Motif ID: Tal1

Z-value: 0.778


Transcription factors associated with Tal1:

Gene SymbolEntrez IDGene Name
Tal1 ENSMUSG00000028717.6 Tal1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tal1mm10_v2_chr4_+_115059507_1150595530.208.6e-02Click!


Activity profile for motif Tal1.

activity profile for motif Tal1


Sorted Z-values histogram for motif Tal1

Sorted Z-values for motif Tal1



Network of associatons between targets according to the STRING database.



First level regulatory network of Tal1

PNG image of the network

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Top targets:


Showing 1 to 20 of 165 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_103853199 15.275 ENSMUST00000033229.3
 Hbb-y
hemoglobin Y, beta-like embryonic chain
chr11_+_32276400 8.096 ENSMUST00000020531.2
 Hba-x
hemoglobin X, alpha-like embryonic chain in Hba complex
chr11_+_32276893 7.514 ENSMUST00000145569.1
 Hba-x
hemoglobin X, alpha-like embryonic chain in Hba complex
chr2_+_180499893 6.482 ENSMUST00000029084.2
 Ntsr1
neurotensin receptor 1
chr8_-_71511762 5.309 ENSMUST00000048452.4
 Plvap
plasmalemma vesicle associated protein
chr17_-_29237759 3.586 ENSMUST00000137727.1
ENSMUST00000024805.7
 Cpne5

copine V

chr16_-_18621366 3.580 ENSMUST00000051160.2
 Gp1bb
glycoprotein Ib, beta polypeptide
chr8_-_125898291 3.521 ENSMUST00000047239.6
 Pcnxl2
pecanex-like 2 (Drosophila)
chr19_+_42247544 3.267 ENSMUST00000122375.1
 Golga7b
golgi autoantigen, golgin subfamily a, 7B
chr6_-_72235559 3.195 ENSMUST00000042646.7
 Atoh8
atonal homolog 8 (Drosophila)
chr6_+_17306335 3.179 ENSMUST00000007799.6
ENSMUST00000115456.1
ENSMUST00000115455.2
ENSMUST00000130505.1
 Cav1



caveolin 1, caveolae protein



chr10_+_116177351 3.099 ENSMUST00000155606.1
ENSMUST00000128399.1
 Ptprr

protein tyrosine phosphatase, receptor type, R

chr10_+_97565436 2.911 ENSMUST00000038160.4
 Lum
lumican
chr5_-_5265224 2.897 ENSMUST00000115450.1
 Cdk14
cyclin-dependent kinase 14
chr7_+_119900099 2.827 ENSMUST00000106516.1
 Lyrm1
LYR motif containing 1
chr8_-_77517898 2.724 ENSMUST00000076316.4
 Arhgap10
Rho GTPase activating protein 10
chr10_-_11082287 2.622 ENSMUST00000105561.2
ENSMUST00000044306.6
 Grm1

glutamate receptor, metabotropic 1

chr1_+_169969409 2.443 ENSMUST00000180638.1
 3110045C21Rik
RIKEN cDNA 3110045C21 gene
chr8_-_36732897 2.437 ENSMUST00000098826.3
 Dlc1
deleted in liver cancer 1
chr9_+_57998036 2.384 ENSMUST00000181289.1
 Gm17322
predicted gene, 17322

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 80 entries
Log-likelihood per target Total log-likelihoodTermDescription
6.2 30.9 GO:0015671 oxygen transport(GO:0015671)
1.6 6.5 GO:0090238 positive regulation of arachidonic acid secretion(GO:0090238)
0.4 5.3 GO:0002693 positive regulation of cellular extravasation(GO:0002693)
0.9 4.5 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
0.0 3.7 GO:0007596 blood coagulation(GO:0007596)
0.1 3.6 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.3 3.3 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.2 3.3 GO:0034390 smooth muscle cell apoptotic process(GO:0034390) regulation of smooth muscle cell apoptotic process(GO:0034391)
0.8 3.2 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.2 3.2 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.8 3.1 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.1 3.0 GO:0042832 defense response to protozoan(GO:0042832)
0.7 2.6 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.2 2.4 GO:0007202 activation of phospholipase C activity(GO:0007202) positive regulation of execution phase of apoptosis(GO:1900119)
0.8 2.3 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.2 2.2 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.0 2.1 GO:0000086 G2/M transition of mitotic cell cycle(GO:0000086)
0.3 2.0 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.3 1.9 GO:1990416 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.2 1.7 GO:0051461 protein import into peroxisome matrix, docking(GO:0016560) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.9 30.9 GO:0005833 hemoglobin complex(GO:0005833)
0.1 9.4 GO:0005901 caveola(GO:0005901)
1.6 6.5 GO:0032280 symmetric synapse(GO:0032280)
0.3 4.5 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.3 3.3 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.3 3.2 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
0.6 2.9 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.3 2.9 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.2 2.8 GO:0071437 invadopodium(GO:0071437)
0.0 2.8 GO:0030496 midbody(GO:0030496)
0.2 2.6 GO:0038037 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
0.2 2.2 GO:0008290 F-actin capping protein complex(GO:0008290)
0.1 1.9 GO:0031209 SCAR complex(GO:0031209)
0.4 1.7 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.5 1.6 GO:0005584 collagen type I trimer(GO:0005584)
0.1 1.6 GO:0031143 pseudopodium(GO:0031143)
0.4 1.5 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.1 1.5 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 1.5 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.4 1.3 GO:1990075 kinesin II complex(GO:0016939) periciliary membrane compartment(GO:1990075)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
6.2 30.9 GO:0005344 oxygen transporter activity(GO:0005344)
0.3 6.5 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.1 5.2 GO:0005518 collagen binding(GO:0005518)
0.9 4.5 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.1 3.3 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.5 3.2 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 3.1 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 2.9 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin binding(GO:0030332)
0.7 2.6 GO:0001639 PLC activating G-protein coupled glutamate receptor activity(GO:0001639) G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.1 2.4 GO:0017166 vinculin binding(GO:0017166)
0.0 2.0 GO:0001540 beta-amyloid binding(GO:0001540)
0.6 1.8 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 1.8 GO:0070888 E-box binding(GO:0070888)
0.3 1.7 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.1 1.7 GO:0045499 chemorepellent activity(GO:0045499)
0.3 1.6 GO:0008865 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.3 1.6 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.3 1.6 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.1 1.6 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.5 1.5 GO:0008502 melatonin receptor activity(GO:0008502)

Gene overrepresentation in C2:CP category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.9 PID_ALK1_PATHWAY ALK1 signaling events
0.1 2.9 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 2.3 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.0 2.0 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.0 1.9 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.8 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 1.6 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.5 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.4 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.3 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 1.2 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 1.1 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.0 0.8 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.1 0.5 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.5 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 0.3 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.3 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 4.9 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 4.8 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.2 4.5 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 3.4 REACTOME_REGULATION_OF_APOPTOSIS Genes involved in Regulation of Apoptosis
0.1 3.2 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.3 2.9 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.1 2.9 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 2.6 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 2.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.2 2.3 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 2.0 REACTOME_INTERFERON_GAMMA_SIGNALING Genes involved in Interferon gamma signaling
0.1 1.7 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.4 1.6 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.0 1.6 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.0 1.5 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 1.4 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 1.3 REACTOME_KINESINS Genes involved in Kinesins
0.0 1.3 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 1.2 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.1 1.2 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins