Motif ID: Tbp

Z-value: 2.213


Transcription factors associated with Tbp:

Gene SymbolEntrez IDGene Name
Tbp ENSMUSG00000014767.10 Tbp

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tbpmm10_v2_chr17_+_15499888_15499960-0.462.4e-05Click!


Activity profile for motif Tbp.

activity profile for motif Tbp


Sorted Z-values histogram for motif Tbp

Sorted Z-values for motif Tbp



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbp

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_87948666 21.852 ENSMUST00000005019.5
 Crabp2
cellular retinoic acid binding protein II
chr8_-_110168204 17.747 ENSMUST00000003754.6
 Calb2
calbindin 2
chr1_-_171196229 17.225 ENSMUST00000111332.1
 Pcp4l1
Purkinje cell protein 4-like 1
chr7_-_103853199 16.597 ENSMUST00000033229.3
 Hbb-y
hemoglobin Y, beta-like embryonic chain
chr15_+_3270767 13.968 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr1_-_138842429 13.657 ENSMUST00000112026.2
ENSMUST00000019374.7
 Lhx9

LIM homeobox protein 9

chr13_+_21717626 13.452 ENSMUST00000091754.2
 Hist1h3h
histone cluster 1, H3h
chr16_+_91225550 12.396 ENSMUST00000035608.8
 Olig2
oligodendrocyte transcription factor 2
chr13_-_23622502 12.115 ENSMUST00000062045.2
 Hist1h1e
histone cluster 1, H1e
chr12_+_85473883 11.831 ENSMUST00000021674.6
 Fos
FBJ osteosarcoma oncogene
chr2_-_164857542 11.707 ENSMUST00000109316.1
ENSMUST00000156255.1
ENSMUST00000128110.1
ENSMUST00000109317.3
 Pltp



phospholipid transfer protein



chr4_+_136143497 10.877 ENSMUST00000008016.2
 Id3
inhibitor of DNA binding 3
chr7_-_142899985 10.819 ENSMUST00000000219.3
 Th
tyrosine hydroxylase
chr1_+_109993982 10.290 ENSMUST00000027542.6
 Cdh7
cadherin 7, type 2
chr5_+_135887905 10.230 ENSMUST00000005077.6
 Hspb1
heat shock protein 1
chr13_+_23581563 9.400 ENSMUST00000102968.1
 Hist1h4d
histone cluster 1, H4d
chr13_-_21780616 8.680 ENSMUST00000080511.2
 Hist1h1b
histone cluster 1, H1b
chr6_-_136875794 8.601 ENSMUST00000032342.1
 Mgp
matrix Gla protein
chr5_+_135887988 8.576 ENSMUST00000111155.1
 Hspb1
heat shock protein 1
chr2_-_93957040 8.508 ENSMUST00000148314.2
 Gm13889
predicted gene 13889

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 148 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 52.0 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.4 28.2 GO:0006334 nucleosome assembly(GO:0006334)
4.9 24.4 GO:0015671 oxygen transport(GO:0015671)
1.7 21.9 GO:0042573 retinoic acid metabolic process(GO:0042573)
3.1 18.8 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
1.4 16.3 GO:0002227 innate immune response in mucosa(GO:0002227)
1.7 15.2 GO:0002536 respiratory burst involved in inflammatory response(GO:0002536)
2.0 14.0 GO:0016584 nucleosome positioning(GO:0016584)
2.7 13.7 GO:0035262 gonad morphogenesis(GO:0035262)
0.9 13.7 GO:0019430 removal of superoxide radicals(GO:0019430)
0.8 13.6 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.7 13.2 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.1 12.9 GO:0006342 chromatin silencing(GO:0006342)
0.1 12.9 GO:0051480 regulation of cytosolic calcium ion concentration(GO:0051480)
4.1 12.4 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
2.9 11.7 GO:0042360 vitamin E metabolic process(GO:0042360)
2.7 10.8 GO:0042414 epinephrine metabolic process(GO:0042414)
0.6 10.1 GO:0035994 response to muscle stretch(GO:0035994)
0.5 9.9 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
1.4 8.7 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.2 74.2 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 69.9 GO:0005615 extracellular space(GO:0005615)
0.0 65.5 GO:0005634 nucleus(GO:0005634)
0.9 32.8 GO:0000786 nucleosome(GO:0000786)
4.0 31.8 GO:0005833 hemoglobin complex(GO:0005833)
0.5 25.4 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
3.1 18.8 GO:0097512 cardiac myofibril(GO:0097512)
0.7 17.0 GO:0005921 gap junction(GO:0005921)
0.0 14.3 GO:0005667 transcription factor complex(GO:0005667)
0.2 13.6 GO:0005871 kinesin complex(GO:0005871)
0.5 12.2 GO:0005680 anaphase-promoting complex(GO:0005680)
2.4 11.8 GO:0035976 AP1 complex(GO:0035976)
0.5 11.4 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
3.6 10.8 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.1 9.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 9.1 GO:0000776 kinetochore(GO:0000776)
1.4 8.7 GO:0032299 ribonuclease H2 complex(GO:0032299)
2.7 8.1 GO:0036488 CHOP-C/EBP complex(GO:0036488)
2.6 7.9 GO:0005584 collagen type I trimer(GO:0005584)
0.0 7.7 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 110 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 54.0 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 46.0 GO:0003677 DNA binding(GO:0003677)
7.9 31.8 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.2 27.0 GO:0003735 structural constituent of ribosome(GO:0003735)
2.7 26.6 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
3.6 21.9 GO:0019841 retinol binding(GO:0019841)
0.6 18.8 GO:0044183 protein binding involved in protein folding(GO:0044183)
2.1 18.5 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 16.6 GO:0042393 histone binding(GO:0042393)
0.0 15.6 GO:0005509 calcium ion binding(GO:0005509)
0.2 13.6 GO:0003777 microtubule motor activity(GO:0003777)
0.4 12.4 GO:0071837 HMG box domain binding(GO:0071837)
0.6 12.1 GO:0016208 AMP binding(GO:0016208)
0.4 11.8 GO:0070412 R-SMAD binding(GO:0070412)
0.3 10.9 GO:0005504 fatty acid binding(GO:0005504)
2.2 10.8 GO:0035240 dopamine binding(GO:0035240)
0.0 10.7 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 10.3 GO:0008201 heparin binding(GO:0008201)
1.2 8.7 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.3 8.6 GO:0005201 extracellular matrix structural constituent(GO:0005201)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 29.6 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.3 24.3 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.4 19.6 PID_AURORA_B_PATHWAY Aurora B signaling
0.4 13.8 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.7 11.8 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.4 11.6 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.6 9.1 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.3 8.7 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.2 8.1 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.2 8.0 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.3 7.9 PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium
0.2 7.8 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.3 6.8 PID_IL3_PATHWAY IL3-mediated signaling events
0.3 6.2 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.2 5.0 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.2 4.9 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.2 4.4 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.1 4.3 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.2 4.1 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.2 4.1 PID_AURORA_A_PATHWAY Aurora A signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 94.7 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
1.9 29.8 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.5 25.4 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.3 20.3 REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.1 16.4 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.5 13.6 REACTOME_KINESINS Genes involved in Kinesins
0.2 13.0 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.7 11.8 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.9 11.7 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
1.0 10.8 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.3 10.3 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.4 10.2 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.6 7.9 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.3 7.6 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 6.9 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.1 6.3 REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE Genes involved in Late Phase of HIV Life Cycle
0.0 6.3 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
1.2 6.2 REACTOME_ANDROGEN_BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.4 5.9 REACTOME_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC_C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.6 5.0 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters