.3 GO:0070829 heterochromatin maintenance(GO:0070829)
1.9 26.5 GO:0045974 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.9 24.9 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 224 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 87.0 GO:0005654 nucleoplasm(GO:0005654)
0.2 83.6 GO:0016604 nuclear body(GO:0016604)
0.2 74.4 GO:0000785 chromatin(GO:0000785)
6.1 61.1 GO:0000796 condensin complex(GO:0000796)
0.3 51.8 GO:0000775 chromosome, centromeric region(GO:0000775)
0.8 44.4 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.5 40.2 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
1.9 39.0 GO:0035253 ciliary rootlet(GO:0035253)
0.2 33.9 GO:0005815 microtubule organizing center(GO:0005815)
0.2 33.8 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
1.1 31.7 GO:0030992 intraciliary transport particle B(GO:0030992)
5.1 30.8 GO:0098536 deuterosome(GO:0098536)
1.8 30.3 GO:0097431 mitotic spindle pole(GO:0097431)
7.5 29.9 GO:1990421 subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707)
1.4 28.7 GO:0016580 Sin3 complex(GO:0016580)
3.8 26.8 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.8 26.5 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
2.6 25.5 GO:0000805 X chromosome(GO:0000805)
0.3 24.7 GO:0005681 spliceosomal complex(GO:0005681)
0.4 24.4 GO:0000922 spindle pole(GO:0000922)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 256 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 119.4 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 99.6 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.3 92.6 GO:0061659 ubiquitin-like protein ligase activity(GO:0061659)
0.2 90.8 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.3 57.9 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
9.3 55.8 GO:0001069 regulatory region RNA binding(GO:0001069)
0.1 54.4 GO:0003677 DNA binding(GO:0003677)
0.7 53.8 GO:0003777 microtubule motor activity(GO:0003777)
0.8 51.4 GO:0034212 peptide N-acetyltransferase activity(GO:0034212)
0.9 46.9 GO:0070063 RNA polymerase binding(GO:0070063)
0.2 43.0 GO:0008017 microtubule binding(GO:0008017)
0.8 42.7 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.4 42.3 GO:0003697 single-stranded DNA binding(GO:0003697)
1.1 39.4 GO:0017091 AU-rich element binding(GO:0017091)
1.7 38.0 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
4.9 34.1 GO:0099609 microtubule lateral binding(GO:0099609)
2.6 33.9 GO:0016929 SUMO-specific protease activity(GO:0016929)
4.8 33.7 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.6 30.1 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
4.3 29.9 GO:0015616 DNA translocase activity(GO:0015616)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.2 107.9 PID_AURORA_B_PATHWAY Aurora B signaling
1.0 61.5 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.7 60.0 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.8 34.9 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.7 30.3 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.5 28.7 PID_PLK1_PATHWAY PLK1 signaling events
0.7 27.5 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.7 25.1 ST_P38_MAPK_PATHWAY p38 MAPK Pathway
0.7 21.9 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.9 21.3 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.9 20.4 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
1.4 19.4 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.4 18.3 PID_TCPTP_PATHWAY Signaling events mediated by TCPTP
0.7 18.2 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.1 17.2 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.7 17.0 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.4 16.7 PID_ATM_PATHWAY ATM pathway
0.4 15.0 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.2 10.7 PID_E2F_PATHWAY E2F transcription factor network
0.6 9.0 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 102 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 99.5 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
2.7 73.0 REACTOME_KINESINS Genes involved in Kinesins
1.3 69.7 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_RAS Genes involved in CREB phosphorylation through the activation of Ras
1.3 54.8 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
1.6 47.8 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.5 46.3 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.5 36.2 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.8 34.1 REACTOME_RNA_POL_III_TRANSCRIPTION Genes involved in RNA Polymerase III Transcription
1.0 31.9 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
1.7 29.7 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.7 28.6 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
1.4 24.2 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs
1.5 21.1 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.3 18.1 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.7 17.6 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.5 15.9 REACTOME_REGULATION_OF_SIGNALING_BY_CBL Genes involved in Regulation of signaling by CBL
0.5 14.9 REACTOME_TRANSPORT_OF_RIBONUCLEOPROTEINS_INTO_THE_HOST_NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.8 14.5 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.3 14.1 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.6 13.6 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism